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Professor Waldemar Vollmer
Professor

Waldemar Vollmer

Email: 
Phone: 
+61 7 334 62055

Overview

Background

Overview

Professor Waldemar Vollmer is a microbiologist working on the structure and biogenesis of the bacterial cell wall in various model bacteria and a range of pathogenic and environmental bacteria. He is particularly interested in how bacteria enlarge their cell wall when they grow and divide, and how antibiotics inhibit cell wall synthesis to kill bacteria. Antimicrobial resistance (AMR) is a global problem that is predicted to claim 10 million lives annually by the year 2050 if no new antibiotics are developed. Currently the pipeline of antibiotic development is almost empty and mostly limited to slightly modified versions to existing antibiotics. Professor Vollmer addresses the problem of AMR by generating tailored assays for the development of novel antibiotics that target AMR bacteria.

Collaborations: Professor Vollmer collaborates world-wide with more than 50 researchers at top national and international institutions on cell wall topics in over 30 different bacteria. These topics include: structure and composition of the cell wall and its role in maintaining cell morphology; molecular mechanisms of cell envelope biogenesis; role of new cell wall modifying enzymes in the interaction of pathogenic bacteria with components of the immune system; mechanisms of antibiotic resistance and targeting of cell wall biogenesis by new antibiotics.

Funding and Publications: Professor Vollmer has been awarded more than $15 million funding from research councils and charities in Germany, UK, Europe and USA. He has published more than 200 articles in international journals and has been recognised as a Highly Cited Researcher in Microbiology.

Honours and Awards: Professor Vollmer has been elected to Fellow of the American Academy of Microbiology (2014) and European Academy of Microbiology (2018). He received the annual Academic Distinction Awards from the Vice Chancellor of Newcastle University (2014), has been awarded a Distinguished Scientist Visiting Scholarships at Ben-Gurion University of the Negev (Israel, 2012) and a Visiting Professorship at the University of Cagliari (Italy, 2015), and won a Wellcome Trust Senior Investigator Award (2014). He has co-organised the 2018 Gordon Conference (GRC) "Bacterial Cell Surfaces" (Mt Snow, USA) and the 2016 EMBO Workshop "Bacterial Cell Division: Orchestrating the Ring Cycle" (Prague, Czech Republic).

Short Biography: Prof Waldemar Vollmer has studied chemistry at the University of Applied Sciences in Reutlingen (Germany) and University of Basel (Switzerland). In 1998 he obtained a PhD degree (Dr.rer.nat.) from the University of Tübingen (Germany) for his work on cell wall synthesis in the model bacterium Escherichia coli undertaken at the Max Planck Institute for Developmental Biology. During his postdoctoral studies at the Rockefeller University (New York, USA) he discovered novel cell wall enzymes that are crucial for the virulence of the pathogenic bacterium Streptococcus pneumoiae. In 2003 he was appointed Assistant Professor at the University of Tübingen and moved 2007 to the Centre for Bacterial Cell Biology at Newcastle University (UK), where he worked as Professor of Bacterial Biochemistry on various bacterial cell wall topics in a range of different bacteria. Since April 2023 he is Professorial Research Fellow and Group Leader at the Centre for Superbug Solutions, Institute for Molecular Bioscience (IMB) at the University of Queensland.

Availability

Professor Waldemar Vollmer is:
Available for supervision

Fields of research

Research impacts

Professor Vollmer's basic research on the bacterial cell envelope has led to key advances in our understanding of bacterial cell function and has discovered molecular mechanisms that can be exploited for antibiotic development.

Key research outputs: Prof Vollmer's group has discovered mechanisms of PG biosynthesis and its regulation, novel cell wall enzymes, and mechanisms of coordination between PG synthesis and outer membrane biogenesis. These discoveries provided the first molecular insights into how bacteria robustly maintain, enlarge and modify their cell envelope when they propagate in diverse environments and under stress conditions, and when exposed to antibiotics.

Key capabilities: Prof Vollmer's group is expert in the analysis of the composition of peptidoglycan, the key shape-maintaining and stress-bearing component of the bacterial cell envelope. They also discover new cell wall enzymes and study the activities and interactions of of key cell wall synthases and hydrolases (lysins or autolysins). They are also expert in determining the cleavage site of cell wall-degrading lysins and establishing biochemical assays for cell wall enzymes, for studying their inhibition by antibiotics. They combine their molecular biology work with studies on the physiology of bacterial cells impaired in cell wall biogenesis.

Works

Search Professor Waldemar Vollmer’s works on UQ eSpace

239 works between 1993 and 2024

41 - 60 of 239 works

2022

Journal Article

Slippery liquid-like solid surfaces with promising antibiofilm performance under both static and flow conditions

Zhu, Yufeng, McHale, Glen, Dawson, Jack, Armstrong, Steven, Wells, Gary, Han, Rui, Liu, Hongzhong, Vollmer, Waldemar, Stoodley, Paul, Jakubovics, Nicholas and Chen, Jinju (2022). Slippery liquid-like solid surfaces with promising antibiofilm performance under both static and flow conditions. ACS Applied Materials and Interfaces, 14 (5), 6307-6319. doi: 10.1021/acsami.1c14533

Slippery liquid-like solid surfaces with promising antibiofilm performance under both static and flow conditions

2021

Journal Article

Commensal Streptococcus mitis produces two different lipoteichoic acids of type I and type IV

Gisch, Nicolas, Peters, Katharina, Thomsen, Simone, Vollmer, Waldemar, Schwudke, Dominik and Denapaite, Dalia (2021). Commensal Streptococcus mitis produces two different lipoteichoic acids of type I and type IV. Glycobiology, 31 (12), 1655-1669. doi: 10.1093/glycob/cwab079

Commensal Streptococcus mitis produces two different lipoteichoic acids of type I and type IV

2021

Journal Article

Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth

Goodall, Emily C. A., Isom, Georgia L., Rooke, Jessica L., Pullela, Karthik, Icke, Christopher, Yang, Zihao, Boelter, Gabriela, Jones, Alun, Warner, Isabel, Da Costa, Rochelle, Zhang, Bing, Rae, James, Tan, Wee Boon, Winkle, Matthias, Delhaye, Antoine, Heinz, Eva, Collet, Jean-Francois, Cunningham, Adam F., Blaskovich, Mark A., Parton, Robert G., Cole, Jeff A., Banzhaf, Manuel, Chng, Shu-Sin, Vollmer, Waldemar, Bryant, Jack A. and Henderson, Ian R. (2021). Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth. PLoS Genetics, 17 (12) e1009586, 1-40. doi: 10.1371/journal.pgen.1009586

Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth

2021

Journal Article

Lytic transglycosylase MltG cleaves in nascent peptidoglycan and produces short glycan strands

Sassine, Jad, Pazos, Manuel, Breukink, Eefjan and Vollmer, Waldemar (2021). Lytic transglycosylase MltG cleaves in nascent peptidoglycan and produces short glycan strands. The Cell Surface, 7 100053, 1-9. doi: 10.1016/j.tcsw.2021.100053

Lytic transglycosylase MltG cleaves in nascent peptidoglycan and produces short glycan strands

2021

Journal Article

Role of endopeptidases in peptidoglycan synthesis mediated by alternative cross-linking enzymes in Escherichia coli

Voedts, Henri, Dorchene, Delphine, Lodge, Adam, Vollmer, Waldemar, Arthur, Michel and Hugonnet, Jean-Emmanuel (2021). Role of endopeptidases in peptidoglycan synthesis mediated by alternative cross-linking enzymes in Escherichia coli. The EMBO Journal, 40 (19) e108126, 1-19. doi: 10.15252/embj.2021108126

Role of endopeptidases in peptidoglycan synthesis mediated by alternative cross-linking enzymes in Escherichia coli

2021

Journal Article

Combining cell envelope stress reporter assays in a screening approach to identify BAM complex inhibitors

Steenhuis, Maurice, Corona, Federico, Ten Hagen-Jongman, Corinne M., Vollmer, Waldemar, Lambin, Dominique, Selhorst, Philippe, Klaassen, Hugo, Versele, Matthias, Chaltin, Patrick and Luirink, Joen (2021). Combining cell envelope stress reporter assays in a screening approach to identify BAM complex inhibitors. ACS Infectious Diseases, 7 (8), 2250-2263. doi: 10.1021/acsinfecdis.0c00728

Combining cell envelope stress reporter assays in a screening approach to identify BAM complex inhibitors

2021

Journal Article

DpaA detaches Braun’s lipoprotein from peptidoglycan

Winkle, Matthias, Hernández-Rocamora, Víctor M., Pullela, Karthik, Goodall, Emily C. A., Martorana, Alessandra M., Gray, Joe, Henderson, Ian R., Polissi, Alessandra and Vollmer, Waldemar (2021). DpaA detaches Braun’s lipoprotein from peptidoglycan. mBio, 12 (3) e00836-21. doi: 10.1128/mbio.00836-21

DpaA detaches Braun’s lipoprotein from peptidoglycan

2021

Journal Article

Discovery of Pyrrolidine-2,3-diones as novel inhibitors of P. aeruginosa PBP3

Lopez-Perez, Arancha, Freischem, Stefan, Grimm, Immanuel, Weiergraeber, Oliver, Dingley, Andrew J., Lopez-Alberca, Maria Pascual, Waldmann, Herbert, Vollmer, Waldemar, Kumar, Kamal and Vuong, Cuong (2021). Discovery of Pyrrolidine-2,3-diones as novel inhibitors of P. aeruginosa PBP3. Antibiotics, 10 (5), 1-18. doi: 10.3390/antibiotics10050529

Discovery of Pyrrolidine-2,3-diones as novel inhibitors of P. aeruginosa PBP3

2021

Journal Article

The active repertoire of Escherichia coli peptidoglycan amidases varies with physiochemical environment

Mueller, Elizabeth A., Iken, Abbygail G., Oeztuerk, Mehmet Ali, Winkle, Matthias, Schmitz, Mirko, Vollmer, Waldemar, Di Ventura, Barbara and Levin, Petra Anne (2021). The active repertoire of Escherichia coli peptidoglycan amidases varies with physiochemical environment. Molecular Microbiology, 116 (1) mmi.14711, 311-328. doi: 10.1111/mmi.14711

The active repertoire of Escherichia coli peptidoglycan amidases varies with physiochemical environment

2021

Journal Article

Localizing peptidoglycan synthesis in Helicobacter pylori using vlickable metabolic probes

Taylor, Jennifer A., Santiago, Cintia C., Gray, Joe, Wodzanowski, Kimberly A., DeMeester, Kristen E., Biboy, Jacob, Vollmer, Waldemar, Grimes, Catherine L. and Salama, Nina R. (2021). Localizing peptidoglycan synthesis in Helicobacter pylori using vlickable metabolic probes. Current Protocols, 1 (4) e80, 1-52. doi: 10.1002/cpz1.80

Localizing peptidoglycan synthesis in Helicobacter pylori using vlickable metabolic probes

2021

Journal Article

Regulation and function of class A Penicillin-binding proteins

Pazos, Manuel and Vollmer, Waldemar (2021). Regulation and function of class A Penicillin-binding proteins. Current Opinion in Microbiology, 60, 80-87. doi: 10.1016/j.mib.2021.01.008

Regulation and function of class A Penicillin-binding proteins

2021

Journal Article

Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction

Sutton, Joshua A. F., Carnell, Oliver T., Lafage, Lucia, Gray, Joe, Biboy, Jacob, Gibson, Josie F., Pollitt, Eric J. G., Tazoll, Simone C., Turnbull, William, Hajdamowicz, Natalia H., Salamaga, Bartlomiej, Pidwill, Grace R., Condliffe, Alison M., Renshaw, Stephen A., Vollmer, Waldemar and Foster, Simon J. (2021). Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction. PLoS Pathogens, 17 (3), e1009468. doi: 10.1371/journal.ppat.1009468

Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction

2021

Journal Article

ActS activates peptidoglycan amidases during outer membrane stress in Escherichia coli

Serrano, Carlos K. Gurnani, Winkle, Matthias, Martorana, Alessandra M., Biboy, Jacob, More, Niccolo, Moynihan, Patrick, Banzhaf, Manuel, Vollmer, Waldemar and Polissi, Alessandra (2021). ActS activates peptidoglycan amidases during outer membrane stress in Escherichia coli. Molecular Microbiology, 116 (1), 329-342. doi: 10.1111/mmi.14712

ActS activates peptidoglycan amidases during outer membrane stress in Escherichia coli

2021

Journal Article

Publisher Correction: Cell morphology maintenance in Bacillus subtilis through balanced peptidoglycan synthesis and hydrolysis

Sassine, Jad, Sousa, Joana, Lalk, Michael, Daniel, Richard A and Vollmer, Waldemar (2021). Publisher Correction: Cell morphology maintenance in Bacillus subtilis through balanced peptidoglycan synthesis and hydrolysis. Scientific Reports, 11 (1). doi: 10.1038/s41598-021-85465-2

Publisher Correction: Cell morphology maintenance in Bacillus subtilis through balanced peptidoglycan synthesis and hydrolysis

2021

Journal Article

The novel membrane-associated auxiliary factors AuxA and AuxB modulate β-lactam resistance in MRSA by stabilizing lipoteichoic acids

Mikkelsen, Kasper, Sirisarn, Wanchat, Alharbi, Ohood, Alharbi, Mohanned, Liu, Huayong, Nohr-Meldgaard, Katrine, Mayer, Katharina, Vestergaard, Martin, Gallagher, Laura A., Derrick, Jeremy P., McBain, Andrew J., Biboy, Jacob, Vollmer, Waldemar, O'Gara, James P., Grunert, Tom, Ingmer, Hanne and Xia, Guoqing (2021). The novel membrane-associated auxiliary factors AuxA and AuxB modulate β-lactam resistance in MRSA by stabilizing lipoteichoic acids. International Journal of Antimicrobial Agents, 57 (3) 106283, 1-9. doi: 10.1016/j.ijantimicag.2021.106283

The novel membrane-associated auxiliary factors AuxA and AuxB modulate β-lactam resistance in MRSA by stabilizing lipoteichoic acids

2021

Journal Article

Septal class A penicillin-binding protein activity and LD-transpeptidases mediate selection of colistin-resistant lipooligosaccharide-deficient Acinetobacter baumannii

Kang, Katie N., Kazi, Misha I., Biboy, Jacob, Gray, Joe, Bovermann, Hannah, Ausman, Jessie, Boutte, Cara C., Vollmer, Waldemar and Boll, Joseph M. (2021). Septal class A penicillin-binding protein activity and LD-transpeptidases mediate selection of colistin-resistant lipooligosaccharide-deficient Acinetobacter baumannii. mBio, 12 (1), 1-16. doi: 10.1128/mBio.02185-20

Septal class A penicillin-binding protein activity and LD-transpeptidases mediate selection of colistin-resistant lipooligosaccharide-deficient Acinetobacter baumannii

2020

Journal Article

Ticks resist skin commensals with immune factor of bacterial origin

Hayes, Beth M., Radkov, Atanas D., Yarza, Fauna, Flores, Sebastian, Kim, Jungyun, Zhao, Ziyi, Lexa, Katrina W., Marnin, Liron, Biboy, Jacob, Bowcut, Victoria, Vollmer, Waldemar, Pedra, Joao H. F. and Chou, Seemay (2020). Ticks resist skin commensals with immune factor of bacterial origin. Cell, 183 (6), 1562-1571.e12. doi: 10.1016/j.cell.2020.10.042

Ticks resist skin commensals with immune factor of bacterial origin

2020

Journal Article

MreC and MreD balance the interaction between the elongasome proteins PBP2 and RodA

Liu, Xiaolong, Biboy, Jacob, Consoli, Elisa, Vollmer, Waldemar and den Blaauwen, Tanneke (2020). MreC and MreD balance the interaction between the elongasome proteins PBP2 and RodA. PLoS Genetics, 16 (12), 1-23. doi: 10.1371/journal.pgen.1009276

MreC and MreD balance the interaction between the elongasome proteins PBP2 and RodA

2020

Journal Article

SPOR proteins are required for functionality of class a penicillin-binding proteins in Escherichia coli

Pazos, Manuel, Peters, Katharina, Boes, Adrien, Safaei, Yalda, Kenward, Calem, Caveney, Nathanael A., Laguri, Cedric, Breukink, Eefjan, Strynadka, Natalie C. J., Simorre, Jean-Pierre, Terrak, Mohammed and Vollmer, Waldemar (2020). SPOR proteins are required for functionality of class a penicillin-binding proteins in Escherichia coli. mBio, 11 (6), 1-16. doi: 10.1128/mBio.02796-20

SPOR proteins are required for functionality of class a penicillin-binding proteins in Escherichia coli

2020

Journal Article

Cell morphology maintenance in Bacillus subtilis through balanced peptidoglycan synthesis and hydrolysis

Sassine, Jad, Sousa, Joana, Lalk, Michael, Daniel, Richard A. and Vollmer, Waldemar (2020). Cell morphology maintenance in Bacillus subtilis through balanced peptidoglycan synthesis and hydrolysis. Scientific Reports, 10 (1) ARTN 17910, 1-14. doi: 10.1038/s41598-020-74609-5

Cell morphology maintenance in Bacillus subtilis through balanced peptidoglycan synthesis and hydrolysis

Supervision

Availability

Professor Waldemar Vollmer is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Novel assays for antibiotic discovery

    Principal Advisor

    Other advisors: Professor Rob Capon

  • Doctor Philosophy

    Dissecting the bacterial cell envelope for antibiotic drug discovery

    Principal Advisor

    Other advisors: Dr Nicholas Ariotti, Professor Rob Capon

  • Doctor Philosophy

    Targeting bacterial cell envelope coordination for antibiotic drug discovery

    Principal Advisor

    Other advisors: Professor Brett Collins

Media

Enquiries

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