
Overview
Background
Overview
Professor Waldemar Vollmer is a microbiologist working on the structure and biogenesis of the bacterial cell wall in various model bacteria and a range of pathogenic and environmental bacteria. He is particularly interested in how bacteria enlarge their cell wall when they grow and divide, and how antibiotics inhibit cell wall synthesis to kill bacteria. Antimicrobial resistance (AMR) is a global problem that is predicted to claim 10 million lives annually by the year 2050 if no new antibiotics are developed. Currently the pipeline of antibiotic development is almost empty and mostly limited to slightly modified versions to existing antibiotics. Professor Vollmer addresses the problem of AMR by generating tailored assays for the development of novel antibiotics that target AMR bacteria.
Collaborations: Professor Vollmer collaborates world-wide with more than 50 researchers at top national and international institutions on cell wall topics in over 30 different bacteria. These topics include: structure and composition of the cell wall and its role in maintaining cell morphology; molecular mechanisms of cell envelope biogenesis; role of new cell wall modifying enzymes in the interaction of pathogenic bacteria with components of the immune system; mechanisms of antibiotic resistance and targeting of cell wall biogenesis by new antibiotics.
Funding and Publications: Professor Vollmer has been awarded more than $15 million funding from research councils and charities in Germany, UK, Europe and USA. He has published more than 200 articles in international journals and has been recognised as a Highly Cited Researcher in Microbiology.
Honours and Awards: Professor Vollmer has been elected to Fellow of the American Academy of Microbiology (2014) and European Academy of Microbiology (2018). He received the annual Academic Distinction Awards from the Vice Chancellor of Newcastle University (2014), has been awarded a Distinguished Scientist Visiting Scholarships at Ben-Gurion University of the Negev (Israel, 2012) and a Visiting Professorship at the University of Cagliari (Italy, 2015), and won a Wellcome Trust Senior Investigator Award (2014). He has co-organised the 2018 Gordon Conference (GRC) "Bacterial Cell Surfaces" (Mt Snow, USA) and the 2016 EMBO Workshop "Bacterial Cell Division: Orchestrating the Ring Cycle" (Prague, Czech Republic).
Short Biography: Prof Waldemar Vollmer has studied chemistry at the University of Applied Sciences in Reutlingen (Germany) and University of Basel (Switzerland). In 1998 he obtained a PhD degree (Dr.rer.nat.) from the University of Tübingen (Germany) for his work on cell wall synthesis in the model bacterium Escherichia coli undertaken at the Max Planck Institute for Developmental Biology. During his postdoctoral studies at the Rockefeller University (New York, USA) he discovered novel cell wall enzymes that are crucial for the virulence of the pathogenic bacterium Streptococcus pneumoiae. In 2003 he was appointed Assistant Professor at the University of Tübingen and moved 2007 to the Centre for Bacterial Cell Biology at Newcastle University (UK), where he worked as Professor of Bacterial Biochemistry on various bacterial cell wall topics in a range of different bacteria. Since April 2023 he is Professorial Research Fellow and Group Leader at the Centre for Superbug Solutions, Institute for Molecular Bioscience (IMB) at the University of Queensland.
Availability
- Professor Waldemar Vollmer is:
- Available for supervision
Fields of research
Research impacts
Professor Vollmer's basic research on the bacterial cell envelope has led to key advances in our understanding of bacterial cell function and has discovered molecular mechanisms that can be exploited for antibiotic development.
Key research outputs: Prof Vollmer's group has discovered mechanisms of PG biosynthesis and its regulation, novel cell wall enzymes, and mechanisms of coordination between PG synthesis and outer membrane biogenesis. These discoveries provided the first molecular insights into how bacteria robustly maintain, enlarge and modify their cell envelope when they propagate in diverse environments and under stress conditions, and when exposed to antibiotics.
Key capabilities: Prof Vollmer's group is expert in the analysis of the composition of peptidoglycan, the key shape-maintaining and stress-bearing component of the bacterial cell envelope. They also discover new cell wall enzymes and study the activities and interactions of of key cell wall synthases and hydrolases (lysins or autolysins). They are also expert in determining the cleavage site of cell wall-degrading lysins and establishing biochemical assays for cell wall enzymes, for studying their inhibition by antibiotics. They combine their molecular biology work with studies on the physiology of bacterial cells impaired in cell wall biogenesis.
Works
Search Professor Waldemar Vollmer’s works on UQ eSpace
2024
Journal Article
A dynamic bactofilin cytoskeleton cooperates with an M23 endopeptidase to control bacterial morphogenesis
Pöhl, Sebastian, Osorio-Valeriano, Manuel, Cserti, Emöke, Harberding, Jannik, Hernandez-Tamayo, Rogelio, Biboy, Jacob, Sobetzko, Patrick, Vollmer, Waldemar, Graumann, Peter L. and Thanbichler, Martin (2024). A dynamic bactofilin cytoskeleton cooperates with an M23 endopeptidase to control bacterial morphogenesis. eLife, 12 RP86577, 1-34. doi: 10.7554/elife.86577.3
2024
Journal Article
Real-time biosynthetic reaction monitoring informs the mechanism of action of antibiotics
Oluwole, Abraham O., Hernández-Rocamora, Víctor M., Cao, Yihui, Li, Xuechen, Vollmer, Waldemar, Robinson, Carol V. and Bolla, Jani R. (2024). Real-time biosynthetic reaction monitoring informs the mechanism of action of antibiotics. Journal of the American Chemical Society, 146 (10), 7007-7017. doi: 10.1021/jacs.4c00081
2024
Book Chapter
Bacterial cell walls: peptidoglycan
Vollmer, W. (2024). Bacterial cell walls: peptidoglycan. Molecular medical microbiology. (pp. 45-67) edited by Yi-Wei Tang, Musa Hindiyeh, Dongyou Liu, Andrew Sails, Paul Spearman and Jingren Zhang. Cambridge, MA, United States: Academic Press. doi: 10.1016/b978-0-12-818619-0.00015-0
2024
Journal Article
A dynamic bactofilin cytoskeleton cooperates with an M23 endopeptidase to control bacterial morphogenesis
Pöhl, Sebastian, Osorio-Valeriano, Manuel, Cserti, Emöke, Harberding, Jannik, Hernandez-Tamayo, Rogelio, Biboy, Jacob, Sobetzko, Patrick, Vollmer, Waldemar, Graumann, Peter L. and Thanbichler, Martin (2024). A dynamic bactofilin cytoskeleton cooperates with an M23 endopeptidase to control bacterial morphogenesis. eLife, 13 RP86577. doi: 10.7554/eLife.86577
2023
Journal Article
Structural basis for the hydrolytic activity of the transpeptidase-like protein DpaA to detach Braun’s lipoprotein from peptidoglycan
Wang, Hsiu-Jung, Hernández-Rocamora, Víctor M., Kuo, Chiao-I, Hsieh, Kan-Yen, Lee, Szu-Hui, Ho, Meng-Ru, Tu, Zhijay, Vollmer, Waldemar and Chang, Chung-I (2023). Structural basis for the hydrolytic activity of the transpeptidase-like protein DpaA to detach Braun’s lipoprotein from peptidoglycan. mBio, 14 (5) e01379, 1-11. doi: 10.1128/mbio.01379-23
2023
Journal Article
NlpC/P60 peptidoglycan hydrolases of Trichomonas vaginalis have complementary activities that empower the protozoan to control host-protective lactobacilli
Barnett, Michael, Pinheiro, Jully P., Keown, Jeremy, Biboy, Jacob C., Gray, Joe J., Lucinescu, Ioana-Wilhelmina, Vollmer, Waldemar J., Hirt, Robert, Simoes-Barbosa, Augusto J. and Goldstone, David (2023). NlpC/P60 peptidoglycan hydrolases of Trichomonas vaginalis have complementary activities that empower the protozoan to control host-protective lactobacilli. PLoS Pathogens, 19 (8) e1011563, e1011563. doi: 10.1371/journal.ppat.1011563
2023
Journal Article
DipM controls multiple autolysins and mediates a regulatory feedback loop promoting cell constriction in Caulobacter crescentus
Izquierdo-Martinez, Adrian, Billini, Maria, Miguel-Ruano, Vega, Hernández-Tamayo, Rogelio, Richter, Pia, Biboy, Jacob, Batuecas, María T., Glatter, Timo, Vollmer, Waldemar, Graumann, Peter L., Hermoso, Juan A. and Thanbichler, Martin (2023). DipM controls multiple autolysins and mediates a regulatory feedback loop promoting cell constriction in Caulobacter crescentus. Nature Communications, 14 (1) 4095, 4095. doi: 10.1038/s41467-023-39783-w
2023
Journal Article
Deciphering the adaption of bacterial cell wall mechanical integrity and turgor to different chemical or mechanical environments
Han, Rui, Feng, Xi-Qiao, Vollmer, Waldemar, Stoodley, Paul and Chen, Jinju (2023). Deciphering the adaption of bacterial cell wall mechanical integrity and turgor to different chemical or mechanical environments. Journal of Colloid and Interface Science, 640, 510-520. doi: 10.1016/j.jcis.2023.02.100
2023
Journal Article
Multiple Campylobacter jejuni proteins affecting the peptidoglycan structure and the degree of helical cell curvature
Frirdich, Emilisa, Vermeulen, Jenny, Biboy, Jacob, Vollmer, Waldemar and Gaynor, Erin C. (2023). Multiple Campylobacter jejuni proteins affecting the peptidoglycan structure and the degree of helical cell curvature. Frontiers in Microbiology, 14, 1162806. doi: 10.3389/fmicb.2023.1162806
2023
Journal Article
An NlpC/P60 protein catalyzes a key step in peptidoglycan recycling at the intersection of energy recovery, cell division and immune evasion in the intracellular pathogen Chlamydia trachomatis
Reuter, Jula, Otten, Christian, Jacquier, Nicolas, Lee, Junghoon, Mengin-Lecreulx, Dominique, Löckener, Iris, Kluj, Robert, Mayer, Christoph, Corona, Federico, Dannenberg, Julia, Aeby, Sébastien, Bühl, Henrike, Greub, Gilbert, Vollmer, Waldemar, Ouellette, Scot P., Schneider, Tanja and Henrichfreise, Beate (2023). An NlpC/P60 protein catalyzes a key step in peptidoglycan recycling at the intersection of energy recovery, cell division and immune evasion in the intracellular pathogen Chlamydia trachomatis. PLoS Pathogens, 19 (2) e1011047, 1-29. doi: 10.1371/journal.ppat.1011047
2022
Journal Article
Outer membrane-anchoring enables LpoB to regulate peptidoglycan synthesis rate
Kermani, Ali A., Biboy, Jacob, Vollmer, Daniela and Vollmer, Waldemar (2022). Outer membrane-anchoring enables LpoB to regulate peptidoglycan synthesis rate. The Cell Surface, 8 100086, 1-9. doi: 10.1016/j.tcsw.2022.100086
2022
Journal Article
Molecular characterization of the type VI secretion system effector Tlde1a reveals a structurally altered fold
Cobo, Neil Lorente, Sibinelli-Sousa, Stephanie, Biboy, Jacob, Vollmer, Waldemar, Bayer-Santos, Ethel and Prehna, Gerd (2022). Molecular characterization of the type VI secretion system effector Tlde1a reveals a structurally altered fold. Journal of Biological Chemistry, 298 (11) 102556, 1-17. doi: 10.1016/j.jbc.2022.102556
2022
Journal Article
Simultaneous determination of the mechanical properties and turgor of a single bacterial cell using atomic force microscopy
Han, Rui, Vollmer, Waldemar, Perry, John D., Stoodley, Paul and Chen, Jinju (2022). Simultaneous determination of the mechanical properties and turgor of a single bacterial cell using atomic force microscopy. Nanoscale, 14 (33), 12060-12068. doi: 10.1039/d2nr02577a
2022
Journal Article
Peptidoglycan from Akkermansia muciniphila Muc(T): chemical structure and immunostimulatory properties of muropeptides
Garcia-Vello, Pilar, Tytgat, Hanne L. P., Gray, Joe, Elzinga, Janneke, Di Lorenzo, Flaviana, Biboy, Jacob, Vollmer, Daniela, De Castro, Cristina, Vollmer, Waldemar, de Vos, Willem M. and Molinaro, Antonio (2022). Peptidoglycan from Akkermansia muciniphila Muc(T): chemical structure and immunostimulatory properties of muropeptides. Glycobiology, 32 (8), 712-719. doi: 10.1093/glycob/cwac027
2022
Journal Article
Metabolic labeling of the bacterial peptidoglycan by functionalized glucosamine
Xu, Yang, Hernandez-Rocamora, Victor M., Lorent, Joseph H., Cox, Ruud, Wang, Xiaoqi, Bao, Xue, Stel, Marjon, Vos, Gael, van den Bos, Ramon M., Pieters, Roland J., Gray, Joe, Vollmer, Waldemar and Breukink, Eefjan (2022). Metabolic labeling of the bacterial peptidoglycan by functionalized glucosamine. iScience, 25 (8) 104753, 1-19. doi: 10.1016/j.isci.2022.104753
2022
Journal Article
Antibacterial potency of type VI amidase effector toxins is dependent on substrate topology and cellular context
Radkov, Atanas, Sapiro, Anne L., Flores, Sebastian, Henderson, Corey, Saunders, Hayden, Kim, Rachel, Massa, Steven, Thompson, Samuel, Mateusiak, Chase, Biboy, Jacob, Zhao, Ziyi, Starita, Lea M., Hatleberg, William L., Vollmer, Waldemar, Russell, Alistair B., Simorre, Jean-Pierre, Anthony-Cahill, Spencer, Brzovic, Peter, Hayes, Beth and Chou, Seemay (2022). Antibacterial potency of type VI amidase effector toxins is dependent on substrate topology and cellular context. eLife, 11, 1-26. doi: 10.7554/eLife.79796
2022
Journal Article
Penicillin-binding protein 1 (PBP1) of Staphylococcus aureus has multiple essential functions in cell division
Wacnik, Katarzyna, Rao, Vincenzo A., Chen, Xinyue, Lafage, Lucia, Pazos, Manuel, Booth, Simon, Vollmer, Waldemar, Hobbs, Jamie K., Lewis, Richard J. and Foster, Simon J. (2022). Penicillin-binding protein 1 (PBP1) of Staphylococcus aureus has multiple essential functions in cell division. mBio, 13 (4), 1-19. doi: 10.1128/mbio.00669-22
2022
Journal Article
Peptidoglycan recycling promotes outer membrane integrity and carbapenem tolerance in Acinetobacter baumannii
Islam, Nowrosh, Kazi, Misha, Kang, Katie N., Biboy, Jacob, Gray, Joe, Ahmed, Feroz, Schargel, Richard D., Boutte, Cara C., Dorr, Tobias, Vollmer, Waldemar and Boll, Joseph M. (2022). Peptidoglycan recycling promotes outer membrane integrity and carbapenem tolerance in Acinetobacter baumannii. mBio, 13 (3), 1-19. doi: 10.1128/mbio.01001-22
2022
Journal Article
Early midcell localization of Escherichia coli PBP4 supports the function of peptidoglycan amidases
Verheul, Jolanda, Lodge, Adam, Yau, Hamish C. L., Liu, Xiaolong, Boelter, Gabriela, Liu, Xinwei, Solovyova, Alexandra S., Typas, Athanasios, Banzhaf, Manuel, Vollmer, Waldemar and den Blaauwen, Tanneke (2022). Early midcell localization of Escherichia coli PBP4 supports the function of peptidoglycan amidases. PLoS Genetics, 18 (5) e1010222, 1-36. doi: 10.1371/journal.pgen.1010222
2022
Journal Article
Peptidoglycan biosynthesis is driven by lipid transfer along enzyme-substrate affinity gradients
Oluwole, Abraham O., Corey, Robin A., Brown, Chelsea M., Hernandez-Rocamora, Victor M., Stansfeld, Phillip J., Vollmer, Waldemar, Bolla, Jani R. and Robinson, Carol (2022). Peptidoglycan biosynthesis is driven by lipid transfer along enzyme-substrate affinity gradients. Nature Communications, 13 (1) 2278, 1-12. doi: 10.1038/s41467-022-29836-x
Funding
Current funding
Supervision
Availability
- Professor Waldemar Vollmer is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
Novel antibacterials from nature targeting the bacterial cell envelope
The project uses methods in molecular microbiology and natural product chemistry to discover new antibiotics from natural sources that kill bacteria by targeting their cell wall.
Supervision history
Current supervision
-
Doctor Philosophy
Dissecting the bacterial cell envelope for antibiotic drug discovery
Principal Advisor
Other advisors: Dr Nicholas Ariotti, Professor Rob Capon
-
Doctor Philosophy
Targeting bacterial cell envelope coordination for antibiotic drug discovery
Principal Advisor
Other advisors: Professor Brett Collins
-
Doctor Philosophy
Novel assays for antibiotic discovery
Principal Advisor
Other advisors: Professor Rob Capon
Media
Enquiries
For media enquiries about Professor Waldemar Vollmer's areas of expertise, story ideas and help finding experts, contact our Media team: