
Overview
Background
Overview
Professor Waldemar Vollmer is a microbiologist working on the structure and biogenesis of the bacterial cell wall in various model bacteria and a range of pathogenic and environmental bacteria. He is particularly interested in how bacteria enlarge their cell wall when they grow and divide, and how antibiotics inhibit cell wall synthesis to kill bacteria. Antimicrobial resistance (AMR) is a global problem that is predicted to claim 10 million lives annually by the year 2050 if no new antibiotics are developed. Currently the pipeline of antibiotic development is almost empty and mostly limited to slightly modified versions to existing antibiotics. Professor Vollmer addresses the problem of AMR by generating tailored assays for the development of novel antibiotics that target AMR bacteria.
Collaborations: Professor Vollmer collaborates world-wide with more than 50 researchers at top national and international institutions on cell wall topics in over 30 different bacteria. These topics include: structure and composition of the cell wall and its role in maintaining cell morphology; molecular mechanisms of cell envelope biogenesis; role of new cell wall modifying enzymes in the interaction of pathogenic bacteria with components of the immune system; mechanisms of antibiotic resistance and targeting of cell wall biogenesis by new antibiotics.
Funding and Publications: Professor Vollmer has been awarded more than $15 million funding from research councils and charities in Germany, UK, Europe and USA. He has published more than 200 articles in international journals and has been recognised as a Highly Cited Researcher in Microbiology.
Honours and Awards: Professor Vollmer has been elected to Fellow of the American Academy of Microbiology (2014) and European Academy of Microbiology (2018). He received the annual Academic Distinction Awards from the Vice Chancellor of Newcastle University (2014), has been awarded a Distinguished Scientist Visiting Scholarships at Ben-Gurion University of the Negev (Israel, 2012) and a Visiting Professorship at the University of Cagliari (Italy, 2015), and won a Wellcome Trust Senior Investigator Award (2014). He has co-organised the 2018 Gordon Conference (GRC) "Bacterial Cell Surfaces" (Mt Snow, USA) and the 2016 EMBO Workshop "Bacterial Cell Division: Orchestrating the Ring Cycle" (Prague, Czech Republic).
Short Biography: Prof Waldemar Vollmer has studied chemistry at the University of Applied Sciences in Reutlingen (Germany) and University of Basel (Switzerland). In 1998 he obtained a PhD degree (Dr.rer.nat.) from the University of Tübingen (Germany) for his work on cell wall synthesis in the model bacterium Escherichia coli undertaken at the Max Planck Institute for Developmental Biology. During his postdoctoral studies at the Rockefeller University (New York, USA) he discovered novel cell wall enzymes that are crucial for the virulence of the pathogenic bacterium Streptococcus pneumoiae. In 2003 he was appointed Assistant Professor at the University of Tübingen and moved 2007 to the Centre for Bacterial Cell Biology at Newcastle University (UK), where he worked as Professor of Bacterial Biochemistry on various bacterial cell wall topics in a range of different bacteria. Since April 2023 he is Professorial Research Fellow and Group Leader at the Centre for Superbug Solutions, Institute for Molecular Bioscience (IMB) at the University of Queensland.
Availability
- Professor Waldemar Vollmer is:
- Available for supervision
Fields of research
Research impacts
Professor Vollmer's basic research on the bacterial cell envelope has led to key advances in our understanding of bacterial cell function and has discovered molecular mechanisms that can be exploited for antibiotic development.
Key research outputs: Prof Vollmer's group has discovered mechanisms of PG biosynthesis and its regulation, novel cell wall enzymes, and mechanisms of coordination between PG synthesis and outer membrane biogenesis. These discoveries provided the first molecular insights into how bacteria robustly maintain, enlarge and modify their cell envelope when they propagate in diverse environments and under stress conditions, and when exposed to antibiotics.
Key capabilities: Prof Vollmer's group is expert in the analysis of the composition of peptidoglycan, the key shape-maintaining and stress-bearing component of the bacterial cell envelope. They also discover new cell wall enzymes and study the activities and interactions of of key cell wall synthases and hydrolases (lysins or autolysins). They are also expert in determining the cleavage site of cell wall-degrading lysins and establishing biochemical assays for cell wall enzymes, for studying their inhibition by antibiotics. They combine their molecular biology work with studies on the physiology of bacterial cells impaired in cell wall biogenesis.
Works
Search Professor Waldemar Vollmer’s works on UQ eSpace
2019
Journal Article
Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus
Rausch, Marvin, Deisinger, Julia P., Ulm, Hannah, Mueller, Anna, Li, Wenjin, Hardt, Patrick, Wang, Xiaogang, Li, Xue, Sylvester, Marc, Engeser, Marianne, Vollmer, Waldemar, Mueller, Christa E., Sahl, Hans Georg, Lee, Jean Claire and Schneider, Tanja (2019). Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus. Nature Communications, 10 (1) 1404, 1404. doi: 10.1038/s41467-019-09356-x
2019
Journal Article
A specialized MreB-dependent cell wall biosynthetic complex mediates the formation of stalk-specific peptidoglycan in Caulobacter crescentus
Billini, Maria, Biboy, Jacob, Kuehn, Juliane, Vollmer, Waldemar and Thanbichler, Martin (2019). A specialized MreB-dependent cell wall biosynthetic complex mediates the formation of stalk-specific peptidoglycan in Caulobacter crescentus. Plos Genetics, 15 (2) e1007897, 1-33. doi: 10.1371/journal.pgen.1007897
2019
Journal Article
Recognition of peptidoglycan fragments by the transpeptidase PBP4 From Staphylococcus aureus
Maya-Martine, Roberto, Alexander, J. Andrew N., Otten, Christian F., Ayala, Isabel, Vollmer, Daniela, Gray, Joe, Bougault, Catherine M., Burt, Alister, Laguri, Cedric, Fonvielles, Matthieu, Arthur, Michel, Strynadka, Natalie C. J., Vollmer, Waldemar and Simorre, Jean-Pierre (2019). Recognition of peptidoglycan fragments by the transpeptidase PBP4 From Staphylococcus aureus. Frontiers in Microbiology, 9, 1-14. doi: 10.3389/fmicb.2018.03223
2019
Journal Article
Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect
More, Niccolo, Martorana, Alessandra M., Biboy, Jacob, Otten, Christian, Winkle, Matthias, Serrano, Carlos K. Gurnani, Silva, Alejandro Monton, Atkinson, Lisa, Yau, Hamish, Breukink, Eefjan, den Blaauwen, Tanneke, Vollmer, Waldemar and Polissi, Alessandra (2019). Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect. Mbio, 10 (1). doi: 10.1128/mBio.02729-18
2019
Journal Article
Role of the putative polysaccharide deacetylase BA1836 from B. anthracis in spore development and germination
Tomatsidou, Anastasia, Koutsioulis, Dimitris, Tzamarias, Dimitris, Kokkinidis, Michael, Vollmer, Waldemar and Bouriotis, Vassilis (2019). Role of the putative polysaccharide deacetylase BA1836 from B. anthracis in spore development and germination. Advances in Microbiology, 09 (08), 679-702. doi: 10.4236/aim.2019.98042
2018
Journal Article
The protozoan Trichomonas vaginalis targets bacteria with laterally acquired NlpC/P60 peptidoglycan hydrolases
Pinheiro, Jully, Biboy, Jacob, Vollmer, Waldemar, Hirt, Robert P., Keown, Jeremy R., Artuyants, Anastasiia, Black, Moyra M., Goldstone, David C. and Simoes-Barbosa, Augusto (2018). The protozoan Trichomonas vaginalis targets bacteria with laterally acquired NlpC/P60 peptidoglycan hydrolases. mBio, 9 (6), 1-17. doi: 10.1128/mBio.01784-18
2018
Journal Article
Inactivation of the monofunctional peptidoglycan glycosyltransferase SgtB allows Staphylococcus aureus to survive in the absence of lipoteichoic acid
Karinou, Eleni, Schuster, Christopher F., Pazos, Manuel, Vollmer, Waldemar and Grundling, Angelika (2018). Inactivation of the monofunctional peptidoglycan glycosyltransferase SgtB allows Staphylococcus aureus to survive in the absence of lipoteichoic acid. Journal of Bacteriology, 201 (1), 1-18. doi: 10.1128/JB.00574-18
2018
Journal Article
Peptidoglycan degradation machinery in Clostridium difficile forespore engulfment
Dembek, Marcin, Kelly, Abigail, Barwinska-Sendra, Anna, Tarrant, Emma, Stanley, Will A., Vollmer, Daniela, Biboy, Jacob, Gray, Joe, Vollmer, Waldemar and Salgado, Paula S. (2018). Peptidoglycan degradation machinery in Clostridium difficile forespore engulfment. Molecular Microbiology, 110 (3), 390-410. doi: 10.1111/mmi.14091
2018
Journal Article
Peptidoglycan editing by a specific LD-transpeptidase controls the muramidase-dependent secretion of typhoid toxin
Geiger, Tobias, Pazos, Manuel, Lara-Tejero, Maria, Vollmer, Waldemar and Galan, Jorge E. (2018). Peptidoglycan editing by a specific LD-transpeptidase controls the muramidase-dependent secretion of typhoid toxin. Nature Microbiology, 3 (11), 1243-1254. doi: 10.1038/s41564-018-0248-x
2018
Journal Article
Induced conformational changes activate the peptidoglycan synthase PBP1B
Egan, Alexander J. F., Maya-Martinez, Roberto, Ayala, Isabel, Bougault, Catherine M., Banzhaf, Manuel, Breukink, Eefjan, Vollmer, Waldemar and Simorre, Jean-Pierre (2018). Induced conformational changes activate the peptidoglycan synthase PBP1B. Molecular Microbiology, 110 (3), 335-356. doi: 10.1111/mmi.14082
2018
Journal Article
Molecular basis for immunity protein recognition of a type VII secretion system exported antibacterial toxin
Klein, Timothy A., Pazos, Manuel, Surette, Michael G., Vollmer, Waldemar and Whitney, John C. (2018). Molecular basis for immunity protein recognition of a type VII secretion system exported antibacterial toxin. Journal of Molecular Biology, 430 (21), 4344-4358. doi: 10.1016/j.jmb.2018.08.027
2018
Journal Article
Two Faces of CwIM, an Essential PknB Substrate, in Mycobacterium tuberculosis
Turapov, Obolbek, Forti, Francesca, Kadhim, Baleegh, Ghisotti, Daniela, Sassine, Jad, Straatman-Iwanowska, Anna, Bottrill, Andrew R., Moynihan, Patrick J., Wallis, Russell, Barthe, Philippe, Cohen-Gonsaud, Martin, Ajuh, Paul, Vollmer, Waldemar and Mukamolova, Galina (2018). Two Faces of CwIM, an Essential PknB Substrate, in Mycobacterium tuberculosis. Cell Reports, 25 (1), 57-67.E5. doi: 10.1016/j.celrep.2018.09.004
2018
Journal Article
High-Resolution Analysis of the Peptidoglycan Composition in Streptomyces coelicolor
van der Aart, Lizah T., Spijksma, Gerwin K., Harms, Amy, Vollmer, Waldemar, Hankemeier, Thomas and van Wezel, Gilles P. (2018). High-Resolution Analysis of the Peptidoglycan Composition in Streptomyces coelicolor. Journal of Bacteriology, 200 (20). doi: 10.1128/JB.00290-18
2018
Journal Article
The Fluorescent D-Amino Acid NADA as a Tool to Study the Conditional Activity of Transpeptidases in Escherichia coli
Montón Silva, Alejandro, Otten, Christian, Biboy, Jacob, Breukink, Eefjan, VanNieuwenhze, Michael, Vollmer, Waldemar and den Blaauwen, Tanneke (2018). The Fluorescent D-Amino Acid NADA as a Tool to Study the Conditional Activity of Transpeptidases in Escherichia coli. Frontiers in Microbiology, 9 2101, 1-15. doi: 10.3389/fmicb.2018.02101
2018
Journal Article
The lytic transglycosylase MltB connects membrane homeostasis and in vivo fitness of Acinetobacter baumannii
Crepin, Sebastien, Ottosen, Elizabeth N., Peters, Katharina, Smith, Sara N., Himpsl, Stephanie D., Vollmer, Waldemar and Mobley, Harry L. T. (2018). The lytic transglycosylase MltB connects membrane homeostasis and in vivo fitness of Acinetobacter baumannii. Molecular Microbiology, 109 (6), 745-762. doi: 10.1111/mmi.14000
2018
Journal Article
Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae
Morlot, Cecile, Straume, Daniel, Peters, Katharina, Hegnar, Olav A., Simon, Nolwenn, Villard, Anne-Marie, Contreras-Martel, Carlos, Leisico, Francisco, Breukink, Eefjan, Gravier-Pelletier, Christine, Le Corre, Laurent, Vollmer, Waldemar, Pietrancosta, Nicolas, Havarstein, Leiv Sigve and Zapun, Andre (2018). Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae. Nature Communications, 9 (1) 3180, 3180. doi: 10.1038/s41467-018-05602-w
2018
Journal Article
Seven-transmembrane receptor protein RgsP and cell wall-binding protein RgsM promote unipolar growth in Rhizobiales
Schaeper, Simon, Yau, Hamish C. L., Krol, Elizaveta, Skotnicka, Dorota, Heimerl, Thomas, Gray, Joe, Kaever, Volkhard, Sogaard-Andersen, Lotte, Vollmer, Waldemar and Becker, Anke (2018). Seven-transmembrane receptor protein RgsP and cell wall-binding protein RgsM promote unipolar growth in Rhizobiales. Plos Genetics, 14 (8), e1007594. doi: 10.1371/journal.pgen.1007594
2018
Journal Article
Mechanical interactions between bacteria and hydrogels
Kandemir, Nehir, Vollmer, Waldemar, Jakubovics, Nicholas S. and Chen, Jinju (2018). Mechanical interactions between bacteria and hydrogels. Scientific Reports, 8 (1) 10893, 10893. doi: 10.1038/s41598-018-29269-x
2018
Journal Article
Coupling of polymerase and carrier lipid phosphatase prevents product inhibition in peptidoglycan synthesis
Hernández-Rocamora, Víctor M, Otten, Christian F., Radkov, Atanas, Simorre, Jean-Pierre, Breukink, Eefjan, VanNieuwenhze, Michael and Vollmer, Waldemar (2018). Coupling of polymerase and carrier lipid phosphatase prevents product inhibition in peptidoglycan synthesis. The Cell Surface, 2, 1-13. doi: 10.1016/j.tcsw.2018.04.002
2018
Journal Article
Targeting the bacterial cytoskeleton of the Burkholderia cepacia complex for antimicrobial development: a cautionary tale
Carnell, Sonya C., Perry, John D., Borthwick, Lee, Vollmer, Daniela, Biboy, Jacob, Facchini, Marcella, Bragonzi, Alessandra, Silipo, Alba, Vergunst, Annette C., Vollmer, Waldemar, Khan, Anjam C. M. and De Soyza, Anthony (2018). Targeting the bacterial cytoskeleton of the Burkholderia cepacia complex for antimicrobial development: a cautionary tale. International Journal of Molecular Sciences, 19 (6) 1604, 1-13. doi: 10.3390/ijms19061604
Funding
Current funding
Supervision
Availability
- Professor Waldemar Vollmer is:
- Available for supervision
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Available projects
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Novel antibacterials from nature targeting the bacterial cell envelope
The project uses methods in molecular microbiology and natural product chemistry to discover new antibiotics from natural sources that kill bacteria by targeting their cell wall.
Supervision history
Current supervision
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Doctor Philosophy
Targeting bacterial cell envelope coordination for antibiotic drug discovery
Principal Advisor
Other advisors: Professor Brett Collins
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Doctor Philosophy
Novel assays for antibiotic discovery
Principal Advisor
Other advisors: Professor Rob Capon
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Doctor Philosophy
Dissecting the bacterial cell envelope for antibiotic drug discovery
Principal Advisor
Other advisors: Dr Nicholas Ariotti, Professor Rob Capon
Media
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