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Professor Waldemar Vollmer
Professor

Waldemar Vollmer

Email: 
Phone: 
+61 7 334 62055

Overview

Background

Overview

Professor Waldemar Vollmer is a microbiologist working on the structure and biogenesis of the bacterial cell wall in various model bacteria and a range of pathogenic and environmental bacteria. He is particularly interested in how bacteria enlarge their cell wall when they grow and divide, and how antibiotics inhibit cell wall synthesis to kill bacteria. Antimicrobial resistance (AMR) is a global problem that is predicted to claim 10 million lives annually by the year 2050 if no new antibiotics are developed. Currently the pipeline of antibiotic development is almost empty and mostly limited to slightly modified versions to existing antibiotics. Professor Vollmer addresses the problem of AMR by generating tailored assays for the development of novel antibiotics that target AMR bacteria.

Collaborations: Professor Vollmer collaborates world-wide with more than 50 researchers at top national and international institutions on cell wall topics in over 30 different bacteria. These topics include: structure and composition of the cell wall and its role in maintaining cell morphology; molecular mechanisms of cell envelope biogenesis; role of new cell wall modifying enzymes in the interaction of pathogenic bacteria with components of the immune system; mechanisms of antibiotic resistance and targeting of cell wall biogenesis by new antibiotics.

Funding and Publications: Professor Vollmer has been awarded more than $15 million funding from research councils and charities in Germany, UK, Europe and USA. He has published more than 200 articles in international journals and has been recognised as a Highly Cited Researcher in Microbiology.

Honours and Awards: Professor Vollmer has been elected to Fellow of the American Academy of Microbiology (2014) and European Academy of Microbiology (2018). He received the annual Academic Distinction Awards from the Vice Chancellor of Newcastle University (2014), has been awarded a Distinguished Scientist Visiting Scholarships at Ben-Gurion University of the Negev (Israel, 2012) and a Visiting Professorship at the University of Cagliari (Italy, 2015), and won a Wellcome Trust Senior Investigator Award (2014). He has co-organised the 2018 Gordon Conference (GRC) "Bacterial Cell Surfaces" (Mt Snow, USA) and the 2016 EMBO Workshop "Bacterial Cell Division: Orchestrating the Ring Cycle" (Prague, Czech Republic).

Short Biography: Prof Waldemar Vollmer has studied chemistry at the University of Applied Sciences in Reutlingen (Germany) and University of Basel (Switzerland). In 1998 he obtained a PhD degree (Dr.rer.nat.) from the University of Tübingen (Germany) for his work on cell wall synthesis in the model bacterium Escherichia coli undertaken at the Max Planck Institute for Developmental Biology. During his postdoctoral studies at the Rockefeller University (New York, USA) he discovered novel cell wall enzymes that are crucial for the virulence of the pathogenic bacterium Streptococcus pneumoiae. In 2003 he was appointed Assistant Professor at the University of Tübingen and moved 2007 to the Centre for Bacterial Cell Biology at Newcastle University (UK), where he worked as Professor of Bacterial Biochemistry on various bacterial cell wall topics in a range of different bacteria. Since April 2023 he is Professorial Research Fellow and Group Leader at the Centre for Superbug Solutions, Institute for Molecular Bioscience (IMB) at the University of Queensland.

Availability

Professor Waldemar Vollmer is:
Available for supervision

Fields of research

Research impacts

Professor Vollmer's basic research on the bacterial cell envelope has led to key advances in our understanding of bacterial cell function and has discovered molecular mechanisms that can be exploited for antibiotic development.

Key research outputs: Prof Vollmer's group has discovered mechanisms of PG biosynthesis and its regulation, novel cell wall enzymes, and mechanisms of coordination between PG synthesis and outer membrane biogenesis. These discoveries provided the first molecular insights into how bacteria robustly maintain, enlarge and modify their cell envelope when they propagate in diverse environments and under stress conditions, and when exposed to antibiotics.

Key capabilities: Prof Vollmer's group is expert in the analysis of the composition of peptidoglycan, the key shape-maintaining and stress-bearing component of the bacterial cell envelope. They also discover new cell wall enzymes and study the activities and interactions of of key cell wall synthases and hydrolases (lysins or autolysins). They are also expert in determining the cleavage site of cell wall-degrading lysins and establishing biochemical assays for cell wall enzymes, for studying their inhibition by antibiotics. They combine their molecular biology work with studies on the physiology of bacterial cells impaired in cell wall biogenesis.

Works

Search Professor Waldemar Vollmer’s works on UQ eSpace

239 works between 1993 and 2024

81 - 100 of 239 works

2019

Journal Article

Recognition of peptidoglycan fragments by the transpeptidase PBP4 From Staphylococcus aureus

Maya-Martine, Roberto, Alexander, J. Andrew N., Otten, Christian F., Ayala, Isabel, Vollmer, Daniela, Gray, Joe, Bougault, Catherine M., Burt, Alister, Laguri, Cedric, Fonvielles, Matthieu, Arthur, Michel, Strynadka, Natalie C. J., Vollmer, Waldemar and Simorre, Jean-Pierre (2019). Recognition of peptidoglycan fragments by the transpeptidase PBP4 From Staphylococcus aureus. Frontiers in Microbiology, 9, 1-14. doi: 10.3389/fmicb.2018.03223

Recognition of peptidoglycan fragments by the transpeptidase PBP4 From Staphylococcus aureus

2019

Journal Article

Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect

More, Niccolo, Martorana, Alessandra M., Biboy, Jacob, Otten, Christian, Winkle, Matthias, Serrano, Carlos K. Gurnani, Silva, Alejandro Monton, Atkinson, Lisa, Yau, Hamish, Breukink, Eefjan, den Blaauwen, Tanneke, Vollmer, Waldemar and Polissi, Alessandra (2019). Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect. Mbio, 10 (1). doi: 10.1128/mBio.02729-18

Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect

2019

Journal Article

Role of the putative polysaccharide deacetylase BA1836 from B. anthracis in spore development and germination

Tomatsidou, Anastasia, Koutsioulis, Dimitris, Tzamarias, Dimitris, Kokkinidis, Michael, Vollmer, Waldemar and Bouriotis, Vassilis (2019). Role of the putative polysaccharide deacetylase BA1836 from B. anthracis in spore development and germination. Advances in Microbiology, 09 (08), 679-702. doi: 10.4236/aim.2019.98042

Role of the putative polysaccharide deacetylase BA1836 from B. anthracis in spore development and germination

2018

Journal Article

The protozoan Trichomonas vaginalis targets bacteria with laterally acquired NlpC/P60 peptidoglycan hydrolases

Pinheiro, Jully, Biboy, Jacob, Vollmer, Waldemar, Hirt, Robert P., Keown, Jeremy R., Artuyants, Anastasiia, Black, Moyra M., Goldstone, David C. and Simoes-Barbosa, Augusto (2018). The protozoan Trichomonas vaginalis targets bacteria with laterally acquired NlpC/P60 peptidoglycan hydrolases. mBio, 9 (6), 1-17. doi: 10.1128/mBio.01784-18

The protozoan Trichomonas vaginalis targets bacteria with laterally acquired NlpC/P60 peptidoglycan hydrolases

2018

Journal Article

Inactivation of the monofunctional peptidoglycan glycosyltransferase SgtB allows Staphylococcus aureus to survive in the absence of lipoteichoic acid

Karinou, Eleni, Schuster, Christopher F., Pazos, Manuel, Vollmer, Waldemar and Grundling, Angelika (2018). Inactivation of the monofunctional peptidoglycan glycosyltransferase SgtB allows Staphylococcus aureus to survive in the absence of lipoteichoic acid. Journal of Bacteriology, 201 (1), 1-18. doi: 10.1128/JB.00574-18

Inactivation of the monofunctional peptidoglycan glycosyltransferase SgtB allows Staphylococcus aureus to survive in the absence of lipoteichoic acid

2018

Journal Article

Peptidoglycan degradation machinery in Clostridium difficile forespore engulfment

Dembek, Marcin, Kelly, Abigail, Barwinska-Sendra, Anna, Tarrant, Emma, Stanley, Will A., Vollmer, Daniela, Biboy, Jacob, Gray, Joe, Vollmer, Waldemar and Salgado, Paula S. (2018). Peptidoglycan degradation machinery in Clostridium difficile forespore engulfment. Molecular Microbiology, 110 (3), 390-410. doi: 10.1111/mmi.14091

Peptidoglycan degradation machinery in Clostridium difficile forespore engulfment

2018

Journal Article

Peptidoglycan editing by a specific LD-transpeptidase controls the muramidase-dependent secretion of typhoid toxin

Geiger, Tobias, Pazos, Manuel, Lara-Tejero, Maria, Vollmer, Waldemar and Galan, Jorge E. (2018). Peptidoglycan editing by a specific LD-transpeptidase controls the muramidase-dependent secretion of typhoid toxin. Nature Microbiology, 3 (11), 1243-1254. doi: 10.1038/s41564-018-0248-x

Peptidoglycan editing by a specific LD-transpeptidase controls the muramidase-dependent secretion of typhoid toxin

2018

Journal Article

Induced conformational changes activate the peptidoglycan synthase PBP1B

Egan, Alexander J. F., Maya-Martinez, Roberto, Ayala, Isabel, Bougault, Catherine M., Banzhaf, Manuel, Breukink, Eefjan, Vollmer, Waldemar and Simorre, Jean-Pierre (2018). Induced conformational changes activate the peptidoglycan synthase PBP1B. Molecular Microbiology, 110 (3), 335-356. doi: 10.1111/mmi.14082

Induced conformational changes activate the peptidoglycan synthase PBP1B

2018

Journal Article

Molecular basis for immunity protein recognition of a type VII secretion system exported antibacterial toxin

Klein, Timothy A., Pazos, Manuel, Surette, Michael G., Vollmer, Waldemar and Whitney, John C. (2018). Molecular basis for immunity protein recognition of a type VII secretion system exported antibacterial toxin. Journal of Molecular Biology, 430 (21), 4344-4358. doi: 10.1016/j.jmb.2018.08.027

Molecular basis for immunity protein recognition of a type VII secretion system exported antibacterial toxin

2018

Journal Article

Two Faces of CwIM, an Essential PknB Substrate, in Mycobacterium tuberculosis

Turapov, Obolbek, Forti, Francesca, Kadhim, Baleegh, Ghisotti, Daniela, Sassine, Jad, Straatman-Iwanowska, Anna, Bottrill, Andrew R., Moynihan, Patrick J., Wallis, Russell, Barthe, Philippe, Cohen-Gonsaud, Martin, Ajuh, Paul, Vollmer, Waldemar and Mukamolova, Galina (2018). Two Faces of CwIM, an Essential PknB Substrate, in Mycobacterium tuberculosis. Cell Reports, 25 (1), 57-67.E5. doi: 10.1016/j.celrep.2018.09.004

Two Faces of CwIM, an Essential PknB Substrate, in Mycobacterium tuberculosis

2018

Journal Article

High-Resolution Analysis of the Peptidoglycan Composition in Streptomyces coelicolor

van der Aart, Lizah T., Spijksma, Gerwin K., Harms, Amy, Vollmer, Waldemar, Hankemeier, Thomas and van Wezel, Gilles P. (2018). High-Resolution Analysis of the Peptidoglycan Composition in Streptomyces coelicolor. Journal of Bacteriology, 200 (20). doi: 10.1128/JB.00290-18

High-Resolution Analysis of the Peptidoglycan Composition in Streptomyces coelicolor

2018

Journal Article

The Fluorescent D-Amino Acid NADA as a Tool to Study the Conditional Activity of Transpeptidases in Escherichia coli

Montón Silva, Alejandro, Otten, Christian, Biboy, Jacob, Breukink, Eefjan, VanNieuwenhze, Michael, Vollmer, Waldemar and den Blaauwen, Tanneke (2018). The Fluorescent D-Amino Acid NADA as a Tool to Study the Conditional Activity of Transpeptidases in Escherichia coli. Frontiers in Microbiology, 9 2101, 1-15. doi: 10.3389/fmicb.2018.02101

The Fluorescent D-Amino Acid NADA as a Tool to Study the Conditional Activity of Transpeptidases in Escherichia coli

2018

Journal Article

The lytic transglycosylase MltB connects membrane homeostasis and in vivo fitness of Acinetobacter baumannii

Crepin, Sebastien, Ottosen, Elizabeth N., Peters, Katharina, Smith, Sara N., Himpsl, Stephanie D., Vollmer, Waldemar and Mobley, Harry L. T. (2018). The lytic transglycosylase MltB connects membrane homeostasis and in vivo fitness of Acinetobacter baumannii. Molecular Microbiology, 109 (6), 745-762. doi: 10.1111/mmi.14000

The lytic transglycosylase MltB connects membrane homeostasis and in vivo fitness of Acinetobacter baumannii

2018

Journal Article

Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae

Morlot, Cecile, Straume, Daniel, Peters, Katharina, Hegnar, Olav A., Simon, Nolwenn, Villard, Anne-Marie, Contreras-Martel, Carlos, Leisico, Francisco, Breukink, Eefjan, Gravier-Pelletier, Christine, Le Corre, Laurent, Vollmer, Waldemar, Pietrancosta, Nicolas, Havarstein, Leiv Sigve and Zapun, Andre (2018). Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae. Nature Communications, 9 (1) 3180, 3180. doi: 10.1038/s41467-018-05602-w

Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae

2018

Journal Article

Seven-transmembrane receptor protein RgsP and cell wall-binding protein RgsM promote unipolar growth in Rhizobiales

Schaeper, Simon, Yau, Hamish C. L., Krol, Elizaveta, Skotnicka, Dorota, Heimerl, Thomas, Gray, Joe, Kaever, Volkhard, Sogaard-Andersen, Lotte, Vollmer, Waldemar and Becker, Anke (2018). Seven-transmembrane receptor protein RgsP and cell wall-binding protein RgsM promote unipolar growth in Rhizobiales. Plos Genetics, 14 (8), e1007594. doi: 10.1371/journal.pgen.1007594

Seven-transmembrane receptor protein RgsP and cell wall-binding protein RgsM promote unipolar growth in Rhizobiales

2018

Journal Article

Mechanical interactions between bacteria and hydrogels

Kandemir, Nehir, Vollmer, Waldemar, Jakubovics, Nicholas S. and Chen, Jinju (2018). Mechanical interactions between bacteria and hydrogels. Scientific Reports, 8 (1) 10893, 10893. doi: 10.1038/s41598-018-29269-x

Mechanical interactions between bacteria and hydrogels

2018

Journal Article

Coupling of polymerase and carrier lipid phosphatase prevents product inhibition in peptidoglycan synthesis

Hernández-Rocamora, Víctor M, Otten, Christian F., Radkov, Atanas, Simorre, Jean-Pierre, Breukink, Eefjan, VanNieuwenhze, Michael and Vollmer, Waldemar (2018). Coupling of polymerase and carrier lipid phosphatase prevents product inhibition in peptidoglycan synthesis. The Cell Surface, 2, 1-13. doi: 10.1016/j.tcsw.2018.04.002

Coupling of polymerase and carrier lipid phosphatase prevents product inhibition in peptidoglycan synthesis

2018

Journal Article

Targeting the bacterial cytoskeleton of the Burkholderia cepacia complex for antimicrobial development: a cautionary tale

Carnell, Sonya C., Perry, John D., Borthwick, Lee, Vollmer, Daniela, Biboy, Jacob, Facchini, Marcella, Bragonzi, Alessandra, Silipo, Alba, Vergunst, Annette C., Vollmer, Waldemar, Khan, Anjam C. M. and De Soyza, Anthony (2018). Targeting the bacterial cytoskeleton of the Burkholderia cepacia complex for antimicrobial development: a cautionary tale. International Journal of Molecular Sciences, 19 (6), 1-13. doi: 10.3390/ijms19061604

Targeting the bacterial cytoskeleton of the Burkholderia cepacia complex for antimicrobial development: a cautionary tale

2018

Journal Article

The cell wall hydrolase Pmp23 is important for assembly and stability of the division ring in Streptococcus pneumoniae

Jacq, Maxime, Arthaud, Christopher, Manuse, Sylvie, Mercy, Chryslene, Bellard, Laure, Peters, Katharina, Gallet, Benoit, Galindo, Jennifer, Doan, Thierry, Vollmer, Waldemar, Brun, Yves V., VanNieuwenhze, Michael S., Di Guilmi, Anne Marie, Vernet, Thierry, Grangeasse, Christophe and Morlot, Cecile (2018). The cell wall hydrolase Pmp23 is important for assembly and stability of the division ring in Streptococcus pneumoniae. Scientific Reports, 8 (1) 7591, 7591. doi: 10.1038/s41598-018-25882-y

The cell wall hydrolase Pmp23 is important for assembly and stability of the division ring in Streptococcus pneumoniae

2018

Journal Article

ArcR modulates biofilm formation in the dental plaque colonizer Streptococcus gordonii

Robinson, J. C., Rostami, N., Casement, J., Vollmer, W., Rickard, A. H. and Jakubovics, N. S. (2018). ArcR modulates biofilm formation in the dental plaque colonizer Streptococcus gordonii. Molecular Oral Microbiology, 33 (2), 143-154. doi: 10.1111/omi.12207

ArcR modulates biofilm formation in the dental plaque colonizer Streptococcus gordonii

Supervision

Availability

Professor Waldemar Vollmer is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Targeting bacterial cell envelope coordination for antibiotic drug discovery

    Principal Advisor

    Other advisors: Professor Brett Collins

  • Doctor Philosophy

    Novel assays for antibiotic discovery

    Principal Advisor

    Other advisors: Professor Rob Capon

  • Doctor Philosophy

    Dissecting the bacterial cell envelope for antibiotic drug discovery

    Principal Advisor

    Other advisors: Dr Nicholas Ariotti, Professor Rob Capon

Media

Enquiries

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