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Professor Waldemar Vollmer
Professor

Waldemar Vollmer

Email: 
Phone: 
+61 7 334 62055

Overview

Background

Overview

Professor Waldemar Vollmer is a microbiologist working on the structure and biogenesis of the bacterial cell wall in various model bacteria and a range of pathogenic and environmental bacteria. He is particularly interested in how bacteria enlarge their cell wall when they grow and divide, and how antibiotics inhibit cell wall synthesis to kill bacteria. Antimicrobial resistance (AMR) is a global problem that is predicted to claim 10 million lives annually by the year 2050 if no new antibiotics are developed. Currently the pipeline of antibiotic development is almost empty and mostly limited to slightly modified versions to existing antibiotics. Professor Vollmer addresses the problem of AMR by generating tailored assays for the development of novel antibiotics that target AMR bacteria.

Collaborations: Professor Vollmer collaborates world-wide with more than 50 researchers at top national and international institutions on cell wall topics in over 30 different bacteria. These topics include: structure and composition of the cell wall and its role in maintaining cell morphology; molecular mechanisms of cell envelope biogenesis; role of new cell wall modifying enzymes in the interaction of pathogenic bacteria with components of the immune system; mechanisms of antibiotic resistance and targeting of cell wall biogenesis by new antibiotics.

Funding and Publications: Professor Vollmer has been awarded more than $15 million funding from research councils and charities in Germany, UK, Europe and USA. He has published more than 200 articles in international journals and has been recognised as a Highly Cited Researcher in Microbiology.

Honours and Awards: Professor Vollmer has been elected to Fellow of the American Academy of Microbiology (2014) and European Academy of Microbiology (2018). He received the annual Academic Distinction Awards from the Vice Chancellor of Newcastle University (2014), has been awarded a Distinguished Scientist Visiting Scholarships at Ben-Gurion University of the Negev (Israel, 2012) and a Visiting Professorship at the University of Cagliari (Italy, 2015), and won a Wellcome Trust Senior Investigator Award (2014). He has co-organised the 2018 Gordon Conference (GRC) "Bacterial Cell Surfaces" (Mt Snow, USA) and the 2016 EMBO Workshop "Bacterial Cell Division: Orchestrating the Ring Cycle" (Prague, Czech Republic).

Short Biography: Prof Waldemar Vollmer has studied chemistry at the University of Applied Sciences in Reutlingen (Germany) and University of Basel (Switzerland). In 1998 he obtained a PhD degree (Dr.rer.nat.) from the University of Tübingen (Germany) for his work on cell wall synthesis in the model bacterium Escherichia coli undertaken at the Max Planck Institute for Developmental Biology. During his postdoctoral studies at the Rockefeller University (New York, USA) he discovered novel cell wall enzymes that are crucial for the virulence of the pathogenic bacterium Streptococcus pneumoiae. In 2003 he was appointed Assistant Professor at the University of Tübingen and moved 2007 to the Centre for Bacterial Cell Biology at Newcastle University (UK), where he worked as Professor of Bacterial Biochemistry on various bacterial cell wall topics in a range of different bacteria. Since April 2023 he is Professorial Research Fellow and Group Leader at the Centre for Superbug Solutions, Institute for Molecular Bioscience (IMB) at the University of Queensland.

Availability

Professor Waldemar Vollmer is:
Available for supervision

Fields of research

Research impacts

Professor Vollmer's basic research on the bacterial cell envelope has led to key advances in our understanding of bacterial cell function and has discovered molecular mechanisms that can be exploited for antibiotic development.

Key research outputs: Prof Vollmer's group has discovered mechanisms of PG biosynthesis and its regulation, novel cell wall enzymes, and mechanisms of coordination between PG synthesis and outer membrane biogenesis. These discoveries provided the first molecular insights into how bacteria robustly maintain, enlarge and modify their cell envelope when they propagate in diverse environments and under stress conditions, and when exposed to antibiotics.

Key capabilities: Prof Vollmer's group is expert in the analysis of the composition of peptidoglycan, the key shape-maintaining and stress-bearing component of the bacterial cell envelope. They also discover new cell wall enzymes and study the activities and interactions of of key cell wall synthases and hydrolases (lysins or autolysins). They are also expert in determining the cleavage site of cell wall-degrading lysins and establishing biochemical assays for cell wall enzymes, for studying their inhibition by antibiotics. They combine their molecular biology work with studies on the physiology of bacterial cells impaired in cell wall biogenesis.

Works

Search Professor Waldemar Vollmer’s works on UQ eSpace

239 works between 1993 and 2024

101 - 120 of 239 works

2018

Journal Article

Bacterial cell wall precursor phosphatase assays using thin-layer chromatography (TLC) and high pressure liquid chromatography (HPLC)

Pazos, Manuel, Otten, Christian and Vollmer, Waldemar (2018). Bacterial cell wall precursor phosphatase assays using thin-layer chromatography (TLC) and high pressure liquid chromatography (HPLC). Bio-protocol, 8 (6), 1-14. doi: 10.21769/BioProtoc.2761

Bacterial cell wall precursor phosphatase assays using thin-layer chromatography (TLC) and high pressure liquid chromatography (HPLC)

2018

Journal Article

Stimulation of PgdA-dependent peptidoglycan N-deacetylation by GpsB-PBP A1 in Listeria monocytogenes

Rismondo, Jeanine, Wamp, Sabrina, Aldridge, Christine, Vollmer, Waldemar and Halbedel, Sven (2018). Stimulation of PgdA-dependent peptidoglycan N-deacetylation by GpsB-PBP A1 in Listeria monocytogenes. Molecular Microbiology, 107 (4), 472-487. doi: 10.1111/mmi.13893

Stimulation of PgdA-dependent peptidoglycan N-deacetylation by GpsB-PBP A1 in Listeria monocytogenes

2018

Journal Article

Structure and activity of ChiX: a peptidoglycan hydrolase required for chitinase secretion by Serratia marcescens

Owen, Richard A., Fyfe, Paul K., Lodge, Adam, Biboy, Jacob, Vollmer, Waldemar, Hunter, William N. and Sargent, Frank (2018). Structure and activity of ChiX: a peptidoglycan hydrolase required for chitinase secretion by Serratia marcescens. Biochemical Journal, 475 (2), 415-428. doi: 10.1042/BCJ20170633

Structure and activity of ChiX: a peptidoglycan hydrolase required for chitinase secretion by Serratia marcescens

2018

Journal Article

Peptidoglycan in obligate intracellular bacteria

Otten, Christian, Brilli, Matteo, Vollmer, Waldemar, Viollier, Patrick H. and Salje, Jeanne (2018). Peptidoglycan in obligate intracellular bacteria. Molecular Microbiology, 107 (2), 142-163. doi: 10.1111/mmi.13880

Peptidoglycan in obligate intracellular bacteria

2017

Journal Article

Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae

Hess, Nathalie, Waldow, Franziska, Kohler, Thomas P., Rohde, Manfred, Kreikemeyer, Bernd, Gomez-Mejia, Alejandro, Hain, Torsten, Schwudke, Dominik, Vollmer, Waldemar, Hammerschmidt, Sven and Gisch, Nicolas (2017). Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae. Nature Communications, 8 (1) 2093, 2093. doi: 10.1038/s41467-017-01720-z

Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae

2017

Journal Article

Fluorescent D-amino-acids reveal bi-cellular cell wall modifications important for Bdellovibrio bacteriovorus predation

Kuru, Erkin, Lambert, Carey, Rittichier, Jonathan, Till, Rob, Ducret, Adrien, Derouaux, Adeline, Gray, Joe, Biboy, Jacob, Vollmer, Waldemar, VanNieuwenhze, Michael, Brun, Yves V. and Sockett, R. Elizabeth (2017). Fluorescent D-amino-acids reveal bi-cellular cell wall modifications important for Bdellovibrio bacteriovorus predation. Nature Microbiology, 2 (12), 1648-1657. doi: 10.1038/s41564-017-0029-y

Fluorescent D-amino-acids reveal bi-cellular cell wall modifications important for Bdellovibrio bacteriovorus predation

2017

Journal Article

Traceless Cleavage of Protein-Biotin Conjugates under Biologically Compatible Conditions

Cowell, Joseph, Buck, Matthew, Essa, Ali H., Clarke, Rebecca, Vollmer, Waldemar, Vollmer, Daniela, Hilkens, Catharien M., Isaacs, John D., Hall, Michael J. and Gray, Joe (2017). Traceless Cleavage of Protein-Biotin Conjugates under Biologically Compatible Conditions. ChemBioChem, 18 (17), 1688-1691. doi: 10.1002/cbic.201700214

Traceless Cleavage of Protein-Biotin Conjugates under Biologically Compatible Conditions

2017

Journal Article

AmiD Is a Novel Peptidoglycan Amidase in Wolbachia Endosymbionts of Drosophila melanogaster

Wilmes, Miriam, Meier, Kirstin, Schiefer, Andrea, Josten, Michaele, Otten, Christian F., Klockner, Anna, Henrichfreise, Beate, Vollmer, Waldemar, Hoerauf, Achim and Pfarr, Kenneth (2017). AmiD Is a Novel Peptidoglycan Amidase in Wolbachia Endosymbionts of Drosophila melanogaster. Frontiers in Cellular and Infection Microbiology, 7, 353. doi: 10.3389/fcimb.2017.00353

AmiD Is a Novel Peptidoglycan Amidase in Wolbachia Endosymbionts of Drosophila melanogaster

2017

Journal Article

A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria

Whitney, John C., Peterson, S. Brook, Kim, Jungyun, Pazos, Manuel, Verster, Adrian J., Radey, Matthew C., Kulasekara, Hemantha D., Ching, Mary Q., Bullen, Nathan P., Bryant, Diane, Goo, Young Ah, Surette, Michael G., Borenstein, Elhanan, Vollmer, Waldemar and Mougous, Joseph D. (2017). A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria. eLife, 6, 1-24. doi: 10.7554/eLife.26938

A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria

2017

Journal Article

New Aspects of the Interplay between Penicillin Binding Proteins, murM, and the Two-Component System CiaRH of Penicillin-Resistant Streptococcus pneumoniae Serotype 19A Isolates from Hungary

Schweizer, Inga, Blaettner, Sebastian, Maurer, Patrick, Peters, Katharina, Vollmer, Daniela, Vollmer, Waldemar, Hakenbeck, Regine and Denapaite, Dalia (2017). New Aspects of the Interplay between Penicillin Binding Proteins, murM, and the Two-Component System CiaRH of Penicillin-Resistant Streptococcus pneumoniae Serotype 19A Isolates from Hungary. Antimicrobial Agents and Chemotherapy, 61 (7). doi: 10.1128/AAC.00414-17

New Aspects of the Interplay between Penicillin Binding Proteins, murM, and the Two-Component System CiaRH of Penicillin-Resistant Streptococcus pneumoniae Serotype 19A Isolates from Hungary

2017

Journal Article

A mutant isoform of ObgE causes cell death by interfering with cell division

Dewachter, Liselot, Verstraeten, Natalie, Jennes, Michiel, Verbeelen, Tom, Biboy, Jacob, Monteyne, Daniel, Perez-Morga, David, Verstrepen, Kevin J., Vollmer, Waldemar, Fauvart, Maarten and Michiels, Jan (2017). A mutant isoform of ObgE causes cell death by interfering with cell division. Frontiers in Microbiology, 8, 1-12. doi: 10.3389/fmicb.2017.01193

A mutant isoform of ObgE causes cell death by interfering with cell division

2017

Journal Article

Morphology heterogeneity within a Campylobacter jejuni helical population: the use of calcofluor white to generate rod-shaped C-jejuni 81-176 clones and the genetic determinants responsible for differences in morphology within 11168 strains

Frirdich, Emilisa, Biboy, Jacob, Huynh, Steven, Parker, Craig T., Vollmer, Waldemar and Gaynor, Erin C. (2017). Morphology heterogeneity within a Campylobacter jejuni helical population: the use of calcofluor white to generate rod-shaped C-jejuni 81-176 clones and the genetic determinants responsible for differences in morphology within 11168 strains. Molecular Microbiology, 104 (6), 948-971. doi: 10.1111/mmi.13672

Morphology heterogeneity within a Campylobacter jejuni helical population: the use of calcofluor white to generate rod-shaped C-jejuni 81-176 clones and the genetic determinants responsible for differences in morphology within 11168 strains

2017

Journal Article

Robust peptidoglycan growth by dynamic and variable multi-protein complexes

Pazos, Manuel, Peters, Katharina and Vollmer, Waldemar (2017). Robust peptidoglycan growth by dynamic and variable multi-protein complexes. Current Opinion in Microbiology, 36, 55-61. doi: 10.1016/j.mib.2017.01.006

Robust peptidoglycan growth by dynamic and variable multi-protein complexes

2017

Journal Article

Regulation of bacterial cell wall growth

Egan, Alexander J. F., Cleverley, Robert M., Peters, Katharina, Lewis, Richard J. and Vollmer, Waldemar (2017). Regulation of bacterial cell wall growth. The FEBS Journal, 284 (6), 851-867. doi: 10.1111/febs.13959

Regulation of bacterial cell wall growth

2017

Journal Article

Interplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis

Leclercq, Sophie, Derouaux, Adeline, Olatunji, Samir, Fraipont, Claudine, Egan, Alexander J. F., Vollmer, Waldemar, Breukink, Eefjan and Terrak, Mohammed (2017). Interplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis. Scientific Reports, 7 ARTN 43306, 1-13. doi: 10.1038/srep43306

Interplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis

2016

Journal Article

Site-Specific Immobilization of the Peptidoglycan Synthase PBP1B on a Surface Plasmon Resonance Chip Surface

van't Veer, Inge L., Leloup, Nadia O. L., Egan, Alexander J. F., Janssen, Bert J. C., Martin, Nathaniel I., Vollmer, Waldemar and Breukink, Eefjan (2016). Site-Specific Immobilization of the Peptidoglycan Synthase PBP1B on a Surface Plasmon Resonance Chip Surface. ChemBioChem, 17 (23), 2250-2256. doi: 10.1002/cbic.201600461

Site-Specific Immobilization of the Peptidoglycan Synthase PBP1B on a Surface Plasmon Resonance Chip Surface

2016

Journal Article

Accumulation of peptidoglycan O-acetylation leads to altered cell wall biochemistry and negatively impacts pathogenesis factors of Campylobacter jejuni

Ha, Reuben, Frirdich, Emilisa, Sychantha, David, Biboy, Jacob, Taveirne, Michael E., Johnson, Jeremiah G., DiRita, Victor J., Vollmer, Waldemar, Clarke, Anthony J. and Gaynor, Erin C. (2016). Accumulation of peptidoglycan O-acetylation leads to altered cell wall biochemistry and negatively impacts pathogenesis factors of Campylobacter jejuni. Journal of Biological Chemistry, 291 (43), 22686-22702. doi: 10.1074/jbc.M116.746404

Accumulation of peptidoglycan O-acetylation leads to altered cell wall biochemistry and negatively impacts pathogenesis factors of Campylobacter jejuni

2016

Journal Article

A penicillin-binding protein inhibits selection of colistin-resistant, lipooligosaccharide-deficient Acinetobacter baumannii

Boll, Joseph M., Crofts, Alexander A., Peters, Katharina, Cattoir, Vincent, Vollmer, Waldemar, Davies, Bryan W. and Trent, M. Stephen (2016). A penicillin-binding protein inhibits selection of colistin-resistant, lipooligosaccharide-deficient Acinetobacter baumannii. Proceedings of the National Academy of Sciences of the United States of America, 113 (41), E6228-E6237. doi: 10.1073/pnas.1611594113

A penicillin-binding protein inhibits selection of colistin-resistant, lipooligosaccharide-deficient Acinetobacter baumannii

2016

Journal Article

Subunit Arrangement in GpsB, a Regulator of Cell Wall Biosynthesis

Cleverley, Robert M., Rismondo, Jeanine, Lockhart-Cairns, Michael P., Van Bentum, Paulien T., Egan, Alexander J. F., Vollmer, Waldemar, Halbedel, Sven, Baldock, Clair, Breukink, Eefjan and Lewis, Richard J. (2016). Subunit Arrangement in GpsB, a Regulator of Cell Wall Biosynthesis. Microbial Drug Resistance, 22 (6), 446-460. doi: 10.1089/mdr.2016.0050

Subunit Arrangement in GpsB, a Regulator of Cell Wall Biosynthesis

2016

Journal Article

Lyme disease and relapsing fever Borrelia elongate through zones of peptidoglycan synthesis that mark division sites of daughter cells

Jutras, Brandon Lyon, Scott, Molly, Parry, Bradley, Biboy, Jacob, Gray, Joe, Vollmer, Waldemar and Jacobs-Wagner, Christine (2016). Lyme disease and relapsing fever Borrelia elongate through zones of peptidoglycan synthesis that mark division sites of daughter cells. Proceedings of the National Academy of Sciences, 113 (33), 9162-9170. doi: 10.1073/pnas.1610805113

Lyme disease and relapsing fever Borrelia elongate through zones of peptidoglycan synthesis that mark division sites of daughter cells

Supervision

Availability

Professor Waldemar Vollmer is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Dissecting the bacterial cell envelope for antibiotic drug discovery

    Principal Advisor

    Other advisors: Dr Nicholas Ariotti, Professor Rob Capon

  • Doctor Philosophy

    Targeting bacterial cell envelope coordination for antibiotic drug discovery

    Principal Advisor

    Other advisors: Professor Brett Collins

  • Doctor Philosophy

    Novel assays for antibiotic discovery

    Principal Advisor

    Other advisors: Professor Rob Capon

Media

Enquiries

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