
Overview
Background
Overview
Professor Waldemar Vollmer is a microbiologist working on the structure and biogenesis of the bacterial cell wall in various model bacteria and a range of pathogenic and environmental bacteria. He is particularly interested in how bacteria enlarge their cell wall when they grow and divide, and how antibiotics inhibit cell wall synthesis to kill bacteria. Antimicrobial resistance (AMR) is a global problem that is predicted to claim 10 million lives annually by the year 2050 if no new antibiotics are developed. Currently the pipeline of antibiotic development is almost empty and mostly limited to slightly modified versions to existing antibiotics. Professor Vollmer addresses the problem of AMR by generating tailored assays for the development of novel antibiotics that target AMR bacteria.
Collaborations: Professor Vollmer collaborates world-wide with more than 50 researchers at top national and international institutions on cell wall topics in over 30 different bacteria. These topics include: structure and composition of the cell wall and its role in maintaining cell morphology; molecular mechanisms of cell envelope biogenesis; role of new cell wall modifying enzymes in the interaction of pathogenic bacteria with components of the immune system; mechanisms of antibiotic resistance and targeting of cell wall biogenesis by new antibiotics.
Funding and Publications: Professor Vollmer has been awarded more than $15 million funding from research councils and charities in Germany, UK, Europe and USA. He has published more than 200 articles in international journals and has been recognised as a Highly Cited Researcher in Microbiology.
Honours and Awards: Professor Vollmer has been elected to Fellow of the American Academy of Microbiology (2014) and European Academy of Microbiology (2018). He received the annual Academic Distinction Awards from the Vice Chancellor of Newcastle University (2014), has been awarded a Distinguished Scientist Visiting Scholarships at Ben-Gurion University of the Negev (Israel, 2012) and a Visiting Professorship at the University of Cagliari (Italy, 2015), and won a Wellcome Trust Senior Investigator Award (2014). He has co-organised the 2018 Gordon Conference (GRC) "Bacterial Cell Surfaces" (Mt Snow, USA) and the 2016 EMBO Workshop "Bacterial Cell Division: Orchestrating the Ring Cycle" (Prague, Czech Republic).
Short Biography: Prof Waldemar Vollmer has studied chemistry at the University of Applied Sciences in Reutlingen (Germany) and University of Basel (Switzerland). In 1998 he obtained a PhD degree (Dr.rer.nat.) from the University of Tübingen (Germany) for his work on cell wall synthesis in the model bacterium Escherichia coli undertaken at the Max Planck Institute for Developmental Biology. During his postdoctoral studies at the Rockefeller University (New York, USA) he discovered novel cell wall enzymes that are crucial for the virulence of the pathogenic bacterium Streptococcus pneumoiae. In 2003 he was appointed Assistant Professor at the University of Tübingen and moved 2007 to the Centre for Bacterial Cell Biology at Newcastle University (UK), where he worked as Professor of Bacterial Biochemistry on various bacterial cell wall topics in a range of different bacteria. Since April 2023 he is Professorial Research Fellow and Group Leader at the Centre for Superbug Solutions, Institute for Molecular Bioscience (IMB) at the University of Queensland.
Availability
- Professor Waldemar Vollmer is:
- Available for supervision
Fields of research
Research impacts
Professor Vollmer's basic research on the bacterial cell envelope has led to key advances in our understanding of bacterial cell function and has discovered molecular mechanisms that can be exploited for antibiotic development.
Key research outputs: Prof Vollmer's group has discovered mechanisms of PG biosynthesis and its regulation, novel cell wall enzymes, and mechanisms of coordination between PG synthesis and outer membrane biogenesis. These discoveries provided the first molecular insights into how bacteria robustly maintain, enlarge and modify their cell envelope when they propagate in diverse environments and under stress conditions, and when exposed to antibiotics.
Key capabilities: Prof Vollmer's group is expert in the analysis of the composition of peptidoglycan, the key shape-maintaining and stress-bearing component of the bacterial cell envelope. They also discover new cell wall enzymes and study the activities and interactions of of key cell wall synthases and hydrolases (lysins or autolysins). They are also expert in determining the cleavage site of cell wall-degrading lysins and establishing biochemical assays for cell wall enzymes, for studying their inhibition by antibiotics. They combine their molecular biology work with studies on the physiology of bacterial cells impaired in cell wall biogenesis.
Works
Search Professor Waldemar Vollmer’s works on UQ eSpace
2011
Journal Article
Self-Resistance and Cell Wall Composition in the Glycopeptide Producer Amycolatopsis balhimycina
Schaeberle, Till F., Vollmer, Waldemar, Frasch, Hans-Joerg, Huettel, Stephan, Kulik, Andreas, Roettgen, Marlene, von Thaler, Anna-Katharina, Wohlleben, Wolfgang and Stegmann, Evi (2011). Self-Resistance and Cell Wall Composition in the Glycopeptide Producer Amycolatopsis balhimycina. Antimicrobial Agents and Chemotherapy, 55 (9), 4283-4289. doi: 10.1128/AAC.01372-10
2011
Journal Article
Type VI secretion delivers bacteriolytic effectors to target cells
Russell, Alistair B., Hood, Rachel D., Bui, Nhat Khai, LeRoux, Michele, Vollmer, Waldemar and Mougous, Joseph D. (2011). Type VI secretion delivers bacteriolytic effectors to target cells. Nature, 475 (7356), 343-347. doi: 10.1038/nature10244
2011
Journal Article
Acquisition of VanB-type vancomycin resistance by Bacillus subtilis: the impact on gene expression, cell wall composition and morphology
Bisicchia, Paola, Nhat Khai Bui, , Aldridge, Christine, Vollmer, Waldemar and Devine, Kevin M. (2011). Acquisition of VanB-type vancomycin resistance by Bacillus subtilis: the impact on gene expression, cell wall composition and morphology. Molecular Microbiology, 81 (1), 157-178. doi: 10.1111/j.1365-2958.2011.07684.x
2011
Journal Article
Development of screening assays and discovery of initial inhibitors of pneumococcal peptidoglycan deacetylase PgdA
Bui, Nhat Khai, Turk, Samo, Buckenmaier, Stephan, Stevenson-Jones, Flint, Zeuch, Benjamin, Gobec, Stanislav and Vollmer, Waldemar (2011). Development of screening assays and discovery of initial inhibitors of pneumococcal peptidoglycan deacetylase PgdA. Biochemical Pharmacology, 82 (1), 43-52. doi: 10.1016/j.bcp.2011.03.028
2011
Journal Article
A Novel in vivo Cell-Wall Labeling Approach Sheds New Light on Peptidoglycan Synthesis in Escherichia coli
Olrichs, Nick K., Aarsman, Mirjam E. G., Verheul, Jolanda, Arnusch, Christopher J., Martin, Nathaniel I., Herve, Mireille, Vollmer, Waldemar, de Kruijff, Ben, Breukink, Eefjan and den Blaauwen, Tanneke (2011). A Novel in vivo Cell-Wall Labeling Approach Sheds New Light on Peptidoglycan Synthesis in Escherichia coli. ChemBioChem, 12 (7), 1124-1133. doi: 10.1002/cbic.201000552
2010
Book Chapter
Bacterial cell envelope peptidoglycan
Vollmer, Waldemar and Born, Petra (2010). Bacterial cell envelope peptidoglycan. Microbial glycobiology. (pp. 15-28) edited by Otto Holst, Patrick J. Brennan and Mark von Itzstein. Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-12-374546-0.00002-x
2010
Journal Article
Dynamics Characterization of Fully Hydrated Bacterial Cell Walls by Solid-State NMR: Evidence for Cooperative Binding of Metal Ions
Kern, Thomas, Giffard, Mathilde, Hediger, Sabine, Amoroso, Ana, Giustini, Cecile, Bui, Nhat Khai, Joris, Bernard, Bougault, Catherine, Vollmer, Waldemar and Simorre, Jean-Pierre (2010). Dynamics Characterization of Fully Hydrated Bacterial Cell Walls by Solid-State NMR: Evidence for Cooperative Binding of Metal Ions. Journal of the American Chemical Society, 132 (31), 10911-10919. doi: 10.1021/ja104533w
2010
Journal Article
A protein critical for cell constriction in the Gram-negative bacterium Caulobacter crescentus localizes at the division site through its peptidoglycan-binding LysM domains
Poggio, Sebastian, Takacs, Constantin N., Vollmer, Waldemar and Jacobs-Wagner, Christine (2010). A protein critical for cell constriction in the Gram-negative bacterium Caulobacter crescentus localizes at the division site through its peptidoglycan-binding LysM domains. Molecular Microbiology, 77 (1), 74-89. doi: 10.1111/j.1365-2958.2010.07223.x
2010
Journal Article
Mutations in the lipopolysaccharide biosynthesis pathway interfere with crescentin-mediated cell curvature in Caulobacter crescentus
Cabeen, Matthew T., Murolo, Michelle A., Briegel, Ariane, Bui, N. Khai, Vollmer, Waldemar, Ausmees, Nora, Jensen, Grant J. and Jacobs-Wagner, Christine (2010). Mutations in the lipopolysaccharide biosynthesis pathway interfere with crescentin-mediated cell curvature in Caulobacter crescentus. Journal of Bacteriology, 192 (13), 3368-3378. doi: 10.1128/JB.01371-09
2010
Journal Article
Septal and lateral wall localization of PBP5, the major D,D-carboxypeptidase of Escherichia coli, requires substrate recognition and membrane attachment
Potluri, Lakshmiprasad, Karczmarek, Aneta, Verheul, Jolanda, Piette, Andre, Wilkin, Jean-Marc, Werth, Nadine, Banzhaf, Manuel, Vollmer, Waldemar, Young, Kevin D., Nguyen-Disteche, Martine and den Blaauwen, Tanneke (2010). Septal and lateral wall localization of PBP5, the major D,D-carboxypeptidase of Escherichia coli, requires substrate recognition and membrane attachment. Molecular Microbiology, 77 (2), 300-323. doi: 10.1111/j.1365-2958.2010.07205.x
2010
Journal Article
Peptidoglycan crosslinking relaxation promotes Helicobacter pylori's helical shape and stomach colonization
Sycuro, Laura K., Pincus, Zachary, Gutierrez, Kimberley D., Biboy, Jacob, Stern, Chelsea A., Vollmer, Waldemar and Salama, Nina R. (2010). Peptidoglycan crosslinking relaxation promotes Helicobacter pylori's helical shape and stomach colonization. Cell, 141 (5), 822-833. doi: 10.1016/j.cell.2010.03.046
2010
Journal Article
Insights into pneumococcal fratricide from the crystal structures of the modular killing factor LytC
Perez-Dorado, Inmaculada, Gonzalez, Ana, Morales, Maria, Sanles, Reyes, Striker, Waldemar, Vollmer, Waldemar, Mobashery, Shahriar, Garcia, Jose L., Martinez-Ripoll, Martin, Garcia, Pedro and Hermoso, Juan A. (2010). Insights into pneumococcal fratricide from the crystal structures of the modular killing factor LytC. Nature Structural and Molecular Biology, 17 (5), 576-581. doi: 10.1038/nsmb.1817
2010
Journal Article
MreB drives de novo rod morphogenesis in Caulobacter crescentus via remodeling of the cell wall
Takacs, Constantin N., Poggio, Sebastian, Charbon, Godefroid, Pucheault, Mathieu, Vollmer, Waldemar and Jacobs-Wagner, Christine (2010). MreB drives de novo rod morphogenesis in Caulobacter crescentus via remodeling of the cell wall. Journal of Bacteriology, 192 (6), 1671-1684. doi: 10.1128/JB.01311-09
2010
Journal Article
Architecture of peptidoglycan: more data and more models
Vollmer, Waldemar and Seligman, Stephen J. (2010). Architecture of peptidoglycan: more data and more models. Trends in Microbiology, 18 (2), 59-66. doi: 10.1016/j.tim.2009.12.004
2009
Journal Article
Cellular localization of choline-utilization proteins in Streptococcus pneumoniae using novel fluorescent reporter systems
Eberhardt, Alice, Wu, Ling J., Errington, Jeff, Vollmer, Waldemar and Veening, Jan-Willem (2009). Cellular localization of choline-utilization proteins in Streptococcus pneumoniae using novel fluorescent reporter systems. Molecular Microbiology, 74 (2), 395-408. doi: 10.1111/j.1365-2958.2009.06872.x
2009
Journal Article
Role of Teichoic Acid Choline Moieties in the Virulence of Streptococcus pneumoniae
Gehre, Florian, Spisek, Radek, Kharat, Arun S., Matthews, Phillip, Kukreja, Anjli, Anthony, Robert M., Dhodapkar, Madhav V., Vollmer, Waldemar and Tomasz, Alexander (2009). Role of Teichoic Acid Choline Moieties in the Virulence of Streptococcus pneumoniae. Infection and Immunity, 77 (7), 2824-2831. doi: 10.1128/IAI.00986-08
2009
Journal Article
Bacterial cell curvature through mechanical control of cell growth
Cabeen, Matthew T., Charbon, Godefroid, Vollmer, Waldemar, Born, Petra, Ausmees, Nora, Weibel, Douglas B. and Jacobs-Wagner, Christine (2009). Bacterial cell curvature through mechanical control of cell growth. Embo Journal, 28 (9), 1208-1219. doi: 10.1038/emboj.2009.61
2009
Journal Article
Murein: The dynamic exoskeleton of bacteria Das dynamische exoskelett der bakterien
Vollmer, Waldemar (2009). Murein: The dynamic exoskeleton of bacteria Das dynamische exoskelett der bakterien. BioSpektrum, 15 (3), 248-251.
2009
Journal Article
Polyphosphates from Mycobacterium bovis- potent inhibitors of class III adenylate cyclases
Guo, Ying Lan, Mayer, Hermann, Vollmer, Waldemar, Dittrich, Dorothea, Sander, Peter, Schultz, Anita and Schultz, Joachim E. (2009). Polyphosphates from Mycobacterium bovis- potent inhibitors of class III adenylate cyclases. FEBS Journal, 276 (4), 1094-1103. doi: 10.1111/j.1742-4658.2008.06852.x
2009
Journal Article
Synthesis of CDP-activated ribitol for teichoic acid precursors in Streptococcus pneumoniae
Baur, Stefanie, Maries-Wright, Jon, Buckenmaier, Stephan, Lewis, Richard J. and Vollmer, Waldemar (2009). Synthesis of CDP-activated ribitol for teichoic acid precursors in Streptococcus pneumoniae. Journal of Bacteriology, 191 (4), 1200-1210. doi: 10.1128/JB.01120-08
Funding
Current funding
Supervision
Availability
- Professor Waldemar Vollmer is:
- Available for supervision
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Available projects
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Novel antibacterials from nature targeting the bacterial cell envelope
The project uses methods in molecular microbiology and natural product chemistry to discover new antibiotics from natural sources that kill bacteria by targeting their cell wall.
Supervision history
Current supervision
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Doctor Philosophy
Targeting bacterial cell envelope coordination for antibiotic drug discovery
Principal Advisor
Other advisors: Professor Brett Collins
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Doctor Philosophy
Novel assays for antibiotic discovery
Principal Advisor
Other advisors: Professor Rob Capon
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Doctor Philosophy
Dissecting the bacterial cell envelope for antibiotic drug discovery
Principal Advisor
Other advisors: Dr Nicholas Ariotti, Professor Rob Capon
Media
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