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Professor Waldemar Vollmer
Professor

Waldemar Vollmer

Email: 
Phone: 
+61 7 334 62055

Overview

Background

Overview

Professor Waldemar Vollmer is a microbiologist working on the structure and biogenesis of the bacterial cell wall in various model bacteria and a range of pathogenic and environmental bacteria. He is particularly interested in how bacteria enlarge their cell wall when they grow and divide, and how antibiotics inhibit cell wall synthesis to kill bacteria. Antimicrobial resistance (AMR) is a global problem that is predicted to claim 10 million lives annually by the year 2050 if no new antibiotics are developed. Currently the pipeline of antibiotic development is almost empty and mostly limited to slightly modified versions to existing antibiotics. Professor Vollmer addresses the problem of AMR by generating tailored assays for the development of novel antibiotics that target AMR bacteria.

Collaborations: Professor Vollmer collaborates world-wide with more than 50 researchers at top national and international institutions on cell wall topics in over 30 different bacteria. These topics include: structure and composition of the cell wall and its role in maintaining cell morphology; molecular mechanisms of cell envelope biogenesis; role of new cell wall modifying enzymes in the interaction of pathogenic bacteria with components of the immune system; mechanisms of antibiotic resistance and targeting of cell wall biogenesis by new antibiotics.

Funding and Publications: Professor Vollmer has been awarded more than $15 million funding from research councils and charities in Germany, UK, Europe and USA. He has published more than 200 articles in international journals and has been recognised as a Highly Cited Researcher in Microbiology.

Honours and Awards: Professor Vollmer has been elected to Fellow of the American Academy of Microbiology (2014) and European Academy of Microbiology (2018). He received the annual Academic Distinction Awards from the Vice Chancellor of Newcastle University (2014), has been awarded a Distinguished Scientist Visiting Scholarships at Ben-Gurion University of the Negev (Israel, 2012) and a Visiting Professorship at the University of Cagliari (Italy, 2015), and won a Wellcome Trust Senior Investigator Award (2014). He has co-organised the 2018 Gordon Conference (GRC) "Bacterial Cell Surfaces" (Mt Snow, USA) and the 2016 EMBO Workshop "Bacterial Cell Division: Orchestrating the Ring Cycle" (Prague, Czech Republic).

Short Biography: Prof Waldemar Vollmer has studied chemistry at the University of Applied Sciences in Reutlingen (Germany) and University of Basel (Switzerland). In 1998 he obtained a PhD degree (Dr.rer.nat.) from the University of Tübingen (Germany) for his work on cell wall synthesis in the model bacterium Escherichia coli undertaken at the Max Planck Institute for Developmental Biology. During his postdoctoral studies at the Rockefeller University (New York, USA) he discovered novel cell wall enzymes that are crucial for the virulence of the pathogenic bacterium Streptococcus pneumoiae. In 2003 he was appointed Assistant Professor at the University of Tübingen and moved 2007 to the Centre for Bacterial Cell Biology at Newcastle University (UK), where he worked as Professor of Bacterial Biochemistry on various bacterial cell wall topics in a range of different bacteria. Since April 2023 he is Professorial Research Fellow and Group Leader at the Centre for Superbug Solutions, Institute for Molecular Bioscience (IMB) at the University of Queensland.

Availability

Professor Waldemar Vollmer is:
Available for supervision

Fields of research

Research impacts

Professor Vollmer's basic research on the bacterial cell envelope has led to key advances in our understanding of bacterial cell function and has discovered molecular mechanisms that can be exploited for antibiotic development.

Key research outputs: Prof Vollmer's group has discovered mechanisms of PG biosynthesis and its regulation, novel cell wall enzymes, and mechanisms of coordination between PG synthesis and outer membrane biogenesis. These discoveries provided the first molecular insights into how bacteria robustly maintain, enlarge and modify their cell envelope when they propagate in diverse environments and under stress conditions, and when exposed to antibiotics.

Key capabilities: Prof Vollmer's group is expert in the analysis of the composition of peptidoglycan, the key shape-maintaining and stress-bearing component of the bacterial cell envelope. They also discover new cell wall enzymes and study the activities and interactions of of key cell wall synthases and hydrolases (lysins or autolysins). They are also expert in determining the cleavage site of cell wall-degrading lysins and establishing biochemical assays for cell wall enzymes, for studying their inhibition by antibiotics. They combine their molecular biology work with studies on the physiology of bacterial cells impaired in cell wall biogenesis.

Works

Search Professor Waldemar Vollmer’s works on UQ eSpace

239 works between 1993 and 2024

201 - 220 of 239 works

2008

Journal Article

Different pathways of choline metabolism in two choline-independent strains of Streptococcus pneumoniae and their impact on virulence

Kharat, Arun S., Denapaite, Dalia, Gehre, Florian, Brueckner, Reinhold, Vollmer, Waldemar, Hakenbeck, Regine and Tomasz, Alexander (2008). Different pathways of choline metabolism in two choline-independent strains of Streptococcus pneumoniae and their impact on virulence. Journal of Bacteriology, 190 (17), 5907-5914. doi: 10.1128/JB.00628-08

Different pathways of choline metabolism in two choline-independent strains of Streptococcus pneumoniae and their impact on virulence

2008

Journal Article

Murein (peptidoglycan) structure, architecture and biosynthesis in Escherichia coli

Vollmer, Waldemar and Bertsche, Ute (2008). Murein (peptidoglycan) structure, architecture and biosynthesis in Escherichia coli. Biochimica Et Biophysica Acta-Biomembranes, 1778 (9), 1714-1734. doi: 10.1016/j.bbamem.2007.06.007

Murein (peptidoglycan) structure, architecture and biosynthesis in Escherichia coli

2008

Journal Article

Toward the characterization of peptidoglycan structure and protein - Peptidoglycan interactions by solid-state NMR Spectroscopy

Kern, Thomas, Hediger, Sabine, Mueller, Patrick, Giustini, Cecile, Joris, Bernard, Bougault, Catherine, Vollmer, Waldemar and Simorre, Jean-Pierre (2008). Toward the characterization of peptidoglycan structure and protein - Peptidoglycan interactions by solid-state NMR Spectroscopy. Journal of the American Chemical Society, 130 (17), 5618-5619. doi: 10.1021/ja7108135

Toward the characterization of peptidoglycan structure and protein - Peptidoglycan interactions by solid-state NMR Spectroscopy

2008

Journal Article

Peptidoglycan structure and architecture

Vollmer, Waldemar, Blanot, Didier and de Pedro, Miguel A. (2008). Peptidoglycan structure and architecture. FEMS Microbiology Reviews, 32 (2), 149-167. doi: 10.1111/j.1574-6976.2007.00094.x

Peptidoglycan structure and architecture

2008

Journal Article

Structural variation in the glycan strands of bacterial peptidoglycan

Vollmer, Waldemar (2008). Structural variation in the glycan strands of bacterial peptidoglycan. FEMS Microbiology Reviews, 32 (2), 287-306. doi: 10.1111/j.1574-6976.2007.00088.x

Structural variation in the glycan strands of bacterial peptidoglycan

2008

Journal Article

Bacterial peptidoglycan (murein) hydrolases

Vollmer, Waldemar, Joris, Bernard, Charlier, Paulette and Foster, Simon (2008). Bacterial peptidoglycan (murein) hydrolases. FEMS Microbiology Reviews, 32 (2), 259-286. doi: 10.1111/j.1574-6976.2007.00099.x

Bacterial peptidoglycan (murein) hydrolases

2008

Journal Article

Targeting the bacterial Z-ring

Vollmer, Waldemar (2008). Targeting the bacterial Z-ring. Chemistry and Biology, 15 (2), 93-94. doi: 10.1016/j.chembiol.2008.02.001

Targeting the bacterial Z-ring

2007

Journal Article

The essential cell division protein FtsN interacts with the murein (peptidoglycan) synthase PBP1B in Escherichia coli

Mueller, Patrick, Ewers, Carolin, Bertsche, Ute, Anstett, Maria, Kallis, Tanja, Breukink, Eefjan, Fraipont, Claudine, Terrak, Mohammed, Nguyen-Disteche, Martine and Vollmer, Waldemar (2007). The essential cell division protein FtsN interacts with the murein (peptidoglycan) synthase PBP1B in Escherichia coli. Journal of Biological Chemistry, 282 (50), 36394-36402. doi: 10.1074/jbc.M706390200

The essential cell division protein FtsN interacts with the murein (peptidoglycan) synthase PBP1B in Escherichia coli

2007

Journal Article

The essential tacF gene is responsible for the choline-dependent growth phenotype of Streptococcus pneumoniae

Damjanovic, Marlen, Kharat, Arun S., Eberhardt, Alice, Tomasz, Alexander and Vollmer, Waldemar (2007). The essential tacF gene is responsible for the choline-dependent growth phenotype of Streptococcus pneumoniae. Journal of Bacteriology, 189 (19), 7105-7111. doi: 10.1128/JB.00681-07

The essential tacF gene is responsible for the choline-dependent growth phenotype of Streptococcus pneumoniae

2007

Journal Article

The tubulin homologue FtsZ contributes to cell elongation by guiding cell wall precursor synthesis in Caulobacter crescentus

Aaron, Michelle, Charbon, Godefroid, Lam, Hubert, Schwarz, Heinz, Vollmer, Waldemar and Jacobs-Wagner, Christine (2007). The tubulin homologue FtsZ contributes to cell elongation by guiding cell wall precursor synthesis in Caulobacter crescentus. Molecular Microbiology, 64 (4), 938-952. doi: 10.1111/j.1365-2958.2007.05720.x

The tubulin homologue FtsZ contributes to cell elongation by guiding cell wall precursor synthesis in Caulobacter crescentus

2007

Book Chapter

Preparation and analysis of pneumococcal murein (peptidoglycan)

Vollmer, W. (2007). Preparation and analysis of pneumococcal murein (peptidoglycan). Molecular Biology of Streptococci. (pp. 531-535) edited by Regine Hakenbeck and Singh Chhatwal. United Kingdom: Taylor & Francis.

Preparation and analysis of pneumococcal murein (peptidoglycan)

2007

Book Chapter

Structure and biosynthesis of the pneumococcal cell wall

Vollmer, W. (2007). Structure and biosynthesis of the pneumococcal cell wall. Molecular Biology of Streptococci. (pp. 83-117) edited by Regine Hakenbeck and Singh Chhatwal. United Kingdom: Taylor & Francis.

Structure and biosynthesis of the pneumococcal cell wall

2006

Book Chapter

Structure and Biosynthesis of the Murein (Peptidoglycan) Sacculus

Vollmer, Waldemar (2006). Structure and Biosynthesis of the Murein (Peptidoglycan) Sacculus. The Periplasm. (pp. 198-213) edited by Michael Ehrmann. Washington, DC United States: ASM Press. doi: 10.1128/9781555815806.ch11

Structure and Biosynthesis of the Murein (Peptidoglycan) Sacculus

2006

Journal Article

The prokaryotic cytoskeleton: a putative target for inhibitors and antibiotics?

Vollmer, Waldemar (2006). The prokaryotic cytoskeleton: a putative target for inhibitors and antibiotics?. Applied Microbiology and Biotechnology, 73 (1), 37-47. doi: 10.1007/s00253-006-0586-0

The prokaryotic cytoskeleton: a putative target for inhibitors and antibiotics?

2006

Journal Article

In vitro synthesis of cross-linked murein and its attachment to sacculi by PBP1A from Escherichia coli

Born, Petra, Breukink, Eefjan and Vollmer, Waldemar (2006). In vitro synthesis of cross-linked murein and its attachment to sacculi by PBP1A from Escherichia coli. Journal of Biological Chemistry, 281 (37), 26985-26993. doi: 10.1074/jbc.M604083200

In vitro synthesis of cross-linked murein and its attachment to sacculi by PBP1A from Escherichia coli

2006

Journal Article

Attenuation of penicillin resistance in a peptidoglycan O-acetyl transferase mutant of Streptococcus pneumoniae

Crisostomo, M. Ines, Vollmer, Waldemar, Kharat, Arun S., Inhuelsen, Silja, Gehre, Florian, Buckenmaier, Stephan and Tomasz, Alexander (2006). Attenuation of penicillin resistance in a peptidoglycan O-acetyl transferase mutant of Streptococcus pneumoniae. Molecular Microbiology, 61 (6), 1497-1509. doi: 10.1111/j.1365-2958.2006.05340.x

Attenuation of penicillin resistance in a peptidoglycan O-acetyl transferase mutant of Streptococcus pneumoniae

2006

Journal Article

A functional dlt operon, encoding proteins required for incorporation of D-alanine in teichoic acids in gram-positive bacteria, confers resistance to cationic antimicrobial peptides in Streptococcus pneumoniae

Kovacs, Marta, Halfmann, Alexander, Fedtke, Iris, Heintz, Manuel, Peschel, Andreas, Vollmer, Waldemar, Hakenbeck, Regine and Brueckner, Reinhold (2006). A functional dlt operon, encoding proteins required for incorporation of D-alanine in teichoic acids in gram-positive bacteria, confers resistance to cationic antimicrobial peptides in Streptococcus pneumoniae. Journal of Bacteriology, 188 (16), 5797-5805. doi: 10.1128/JB.00336-06

A functional dlt operon, encoding proteins required for incorporation of D-alanine in teichoic acids in gram-positive bacteria, confers resistance to cationic antimicrobial peptides in Streptococcus pneumoniae

2006

Journal Article

Interaction between two murein (peptidoglycan) synthases, PBP3 and PBP1B, in Escherichia coli

Bertsche, Ute, Kast, Thomas, Wolf, Benoit, Fraipont, Claudine, Aarsman, Mirjam E. G., Kannenberg, Kai, von Rechenberg, Moritz, Nguyen-Disteche, Martine, den Blaauwen, Tanneke, Hoeltje, Joachim-Volker and Vollmer, Waldemar (2006). Interaction between two murein (peptidoglycan) synthases, PBP3 and PBP1B, in Escherichia coli. Molecular Microbiology, 61 (3), 675-690. doi: 10.1111/j.1365-2958.2006.05280.x

Interaction between two murein (peptidoglycan) synthases, PBP3 and PBP1B, in Escherichia coli

2006

Book Chapter

Cytoskeletal elements in prokaryotes

Vollmer, Waldemar (2006). Cytoskeletal elements in prokaryotes. Complex intracellular structures in prokaryotes. (pp. 305-311) edited by Jessup M. Shively. Berlin, Heidelberg: Springer Berlin Heidelberg. doi: 10.1007/7171_029

Cytoskeletal elements in prokaryotes

2005

Journal Article

In vitro murein (peptidoglycan) synthesis by dimers of the bifunctional transglycosylase-transpeptidase PBP1B from Escherichia coli

Bertsche, Ute, Breukink, Eefjan, Kast, Thomas and Vollmer, Waldemar (2005). In vitro murein (peptidoglycan) synthesis by dimers of the bifunctional transglycosylase-transpeptidase PBP1B from Escherichia coli. Journal of Biological Chemistry, 280 (45), 38096-38101. doi: 10.1074/jbc.M508646200

In vitro murein (peptidoglycan) synthesis by dimers of the bifunctional transglycosylase-transpeptidase PBP1B from Escherichia coli

Supervision

Availability

Professor Waldemar Vollmer is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Targeting bacterial cell envelope coordination for antibiotic drug discovery

    Principal Advisor

    Other advisors: Professor Brett Collins

  • Doctor Philosophy

    Novel assays for antibiotic discovery

    Principal Advisor

    Other advisors: Professor Rob Capon

  • Doctor Philosophy

    Dissecting the bacterial cell envelope for antibiotic drug discovery

    Principal Advisor

    Other advisors: Dr Nicholas Ariotti, Professor Rob Capon

Media

Enquiries

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