
Overview
Background
Overview
Professor Waldemar Vollmer is a microbiologist working on the structure and biogenesis of the bacterial cell wall in various model bacteria and a range of pathogenic and environmental bacteria. He is particularly interested in how bacteria enlarge their cell wall when they grow and divide, and how antibiotics inhibit cell wall synthesis to kill bacteria. Antimicrobial resistance (AMR) is a global problem that is predicted to claim 10 million lives annually by the year 2050 if no new antibiotics are developed. Currently the pipeline of antibiotic development is almost empty and mostly limited to slightly modified versions to existing antibiotics. Professor Vollmer addresses the problem of AMR by generating tailored assays for the development of novel antibiotics that target AMR bacteria.
Collaborations: Professor Vollmer collaborates world-wide with more than 50 researchers at top national and international institutions on cell wall topics in over 30 different bacteria. These topics include: structure and composition of the cell wall and its role in maintaining cell morphology; molecular mechanisms of cell envelope biogenesis; role of new cell wall modifying enzymes in the interaction of pathogenic bacteria with components of the immune system; mechanisms of antibiotic resistance and targeting of cell wall biogenesis by new antibiotics.
Funding and Publications: Professor Vollmer has been awarded more than $15 million funding from research councils and charities in Germany, UK, Europe and USA. He has published more than 200 articles in international journals and has been recognised as a Highly Cited Researcher in Microbiology.
Honours and Awards: Professor Vollmer has been elected to Fellow of the American Academy of Microbiology (2014) and European Academy of Microbiology (2018). He received the annual Academic Distinction Awards from the Vice Chancellor of Newcastle University (2014), has been awarded a Distinguished Scientist Visiting Scholarships at Ben-Gurion University of the Negev (Israel, 2012) and a Visiting Professorship at the University of Cagliari (Italy, 2015), and won a Wellcome Trust Senior Investigator Award (2014). He has co-organised the 2018 Gordon Conference (GRC) "Bacterial Cell Surfaces" (Mt Snow, USA) and the 2016 EMBO Workshop "Bacterial Cell Division: Orchestrating the Ring Cycle" (Prague, Czech Republic).
Short Biography: Prof Waldemar Vollmer has studied chemistry at the University of Applied Sciences in Reutlingen (Germany) and University of Basel (Switzerland). In 1998 he obtained a PhD degree (Dr.rer.nat.) from the University of Tübingen (Germany) for his work on cell wall synthesis in the model bacterium Escherichia coli undertaken at the Max Planck Institute for Developmental Biology. During his postdoctoral studies at the Rockefeller University (New York, USA) he discovered novel cell wall enzymes that are crucial for the virulence of the pathogenic bacterium Streptococcus pneumoiae. In 2003 he was appointed Assistant Professor at the University of Tübingen and moved 2007 to the Centre for Bacterial Cell Biology at Newcastle University (UK), where he worked as Professor of Bacterial Biochemistry on various bacterial cell wall topics in a range of different bacteria. Since April 2023 he is Professorial Research Fellow and Group Leader at the Centre for Superbug Solutions, Institute for Molecular Bioscience (IMB) at the University of Queensland.
Availability
- Professor Waldemar Vollmer is:
- Available for supervision
Fields of research
Research impacts
Professor Vollmer's basic research on the bacterial cell envelope has led to key advances in our understanding of bacterial cell function and has discovered molecular mechanisms that can be exploited for antibiotic development.
Key research outputs: Prof Vollmer's group has discovered mechanisms of PG biosynthesis and its regulation, novel cell wall enzymes, and mechanisms of coordination between PG synthesis and outer membrane biogenesis. These discoveries provided the first molecular insights into how bacteria robustly maintain, enlarge and modify their cell envelope when they propagate in diverse environments and under stress conditions, and when exposed to antibiotics.
Key capabilities: Prof Vollmer's group is expert in the analysis of the composition of peptidoglycan, the key shape-maintaining and stress-bearing component of the bacterial cell envelope. They also discover new cell wall enzymes and study the activities and interactions of of key cell wall synthases and hydrolases (lysins or autolysins). They are also expert in determining the cleavage site of cell wall-degrading lysins and establishing biochemical assays for cell wall enzymes, for studying their inhibition by antibiotics. They combine their molecular biology work with studies on the physiology of bacterial cells impaired in cell wall biogenesis.
Works
Search Professor Waldemar Vollmer’s works on UQ eSpace
2006
Book Chapter
Cytoskeletal elements in prokaryotes
Vollmer, Waldemar (2006). Cytoskeletal elements in prokaryotes. Complex intracellular structures in prokaryotes. (pp. 305-311) edited by Jessup M. Shively. Berlin, Heidelberg: Springer Berlin Heidelberg. doi: 10.1007/7171_029
2005
Journal Article
In vitro murein (peptidoglycan) synthesis by dimers of the bifunctional transglycosylase-transpeptidase PBP1B from Escherichia coli
Bertsche, Ute, Breukink, Eefjan, Kast, Thomas and Vollmer, Waldemar (2005). In vitro murein (peptidoglycan) synthesis by dimers of the bifunctional transglycosylase-transpeptidase PBP1B from Escherichia coli. Journal of Biological Chemistry, 280 (45), 38096-38101. doi: 10.1074/jbc.M508646200
2005
Journal Article
Listeria monocytogenes EGD lacking penicillin-binding protein 5 (PBP5) produces a thicker cell wall
Korsak, Dorota, Vollmer, Waldemar and Markiewicz, Zdzislaw (2005). Listeria monocytogenes EGD lacking penicillin-binding protein 5 (PBP5) produces a thicker cell wall. FEMS Microbiology Letters, 251 (2), 281-288. doi: 10.1016/j.femsle.2005.08.009
2005
Journal Article
Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold
van Straaten, Karin E., Dijkstra, Bauke W., Vollmer, Waldemar and Thunnissen, Andy-Mark W.H. (2005). Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold. Journal of Molecular Biology, 352 (5), 1068-1080. doi: 10.1016/j.jmb.2005.07.067
2005
Journal Article
Susceptibility to antibiotics and beta-lactamase induction in murein hydrolase mutants of Escherichia coli
Korsak, Dorota, Liebscher, Sylvia and Vollmer, Waldemar (2005). Susceptibility to antibiotics and beta-lactamase induction in murein hydrolase mutants of Escherichia coli. Antimicrobial Agents and Chemotherapy, 49 (4), 1404-1409. doi: 10.1128/AAC.49.4.1404-1409.2005
2005
Journal Article
Why are pathogenic staphylococci so lysozyme resistant? The peptidoglycan O-acetyltransferase OatA is the major determinant for lysozyme resistance of Staphylococcus aureus
Bera, Agnieszka, Herbert, Silvia, Jakob, Andreas, Vollmer, Waldemar and Gotz, Friedrich (2005). Why are pathogenic staphylococci so lysozyme resistant? The peptidoglycan O-acetyltransferase OatA is the major determinant for lysozyme resistance of Staphylococcus aureus. Molecular Microbiology, 55 (3), 778-787. doi: 10.1111/j.1365-2958.2004.04446.x
2004
Journal Article
Murein (peptidoglycan) binding property of the essential cell division protein FtsN from Escherichia coli
Ursinus, Astrid, van den Ent, Fusinita, Brechtel, Sonja, de Pedro, Miguel, Holtje, Joachim-Volker, Lowe, Jan and Vollmer, Waldemar (2004). Murein (peptidoglycan) binding property of the essential cell division protein FtsN from Escherichia coli. Journal of Bacteriology, 186 (20), 6728-6737. doi: 10.1128/JB.186.20.6728-6737.2004
2004
Journal Article
The architecture of the murein (peptidoglycan) in gram-negative bacteria: Vertical scaffold or horizontal layer(s)?
Vollmer, Waldemar and Holtje, Joachim-Volker (2004). The architecture of the murein (peptidoglycan) in gram-negative bacteria: Vertical scaffold or horizontal layer(s)?. Journal of Bacteriology, 186 (18), 5978-5987. doi: 10.1128/JB.186.18.5978-5987.2004
2003
Journal Article
Overproduction of inactive variants of the murein synthase PBP1B causes lysis in Escherichia coli
Meisel, Ute, Holtje, Joachim-Volker and Vollmer, Waldemar (2003). Overproduction of inactive variants of the murein synthase PBP1B causes lysis in Escherichia coli. Journal of Bacteriology, 185 (18), 5342-5348. doi: 10.1128/JB.185.18.5342-5348.2003
2002
Journal Article
Peptidoglycan N-acetylglucosamine deacetylase, a putative virulence factor in Streptococcus pneumoniae
Vollmer, Waldemar and Tomasz, Alexander (2002). Peptidoglycan N-acetylglucosamine deacetylase, a putative virulence factor in Streptococcus pneumoniae. Infection and Immunity, 70 (12), 7176-7178. doi: 10.1128/IAI.70.12.7176-7178.2002
2002
Book Chapter
Murein (Peptidoglycan)
Heidrich, C. and Vollmer, W. (2002). Murein (Peptidoglycan). Biopolymers, Polysaccharides I: Polysaccharides from Prokaryotes. (pp. 431-463) edited by Alexander Steinbüchel, Erick J. Vandamme, Martin Hofrichter and Sophie De Baets. Weinheim, Germany: Wiley.
2001
Journal Article
Morphogenesis of Escherichia coli
Vollmer, Waldemar and Holtje, Joachim-Volker (2001). Morphogenesis of Escherichia coli. Current Opinion in Microbiology, 4 (6), 625-633. doi: 10.1016/S1369-5274(01)00261-2
2001
Journal Article
Identification of the teichoic acid phosphorylcholine esterase in Streptococcus pneumoniae
Vollmer, Waldemar and Tomasz, Alexander (2001). Identification of the teichoic acid phosphorylcholine esterase in Streptococcus pneumoniae. Molecular Microbiology, 39 (6), 1610-1622. doi: 10.1046/j.1365-2958.2001.02349.x
2001
Book Chapter
A multienzyme complex involved in murein synthesis of Escherichia coli
von Rechenberg, M., Vollmer, W. and Höltje, J.V. (2001). A multienzyme complex involved in murein synthesis of Escherichia coli. Microbial fundamentals of biotechnology. (pp. 249-262) edited by Volkmar Braun and Friedrich Götz. Weinheim, Germany: Wiley.
2000
Journal Article
The pgdA gene encodes for a peptidoglycan N-acetylglucosamine deacetylase in Streptococcus pneumoniae
Vollmer, Waldemar and Tomasz, Alexander (2000). The pgdA gene encodes for a peptidoglycan N-acetylglucosamine deacetylase in Streptococcus pneumoniae. Journal of Biological Chemistry, 275 (27), 20496-20501. doi: 10.1074/jbc.M910189199
2000
Journal Article
A simple screen for murein transglycosylase inhibitors
Vollmer, Waldemar and Holtje, Joachim-Volker (2000). A simple screen for murein transglycosylase inhibitors. Antimicrobial Agents and Chemotherapy, 44 (5), 1181-1185. doi: 10.1128/AAC.44.5.1181-1185.2000
1999
Journal Article
Demonstration of molecular interactions between the murein polymerase PBP1B, the lytic transglycosylase MltA, and the scaffolding protein MipA of Escherichia coli
Vollmer, Waldemar, von Rechenberg, Moritz and Holtje, Joachim-Volker (1999). Demonstration of molecular interactions between the murein polymerase PBP1B, the lytic transglycosylase MltA, and the scaffolding protein MipA of Escherichia coli. Journal of Biological Chemistry, 274 (10), 6726-6734. doi: 10.1074/jbc.274.10.6726
1998
Book Chapter
Growth of the bacterial sacculus requires both polymerization and depolymerization of murein
Höltje, J.V., Schiffer, G., Vollmer, W. and von Rechenberg, M. (1998). Growth of the bacterial sacculus requires both polymerization and depolymerization of murein. Biochemical principles and mechanisms of biosynthesis and biodegradation of polymers. (pp. 68-76) edited by A. Steinbüchel. Münster, Germany: Wiley.
1997
Journal Article
Outer membrane localization of murein hydrolases: MltA, a third lipoprotein lytic transglycosylase in Escherichia coli
Lommatzsch, J., Templin, M. F., Kraft, A. R., Vollmer, W. and Holtje, J. V. (1997). Outer membrane localization of murein hydrolases: MltA, a third lipoprotein lytic transglycosylase in Escherichia coli. Journal of Bacteriology, 179 (17), 5465-5470. doi: 10.1128/jb.179.17.5465-5470.1997
1997
Journal Article
Pesticin displays muramidase activity
Vollmer, W., Pilsl, H., Hantke, K., Holtje, J. V. and Braun, V. (1997). Pesticin displays muramidase activity. Journal of Bacteriology, 179 (5), 1580-1583. doi: 10.1128/jb.179.5.1580-1583.1997
Funding
Current funding
Supervision
Availability
- Professor Waldemar Vollmer is:
- Available for supervision
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Available projects
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Novel antibacterials from nature targeting the bacterial cell envelope
The project uses methods in molecular microbiology and natural product chemistry to discover new antibiotics from natural sources that kill bacteria by targeting their cell wall.
Supervision history
Current supervision
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Doctor Philosophy
Targeting bacterial cell envelope coordination for antibiotic drug discovery
Principal Advisor
Other advisors: Professor Brett Collins
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Doctor Philosophy
Novel assays for antibiotic discovery
Principal Advisor
Other advisors: Professor Rob Capon
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Doctor Philosophy
Dissecting the bacterial cell envelope for antibiotic drug discovery
Principal Advisor
Other advisors: Dr Nicholas Ariotti, Professor Rob Capon
Media
Enquiries
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