Regulatory cellular microRNAs and their role in insect anti-viral responses (2011-2013)
Abstract
microRNAs are small non-coding RNAs, which play essential roles in gene regulation, affecting various processes such as development, differentiation, oncogenesis and host-virus interactions. Understanding their role in regulating anti-viral responses of insects provides a means to target physiological processes and interfere with replication of vector-borne diseases. Using cutting edge technology, we will characterize regulatory microRNAs from a key pest and a mosquito vector to identify those involved in anti-viral immune responses. The outcomes will provide a basis for designing novel control strategies for economically and medically significant insects, interrupting virus transmission and enhancing strategies that address biosecurity.
