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Dr Botella's research interests are in genetic engineering, molecular biology and signal transduction in plants.

Dr. Jimmy Botella is Professor of Plant Biotechnology at the University of Queensland. He obtained a degree in Quantum Chemistry from the University of Madrid (Spain) and a PhD in Biochemistry from the University of Malaga (Spain). After postdoctoral positions at Michigan State University and Pennsylvania State University he joined the University of Queensland in 1995. At UQ he founded the Plant Genetic Engineering Laboratory (PGEL) specialising in the fields of tropical and subtropical agricultural biotechnology for almost 15 years. J. Botella has eleven international patents in the field of Plant Biotechnology and is a founding member of two biotechnology companies (Coridon Ltd. and Origo Biotech).

Dr Botella is a member of the Plant Molecular Biology and Biotechnology research group.

Some highlights of the Plant Genetic Engineering Laboratory’s research:

• Production and field trial of the world’s first genetically modified pineapples with genetic constructs to control flowering time. These pineapples will allow farmer control over harvesting times.
• Development of a new technology to confer protection against nematode infestation.
• Discovery of a gene that can confer resistance to the devastating fungus Fusarium oxysporum in plants.
• Development of a new technology to confer protection against pathogenic fungi in plants.

Research interests

Dr. Botella’s research has two major foci: basic cell biology and applied biotechnology. In cell biology he is interested in studying the function of the Heterotrimeric G proteins in plants. This family of proteins is extremely important in humans but their role in pant systems is still largely unknown. Dr. Botella’s research has strongly contributed to the current body of knowledge available in plants with critical contributions such as the discovery and characterization of the first plant gamma subunits and the establishment of these subunits as the critical element conferring function specificity to all plant G proteins. Dr. Botella’s team has also discovered the important role that these proteins play in defense against pathogens. New and unpublished data has now revealed that G proteins are important yield enhancing factors in crops such as rice. Another research interest resides in the communication between plants and insects. There is plenty of knowledge of how important smell, volatiles emitted by the plant, is for foraging insects in order to determine their host preferences. Nevertheless, most of the available studies have been performed using synthetic chemicals in artificial experimental settings. Dr. Botella’s team and collaborators have genetically engineered plants to produce different volatile mixes in the flowers in order to perform in vivo behavioral studies in insects.

Biotechnology research at the Plant Genetic Engineering Laboratory mostly arises from discoveries made in basic research. The PGEL focuses in tropical and subtropical crops. These crops have attracted little attention in terms of biotechnology but are essential sources of food and energy for a large part of the world’s population, especially in Asia and the Indian subcontinent. The PGEL has developed a number of platform technologies that can be applied to multiple crops in order to confer resistance to pathogens, modify plant architecture and control flowering time.

Current research projects include:

• Plant heterotrimeric G proteins: New roles in defence, stomatal control and ABA perception.
• Putting smells into context: using in vivo technologies to understand plant-insect odour communication.
• Use of host-derived RNA interference technology to control plant pathogens (especially pathogenic fungi and nematodes).
• Control of Fusarium wilt disease.
• Genetic improvement of grain crops.
• Genetic engineering research projects

Stress, reproduction and chemical communication in marsupials. Effects of stress on ageing and neurodegenerative diseases. Vertebrate ecophysiology.

Adrian Bradley’s laboratory focuses on the following areas:

The role of hormones on behaviour in vertebrates, especially marsupials.Chemical communication in vertebratesStructure and function of the vomeronasal and olfactory organs in marsupials and their role in stress and reproduction.Vertebrate ecophysiology, with emphasis upon marsupials inhabiting environments ranging from cool temperate to subtropical rainforests.Metabolic strategies in adaptation in vertebrates.The effect of stress upon the brain, and modulation of adrenocortical and reproductive axes.Effect of stress on accelerated ageing and neurodegenerative processes in the brain of marsupials.Effect of stress and ageing upon cognitive performance and the role of the hippocampus. Includes the effect of stress on hippocampal neuronal connectivity and function.The pathogenesis of peptic ulcer in small marsupials, a model in which Helicobacter sp. do not appear to be involved. Reproduction, chemical communication and social organization in marsupial glidersThe Bradley laboratory has carried out some of the pioneering work on pituitary-adrenocortical and pituitary-gonadal function in marsupials and was the first to describe the role of free cortisol in the spectacular annual mortality of males in populations of small dasyurid marsupials. These studies also demonstrated the significant role of haemorrhage from gastric ulcers in contributing to the male mortality.This laboratory employs a range of sensitive endocrine techniques both in the laboratory and in the field to interpret metabolic and reproductive strategies that are used by a range of vertebrates as they adapt to changes in the physical and social environment during their life history.Neuroendocrine studies use immunohistochemical, confocal and EM techniques to examine neurons and glial cells within the hippocampus and in the olfactory and vomeronasal pathways..Dr Bradley has ongoing collaborative projects in various locations that include the Daintree World Heritage Rainforest Region, North Queensland, South Stradbroke Island, Tasmania and in Kluane National Park, Yukon, Canada. Previous collaborative projects have been carried out on mammal populations in the following locations:In Western Australia, the Kimberley, the SW wheatbelt, Karri forests and islands off the West Australian coast,Moreton Island, North & South Stradbroke Islands, QueenslandKakadu National Park, Northern TerritoryThe Daintree World Heritage area, North QueenslandForest and alpine mammals in Tasmania and VictoriaYunnan Province, SW ChinaKluane National Park, Yukon, Canada

Research in the Bredy laboratory is aimed at elucidating how the genome is connected to the environment through epigenetic modifications, and how this relationship shapes brain and behaviour throughout life. The group is particularly interested in how epigenetic mechanisms, including DNA methylation, histone modifications. the activity of non-coding RNAs, and RNA modification regulate the formation and maintenance of associative fear-related memory.

Dr Sandra Brosda is a Research Fellow within the Surgical Oncology group led by Professor Andrew Barbour.

Dr Brosda was awarded a PhD in bioinformatics and cancer genetics from the University of Queensland in November 2020. Her research focused on biomarker discovery and intra-tumour heterogeneity and tumour evolution in oesophageal adenocarcinoma (OAC). In 2021, Dr Brosda was awarded a Cure Cancer Australia PdCCRS grant and an MSH project grant to further investigate tumour evolution to improve precision medicine in OAC.

She has been involved in research projects covering genetics, epigenetics, spatial transcriptomics, radiomics, ctDNA and quality of life assessments in the context of cancer. Overall, her research applies bioinformatics tools and approaches to cancer genomics to improve precision medicine and health outcomes for patients with melanoma, oesophago-gastric cancer and pancreatic cancer.

Melissa is no longer active in research, and so is unable to supervise new students.

BIOGRAPHY

Melissa Brown completed her PhD at the Walter and Eliza Hall Institute in Melbourne in 1993, on the structure and regulation of genes encoding colony-stimulating factor receptors in human leukaemia.

She then undertook postdoctoral training at the Imperial Cancer Research Fund (now Cancer Research UK) in London, funded firstly by an EMBO and then by an ICRF postdoctoral fellowship, working on the isolation and characterization of the first breast cancer susceptibility gene, BRCA1.

She joined The University of Queensland in 2000 as a Lecturer and is now a Professor and Executive Dean. In 2005 she undertook a six-month sabbatical at the Sir William Dunn School of Pathology at The University of Oxford.

The focus of Melissa’s research is cancer genetics, in particular understanding the transcriptional and post-transcriptional regulation of breast cancer genes and the impact of genetic variants on cancer risk and progression.

A/Prof Lucy Burr is an experienced respiratory physician, training supervisor and clinical trials researcher at Mater Health and Mater Research – University of Queensland (UQ). She has a PhD (2017) in bronchiectasis microbiology and is an Associate Professor at the School of Medicine, UQ. She is the Director of Respiratory, Sleep and Cystic Fibrosis medicine at the Mater Hospital, Brisbane.

As well as directing the respiratory clinical service at the Mater, Lucy has an active role in teaching both specialist trainees and medical students. She is a RACP college supervisor and trains one advanced trainee and four basic trainees per year. She directly supervises four medical students in her clinical team per year. Lucy is also currently supervising 5 PhD students, researching diverse fields such as glucose control in cystic fibrosis, asthma, fatigue, IL-22 and the effect of sleep on social cognition.

Lucy is recognised nationally for her clinical work on respiratory infections. She is the chair of the Acute and Critical Care panel for the National COVID-19 clinical evidence taskforce and a member of the guideline leadership group. Additionally, she is the recent chair (2020-2022) of the expert reference group on COVID-19 for the Royal Australasian College of Physicians. She is a recent (2019- 2021) convenor of the respiratory infectious disease special interest group of the Thoracic Society of Australia and New Zealand, the Queensland TSANZ branch president and past president (2017-2020), a recent board director of the TSANZ national body and current Chair of the Australian Bronchiectasis Consortium. Lucy is currently serving on the TSANZ annual scientific meeting and World Bronchiectasis conference steering committees. She is recognised internationally for her work on Cystic Fibrosis (top 1.8% expertscape February 2024) and Bronchiectasis (top 2.2% expertscape February 2024) and has published in high impact clinical journals including the New England Journal of Medicine and the Lancet Respiratory Medicine, across a range of respiratory and infectious disease subjects, with >1500 citations in the past 5 years.

In addition to her clinical work, Lucy is the custodian and manager of the David Serisier Research biobank at Mater Research, a clinical repository of human samples from patients living with respiratory diseases. Lucy is also an experienced principal investigator on many pharmaceutical studies ranging from phase 1b to phase 4 studies investigating therapeutics for CF, IPF, COPD, COVID, influenza pulmonary hypertension and bronchiectasis. She has designed and lead non-pharmaceutical interventional studies investigating the role of macrolide in modulating inflammation in healthy adults. She is the group leader of the respiratory clinical trials unit at Mater Research, and the program lead for the chronic and integrated care program at Mater Research.

Lucy has a proven track record in collaborative and translational research. She is currently a consultant on 2 peer reviewed external grants totalling $1,306,000, including one involving biobanked samples, and is a chief investigator on a 2021 Ideas grant and a 2021 MRFF grant totalling more than $3 million dollars.

Before joining the University of Queensland, Dave P. Callaghan held positions within industry including Parsons Brinckerhoff and Lawson and Treloar and research sector including Nederlands Instituut voor Ecologie and the University of Queensland. He is an observer of the Queensland Water Panel and active in the newly created Australian Hydraulic Modelling Association. He is the author of a book section and more than 50 other technical documents with applied and research applications. He is a consultant to private and government organisations. He has worked recently with private and government organisations to improve understanding of extreme coastal weather responses. He is recognised for leading edge research in coastal engineering including statistics of extremes, beach erosion from extreme events, physical and biological interactions of salt marshes and coral reefs, lagoon dynamics and wave propagation.

Dr Bradley Campbell has over 10 years’ experience in plant biotechnology research and since 2003 has held research positions focused on plant molecular genetics. His research involves the use of genomic tools for crop improvement, with an emphasis on the sustainable production of grain crops. Major focus is on the improvement of crops for food, feed and bio-industrial end-uses. For the past 5 years he has also been involved in hay fever studies, focused on metagenomics of the aerobiome of Australian climates and its links to allergy. Current projects involve the genotyping of the Pacific Islands in vitro taro collection for germplasm preservation and breeding purposes, investigation into infrared spectral cameras and their applicability to taro salinity screening, as well as a comphrehensive bio-geographic analysis of the urban Australian aerobiome and its links to allergic rhinitis.

Lilia works to unravel the overwhelming complexity of the biological world and to assess ways to use it to solve problems of our time. She finds especially intriguing all the invisible interactions between plant and microbes. She investigates the drivers of these interactions and aims to address major societal challenges. Her purpose is to make use of nature’s arsenal to tackle problems that threaten environmental conservation and food security. She has worked with a range of beneficial and pathogenic microbes across model, forestry, grain, and horticultural plant species, grown in managed and natural habitats in different countries, including Brazil, Germany, Australia, USA, Costa Rica, and Papua New Guinea. Her expertise lies within plant pathology, molecular biology, plant nutrition, microbial ecology, biological indicators of soil health, bio-prospection of natural products produced by microbes, plant biotechnology, and molecular diagnostics.

Dr Chan has a PhD in Genomics and Computational Biology from UQ. He underwent postdoctoral training at Rutgers University (USA) in algal genomics and evolution. He returmed to UQ in late 2011 as one of the inaugural Great Barrier Reef Foundation Bioinformatics Fellows.

Dr Chan joined the School of Chemistry and Molecular Biosciences in 2020 as a group leader at the Australian Centre for Ecogenomics (ACE). His group uses advanced computational approaches to study genome evolution and develop scalable approaches for comparative genomics.

Summary of Research:

• My current research at UQ is as Professor in this School (teaching AGRC3040 Crop Physiology) and as an Affiliate Professor of QAAFI. Since 2020, with full-time appointment at UQ, my research portfolio has included multiple projects in applications of machine learning and artificial intelligence into the ag domain. This area is developing rapidly and across UQ, I am engaging with faculty in multiple schools (ITEE, Maths and Physics, Mining and Mech Engineering) as well as in the Research Computing Centre to develop new projects and training opportunities at the interface of field agriculture and these new digital analytics.
• My career research has been around genetic and environment effects on physiology of field crops, particularly where drought dominates. Application of quantitative approaches (crop simulation and statistical methods) and phenotyping (aerial imaging, canopy monitoring) to integrate the understanding of interactions of genetics, growth and development and the bio-physical environment on crop yield. In recent years, this work has expanded more generally into various applications in digital agriculture from work on canopy temperature sensing for irrigation decisions (CSIRO Entrepreneurship Award 2022) through to applications of deep-learning to imagery to assist breeding programs.
• Much of this research was undertaken with CSIRO since 1996. Building on an almost continuous collaboration with UQ over that time, including as an Adjunct Professor to QAAFI, Prof Chapman was jointly appointed (50%) as a Professor in Crop Physiology in the UQ School of Agriculture and Food Sciences from 2017 to 2020, and at 100% with UQ from Sep 2020. He has led numerous research projects that impact local and global public and private breeding programs in wheat, sorghum, sunflower and sugarcane; led a national research program on research in ‘Climate-Ready Cereals’ in the early 2010s; and was one of the first researchers to deploy UAV technologies to monitor plant breeding programs. Current projects include a US DoE project with Purdue University, and multiple projects with CSIRO, U Adelaide, La Trobe, INRA (France) and U Tokyo. With > 8500 citations, Prof Chapman is currently in the top 1% of authors cited in the ESI fields of Plant and Animal Sciences and in Agricultural Sciences.

Keith is Molecular Virologist and group leader with a dual appointment within the Australian Bioengineering and Nanotechnology Institute and the School of Chemistry and Molecular Biosciences. His research is focused on vaccine development and the understanding of medically and environmentally significant viruses. Keith is one of the inventors of a UQ’s molecular clamp platform and is the co-leader of a program to produce a vaccine for COVID-19 at UQ. Keith has played a leading role in designing and implementing an epidemic response vaccine pipeline which enabled the progression of UQ’s COVID-19 vaccine candidate from sequence information to clinical trial dosing within 6 months.

Keith completed his PhD at the University of Queensland in 2007 on the structure and function of flavivirus NS3 protease. Subsequently, he spent three years (2007-2010) as a post-doctoral researcher at one of Spain’s most respected research institutes, Instituto Salud Carlos III, where I conducted research on the fusion protein of Respiratory Syncytial viurs as a target for conformationally specific neutralizing antibodies. Keith returned to UQ in 2011 and his research has focused on understanding of many medically and environmentally important viruses and bacteria, particularly focussing on Influenza, Respiratory Syncytial virus (RSV), SARS-CoV-2, Koala Retrovirus and Streptococcus pneumoniae.

A/Prof. Seth Cheetham is an ARC Discovery Early Career Award Fellow and Group Leader at the Australian Institute for Bioengineering and Nanotechnology. He is also the Deputy Director of the BASE facility, Australia's leading mRNA manufacturing hub. He completed his PhD at the University of Cambridge, supported by the Herchel Smith Research Studentship. Seth is a molecular biologist and geneticist with a focus on mRNA drugs, synthetic biology and epigenetics. He has authored 25 publications, in some of the most influential molecular biology journals including Science, Molecular Cell, Nature Reviews Genetics , Genome Biology and Nature Structural and Molecular Biology. His work has attracted > $15M including back-to-back NHMRC and ARC Fellowships. In 2021 Seth was awarded the Genetics Society of Australasia Alan Wilton ECR awarded for his research in the field of RNA and epigenetics.

I am a Senior Research Fellow, NHMRC Emerging Leader Fellow, and Group Leader at UQ Frazer Institute. I was awarded my PhD in late 2017 by Biomedicine Discovery Institute, Monash University. Under the UQ Health Research Accelerator (HERA) program, I lead a team to investigate T and B cell responses that profoundly regulate vaccine responses, viral clearance, and anti-tumour immunity.

My research program employs combinatorial methodologies of Biochemistry and Immunology to uncover new molecular mechanisms controlling T-cell-mediated immunity:

1. The action of T cells is required in antibody responses for suppressing viral infection or tumour growth and to confer protection upon vaccination. In particular, follicular helper T (Tfh) cells, a specialised subset of CD4+ T cells, essentially instruct the B cells to produce long-lived antibody protection. The knowledge of Tfh cells has fundamentally enabled vaccine development and therapy design for autoimmune diseases.

2. T-cell-derived cytokines play pivotal roles in both humoral and cellular immunity. Particularly, interleukin-21 (IL-21) is essential for supporting germinal centre (GC) reaction, where the B cell memory and long-lived antibody responses are generated. Besides, IL-21 is also the only known cytokine to maintain the functionalities of CD8+ T cells in the context of chronic infections or cancers by preventing a loss-of-function program termed 'exhaustion'.

This research program has generated multiple cutting-edge discoveries in the field, producing publications as 1st or joint 1st authors in top-tier journals including Nature Immunology, Science Immunology, and Nature Communications.

A/ Prof. Karen Cheney is a marine ecologist employing a multidisciplinary approach to explore predator-prey interactions, animal signalling, and the fundamental principles behind the evolution and function of animal colour patterns. Her research spans sensory, behavioral, and chemical marine ecology, with a particular focus on marine fish and molluscs. She co-leads the Marine Sensory Ecology Group at UQ.

She is also the Academic Director of the Moreton Bay Research Station, where she is oversees the teaching and research conducted at the station. She also co-leads research projects on understanding the ecosystem services of shellfish reef restoration, and the conservation of the threatened seahorse, Hippocampus whitei, in SE Queensland. She is also the Deputy Director of the Centre for Marine Science.

Animal Signalling: She focuses on the evolution of animal signals in the marine environment, particularly those used for camouflage and warning signals (aposematism). Her research employs spectrophotometry, theoretical vision models, phylogenetic comparative analysis, and a novel method using a calibrated underwater camera system to analyse complex animal colour patterns. This innovative approach enables simultaneous in-situ collection of spatial and spectral properties of animals and their backgrounds. She specifically investigates the diversity of colour signals displayed by nudibranch molluscs, examining how these patterns are perceived by potential predators and their relationship to the unpalatability and toxicity of the molluscs’ stored chemical defences.

Colour Vision: She studies the visual performance of coral reef fish using behavioural assays inspired by tests used to screen for human color vision deficiencies. By relating behavioural data to theoretical visual modelling, she assesses the accuracy of these models. More broadly, she explores the sensory, neural, and cognitive foundations of colour perception and investigates the genetic basis for the diversification of visual systems.

Our lab aims to test fundamental hypotheses in genetics and evolutionary biology. Principally, we are interested the relationship between genotypic and phenotypic change during adaptive evolution. This line of inquiry requires an understanding of both the type of selection acting on traits as they evolve and ultimately the functional polymorphisms available for selection to act upon. We presently use both native and exotic species of Drosophila in our work but also undertake collaborative study in other organisms that represent examples of recurring ecological and evolutionary phenomena. We are equipped to use a broad range of techniques in our investigations including experimental evolution, field-based selection studies, quantitative genetics, molecular population genetics, genomics and advanced quantitative methods in statistics and computational biology. The broad range of techniques available to our group provides students with a unique opportunity to broaden their skill sets as they address fundamental questions.

Dr Karine Chenu is Associate Professor at the Queensland Alliance for Agriculture and Food Innovation (QAAFI) at the University of Queensland. Karine has expertise in ecophysiology, genetics and modelling with a focus on drought and heat adaptation.

Her group is conducting research that supports crop modelling technology, plant design and breeding strategies in winter cereals.

Her research mainly concerns: - understanding trait physiology and genetics, - developing gene-to-phenotype crop modelling - exploring novel combinations of genotypes, environments and management practices to assist productivity improvement in changing environments.

Karine collaborates with plant breeders, geneticists, modellers and agronomists in a range of national and international research projects in both public and private sectors.

She is also one of the UQ representatives on the APSIM Initiative Reference Panel, which is responsible for the on-going development of the APSIM model (www.apsim.info), which is now used world-wide.