![Dr Angeline Chan](/sites/default/files/profiles/1879.jpeg)
Overview
Availability
- Dr Angeline Chan is:
- Available for supervision
Fields of research
Qualifications
- Bachelor, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Angeline Chan’s works on UQ eSpace
Featured
2022
Journal Article
An N-capping asparagine–lysine–proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold
Cardoso, Marlon H., Chan, Lai Y., Cândido, Elizabete S., Buccini, Danieli F., Rezende, Samilla B., Torres, Marcelo D. T., Oshiro, Karen G. N., Silva, Ítala C., Gonçalves, Sónia, Lu, Timothy K., Santos, Nuno C., de la Fuente-Nunez, Cesar, Craik, David J. and Franco, Octávio L. (2022). An N-capping asparagine–lysine–proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold. Chemical Science, 13 (32), 9410-9424. doi: 10.1039/d1sc06998e
Featured
2021
Journal Article
Tuning the anti-angiogenic effect of the P15 peptide using cyclic trypsin inhibitor scaffolds
Chan, Lai Yue, Du, Junqiao and Craik, David J. (2021). Tuning the anti-angiogenic effect of the P15 peptide using cyclic trypsin inhibitor scaffolds. ACS Chemical Biology, 16 (5), 829-837. doi: 10.1021/acschembio.0c00907
Featured
2020
Journal Article
A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors
Du, Junqiao, Yap, Kuok, Chan, Lai Yue, Rehm, Fabian B. H., Looi, Fong Yang, Poth, Aaron G., Gilding, Edward K., Kaas, Quentin, Durek, Thomas and Craik, David J. (2020). A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors. Nature Communications, 11 (1) 1575, 1-11. doi: 10.1038/s41467-020-15418-2
Featured
2016
Journal Article
Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy
Chan, LaiYue, Craik, David J. and Daly, Norelle L. (2016). Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy. Scientific Reports, 6 (1) 35347, 35347. doi: 10.1038/srep35347
Featured
2013
Journal Article
Cyclization of the antimicrobial peptide gomesin with native chemical ligation: influences on stability and bioactivity
Chan, Lai Yue, Zhang, Veronica M., Huang, Yen-hua, Waters, Norman C., Bansal, Paramjit S., Craik, David J. and Daly, Norelle L. (2013). Cyclization of the antimicrobial peptide gomesin with native chemical ligation: influences on stability and bioactivity. Chembiochem, 14 (5), 617-624. doi: 10.1002/cbic.201300034
Featured
2011
Journal Article
Engineering pro-angiogenic peptides using stable disulfide-rich cyclic scaffolds
Chan, Lai Y., Gunasekera, Sunithi, Henriques, Sonia T., Worth, Natalie F., Le, Sarah-Jane, Clark, Richard J., Campbell, Julie H., Craik, David J. and Daly, Norelle L. (2011). Engineering pro-angiogenic peptides using stable disulfide-rich cyclic scaffolds. Blood, 118 (25), 6709-6717. doi: 10.1182/blood-2011-06-359141
Featured
2009
Journal Article
Isolation and characterization of peptides from momordica cochinchinensis seeds
Chan, L. Y., Wang, C. K., Major, J. M., Greenwood, K. P., Lewis, R. J., Craik, D. J. and Daly, N. L. (2009). Isolation and characterization of peptides from momordica cochinchinensis seeds. JOURNAL OF NATURAL PRODUCTS, 72 (8), 1453-1458. doi: 10.1021/np900174n
2024
Journal Article
Peptide PaDBS1R6 has potent antibacterial activity on clinical bacterial isolates and integrates an immunomodulatory peptide fragment within its sequence
Rezende, Samilla B., Chan, Lai Yue, Oshiro, Karen G.N., Buccini, Danieli F., Leal, Ana Paula Ferreira, Ribeiro, Camila F., Souza, Carolina M., Brandão, Amanda L.O., Gonçalves, Regina M., Cândido, Elizabete S., Macedo, Maria L.R., Craik, David J., Franco, Octávio L. and Cardoso, Marlon H. (2024). Peptide PaDBS1R6 has potent antibacterial activity on clinical bacterial isolates and integrates an immunomodulatory peptide fragment within its sequence. Biochimica et Biophysica Acta (BBA) - General Subjects, 1868 (11) 130693, 130693. doi: 10.1016/j.bbagen.2024.130693
2024
Journal Article
Deciphering the structure and mechanism‐of‐action of computer‐designed mastoparan peptides
Oshiro, Karen G. N., Freitas, Carlos D. P., Rezende, Samilla B., Orozco, Raquel M. Q., Chan, Lai Y., Lawrence, Nicole, Lião, Luciano M., Macedo, Maria L. R., Craik, David J., Cardoso, Marlon H. and Franco, Octávio L. (2024). Deciphering the structure and mechanism‐of‐action of computer‐designed mastoparan peptides. The FEBS Journal, 291 (5), 865-883. doi: 10.1111/febs.17010
2023
Journal Article
A chemoenzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide)
Zhou, Yan, Harvey, Peta J., Koehbach, Johannes, Chan, Lai Yue, Jones, Alun, Andersson, Åsa, Vetter, Irina, Durek, Thomas and Craik, David J. (2023). A chemoenzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide). Angewandte Chemie, 135 (29) e202302812, 1-5. doi: 10.1002/ange.202302812
2023
Journal Article
A chemo-enzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide)
Zhou, Yan, Harvey, Peta J., Koehbach, Johannes, Chan, Lai Yue, Jones, Alun, Andersson, Åsa, Vetter, Irina, Durek, Thomas and Craik, David J. (2023). A chemo-enzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide). Angewandte Chemie, 62 (29) e202302812, e202302812. doi: 10.1002/anie.202302812
2023
Journal Article
Editorial: Plant antimicrobial peptides (PAMPs) as biotechnological tools
Chan, Lai Yue, Cândido, Elizabete and Gunasekera, Sunithi (2023). Editorial: Plant antimicrobial peptides (PAMPs) as biotechnological tools. Frontiers in Molecular Biosciences, 10 1195043, 1-2. doi: 10.3389/fmolb.2023.1195043
2023
Journal Article
Unlocking the potential of the antimicrobial peptide gomesin: from discovery and structure–activity relationships to therapeutic applications
Liu, Xiaorong, Henriques, Sónia T., Craik, David J. and Chan, Lai Yue (2023). Unlocking the potential of the antimicrobial peptide gomesin: from discovery and structure–activity relationships to therapeutic applications. International Journal of Molecular Sciences, 24 (6) 5893, 1-15. doi: 10.3390/ijms24065893
2022
Journal Article
Peptide-based LDH5 inhibitors enter cancer cells and impair proliferation
Nadal-Bufí, Ferran, Chan, Lai Y., Mohammad, Hadi H., Mason, Jody M., Salomon, Carlos, Lai, Andrew, Thompson, Erik W., Craik, David J., Kaas, Quentin and Henriques, Sónia T. (2022). Peptide-based LDH5 inhibitors enter cancer cells and impair proliferation. Cellular and Molecular Life Sciences, 79 (12) 606, 606. doi: 10.1007/s00018-022-04633-3
2022
Journal Article
Rational domestication of a plant-based recombinant expression system expands its biosynthetic range
Jackson, Mark A., Chan, Lai Yue , Harding, Maxim D., Craik, David J. and Gilding, Edward K. (2022). Rational domestication of a plant-based recombinant expression system expands its biosynthetic range. Journal of Experimental Botany, 73 (18), 6103-6114. doi: 10.1093/jxb/erac273
2022
Journal Article
The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila
Dang, Tien T., Huang, Yen-Hua, Ott, Stanislav, Harvey, Peta J., Gilding, Edward K., Tombling, Benjamin J., Chan, Lai Y., Kaas, Quentin, Claridge-Chang, Adam and Craik, David J. (2022). The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila. Journal of Biological Chemistry, 298 (10) 102413, 1-11. doi: 10.1016/j.jbc.2022.102413
2022
Journal Article
Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox
Xie, Jing, Robinson, Samuel D., Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Rehm, Fabian B.H., Yap, Kuok, Ragnarsson, Lotten, Chan, Lai Yue, Hamilton, Brett R., Harvey, Peta J., Craik, David J., Vetter, Irina and Durek, Thomas (2022). Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox. Journal of Biological Chemistry, 298 (8) 102218, 1-12. doi: 10.1016/j.jbc.2022.102218
2022
Journal Article
Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides
Dang, Tien T., Harvey, Peta J., Chan, Lai Yue, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2022). Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides. Peptide Science, 114 (6) e24284. doi: 10.1002/pep2.24284
2022
Journal Article
Antinociceptive peptides from venomous arthropods
Muller, Jessica A. I., Chan, Lai Y., Toffoli-Kadri, Monica C., Mortari, Marcia R., Craik, David J. and Koehbach, Johannes (2022). Antinociceptive peptides from venomous arthropods. Toxin Reviews, 42 (1), 1-20. doi: 10.1080/15569543.2022.2065510
2022
Journal Article
Comparative analysis of cyclotide-producing plant cell suspensions presents opportunities for cyclotide plant molecular farming
Doffek, Benjamin, Huang, Yvonne, Huang, Yen-Hua, Chan, Lai Yue, Gilding, Edward K., Jackson, Mark A. and Craik, David J. (2022). Comparative analysis of cyclotide-producing plant cell suspensions presents opportunities for cyclotide plant molecular farming. Phytochemistry, 195 113053, 113053. doi: 10.1016/j.phytochem.2021.113053
Funding
Past funding
Supervision
Availability
- Dr Angeline Chan is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Development of novel cell penetrating peptides as cancer therapies.
Associate Advisor
Other advisors: Professor David Craik
Completed supervision
-
2022
Doctor Philosophy
Discovery and Design of Plant-Derived Cyclotides for Medicinal Applications
Associate Advisor
Other advisors: Dr Yen-Hua Crystal Huang, Professor David Craik
-
2021
Doctor Philosophy
Structures and Activities of Cystine Knot Peptides from the Violaceae Plant Family
Associate Advisor
Other advisors: Dr Yen-Hua Crystal Huang, Professor David Craik
-
2020
Doctor Philosophy
Discovery and applications of disulfide-rich peptides in drug design
Associate Advisor
Other advisors: Professor David Craik
Media
Enquiries
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