Dr Angeline Chan
Dr

Angeline Chan

Email: 
Phone: 
+61 7 344 36299

Availability

Dr Angeline Chan is:
Available for supervision

Fields of research

Analytical biochemistry Analytical chemistry Analytical spectrometry Basic pharmacology Bioassays Biochemistry and cell biology Biological Sciences Biomedical and Clinical Sciences Cardiovascular medicine and haematology Cell metabolism Chemical Sciences Health Sciences Medical biochemistry - proteins and peptides (incl. medical proteomics) Medical biochemistry and metabolomics Medicinal and biomolecular chemistry Pharmacology and pharmaceutical sciences Proteins and peptides Proteomics and intermolecular interactions (excl. medical proteomics) Receptors and membrane biology

Qualifications

  • Bachelor, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Search Professor Angeline Chan’s works on UQ eSpace

54 works between 2009 and 2024
All (54) Journal Article (50) Conference Publication (3) Other Outputs (1)

1 - 20 of 54 works

Featured

2022

Journal Article

An N-capping asparagine–lysine–proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold

Cardoso, Marlon H., Chan, Lai Y., Cândido, Elizabete S., Buccini, Danieli F., Rezende, Samilla B., Torres, Marcelo D. T., Oshiro, Karen G. N., Silva, Ítala C., Gonçalves, Sónia, Lu, Timothy K., Santos, Nuno C., de la Fuente-Nunez, Cesar, Craik, David J. and Franco, Octávio L. (2022). An N-capping asparagine–lysine–proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold. Chemical Science, 13 (32), 9410-9424. doi: 10.1039/d1sc06998e

An N-capping asparagine–lysine–proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold

Featured

2021

Journal Article

Tuning the anti-angiogenic effect of the P15 peptide using cyclic trypsin inhibitor scaffolds

Chan, Lai Yue, Du, Junqiao and Craik, David J. (2021). Tuning the anti-angiogenic effect of the P15 peptide using cyclic trypsin inhibitor scaffolds. ACS Chemical Biology, 16 (5), 829-837. doi: 10.1021/acschembio.0c00907

Tuning the anti-angiogenic effect of the P15 peptide using cyclic trypsin inhibitor scaffolds

Featured

2020

Journal Article

A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors

Du, Junqiao, Yap, Kuok, Chan, Lai Yue, Rehm, Fabian B. H., Looi, Fong Yang, Poth, Aaron G., Gilding, Edward K., Kaas, Quentin, Durek, Thomas and Craik, David J. (2020). A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors. Nature Communications, 11 (1) 1575, 1-11. doi: 10.1038/s41467-020-15418-2

A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors

Featured

2016

Journal Article

Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy

Chan, LaiYue, Craik, David J. and Daly, Norelle L. (2016). Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy. Scientific Reports, 6 (1) 35347, 35347. doi: 10.1038/srep35347

Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy

Featured

2013

Journal Article

Cyclization of the antimicrobial peptide gomesin with native chemical ligation: influences on stability and bioactivity

Chan, Lai Yue, Zhang, Veronica M., Huang, Yen-hua, Waters, Norman C., Bansal, Paramjit S., Craik, David J. and Daly, Norelle L. (2013). Cyclization of the antimicrobial peptide gomesin with native chemical ligation: influences on stability and bioactivity. Chembiochem, 14 (5), 617-624. doi: 10.1002/cbic.201300034

Cyclization of the antimicrobial peptide gomesin with native chemical ligation: influences on stability and bioactivity

Featured

2011

Journal Article

Engineering pro-angiogenic peptides using stable disulfide-rich cyclic scaffolds

Chan, Lai Y., Gunasekera, Sunithi, Henriques, Sonia T., Worth, Natalie F., Le, Sarah-Jane, Clark, Richard J., Campbell, Julie H., Craik, David J. and Daly, Norelle L. (2011). Engineering pro-angiogenic peptides using stable disulfide-rich cyclic scaffolds. Blood, 118 (25), 6709-6717. doi: 10.1182/blood-2011-06-359141

Engineering pro-angiogenic peptides using stable disulfide-rich cyclic scaffolds

Featured

2009

Journal Article

Isolation and characterization of peptides from momordica cochinchinensis seeds

Chan, L. Y., Wang, C. K., Major, J. M., Greenwood, K. P., Lewis, R. J., Craik, D. J. and Daly, N. L. (2009). Isolation and characterization of peptides from momordica cochinchinensis seeds. JOURNAL OF NATURAL PRODUCTS, 72 (8), 1453-1458. doi: 10.1021/np900174n

Isolation and characterization of peptides from momordica cochinchinensis seeds

2024

Journal Article

Peptide PaDBS1R6 has potent antibacterial activity on clinical bacterial isolates and integrates an immunomodulatory peptide fragment within its sequence

Rezende, Samilla B., Chan, Lai Yue, Oshiro, Karen G.N., Buccini, Danieli F., Leal, Ana Paula Ferreira, Ribeiro, Camila F., Souza, Carolina M., Brandão, Amanda L.O., Gonçalves, Regina M., Cândido, Elizabete S., Macedo, Maria L.R., Craik, David J., Franco, Octávio L. and Cardoso, Marlon H. (2024). Peptide PaDBS1R6 has potent antibacterial activity on clinical bacterial isolates and integrates an immunomodulatory peptide fragment within its sequence. Biochimica et Biophysica Acta (BBA) - General Subjects, 1868 (11) 130693, 130693. doi: 10.1016/j.bbagen.2024.130693

Peptide PaDBS1R6 has potent antibacterial activity on clinical bacterial isolates and integrates an immunomodulatory peptide fragment within its sequence

2024

Journal Article

Deciphering the structure and mechanism‐of‐action of computer‐designed mastoparan peptides

Oshiro, Karen G. N., Freitas, Carlos D. P., Rezende, Samilla B., Orozco, Raquel M. Q., Chan, Lai Y., Lawrence, Nicole, Lião, Luciano M., Macedo, Maria L. R., Craik, David J., Cardoso, Marlon H. and Franco, Octávio L. (2024). Deciphering the structure and mechanism‐of‐action of computer‐designed mastoparan peptides. The FEBS Journal, 291 (5), 865-883. doi: 10.1111/febs.17010

Deciphering the structure and mechanism‐of‐action of computer‐designed mastoparan peptides

Featured

2023

Journal Article

A chemoenzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide)

Zhou, Yan, Harvey, Peta J., Koehbach, Johannes, Chan, Lai Yue, Jones, Alun, Andersson, Åsa, Vetter, Irina, Durek, Thomas and Craik, David J. (2023). A chemoenzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide). Angewandte Chemie, 135 (29) e202302812, 1-5. doi: 10.1002/ange.202302812

A chemoenzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide)

2023

Journal Article

A chemo-enzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide)

Zhou, Yan, Harvey, Peta J., Koehbach, Johannes, Chan, Lai Yue, Jones, Alun, Andersson, Åsa, Vetter, Irina, Durek, Thomas and Craik, David J. (2023). A chemo-enzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide). Angewandte Chemie, 62 (29) e202302812, e202302812. doi: 10.1002/anie.202302812

A chemo-enzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide)

2023

Journal Article

Editorial: Plant antimicrobial peptides (PAMPs) as biotechnological tools

Chan, Lai Yue, Cândido, Elizabete and Gunasekera, Sunithi (2023). Editorial: Plant antimicrobial peptides (PAMPs) as biotechnological tools. Frontiers in Molecular Biosciences, 10 1195043, 1-2. doi: 10.3389/fmolb.2023.1195043

Editorial: Plant antimicrobial peptides (PAMPs) as biotechnological tools

2023

Journal Article

Unlocking the potential of the antimicrobial peptide gomesin: from discovery and structure–activity relationships to therapeutic applications

Liu, Xiaorong, Henriques, Sónia T., Craik, David J. and Chan, Lai Yue (2023). Unlocking the potential of the antimicrobial peptide gomesin: from discovery and structure–activity relationships to therapeutic applications. International Journal of Molecular Sciences, 24 (6) 5893, 1-15. doi: 10.3390/ijms24065893

Unlocking the potential of the antimicrobial peptide gomesin: from discovery and structure–activity relationships to therapeutic applications

Featured

2022

Journal Article

Peptide-based LDH5 inhibitors enter cancer cells and impair proliferation

Nadal-Bufí, Ferran, Chan, Lai Y., Mohammad, Hadi H., Mason, Jody M., Salomon, Carlos, Lai, Andrew, Thompson, Erik W., Craik, David J., Kaas, Quentin and Henriques, Sónia T. (2022). Peptide-based LDH5 inhibitors enter cancer cells and impair proliferation. Cellular and Molecular Life Sciences, 79 (12) 606, 606. doi: 10.1007/s00018-022-04633-3

Peptide-based LDH5 inhibitors enter cancer cells and impair proliferation

2022

Journal Article

Rational domestication of a plant-based recombinant expression system expands its biosynthetic range

Jackson, Mark A., Chan, Lai Yue , Harding, Maxim D., Craik, David J. and Gilding, Edward K. (2022). Rational domestication of a plant-based recombinant expression system expands its biosynthetic range. Journal of Experimental Botany, 73 (18), 6103-6114. doi: 10.1093/jxb/erac273

Rational domestication of a plant-based recombinant expression system expands its biosynthetic range

2022

Journal Article

The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila

Dang, Tien T., Huang, Yen-Hua, Ott, Stanislav, Harvey, Peta J., Gilding, Edward K., Tombling, Benjamin J., Chan, Lai Y., Kaas, Quentin, Claridge-Chang, Adam and Craik, David J. (2022). The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila. Journal of Biological Chemistry, 298 (10) 102413, 1-11. doi: 10.1016/j.jbc.2022.102413

The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila

2022

Journal Article

Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox

Xie, Jing, Robinson, Samuel D., Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Rehm, Fabian B.H., Yap, Kuok, Ragnarsson, Lotten, Chan, Lai Yue, Hamilton, Brett R., Harvey, Peta J., Craik, David J., Vetter, Irina and Durek, Thomas (2022). Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox. Journal of Biological Chemistry, 298 (8) 102218, 1-12. doi: 10.1016/j.jbc.2022.102218

Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox

2022

Journal Article

Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides

Dang, Tien T., Harvey, Peta J., Chan, Lai Yue, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2022). Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides. Peptide Science, 114 (6) e24284. doi: 10.1002/pep2.24284

Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides

2022

Journal Article

Antinociceptive peptides from venomous arthropods

Muller, Jessica A. I., Chan, Lai Y., Toffoli-Kadri, Monica C., Mortari, Marcia R., Craik, David J. and Koehbach, Johannes (2022). Antinociceptive peptides from venomous arthropods. Toxin Reviews, 42 (1), 1-20. doi: 10.1080/15569543.2022.2065510

Antinociceptive peptides from venomous arthropods

2022

Journal Article

Comparative analysis of cyclotide-producing plant cell suspensions presents opportunities for cyclotide plant molecular farming

Doffek, Benjamin, Huang, Yvonne, Huang, Yen-Hua, Chan, Lai Yue, Gilding, Edward K., Jackson, Mark A. and Craik, David J. (2022). Comparative analysis of cyclotide-producing plant cell suspensions presents opportunities for cyclotide plant molecular farming. Phytochemistry, 195 113053, 113053. doi: 10.1016/j.phytochem.2021.113053

Comparative analysis of cyclotide-producing plant cell suspensions presents opportunities for cyclotide plant molecular farming

Past funding

  • 2017
    Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy
    The Cass Foundation Limited
    Open grant
  • 2016 - 2017
    Dr Lai Yue (Angeline) Chan - Maternity Funding (Advance Queensland Women's Academic Fund)
    Queensland Government Advance Queensland Women's Academic Fund
    Open grant

Availability

Dr Angeline Chan is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Development of novel cell penetrating peptides as cancer therapies.

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    Investigating the antifungal activity of cyclotides from butterfly pea

    Associate Advisor

    Other advisors: Professor David Craik

Completed supervision

Enquiries

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