Dr Yen-Hua Crystal Huang
Dr

Yen-Hua Crystal Huang

Email: 
Phone: 
+61 7 334 62020

Availability

Dr Yen-Hua Crystal Huang is:
Available for supervision

Fields of research

Agricultural, Veterinary and Food Sciences Analytical chemistry Biological Sciences Chemical Sciences Crop and pasture production Medicinal and biomolecular chemistry

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Yen-Hua Crystal Huang’s works on UQ eSpace

91 works between 2008 and 2025
All (91) Journal Article (73) Book Chapter (2) Conference Publication (15) Other Outputs (1)

1 - 20 of 91 works

Featured

2024

Journal Article

Repurposing a plant peptide cyclase for targeted lysine acylation

Rehm, Fabian B. H., Tyler, Tristan J., Zhou, Yan, Huang, Yen-Hua, Wang, Conan K., Lawrence, Nicole, Craik, David J. and Durek, Thomas (2024). Repurposing a plant peptide cyclase for targeted lysine acylation. Nature Chemistry, 2024 (9), 1-1. doi: 10.1038/s41557-024-01520-1

Repurposing a plant peptide cyclase for targeted lysine acylation

Featured

2024

Journal Article

Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1

Huang, Yen-Hua, Jiang, Zhihao, Du, Qingdan, Yap, Kuok, Bigot, Aurélien, Kaas, Quentin, Wang, Conan K. and Craik, David J. (2024). Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1. Journal of Biological Chemistry, 300 (3) 105682. doi: 10.1016/j.jbc.2024.105682

Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1

Featured

2024

Journal Article

Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide

Philippe, Grégoire Jean-Baptiste, Huang, Yen-Hua, Mittermeier, Anna, Brown, Christopher J., Kaas, Quentin, Ramlan, Siti Radhiah, Wang, Conan K., Lane, David, Loewer, Alexander, Troeira Henriques, Sónia and Craik, David J. (2024). Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide. Journal of Medicinal Chemistry, 67 (2), 1197-1208. doi: 10.1021/acs.jmedchem.3c01682

Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide

Featured

2024

Journal Article

The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance

Biswas, Biswajit, Huang, Yen-Hua, Craik, David J. and Wang, Conan K. (2024). The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance. Chemical Science, 15 (33), 13130-13147. doi: 10.1039/d4sc01088d

The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance

Featured

2023

Journal Article

Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation

Chen, Zhian, Cui, Yanfang, Yao, Yin, Liu, Bo, Yunis, Joseph, Gao, Xin, Wang, Naiqi, Cañete, Pablo F., Tuong, Zewen Kelvin, Sun, Hongjian, Wang, Hao, Yang, Siling, Wang, Runli, Leong, Yew Ann, Simon Davis, David, Qin, Jiahuan, Liang, Kaili, Deng, Jun, Wang, Conan K., Huang, Yen-Hua, Roco, Jonathan A., Nettelfield, Sam, Zhu, Huaming, Xu, Huajun, Yu, Zhijia, Craik, David, Liu, Zheng, Qi, Hai, Parish, Christopher and Yu, Di (2023). Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Science immunology, 8 (80) eadd1728, 1-17. doi: 10.1126/sciimmunol.add1728

Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation

Featured

2022

Journal Article

Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide

Zhang, Yuhui, Wang, Li, Tombling, Benjamin J., Lammi, Carmen, Huang, Yen-Hua, Li, Yue, Bartolomei, Martina, Hong, Bin, Craik, David J. and Wang, Conan K. (2022). Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide. Journal of the American Chemical Society, 144 (42), 19485-19498. doi: 10.1021/jacs.2c08029

Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide

2022

Journal Article

Accurate de novo design of membrane-traversing macrocycles

Bhardwaj, Gaurav, O’Connor, Jacob, Rettie, Stephen, Huang, Yen-Hua, Ramelot, Theresa A., Mulligan, Vikram Khipple, Alpkilic, Gizem Gokce, Palmer, Jonathan, Bera, Asim K., Bick, Matthew J., Di Piazza, Maddalena, Li, Xinting, Hosseinzadeh, Parisa, Craven, Timothy W., Tejero, Roberto, Lauko, Anna, Choi, Ryan, Glynn, Calina, Dong, Linlin, Griffin, Robert, van Voorhis, Wesley C., Rodriguez, Jose, Stewart, Lance, Montelione, Gaetano T., Craik, David and Baker, David (2022). Accurate de novo design of membrane-traversing macrocycles. Cell, 185 (19), 3520-3532.e26. doi: 10.1016/j.cell.2022.07.019

Accurate de novo design of membrane-traversing macrocycles

2022

Journal Article

Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system

Wu, Yue, Cui, Zhenling, Huang, Yen-Hua, de Veer, Simon J., Aralov, Andrey V., Guo, Zhong, Moradi, Shayli V., Hinton, Alexandra O., Deuis, Jennifer R., Guo, Shaodong, Chen, Kai-En, Collins, Brett M., Vetter, Irina, Herzig, Volker, Jones, Alun, Cooper, Matthew A., King, Glenn F., Craik, David J., Alexandrov, Kirill and Mureev, Sergey (2022). Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system. Nature Communications, 13 (1) 260, 260. doi: 10.1038/s41467-021-27854-9

Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system

Featured

2021

Journal Article

Rational design of potent peptide inhibitors of the PD-1:PD-L1 interaction for cancer immunotherapy

Yin, Huawu, Zhou, Xiuman, Huang, Yen-Hua, King, Gordon J., Collins, Brett M., Gao, Yanfeng, Craik, David J. and Wang, Conan K. (2021). Rational design of potent peptide inhibitors of the PD-1:PD-L1 interaction for cancer immunotherapy. Journal of the American Chemical Society, 143 (44) jacs.1c08132, 18536-18547. doi: 10.1021/jacs.1c08132

Rational design of potent peptide inhibitors of the PD-1:PD-L1 interaction for cancer immunotherapy

Featured

2021

Journal Article

An ultrapotent and selective cyclic peptide inhibitor of human β-factor XIIa in a cyclotide scaffold

Liu, Wenyu, de Veer, Simon J., Huang, Yen-Hua, Sengoku, Toru, Okada, Chikako, Ogata, Kazuhiro, Zdenek, Christina N., Fry, Bryan G., Swedberg, Joakim E., Passioura, Toby, Craik, David J. and Suga, Hiroaki (2021). An ultrapotent and selective cyclic peptide inhibitor of human β-factor XIIa in a cyclotide scaffold. Journal of the American Chemical Society, 143 (44) jacs.1c07574, 18481-18489. doi: 10.1021/jacs.1c07574

An ultrapotent and selective cyclic peptide inhibitor of human β-factor XIIa in a cyclotide scaffold

Featured

2021

Journal Article

Enabling efficient folding and high-resolution crystallographic analysis of bracelet cyclotides

Huang, Yen-Hua, Du, Qingdan, Jiang, Zhihao, King, Gordon J., Collins, Brett M., Wang, Conan K. and Craik, David J. (2021). Enabling efficient folding and high-resolution crystallographic analysis of bracelet cyclotides. Molecules, 26 (18) 5554, 5554. doi: 10.3390/molecules26185554

Enabling efficient folding and high-resolution crystallographic analysis of bracelet cyclotides

Featured

2019

Journal Article

Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor

Chambers, Chris, Cutler, Penny, Huang, Yen-Hua, Goodchild, James A., Blythe, Judith, Wang, Conan K., Bigot, Aurélien, Kaas, Quentin, Craik, David J., Sabbadin, Davide and Earley, Fergus G. (2019). Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor. FEBS Letters, 593 (12) 1873-3468.13435, 1336-1350. doi: 10.1002/1873-3468.13435

Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor

2025

Journal Article

Recombinant production of the cyclotide kalata B1 by conditional split inteins

Craik, David J., Yayci, Abdulkadir, Huang, Yen-Hua and Harvey, Peta J. (2025). Recombinant production of the cyclotide kalata B1 by conditional split inteins. ChemBioChem, 26 (4) e202400591. doi: 10.1002/cbic.202400591

Recombinant production of the cyclotide kalata B1 by conditional split inteins

2024

Journal Article

Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylation

Rehm, Fabian B. H., Tyler, Tristan J., Zhou, Yan, Huang, Yen-Hua, Wang, Conan K., Lawrence, Nicole, Craik, David J. and Durek, Thomas (2024). Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylation. Nature Chemistry, 16 (9), 1565-1565. doi: 10.1038/s41557-024-01625-7

Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylation

2024

Conference Publication

Site-directed scanning mutagenesis reveals specific residues that enhance both the enduring stability and insecticidal efficacy of the cyclotide kalata B1

Huang, Yen-Hua, Jiang, Zhihao, Yap, Kuok, Bigot, Aurelien, Kaas, Quentin, Wang, Conan and Craik, David (2024). Site-directed scanning mutagenesis reveals specific residues that enhance both the enduring stability and insecticidal efficacy of the cyclotide kalata B1. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons.

Site-directed scanning mutagenesis reveals specific residues that enhance both the enduring stability and insecticidal efficacy of the cyclotide kalata B1

2024

Conference Publication

Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide

Zhang, Yuhui, Wang, Li, Tombling, Benjamin, Lammi, Carmen, Huang, Yen-Hua, Yue, Li, Bartolomei, Martina, Hong, Bin, Craik, David and Wang, Conan (2024). Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons.

Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide

2024

Journal Article

Structure and activity of reconstructed pseudo‐ancestral cyclotides

Jiang, Zhihao, Huang, Yen-Hua, Kaas, Quentin, Craik, David J. and Wang, Conan K. (2024). Structure and activity of reconstructed pseudo‐ancestral cyclotides. ChemMedChem, 19 (14) e202400124, e202400124. doi: 10.1002/cmdc.202400124

Structure and activity of reconstructed pseudo‐ancestral cyclotides

2024

Journal Article

Isolation and characterization of insecticidal cyclotides from Viola communis

Khatibi, Negin, Huang, Yen-Hua, Wang, Conan K., Durek, Thomas, Gilding, Edward K. and Craik, David J. (2024). Isolation and characterization of insecticidal cyclotides from Viola communis. Journal of Natural Products, 88 (1), 24-35. doi: 10.1021/acs.jnatprod.4c00168

Isolation and characterization of insecticidal cyclotides from Viola communis

2024

Journal Article

Molecular dynamics simulations support a preference of cyclotide kalata B1 for phosphatidylethanolamine phospholipids

Roseli, Ras Baizureen, Huang, Yen-Hua, Henriques, Sónia Troeira, Kaas, Quentin and Craik, David J. (2024). Molecular dynamics simulations support a preference of cyclotide kalata B1 for phosphatidylethanolamine phospholipids. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1866 (3) 184268, 1-13. doi: 10.1016/j.bbamem.2023.184268

Molecular dynamics simulations support a preference of cyclotide kalata B1 for phosphatidylethanolamine phospholipids

2024

Journal Article

Computational design of α‐conotoxins to target specific nicotinic acetylcholine receptor subtypes

Wu, Xiaosa, Hone, Arik J., Huang, Yen-Hua, Clark, Richard J., McIntosh, J. Michael, Kaas, Quentin and Craik, David J. (2024). Computational design of α‐conotoxins to target specific nicotinic acetylcholine receptor subtypes. Chemistry – A European Journal, 30 (7) e202302909, 1-5. doi: 10.1002/chem.202302909

Computational design of α‐conotoxins to target specific nicotinic acetylcholine receptor subtypes

Current funding

  • 2025 - 2028
    Disruptive technologies for targeting tyrosine kinase substrate sites
    NHMRC IDEAS Grants
    Open grant
  • 2025 - 2028
    Unleashing the biocontrol potential of venom peptides with cyclotides
    ARC Linkage Projects
    Open grant
  • 2025 - 2028
    A molecular platform for design and production of next-generation peptides
    ARC Linkage Projects
    Open grant
  • 2024 - 2026
    Developing novel peptide tracers for improving immunotherapy outcomes
    NHMRC Development Grant
    Open grant

Past funding

  • 2021 - 2024
    Plant cyclotides as novel sustainable tools for crop protection
    ARC Linkage Projects
    Open grant

Availability

Dr Yen-Hua Crystal Huang is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Exploring delivery strategies for cyclotide-based therapeutics

    Principal Advisor

    Other advisors: Dr Conan Wang, Professor David Craik

  • Doctor Philosophy

    Patient-friendly peptide tracers for improving immunotherapy outcomes

    Associate Advisor

    Other advisors: Dr Conan Wang

  • Doctor Philosophy

    Applications of cyclic peptides in drug design

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    Discovery and Development of Substrate-Based Peptide Kinase Inhibitors

    Associate Advisor

    Other advisors: Professor David Craik, Dr Conan Wang

Completed supervision

Enquiries

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