![Dr Yen-Hua Crystal Huang](/sites/default/files/profiles/1454.jpeg)
Overview
Availability
- Dr Yen-Hua Crystal Huang is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Yen-Hua Crystal Huang’s works on UQ eSpace
2024
Journal Article
Repurposing a plant peptide cyclase for targeted lysine acylation
Rehm, Fabian B. H., Tyler, Tristan J., Zhou, Yan, Huang, Yen-Hua, Wang, Conan K., Lawrence, Nicole, Craik, David J. and Durek, Thomas (2024). Repurposing a plant peptide cyclase for targeted lysine acylation. Nature Chemistry, 2024, 1-1. doi: 10.1038/s41557-024-01520-1
2024
Journal Article
Isolation and Characterization of Insecticidal Cyclotides from <i>Viola communis</i>
Khatibi, Negin, Huang, Yen-Hua, Wang, Conan K., Durek, Thomas, Gilding, Edward K. and Craik, David J. (2024). Isolation and Characterization of Insecticidal Cyclotides from Viola communis. Journal of Natural Products. doi: 10.1021/acs.jnatprod.4c00168
2024
Journal Article
Structure and Activity of Reconstructed Pseudo‐Ancestral Cyclotides
Jiang, Zhihao, Huang, Yen-Hua, Kaas, Quentin, Craik, David J. and Wang, Conan K. (2024). Structure and Activity of Reconstructed Pseudo‐Ancestral Cyclotides. ChemMedChem, 19 (14), e202400124. doi: 10.1002/cmdc.202400124
2024
Journal Article
Molecular dynamics simulations support a preference of cyclotide kalata B1 for phosphatidylethanolamine phospholipids
Roseli, Ras Baizureen, Huang, Yen-Hua, Henriques, Sónia Troeira, Kaas, Quentin and Craik, David J. (2024). Molecular dynamics simulations support a preference of cyclotide kalata B1 for phosphatidylethanolamine phospholipids. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1866 (3) 184268, 184268. doi: 10.1016/j.bbamem.2023.184268
2024
Journal Article
Computational design of α‐conotoxins to target specific nicotinic acetylcholine receptor subtypes
Wu, Xiaosa, Hone, Arik J., Huang, Yen-Hua, Clark, Richard J., McIntosh, J. Michael, Kaas, Quentin and Craik, David J. (2024). Computational design of α‐conotoxins to target specific nicotinic acetylcholine receptor subtypes. Chemistry – A European Journal, 30 (7) e202302909, 1-5. doi: 10.1002/chem.202302909
2024
Journal Article
Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide
Philippe, Grégoire Jean-Baptiste, Huang, Yen-Hua, Mittermeier, Anna, Brown, Christopher J., Kaas, Quentin, Ramlan, Siti Radhiah, Wang, Conan K., Lane, David, Loewer, Alexander, Troeira Henriques, Sónia and Craik, David J. (2024). Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide. Journal of Medicinal Chemistry, 67 (2), 1197-1208. doi: 10.1021/acs.jmedchem.3c01682
2024
Journal Article
Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1
Huang, Yen-Hua, Jiang, Zhihao, Du, Qingdan, Yap, Kuok, Bigot, Aurélien, Kaas, Quentin, Wang, Conan K. and Craik, David J. (2024). Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1. Journal of Biological Chemistry, 300 (3) 105682, 105682. doi: 10.1016/j.jbc.2024.105682
2024
Journal Article
The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance
Biswas, Biswajit, Huang, Yen-Hua, Craik, David J. and Wang, Conan K. (2024). The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance. Chemical Science, 15 (33), 13130-13147. doi: 10.1039/d4sc01088d
2023
Journal Article
The circular bacteriocin enterocin NKR-5-3B has an improved stability profile over nisin
Wang, Conan K., Huang, Yen-Hua, Shabbir, Fatima, Pham, Huong T., Lawrence, Nicole, Benfield, Aurélie H., van der Donk, Wilfred, Henriques, Sónia T., Turner, Mark S. and Craik, David J. (2023). The circular bacteriocin enterocin NKR-5-3B has an improved stability profile over nisin. Peptides, 167 171049, 171049. doi: 10.1016/j.peptides.2023.171049
2023
Journal Article
Nematicidal activity of cyclotides: toxicity against Caenorhabditis elegans
Bajpai, Abhishek, Jackson, Mark A., Huang, Yen-Hua, Yap, Kuok, Du, Qingdan, Chau, Tevin Chui-Ying, Craik, David J. and Gilding, Edward K. (2023). Nematicidal activity of cyclotides: toxicity against Caenorhabditis elegans. Journal of Natural Products, 86 (5), 1222-1229. doi: 10.1021/acs.jnatprod.2c01124
2023
Journal Article
Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation
Chen, Zhian, Cui, Yanfang, Yao, Yin, Liu, Bo, Yunis, Joseph, Gao, Xin, Wang, Naiqi, Cañete, Pablo F., Tuong, Zewen Kelvin, Sun, Hongjian, Wang, Hao, Yang, Siling, Wang, Runli, Leong, Yew Ann, Simon Davis, David, Qin, Jiahuan, Liang, Kaili, Deng, Jun, Wang, Conan K., Huang, Yen-Hua, Roco, Jonathan A., Nettelfield, Sam, Zhu, Huaming, Xu, Huajun, Yu, Zhijia, Craik, David, Liu, Zheng, Qi, Hai, Parish, Christopher and Yu, Di (2023). Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Science immunology, 8 (80) eadd1728, 1-17. doi: 10.1126/sciimmunol.add1728
2022
Journal Article
Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide
Zhang, Yuhui, Wang, Li, Tombling, Benjamin J., Lammi, Carmen, Huang, Yen-Hua, Li, Yue, Bartolomei, Martina, Hong, Bin, Craik, David J. and Wang, Conan K. (2022). Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide. Journal of the American Chemical Society, 144 (42), 19485-19498. doi: 10.1021/jacs.2c08029
2022
Journal Article
The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila
Dang, Tien T., Huang, Yen-Hua, Ott, Stanislav, Harvey, Peta J., Gilding, Edward K., Tombling, Benjamin J., Chan, Lai Y., Kaas, Quentin, Claridge-Chang, Adam and Craik, David J. (2022). The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila. Journal of Biological Chemistry, 298 (10) 102413, 1-11. doi: 10.1016/j.jbc.2022.102413
2022
Journal Article
Accurate de novo design of membrane-traversing macrocycles
Bhardwaj, Gaurav, O’Connor, Jacob, Rettie, Stephen, Huang, Yen-Hua, Ramelot, Theresa A., Mulligan, Vikram Khipple, Alpkilic, Gizem Gokce, Palmer, Jonathan, Bera, Asim K., Bick, Matthew J., Di Piazza, Maddalena, Li, Xinting, Hosseinzadeh, Parisa, Craven, Timothy W., Tejero, Roberto, Lauko, Anna, Choi, Ryan, Glynn, Calina, Dong, Linlin, Griffin, Robert, van Voorhis, Wesley C., Rodriguez, Jose, Stewart, Lance, Montelione, Gaetano T., Craik, David and Baker, David (2022). Accurate de novo design of membrane-traversing macrocycles. Cell, 185 (19), 3520-3532.e26. doi: 10.1016/j.cell.2022.07.019
2022
Journal Article
Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides
Dang, Tien T., Harvey, Peta J., Chan, Lai Yue, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2022). Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides. Peptide Science, 114 (6) e24284. doi: 10.1002/pep2.24284
2022
Journal Article
Mutagenesis of bracelet cyclotide hyen D reveals functionally and structurally critical residues for membrane binding and cytotoxicity
Du, Qingdan, Huang, Yen-Hua, Wang, Conan K., Kaas, Quentin and Craik, David J. (2022). Mutagenesis of bracelet cyclotide hyen D reveals functionally and structurally critical residues for membrane binding and cytotoxicity. Journal of Biological Chemistry, 298 (4) 101822, 101822. doi: 10.1016/j.jbc.2022.101822
2022
Journal Article
Comparative analysis of cyclotide-producing plant cell suspensions presents opportunities for cyclotide plant molecular farming
Doffek, Benjamin, Huang, Yvonne, Huang, Yen-Hua, Chan, Lai Yue, Gilding, Edward K., Jackson, Mark A. and Craik, David J. (2022). Comparative analysis of cyclotide-producing plant cell suspensions presents opportunities for cyclotide plant molecular farming. Phytochemistry, 195 113053, 113053. doi: 10.1016/j.phytochem.2021.113053
2022
Journal Article
Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system
Wu, Yue, Cui, Zhenling, Huang, Yen-Hua, de Veer, Simon J., Aralov, Andrey V., Guo, Zhong, Moradi, Shayli V., Hinton, Alexandra O., Deuis, Jennifer R., Guo, Shaodong, Chen, Kai-En, Collins, Brett M., Vetter, Irina, Herzig, Volker, Jones, Alun, Cooper, Matthew A., King, Glenn F., Craik, David J., Alexandrov, Kirill and Mureev, Sergey (2022). Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system. Nature Communications, 13 (1) 260, 260. doi: 10.1038/s41467-021-27854-9
2022
Journal Article
ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation
Yousuf, Arsalan, Wu, Xiaosa, Bony, Anuja R., Sadeghi, Mahsa, Huang, Yen-Hua, Craik, David J. and Adams, David J. (2022). ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation. Journal of Neurochemistry, 160 (2), 154-171. doi: 10.1111/jnc.15535
2021
Journal Article
Rational design of potent peptide inhibitors of the PD-1:PD-L1 interaction for cancer immunotherapy
Yin, Huawu, Zhou, Xiuman, Huang, Yen-Hua, King, Gordon J., Collins, Brett M., Gao, Yanfeng, Craik, David J. and Wang, Conan K. (2021). Rational design of potent peptide inhibitors of the PD-1:PD-L1 interaction for cancer immunotherapy. Journal of the American Chemical Society, 143 (44) jacs.1c08132, 18536-18547. doi: 10.1021/jacs.1c08132
Funding
Current funding
Supervision
Availability
- Dr Yen-Hua Crystal Huang is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Novel peptide-based drug leads for targeting leukaemia.
Associate Advisor
Other advisors: Professor David Craik
-
Doctor Philosophy
Development of novel peptide based drug leads for chronic myeloid leukaemia
Associate Advisor
Other advisors: Professor David Craik
-
Doctor Philosophy
Patient-friendly peptide tracers for improving immunotherapy outcomes
Associate Advisor
Other advisors: Dr Conan Wang
-
Doctor Philosophy
Applications of cyclic peptides in drug design
Associate Advisor
Other advisors: Professor David Craik
-
Doctor Philosophy
Discovery and Development of Substrate-Based Peptide Kinase Inhibitors
Associate Advisor
Other advisors: Professor David Craik, Dr Conan Wang
Completed supervision
-
2022
Doctor Philosophy
Investigating approaches for the design and delivery of disulfide-rich peptide therapeutics
Associate Advisor
Other advisors: Dr Conan Wang, Professor David Craik
-
2022
Doctor Philosophy
Discovery and Design of Plant-Derived Cyclotides for Medicinal Applications
Associate Advisor
Other advisors: Dr Angeline Chan, Professor David Craik
-
2021
Doctor Philosophy
Structures and Activities of Cystine Knot Peptides from the Violaceae Plant Family
Associate Advisor
Other advisors: Dr Angeline Chan, Professor David Craik
-
2019
Doctor Philosophy
Engineering the ribbon isomer of alpha-conotoxins in the drug design application
Associate Advisor
Other advisors: Professor David Craik
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