Dr Yen-Hua Crystal Huang
Dr

Yen-Hua Crystal Huang

Email: 
Phone: 
+61 7 334 62020

Availability

Dr Yen-Hua Crystal Huang is:
Available for supervision

Fields of research

Agricultural, Veterinary and Food Sciences Analytical chemistry Biological Sciences Chemical Sciences Crop and pasture production Medicinal and biomolecular chemistry

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Yen-Hua Crystal Huang’s works on UQ eSpace

86 works between 2008 and 2024
All (86) Journal Article (71) Book Chapter (2) Conference Publication (12) Other Outputs (1)

1 - 20 of 86 works

2024

Journal Article

Repurposing a plant peptide cyclase for targeted lysine acylation

Rehm, Fabian B. H., Tyler, Tristan J., Zhou, Yan, Huang, Yen-Hua, Wang, Conan K., Lawrence, Nicole, Craik, David J. and Durek, Thomas (2024). Repurposing a plant peptide cyclase for targeted lysine acylation. Nature Chemistry, 2024, 1-1. doi: 10.1038/s41557-024-01520-1

Repurposing a plant peptide cyclase for targeted lysine acylation

2024

Journal Article

Isolation and Characterization of Insecticidal Cyclotides from <i>Viola communis</i>

Khatibi, Negin, Huang, Yen-Hua, Wang, Conan K., Durek, Thomas, Gilding, Edward K. and Craik, David J. (2024). Isolation and Characterization of Insecticidal Cyclotides from Viola communis. Journal of Natural Products. doi: 10.1021/acs.jnatprod.4c00168

Isolation and Characterization of Insecticidal Cyclotides from <i>Viola communis</i>

2024

Journal Article

Structure and Activity of Reconstructed Pseudo‐Ancestral Cyclotides

Jiang, Zhihao, Huang, Yen-Hua, Kaas, Quentin, Craik, David J. and Wang, Conan K. (2024). Structure and Activity of Reconstructed Pseudo‐Ancestral Cyclotides. ChemMedChem, 19 (14), e202400124. doi: 10.1002/cmdc.202400124

Structure and Activity of Reconstructed Pseudo‐Ancestral Cyclotides

2024

Journal Article

Molecular dynamics simulations support a preference of cyclotide kalata B1 for phosphatidylethanolamine phospholipids

Roseli, Ras Baizureen, Huang, Yen-Hua, Henriques, Sónia Troeira, Kaas, Quentin and Craik, David J. (2024). Molecular dynamics simulations support a preference of cyclotide kalata B1 for phosphatidylethanolamine phospholipids. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1866 (3) 184268, 184268. doi: 10.1016/j.bbamem.2023.184268

Molecular dynamics simulations support a preference of cyclotide kalata B1 for phosphatidylethanolamine phospholipids

2024

Journal Article

Computational design of α‐conotoxins to target specific nicotinic acetylcholine receptor subtypes

Wu, Xiaosa, Hone, Arik J., Huang, Yen-Hua, Clark, Richard J., McIntosh, J. Michael, Kaas, Quentin and Craik, David J. (2024). Computational design of α‐conotoxins to target specific nicotinic acetylcholine receptor subtypes. Chemistry – A European Journal, 30 (7) e202302909, 1-5. doi: 10.1002/chem.202302909

Computational design of α‐conotoxins to target specific nicotinic acetylcholine receptor subtypes

2024

Journal Article

Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide

Philippe, Grégoire Jean-Baptiste, Huang, Yen-Hua, Mittermeier, Anna, Brown, Christopher J., Kaas, Quentin, Ramlan, Siti Radhiah, Wang, Conan K., Lane, David, Loewer, Alexander, Troeira Henriques, Sónia and Craik, David J. (2024). Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide. Journal of Medicinal Chemistry, 67 (2), 1197-1208. doi: 10.1021/acs.jmedchem.3c01682

Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide

2024

Journal Article

Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1

Huang, Yen-Hua, Jiang, Zhihao, Du, Qingdan, Yap, Kuok, Bigot, Aurélien, Kaas, Quentin, Wang, Conan K. and Craik, David J. (2024). Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1. Journal of Biological Chemistry, 300 (3) 105682, 105682. doi: 10.1016/j.jbc.2024.105682

Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1

2024

Journal Article

The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance

Biswas, Biswajit, Huang, Yen-Hua, Craik, David J. and Wang, Conan K. (2024). The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance. Chemical Science, 15 (33), 13130-13147. doi: 10.1039/d4sc01088d

The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance

2023

Journal Article

The circular bacteriocin enterocin NKR-5-3B has an improved stability profile over nisin

Wang, Conan K., Huang, Yen-Hua, Shabbir, Fatima, Pham, Huong T., Lawrence, Nicole, Benfield, Aurélie H., van der Donk, Wilfred, Henriques, Sónia T., Turner, Mark S. and Craik, David J. (2023). The circular bacteriocin enterocin NKR-5-3B has an improved stability profile over nisin. Peptides, 167 171049, 171049. doi: 10.1016/j.peptides.2023.171049

The circular bacteriocin enterocin NKR-5-3B has an improved stability profile over nisin

2023

Journal Article

Nematicidal activity of cyclotides: toxicity against​​​​​​​ Caenorhabditis elegans

Bajpai, Abhishek, Jackson, Mark A., Huang, Yen-Hua, Yap, Kuok, Du, Qingdan, Chau, Tevin Chui-Ying, Craik, David J. and Gilding, Edward K. (2023). Nematicidal activity of cyclotides: toxicity against​​​​​​​ Caenorhabditis elegans. Journal of Natural Products, 86 (5), 1222-1229. doi: 10.1021/acs.jnatprod.2c01124

Nematicidal activity of cyclotides: toxicity against​​​​​​​ Caenorhabditis elegans

2023

Journal Article

Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation

Chen, Zhian, Cui, Yanfang, Yao, Yin, Liu, Bo, Yunis, Joseph, Gao, Xin, Wang, Naiqi, Cañete, Pablo F., Tuong, Zewen Kelvin, Sun, Hongjian, Wang, Hao, Yang, Siling, Wang, Runli, Leong, Yew Ann, Simon Davis, David, Qin, Jiahuan, Liang, Kaili, Deng, Jun, Wang, Conan K., Huang, Yen-Hua, Roco, Jonathan A., Nettelfield, Sam, Zhu, Huaming, Xu, Huajun, Yu, Zhijia, Craik, David, Liu, Zheng, Qi, Hai, Parish, Christopher and Yu, Di (2023). Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Science immunology, 8 (80) eadd1728, 1-17. doi: 10.1126/sciimmunol.add1728

Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation

2022

Journal Article

Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide

Zhang, Yuhui, Wang, Li, Tombling, Benjamin J., Lammi, Carmen, Huang, Yen-Hua, Li, Yue, Bartolomei, Martina, Hong, Bin, Craik, David J. and Wang, Conan K. (2022). Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide. Journal of the American Chemical Society, 144 (42), 19485-19498. doi: 10.1021/jacs.2c08029

Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide

2022

Journal Article

The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila

Dang, Tien T., Huang, Yen-Hua, Ott, Stanislav, Harvey, Peta J., Gilding, Edward K., Tombling, Benjamin J., Chan, Lai Y., Kaas, Quentin, Claridge-Chang, Adam and Craik, David J. (2022). The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila. Journal of Biological Chemistry, 298 (10) 102413, 1-11. doi: 10.1016/j.jbc.2022.102413

The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila

2022

Journal Article

Accurate de novo design of membrane-traversing macrocycles

Bhardwaj, Gaurav, O’Connor, Jacob, Rettie, Stephen, Huang, Yen-Hua, Ramelot, Theresa A., Mulligan, Vikram Khipple, Alpkilic, Gizem Gokce, Palmer, Jonathan, Bera, Asim K., Bick, Matthew J., Di Piazza, Maddalena, Li, Xinting, Hosseinzadeh, Parisa, Craven, Timothy W., Tejero, Roberto, Lauko, Anna, Choi, Ryan, Glynn, Calina, Dong, Linlin, Griffin, Robert, van Voorhis, Wesley C., Rodriguez, Jose, Stewart, Lance, Montelione, Gaetano T., Craik, David and Baker, David (2022). Accurate de novo design of membrane-traversing macrocycles. Cell, 185 (19), 3520-3532.e26. doi: 10.1016/j.cell.2022.07.019

Accurate de novo design of membrane-traversing macrocycles

2022

Journal Article

Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides

Dang, Tien T., Harvey, Peta J., Chan, Lai Yue, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2022). Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides. Peptide Science, 114 (6) e24284. doi: 10.1002/pep2.24284

Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides

2022

Journal Article

Mutagenesis of bracelet cyclotide hyen D reveals functionally and structurally critical residues for membrane binding and cytotoxicity

Du, Qingdan, Huang, Yen-Hua, Wang, Conan K., Kaas, Quentin and Craik, David J. (2022). Mutagenesis of bracelet cyclotide hyen D reveals functionally and structurally critical residues for membrane binding and cytotoxicity. Journal of Biological Chemistry, 298 (4) 101822, 101822. doi: 10.1016/j.jbc.2022.101822

Mutagenesis of bracelet cyclotide hyen D reveals functionally and structurally critical residues for membrane binding and cytotoxicity

2022

Journal Article

Comparative analysis of cyclotide-producing plant cell suspensions presents opportunities for cyclotide plant molecular farming

Doffek, Benjamin, Huang, Yvonne, Huang, Yen-Hua, Chan, Lai Yue, Gilding, Edward K., Jackson, Mark A. and Craik, David J. (2022). Comparative analysis of cyclotide-producing plant cell suspensions presents opportunities for cyclotide plant molecular farming. Phytochemistry, 195 113053, 113053. doi: 10.1016/j.phytochem.2021.113053

Comparative analysis of cyclotide-producing plant cell suspensions presents opportunities for cyclotide plant molecular farming

2022

Journal Article

Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system

Wu, Yue, Cui, Zhenling, Huang, Yen-Hua, de Veer, Simon J., Aralov, Andrey V., Guo, Zhong, Moradi, Shayli V., Hinton, Alexandra O., Deuis, Jennifer R., Guo, Shaodong, Chen, Kai-En, Collins, Brett M., Vetter, Irina, Herzig, Volker, Jones, Alun, Cooper, Matthew A., King, Glenn F., Craik, David J., Alexandrov, Kirill and Mureev, Sergey (2022). Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system. Nature Communications, 13 (1) 260, 260. doi: 10.1038/s41467-021-27854-9

Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system

2022

Journal Article

ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation

Yousuf, Arsalan, Wu, Xiaosa, Bony, Anuja R., Sadeghi, Mahsa, Huang, Yen-Hua, Craik, David J. and Adams, David J. (2022). ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation. Journal of Neurochemistry, 160 (2), 154-171. doi: 10.1111/jnc.15535

ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation

2021

Journal Article

Rational design of potent peptide inhibitors of the PD-1:PD-L1 interaction for cancer immunotherapy

Yin, Huawu, Zhou, Xiuman, Huang, Yen-Hua, King, Gordon J., Collins, Brett M., Gao, Yanfeng, Craik, David J. and Wang, Conan K. (2021). Rational design of potent peptide inhibitors of the PD-1:PD-L1 interaction for cancer immunotherapy. Journal of the American Chemical Society, 143 (44) jacs.1c08132, 18536-18547. doi: 10.1021/jacs.1c08132

Rational design of potent peptide inhibitors of the PD-1:PD-L1 interaction for cancer immunotherapy

Current funding

  • 2024 - 2026
    Developing novel peptide tracers for improving immunotherapy outcomes
    NHMRC Development Grant
    Open grant
  • 2021 - 2024
    Plant cyclotides as novel sustainable tools for crop protection
    ARC Linkage Projects
    Open grant

Availability

Dr Yen-Hua Crystal Huang is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Novel peptide-based drug leads for targeting leukaemia.

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    Development of novel peptide based drug leads for chronic myeloid leukaemia

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    Patient-friendly peptide tracers for improving immunotherapy outcomes

    Associate Advisor

    Other advisors: Dr Conan Wang

  • Doctor Philosophy

    Applications of cyclic peptides in drug design

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    Discovery and Development of Substrate-Based Peptide Kinase Inhibitors

    Associate Advisor

    Other advisors: Professor David Craik, Dr Conan Wang

Completed supervision

Enquiries

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