Overview
Availability
- Dr Yen-Hua Crystal Huang is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Yen-Hua Crystal Huang’s works on UQ eSpace
2021
Journal Article
An ultrapotent and selective cyclic peptide inhibitor of human β-factor XIIa in a cyclotide scaffold
Liu, Wenyu, de Veer, Simon J., Huang, Yen-Hua, Sengoku, Toru, Okada, Chikako, Ogata, Kazuhiro, Zdenek, Christina N., Fry, Bryan G., Swedberg, Joakim E., Passioura, Toby, Craik, David J. and Suga, Hiroaki (2021). An ultrapotent and selective cyclic peptide inhibitor of human β-factor XIIa in a cyclotide scaffold. Journal of the American Chemical Society, 143 (44) jacs.1c07574, 18481-18489. doi: 10.1021/jacs.1c07574
2021
Journal Article
Enabling efficient folding and high-resolution crystallographic analysis of bracelet cyclotides
Huang, Yen-Hua, Du, Qingdan, Jiang, Zhihao, King, Gordon J., Collins, Brett M., Wang, Conan K. and Craik, David J. (2021). Enabling efficient folding and high-resolution crystallographic analysis of bracelet cyclotides. Molecules, 26 (18) 5554, 5554. doi: 10.3390/molecules26185554
2021
Journal Article
The emerging landscape of peptide-based inhibitors of PCSK9
Tombling, Benjamin J., Zhang, Yuhui, Huang, Yen-Hua, Craik, David J. and Wang, Conan K. (2021). The emerging landscape of peptide-based inhibitors of PCSK9. Atherosclerosis, 330, 52-60. doi: 10.1016/j.atherosclerosis.2021.06.903
2021
Journal Article
An integrated molecular grafting approach for the design of Keap1-targeted peptide inhibitors
Yin, Huawu, Huang, Yen-Hua, Best, Sarah A., Sutherland, Kate D., Craik, David J. and Wang, Conan K. (2021). An integrated molecular grafting approach for the design of Keap1-targeted peptide inhibitors. ACS Chemical Biology, 16 (7) acschembio.1c00388, 1276-1287. doi: 10.1021/acschembio.1c00388
2021
Journal Article
Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1
Poth, Aaron G., Chiu, Francis C.K., Stalmans, Sofie, Hamilton, Brett R., Huang, Yen-Hua, Shackleford, David M., Patil, Rahul, Le, Thao T., Kan, Meng-Wei, Durek, Thomas, Wynendaele, Evelien, De Spiegeleer, Bart, Powell, Andrew K., Venter, Deon J., Clark, Richard J., Charman, Susan A. and Craik, David J. (2021). Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1. Medicine in Drug Discovery, 10 100087, 1-10. doi: 10.1016/j.medidd.2021.100087
2021
Journal Article
Angler peptides: macrocyclic conjugates inhibit p53:MDM2/X interactions and activate apoptosis in cancer cells
Philippe, Grégoire J.-B., Mittermeier, Anna, Lawrence, Nicole, Huang, Yen-Hua, Condon, Nicholas D., Loewer, Alexander, Craik, David J. and Henriques, Sónia T. (2021). Angler peptides: macrocyclic conjugates inhibit p53:MDM2/X interactions and activate apoptosis in cancer cells. ACS Chemical Biology, 16 (2) acschembio.0c00988, 414-428. doi: 10.1021/acschembio.0c00988
2021
Book Chapter
Protocols for measuring the stability and cytotoxicity of cyclotides
Huang, Yen-Hua, Kan, Meng-Wei and Craik, David J. (2021). Protocols for measuring the stability and cytotoxicity of cyclotides. Antimicrobial peptides. (pp. 19-40) edited by Leslie M. Hicks. Cambridge, MA, United States: Academic Press. doi: 10.1016/bs.mie.2021.09.007
2021
Journal Article
Cyclic gomesin, a stable redesigned spider peptide able to enter cancer cells
Benfield, Aurélie H., Defaus, Sira, Lawrence, Nicole, Chaousis, Stephanie, Condon, Nicholas, Cheneval, Olivier, Huang, Yen-Hua, Chan, Lai Yue, Andreu, David, Craik, David J. and Henriques, Sónia Troeira (2021). Cyclic gomesin, a stable redesigned spider peptide able to enter cancer cells. Biochimica et Biophysica Acta - Biomembranes, 1863 (1) 183480, 183480. doi: 10.1016/j.bbamem.2020.183480
2020
Journal Article
Evaluation of the in vivo aphrodisiac activity of a cyclotide extract from Hybanthus enneaspermus
Du, Qingdan, Huang, Yen-Hua, Bajpai, Abhishek, Frosig- Jorgensen, Majbrit, Zhao, Guangzu and Craik, David J. (2020). Evaluation of the in vivo aphrodisiac activity of a cyclotide extract from Hybanthus enneaspermus. Journal of Natural Products, 83 (12), 3736-3743. doi: 10.1021/acs.jnatprod.0c01045
2020
Journal Article
Exploring the sequence diversity of cyclotides from Vietnamese Viola species
Dang, Tien T., Chan, Lai Y., Huang, Yen-Hua, Nguyen, Linh T. T., Kaas, Quentin, Huynh, Tien and Craik, David J. (2020). Exploring the sequence diversity of cyclotides from Vietnamese Viola species. Journal of Natural Products, 83 (6) acs.jnatprod.9b01218, 1817-1828. doi: 10.1021/acs.jnatprod.9b01218
2020
Journal Article
Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus
Du, Qingdan, Chan, Lai Y., Gilding, Edward K., Henriques, Sónia Troeira, Condon, Nicholas D., Ravipati, Anjaneya S., Kaas, Quentin, Huang, Yen-Hua and Craik, David J. (2020). Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus. Journal of Biological Chemistry, 295 (32), jbc.RA120.012627-10925. doi: 10.1074/jbc.ra120.012627
2020
Journal Article
Cellular uptake and cytosolic delivery of a cyclic cystine knot scaffold
Yin, Huawu, Huang, Yen-Hua, Deprey, Kirsten, Condon, Nicholas D., Kritzer, Joshua A., Craik, David J. and Wang, Conan K. (2020). Cellular uptake and cytosolic delivery of a cyclic cystine knot scaffold. ACS Chemical Biology, 15 (6), 1650-1661. doi: 10.1021/acschembio.0c00297
2020
Journal Article
Insecticidal diversity of butterfly pea (Clitoria ternatea) accessions
Oguis, Georgianna K., Gilding, Edward K., Huang, Yen-Hua, Poth, Aaron G., Jackson, Mark A. and Craik, David J. (2020). Insecticidal diversity of butterfly pea (Clitoria ternatea) accessions. Industrial Crops and Products, 147 112214, 112214. doi: 10.1016/j.indcrop.2020.112214
2020
Journal Article
Enhanced activity against multi-drug resistant bacteria through coapplication of an analogue of Tachyplesin I and an inhibitor of the QseC/B signaling pathway
Yu, Rilei, Wang, Jiayi, So, Lok-Yan, Harvey, Peta J., Shi, Juan, Liang, Jiazhen, Dou, Qin, Li, Xiao, Yan, Xiayi, Huang, Yen-Hua, Xu, Qingliang, Kaas, Quentin, Chow, Ho-Yin, Wong, Kwok-Yin, Craik, David J, Zhang, Xiaohua, Jiang, Tao and Wang, Yan (2020). Enhanced activity against multi-drug resistant bacteria through coapplication of an analogue of Tachyplesin I and an inhibitor of the QseC/B signaling pathway. Journal of Medicinal Chemistry, 63 (7), 3475-3484. doi: 10.1021/acs.jmedchem.9b01563
2020
Journal Article
Circular permutation of the native enzyme-mediated cyclization position in cyclotides
Smithies, Bronwyn J., Huang, Yen-Hua, Jackson, Mark A., Yap, Kuok, Gilding, Edward K., Harris, Karen S., Anderson, Marilyn A. and Craik, David J. (2020). Circular permutation of the native enzyme-mediated cyclization position in cyclotides. ACS Chemical Biology, 15 (4) acschembio.9b00996, 962-969. doi: 10.1021/acschembio.9b00996
2019
Journal Article
Cyclotides: disulfide-rich peptide toxins in plants
Huang, Yen-Hua, Du, Qingdan and Craik, David J. (2019). Cyclotides: disulfide-rich peptide toxins in plants. Toxicon, 172, 33-44. doi: 10.1016/j.toxicon.2019.10.244
2019
Journal Article
Characterization of tachyplesin peptides and their cyclized analogues to improve antimicrobial and anticancer properties
Vernen, Felicitas, Harvey, Peta J., Dias, Susana A., Veiga, Ana Salomé, Huang, Yen-Hua, Craik, David J., Lawrence, Nicole and Troeira Henriques, Sónia (2019). Characterization of tachyplesin peptides and their cyclized analogues to improve antimicrobial and anticancer properties. International Journal of Molecular Sciences, 20 (17) 4184, 4184. doi: 10.3390/ijms20174184
2019
Conference Publication
Spider toxins as novel allosteric modulators of insect nicotinic receptors
Earley, Fergus, Chambers, Chris, Cutler, Penny, Huang, Yen-Hua and Craik, David (2019). Spider toxins as novel allosteric modulators of insect nicotinic receptors. ACS Fall National Meeting and Exposition, San Diego, CA, United States, 25-29 August, 2019. Washington, DC United States: American Chemical Society.
2019
Journal Article
Cell membrane composition drives selectivity and toxicity of designed cyclic helix-loop-helix peptides with cell penetrating and tumor suppressor properties
Philippe, Grégoire J. -B., Gaspar, Diana, Sheng, Caibin, Huang, Yen-Hua, Benfield, Aurélie H., Condon, Nicholas D., Weidmann, Joachim, Lawrence, Nicole, Löwer, Alexander, Castanho, Miguel A. R. B., Craik, David J. and Troeira Henriques, Sónia (2019). Cell membrane composition drives selectivity and toxicity of designed cyclic helix-loop-helix peptides with cell penetrating and tumor suppressor properties. ACS Chemical Biology, 14 (9), 2071-2087. doi: 10.1021/acschembio.9b00593
2019
Journal Article
Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold
Poth, Aaron G., Huang, Yen-Hua, Le, Thao T., Kan, Meng-Wei and Craik, David J. (2019). Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold. International Journal of Pharmaceutics, 565, 437-446. doi: 10.1016/j.ijpharm.2019.05.001
Funding
Current funding
Supervision
Availability
- Dr Yen-Hua Crystal Huang is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Discovery and Development of Substrate-Based Peptide Kinase Inhibitors
Associate Advisor
Other advisors: Professor David Craik, Dr Conan Wang
-
Doctor Philosophy
Novel peptide-based drug leads for targeting leukaemia.
Associate Advisor
Other advisors: Professor David Craik
-
Doctor Philosophy
Applications of cyclic peptides in drug design
Associate Advisor
Other advisors: Professor David Craik
-
Doctor Philosophy
Development of novel peptide based drug leads for chronic myeloid leukaemia
Associate Advisor
Other advisors: Professor David Craik
-
Doctor Philosophy
Patient-friendly peptide tracers for improving immunotherapy outcomes
Associate Advisor
Other advisors: Dr Conan Wang
Completed supervision
-
2022
Doctor Philosophy
Investigating approaches for the design and delivery of disulfide-rich peptide therapeutics
Associate Advisor
Other advisors: Dr Conan Wang, Professor David Craik
-
2022
Doctor Philosophy
Discovery and Design of Plant-Derived Cyclotides for Medicinal Applications
Associate Advisor
Other advisors: Dr Angeline Chan, Professor David Craik
-
2021
Doctor Philosophy
Structures and Activities of Cystine Knot Peptides from the Violaceae Plant Family
Associate Advisor
Other advisors: Dr Angeline Chan, Professor David Craik
-
2019
Doctor Philosophy
Engineering the ribbon isomer of alpha-conotoxins in the drug design application
Associate Advisor
Other advisors: Professor David Craik
Media
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