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2024 Journal Article Recombinant production of the cyclotide kalata B1 by conditional split inteinsCraik, David J, Yayci, Abdulkadir, Huang, Yen-Hua and Harvey, Peta J (2024). Recombinant production of the cyclotide kalata B1 by conditional split inteins. ChemBioChem, 26 (4) e202400591, e202400591. doi: 10.1002/cbic.202400591 |
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2024 Journal Article Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylationRehm, Fabian B. H., Tyler, Tristan J., Zhou, Yan, Huang, Yen-Hua, Wang, Conan K., Lawrence, Nicole, Craik, David J. and Durek, Thomas (2024). Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylation. Nature Chemistry, 16 (9), 1565-1565. doi: 10.1038/s41557-024-01625-7 |
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2024 Conference Publication Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptideZhang, Yuhui, Wang, Li, Tombling, Benjamin, Lammi, Carmen, Huang, Yen-Hua, Yue, Li, Bartolomei, Martina, Hong, Bin, Craik, David and Wang, Conan (2024). Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons. |
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2024 Conference Publication Site-directed scanning mutagenesis reveals specific residues that enhance both the enduring stability and insecticidal efficacy of the cyclotide kalata B1Huang, Yen-Hua, Jiang, Zhihao, Yap, Kuok, Bigot, Aurelien, Kaas, Quentin, Wang, Conan and Craik, David (2024). Site-directed scanning mutagenesis reveals specific residues that enhance both the enduring stability and insecticidal efficacy of the cyclotide kalata B1. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons. |
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2024 Journal Article Structure and activity of reconstructed pseudo‐ancestral cyclotidesJiang, Zhihao, Huang, Yen-Hua, Kaas, Quentin, Craik, David J. and Wang, Conan K. (2024). Structure and activity of reconstructed pseudo‐ancestral cyclotides. ChemMedChem, 19 (14) e202400124, e202400124. doi: 10.1002/cmdc.202400124 |
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2024 Journal Article Repurposing a plant peptide cyclase for targeted lysine acylationRehm, Fabian B. H., Tyler, Tristan J., Zhou, Yan, Huang, Yen-Hua, Wang, Conan K., Lawrence, Nicole, Craik, David J. and Durek, Thomas (2024). Repurposing a plant peptide cyclase for targeted lysine acylation. Nature Chemistry, 2024 (9), 1-1. doi: 10.1038/s41557-024-01520-1 |
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2024 Journal Article Isolation and characterization of insecticidal cyclotides from Viola communisKhatibi, Negin, Huang, Yen-Hua, Wang, Conan K., Durek, Thomas, Gilding, Edward K. and Craik, David J. (2024). Isolation and characterization of insecticidal cyclotides from Viola communis. Journal of Natural Products, 88 (1), 24-35. doi: 10.1021/acs.jnatprod.4c00168 |
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2024 Journal Article Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1Huang, Yen-Hua, Jiang, Zhihao, Du, Qingdan, Yap, Kuok, Bigot, Aurélien, Kaas, Quentin, Wang, Conan K. and Craik, David J. (2024). Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1. Journal of Biological Chemistry, 300 (3) 105682. doi: 10.1016/j.jbc.2024.105682 |
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2024 Journal Article Molecular dynamics simulations support a preference of cyclotide kalata B1 for phosphatidylethanolamine phospholipidsRoseli, Ras Baizureen, Huang, Yen-Hua, Henriques, Sónia Troeira, Kaas, Quentin and Craik, David J. (2024). Molecular dynamics simulations support a preference of cyclotide kalata B1 for phosphatidylethanolamine phospholipids. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1866 (3) 184268, 1-13. doi: 10.1016/j.bbamem.2023.184268 |
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2024 Journal Article Computational design of α‐conotoxins to target specific nicotinic acetylcholine receptor subtypesWu, Xiaosa, Hone, Arik J., Huang, Yen-Hua, Clark, Richard J., McIntosh, J. Michael, Kaas, Quentin and Craik, David J. (2024). Computational design of α‐conotoxins to target specific nicotinic acetylcholine receptor subtypes. Chemistry – A European Journal, 30 (7) e202302909, 1-5. doi: 10.1002/chem.202302909 |
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2024 Journal Article Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating PeptidePhilippe, Grégoire Jean-Baptiste, Huang, Yen-Hua, Mittermeier, Anna, Brown, Christopher J., Kaas, Quentin, Ramlan, Siti Radhiah, Wang, Conan K., Lane, David, Loewer, Alexander, Troeira Henriques, Sónia and Craik, David J. (2024). Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide. Journal of Medicinal Chemistry, 67 (2), 1197-1208. doi: 10.1021/acs.jmedchem.3c01682 |
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2024 Journal Article The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistanceBiswas, Biswajit, Huang, Yen-Hua, Craik, David J. and Wang, Conan K. (2024). The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance. Chemical Science, 15 (33), 13130-13147. doi: 10.1039/d4sc01088d |
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2023 Journal Article The circular bacteriocin enterocin NKR-5-3B has an improved stability profile over nisinWang, Conan K., Huang, Yen-Hua, Shabbir, Fatima, Pham, Huong T., Lawrence, Nicole, Benfield, Aurélie H., van der Donk, Wilfred, Henriques, Sónia T., Turner, Mark S. and Craik, David J. (2023). The circular bacteriocin enterocin NKR-5-3B has an improved stability profile over nisin. Peptides, 167 171049, 171049. doi: 10.1016/j.peptides.2023.171049 |
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2023 Journal Article Nematicidal activity of cyclotides: toxicity against Caenorhabditis elegansBajpai, Abhishek, Jackson, Mark A., Huang, Yen-Hua, Yap, Kuok, Du, Qingdan, Chau, Tevin Chui-Ying, Craik, David J. and Gilding, Edward K. (2023). Nematicidal activity of cyclotides: toxicity against Caenorhabditis elegans. Journal of Natural Products, 86 (5), 1222-1229. doi: 10.1021/acs.jnatprod.2c01124 |
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2023 Journal Article Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiationChen, Zhian, Cui, Yanfang, Yao, Yin, Liu, Bo, Yunis, Joseph, Gao, Xin, Wang, Naiqi, Cañete, Pablo F., Tuong, Zewen Kelvin, Sun, Hongjian, Wang, Hao, Yang, Siling, Wang, Runli, Leong, Yew Ann, Simon Davis, David, Qin, Jiahuan, Liang, Kaili, Deng, Jun, Wang, Conan K., Huang, Yen-Hua, Roco, Jonathan A., Nettelfield, Sam, Zhu, Huaming, Xu, Huajun, Yu, Zhijia, Craik, David, Liu, Zheng, Qi, Hai, Parish, Christopher and Yu, Di (2023). Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Science immunology, 8 (80) eadd1728, 1-17. doi: 10.1126/sciimmunol.add1728 |
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2022 Journal Article Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptideZhang, Yuhui, Wang, Li, Tombling, Benjamin J., Lammi, Carmen, Huang, Yen-Hua, Li, Yue, Bartolomei, Martina, Hong, Bin, Craik, David J. and Wang, Conan K. (2022). Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide. Journal of the American Chemical Society, 144 (42), 19485-19498. doi: 10.1021/jacs.2c08029 |
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2022 Journal Article The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in DrosophilaDang, Tien T., Huang, Yen-Hua, Ott, Stanislav, Harvey, Peta J., Gilding, Edward K., Tombling, Benjamin J., Chan, Lai Y., Kaas, Quentin, Claridge-Chang, Adam and Craik, David J. (2022). The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila. Journal of Biological Chemistry, 298 (10) 102413, 1-11. doi: 10.1016/j.jbc.2022.102413 |
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2022 Journal Article Accurate de novo design of membrane-traversing macrocyclesBhardwaj, Gaurav, O’Connor, Jacob, Rettie, Stephen, Huang, Yen-Hua, Ramelot, Theresa A., Mulligan, Vikram Khipple, Alpkilic, Gizem Gokce, Palmer, Jonathan, Bera, Asim K., Bick, Matthew J., Di Piazza, Maddalena, Li, Xinting, Hosseinzadeh, Parisa, Craven, Timothy W., Tejero, Roberto, Lauko, Anna, Choi, Ryan, Glynn, Calina, Dong, Linlin, Griffin, Robert, van Voorhis, Wesley C., Rodriguez, Jose, Stewart, Lance, Montelione, Gaetano T., Craik, David and Baker, David (2022). Accurate de novo design of membrane-traversing macrocycles. Cell, 185 (19), 3520-3532.e26. doi: 10.1016/j.cell.2022.07.019 |
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2022 Conference Publication Activating the p53 pathway with peptide conjugates: synthesis, structure, activity and cellular uptakePhilippe, Gregoire, Huang, Yen-Hua, Mittermeier, Anna, Brown, Christopher, Wang, Conan, Kaas, Quentin, Lawrence, Nicole, Condon, Nicholas, Lane, David, Loewer, Alexander, Craik, David and Henriques, Sonia (2022). Activating the p53 pathway with peptide conjugates: synthesis, structure, activity and cellular uptake. 36th European Peptide Symposium 12th International Peptide Symposium, Barcelona, Spain, 28 August - 2 September 2022. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.3445 |
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2022 Journal Article Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotidesDang, Tien T., Harvey, Peta J., Chan, Lai Yue, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2022). Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides. Peptide Science, 114 (6) e24284. doi: 10.1002/pep2.24284 |
