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2016 Conference Publication Inhibitory Effects of Substrate-Based Bcr-Abl1 Kinase Inhibitors On the Growth of Chronic Myeloid Leukemia Cell Line K562Huang, Y. -H., Henriques, S. Troeira, Lawrence, N., Kaas, Q. and Craik, D. J. (2016). Inhibitory Effects of Substrate-Based Bcr-Abl1 Kinase Inhibitors On the Growth of Chronic Myeloid Leukemia Cell Line K562. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2950 |
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2016 Conference Publication Cyclotides, stable drug scaffolds and delivery systems to target intracellular cancer pathwaysHenriques, S. Troeira, Huang, Y. -H. and Craik, D. (2016). Cyclotides, stable drug scaffolds and delivery systems to target intracellular cancer pathways. 34th European Peptide Symposium, Leipzig, Germany, 4-9 September 2016. Oxford, United Kingdom: John Wiley & Sons. |
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2015 Journal Article The Prototypic Cyclotide Kalata B1 Has a Unique Mechanism of Entering CellsHenriques, Sonia Troeira, Huang, Yen-Hua, Chaousis, Stephanie, Sani, Marc-Antoine, Poth, Aaron G., Separovic, Frances and Craik, David J. (2015). The Prototypic Cyclotide Kalata B1 Has a Unique Mechanism of Entering Cells. Chemistry and Biology, 22 (8) 3107, 1087-1097. doi: 10.1016/j.chembiol.2015.07.012 |
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2015 Journal Article Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffoldHuang, Yen-Hua, Henriques, Sonia T., Wang, Conan K., Thorstholm, Louise, Daly, Norelle L., Kaas, Quentin and Craik, David J. (2015). Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold. Scientific Reports, 5 (1) 12974, 1-15. doi: 10.1038/srep12974 |
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2015 Journal Article Optimization of the cyclotide framework to improve cell penetration propertiesHuang, Yen-Hua, Chaousis, Steph, Cheneval, Olivier, Craik, David J. and Henriques, Sonia Troeira (2015). Optimization of the cyclotide framework to improve cell penetration properties. Frontiers in Pharmacology, 6 (17) 17, 1-7. doi: 10.3389/fphar.2015.00017 |
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2015 Conference Publication Cyclotides, stable drug scaffolds that enter cells after binding to PE-phospholipidsHenriques, S. T., Huang, Y. -H., Chaouis, S., Sani, M. -A., Poth, A. G., Separovic, F. and Craik, D. J. (2015). Cyclotides, stable drug scaffolds that enter cells after binding to PE-phospholipids. 10th European Biophysical Societies Association (EBSA) European Biophysics Congress, Dresden, Germany, Jul 18-22, 2015. Heidelberg, Germany: Springer. |
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2014 Journal Article Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targetingHenriques, Sonia Troeira, Huang, Yen-Hua, Chaousis, Steph, Wang, Conan and Craik, David J. (2014). Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting. Chembiochem, 15 (13), 1956-1965. doi: 10.1002/cbic.201402144 |
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2014 Journal Article Effects of arginine 10 to lysine substitution on omega-conotoxin CVIE and CVIF block of Ca(v)2.2 channelsBerecki, G., Daly, N. L., Huang, Y. H., Vink, S., Craik, D. J., Alewood, P. F. and Adams, D. J. (2014). Effects of arginine 10 to lysine substitution on omega-conotoxin CVIE and CVIF block of Ca(v)2.2 channels. British Journal of Pharmacology, 171 (13), 3313-3327. doi: 10.1111/bph.12686 |
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2014 Journal Article Fmoc-based synthesis of disulfide-rich cyclic peptidesCheneval, Olivier, Schroeder, Christina I., Durek, Thomas, Walsh, Phillip, Huang, Yen-Hua, Liras, Spiros, Price, David A. and Craik, David J. (2014). Fmoc-based synthesis of disulfide-rich cyclic peptides. Journal of Organic Chemistry, 79 (12), 5538-5544. doi: 10.1021/jo500699m |
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2014 Journal Article Semienzymatic cyclization of disulfide-rich peptides using sortase AJia, Xinying, Kwon, Soohyun, Wang, Ching-I Anderson, Huang, Yen-Hua, Chan, Lai Y., Tan, Chia Chia, Rosengren, K. Johan, Mulvenna, Jason P., Schroeder, Christina I. and Craik, David J. (2014). Semienzymatic cyclization of disulfide-rich peptides using sortase A. Journal of Biological Chemistry, Papers in Press (10), 1-25. doi: 10.1074/jbc.M113.539262 |
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2014 Conference Publication Cyclotides use specific lipids as a switch to internalize inside cellsHenriques, S. T., Huang, Y-H., Chaousis, S. and Craik, D. J. (2014). Cyclotides use specific lipids as a switch to internalize inside cells. IUPAB Congress 2014, Brisbane, QLD, Australia, 3-7 August 2014. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2687 |
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2013 Journal Article A novel quantitative kinase assay using bacterial surface display and flow cytometryHenriques, Sónia Troeira, Thorstholm, Louise, Huang, Yen-Hua, Getz, Jennifer A., Daugherty, Patrick S. and Craik, David J. (2013). A novel quantitative kinase assay using bacterial surface display and flow cytometry. PloS One, 8 (11) e80474, e80474.1-e80474.7. doi: 10.1371/journal.pone.0080474 |
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2013 Journal Article The Antimicrobial Activity of Sub3 is Dependent on Membrane Binding and Cell-Penetrating AbilityTorcato, Ines M., Huang, Yen-Hua, Franquelim, Henri G., Gaspar, Diana D., Craik, David J., Castanho, Miguel A. R. B. and Henriques, Sonia Troeira (2013). The Antimicrobial Activity of Sub3 is Dependent on Membrane Binding and Cell-Penetrating Ability. Chembiochem, 14 (15), 2013-2022. doi: 10.1002/cbic.201300274 |
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2013 Journal Article Cyclotides suppress human T-Lymphocyte proliferation by an interleukin 2-dependent mechanismGruendemann, Carsten, Thell, Kathrin, Lengen, Karin, Garcia-Kaeufer, Manuel, Huang, Yen-Hua, Huber, Roman, Craik, David J., Schabbauer, Gernot and Gruber, Christian W. (2013). Cyclotides suppress human T-Lymphocyte proliferation by an interleukin 2-dependent mechanism. Plos One, 8 (6) e68016, e68016.1-e68016.12. doi: 10.1371/journal.pone.0068016 |
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2013 Journal Article High-affinity cyclic peptide matriptase inhibitorsQuimbar, Pedro, Malik, Uru, Sommerhoff, Christian P., Kaas, Quentin, Chan, Lai Y., Huang, Yen-Hua, Grundhuber, Maresa, Dunse, Kerry, Craik, David J., Anderson, Marilyn A. and Daly, Norelle L. (2013). High-affinity cyclic peptide matriptase inhibitors. Journal of Biological Chemistry, 288 (19), 13885-13896. doi: 10.1074/jbc.M113.460030 |
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2013 Journal Article Cyclization of the antimicrobial peptide gomesin with native chemical ligation: influences on stability and bioactivityChan, Lai Yue, Zhang, Veronica M., Huang, Yen-hua, Waters, Norman C., Bansal, Paramjit S., Craik, David J. and Daly, Norelle L. (2013). Cyclization of the antimicrobial peptide gomesin with native chemical ligation: influences on stability and bioactivity. Chembiochem, 14 (5), 617-624. doi: 10.1002/cbic.201300034 |
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2013 Journal Article Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteriaTorcato, Inês M., Huang, Yen-Hua, Franquelim, Henri G., Gaspar, Diana, Craik, David J., Castanho, Miguel A. R. B. and Henriques, Sonia Troeira (2013). Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria. Biochimica et Biophysica Acta, 1828 (3), 944-955. doi: 10.1016/j.bbamem.2012.12.002 |
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2012 Journal Article Phosphatidylethanolamine-binding is a conserved feature of cyclotide-membrane interactionsHenriques, Sonia Troeira, Huang, Yen-Hua, Castanho, Miguel A. R. B., Bagatolli, Luis A., Sonza, Secondo, Tachedjan, Gilda, Daly, Norelle L. and Craik, David J. (2012). Phosphatidylethanolamine-binding is a conserved feature of cyclotide-membrane interactions. Journal of Biological Chemistry, 287 (40), 33629-33643. doi: 10.1074/jbc.M112.372011 |
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2012 Conference Publication The Importance of the cell membrane on the mechanism of action of cyclotidesHenriques, S. T., Huang, Y. -H., Castanho, M. A. R. B., Daly, N. L. and Craik, D. J. (2012). The Importance of the cell membrane on the mechanism of action of cyclotides. 32nd European Peptide Symposium "Peptides 2012", Athens, Greece, 02-07 September 2012. West Sussex, United Kingdom: John Wiley and Sons. doi: 10.1002/psc.2449 |
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2011 Journal Article Decoding the membrane activity of the cyclotide kalata B1: The importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activitiesHenriques, Sónia Troeira, Huang, Yen-Hua, Rosengren, K. Johan, Franquelim, Henri G., Carvalho, Filomena A., Johnson, Adam, Sonza, Secondo, Tachedjian, Gilda, Castanho, Miguel A. R. B., Daly, Norelle L. and Craik, David J. (2011). Decoding the membrane activity of the cyclotide kalata B1: The importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities. Journal of Biological Chemistry, 286 (27), 24231-24241. doi: 10.1074/jbc.M111.253393 |
