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2023 Journal Article The circular bacteriocin enterocin NKR-5-3B has an improved stability profile over nisinWang, Conan K., Huang, Yen-Hua, Shabbir, Fatima, Pham, Huong T., Lawrence, Nicole, Benfield, Aurélie H., van der Donk, Wilfred, Henriques, Sónia T., Turner, Mark S. and Craik, David J. (2023). The circular bacteriocin enterocin NKR-5-3B has an improved stability profile over nisin. Peptides, 167 171049, 171049. doi: 10.1016/j.peptides.2023.171049 |
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2023 Journal Article Nematicidal activity of cyclotides: toxicity against Caenorhabditis elegansBajpai, Abhishek, Jackson, Mark A., Huang, Yen-Hua, Yap, Kuok, Du, Qingdan, Chau, Tevin Chui-Ying, Craik, David J. and Gilding, Edward K. (2023). Nematicidal activity of cyclotides: toxicity against Caenorhabditis elegans. Journal of Natural Products, 86 (5), 1222-1229. doi: 10.1021/acs.jnatprod.2c01124 |
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2022 Journal Article The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in DrosophilaDang, Tien T., Huang, Yen-Hua, Ott, Stanislav, Harvey, Peta J., Gilding, Edward K., Tombling, Benjamin J., Chan, Lai Y., Kaas, Quentin, Claridge-Chang, Adam and Craik, David J. (2022). The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila. Journal of Biological Chemistry, 298 (10) 102413, 1-11. doi: 10.1016/j.jbc.2022.102413 |
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2022 Conference Publication Activating the p53 pathway with peptide conjugates: synthesis, structure, activity and cellular uptakePhilippe, Gregoire, Huang, Yen-Hua, Mittermeier, Anna, Brown, Christopher, Wang, Conan, Kaas, Quentin, Lawrence, Nicole, Condon, Nicholas, Lane, David, Loewer, Alexander, Craik, David and Henriques, Sonia (2022). Activating the p53 pathway with peptide conjugates: synthesis, structure, activity and cellular uptake. 36th European Peptide Symposium 12th International Peptide Symposium, Barcelona, Spain, 28 August - 2 September 2022. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.3445 |
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2022 Journal Article Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotidesDang, Tien T., Harvey, Peta J., Chan, Lai Yue, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2022). Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides. Peptide Science, 114 (6) e24284. doi: 10.1002/pep2.24284 |
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2022 Journal Article Mutagenesis of bracelet cyclotide hyen D reveals functionally and structurally critical residues for membrane binding and cytotoxicityDu, Qingdan, Huang, Yen-Hua, Wang, Conan K., Kaas, Quentin and Craik, David J. (2022). Mutagenesis of bracelet cyclotide hyen D reveals functionally and structurally critical residues for membrane binding and cytotoxicity. Journal of Biological Chemistry, 298 (4) 101822, 101822. doi: 10.1016/j.jbc.2022.101822 |
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2022 Journal Article Comparative analysis of cyclotide-producing plant cell suspensions presents opportunities for cyclotide plant molecular farmingDoffek, Benjamin, Huang, Yvonne, Huang, Yen-Hua, Chan, Lai Yue, Gilding, Edward K., Jackson, Mark A. and Craik, David J. (2022). Comparative analysis of cyclotide-producing plant cell suspensions presents opportunities for cyclotide plant molecular farming. Phytochemistry, 195 113053, 1-10. doi: 10.1016/j.phytochem.2021.113053 |
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2022 Journal Article ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activationYousuf, Arsalan, Wu, Xiaosa, Bony, Anuja R., Sadeghi, Mahsa, Huang, Yen-Hua, Craik, David J. and Adams, David J. (2022). ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation. Journal of Neurochemistry, 160 (2), 154-171. doi: 10.1111/jnc.15535 |
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2021 Journal Article The emerging landscape of peptide-based inhibitors of PCSK9Tombling, Benjamin J., Zhang, Yuhui, Huang, Yen-Hua, Craik, David J. and Wang, Conan K. (2021). The emerging landscape of peptide-based inhibitors of PCSK9. Atherosclerosis, 330, 52-60. doi: 10.1016/j.atherosclerosis.2021.06.903 |
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2021 Journal Article An integrated molecular grafting approach for the design of Keap1-targeted peptide inhibitorsYin, Huawu, Huang, Yen-Hua, Best, Sarah A., Sutherland, Kate D., Craik, David J. and Wang, Conan K. (2021). An integrated molecular grafting approach for the design of Keap1-targeted peptide inhibitors. ACS Chemical Biology, 16 (7) acschembio.1c00388, 1276-1287. doi: 10.1021/acschembio.1c00388 |
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2021 Journal Article Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1Poth, Aaron G., Chiu, Francis C.K., Stalmans, Sofie, Hamilton, Brett R., Huang, Yen-Hua, Shackleford, David M., Patil, Rahul, Le, Thao T., Kan, Meng-Wei, Durek, Thomas, Wynendaele, Evelien, De Spiegeleer, Bart, Powell, Andrew K., Venter, Deon J., Clark, Richard J., Charman, Susan A. and Craik, David J. (2021). Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1. Medicine in Drug Discovery, 10 100087, 1-10. doi: 10.1016/j.medidd.2021.100087 |
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2021 Journal Article Angler peptides: macrocyclic conjugates inhibit p53:MDM2/X interactions and activate apoptosis in cancer cellsPhilippe, Grégoire J.-B., Mittermeier, Anna, Lawrence, Nicole, Huang, Yen-Hua, Condon, Nicholas D., Loewer, Alexander, Craik, David J. and Henriques, Sónia T. (2021). Angler peptides: macrocyclic conjugates inhibit p53:MDM2/X interactions and activate apoptosis in cancer cells. ACS Chemical Biology, 16 (2) acschembio.0c00988, 414-428. doi: 10.1021/acschembio.0c00988 |
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2021 Book Chapter Protocols for measuring the stability and cytotoxicity of cyclotidesHuang, Yen-Hua, Kan, Meng-Wei and Craik, David J. (2021). Protocols for measuring the stability and cytotoxicity of cyclotides. Antimicrobial peptides. (pp. 19-40) edited by Leslie M. Hicks. Cambridge, MA, United States: Academic Press. doi: 10.1016/bs.mie.2021.09.007 |
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2021 Journal Article Cyclic gomesin, a stable redesigned spider peptide able to enter cancer cellsBenfield, Aurélie H., Defaus, Sira, Lawrence, Nicole, Chaousis, Stephanie, Condon, Nicholas, Cheneval, Olivier, Huang, Yen-Hua, Chan, Lai Yue, Andreu, David, Craik, David J. and Henriques, Sónia Troeira (2021). Cyclic gomesin, a stable redesigned spider peptide able to enter cancer cells. Biochimica et Biophysica Acta - Biomembranes, 1863 (1) 183480, 183480. doi: 10.1016/j.bbamem.2020.183480 |
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2020 Journal Article Evaluation of the in vivo aphrodisiac activity of a cyclotide extract from Hybanthus enneaspermusDu, Qingdan, Huang, Yen-Hua, Bajpai, Abhishek, Frosig- Jorgensen, Majbrit, Zhao, Guangzu and Craik, David J. (2020). Evaluation of the in vivo aphrodisiac activity of a cyclotide extract from Hybanthus enneaspermus. Journal of Natural Products, 83 (12), 3736-3743. doi: 10.1021/acs.jnatprod.0c01045 |
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2020 Journal Article Exploring the sequence diversity of cyclotides from Vietnamese Viola speciesDang, Tien T., Chan, Lai Y., Huang, Yen-Hua, Nguyen, Linh T. T., Kaas, Quentin, Huynh, Tien and Craik, David J. (2020). Exploring the sequence diversity of cyclotides from Vietnamese Viola species. Journal of Natural Products, 83 (6) acs.jnatprod.9b01218, 1817-1828. doi: 10.1021/acs.jnatprod.9b01218 |
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2020 Journal Article Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermusDu, Qingdan, Chan, Lai Y., Gilding, Edward K., Henriques, Sónia Troeira, Condon, Nicholas D., Ravipati, Anjaneya S., Kaas, Quentin, Huang, Yen-Hua and Craik, David J. (2020). Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus. Journal of Biological Chemistry, 295 (32), jbc.RA120.012627-10925. doi: 10.1074/jbc.ra120.012627 |
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2020 Journal Article Cellular uptake and cytosolic delivery of a cyclic cystine knot scaffoldYin, Huawu, Huang, Yen-Hua, Deprey, Kirsten, Condon, Nicholas D., Kritzer, Joshua A., Craik, David J. and Wang, Conan K. (2020). Cellular uptake and cytosolic delivery of a cyclic cystine knot scaffold. ACS Chemical Biology, 15 (6), 1650-1661. doi: 10.1021/acschembio.0c00297 |
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2020 Journal Article Insecticidal diversity of butterfly pea (Clitoria ternatea) accessionsOguis, Georgianna K., Gilding, Edward K., Huang, Yen-Hua, Poth, Aaron G., Jackson, Mark A. and Craik, David J. (2020). Insecticidal diversity of butterfly pea (Clitoria ternatea) accessions. Industrial Crops and Products, 147 112214, 112214. doi: 10.1016/j.indcrop.2020.112214 |
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2020 Journal Article Enhanced activity against multi-drug resistant bacteria through coapplication of an analogue of Tachyplesin I and an inhibitor of the QseC/B signaling pathwayYu, Rilei, Wang, Jiayi, So, Lok-Yan, Harvey, Peta J., Shi, Juan, Liang, Jiazhen, Dou, Qin, Li, Xiao, Yan, Xiayi, Huang, Yen-Hua, Xu, Qingliang, Kaas, Quentin, Chow, Ho-Yin, Wong, Kwok-Yin, Craik, David J, Zhang, Xiaohua, Jiang, Tao and Wang, Yan (2020). Enhanced activity against multi-drug resistant bacteria through coapplication of an analogue of Tachyplesin I and an inhibitor of the QseC/B signaling pathway. Journal of Medicinal Chemistry, 63 (7), 3475-3484. doi: 10.1021/acs.jmedchem.9b01563 |
