Overview
Background
I lead the Technology-Driven Drug Discovery (Tech3D) Group at the Institute for Molecular Bioscience, UQ. We believe that the key to solving some of our world's biggest challenges, whether that be in medicine or agriculture, relies on the ability to precision engineer molecules at will. My group harnesses three technological pillars to engineer peptides and proteins, which are computational biology, molecular libraries, and nanotechnology. We aspire to design better drugs, creating next generation biotechnological agents that have real impact. These could be new cancer drugs that harness the body's immune system or new insecticides that are environmentally friendly. In these pursuits, we value advancement, fun, balance, respect, fairness, and integrity.
I have been involved in peptide and protein research for over two decades, and am highly experienced in bioinformatics, chemistry, structural characterization, biophysics, and biochemistry. I trained with experts in peptide and protein characterization: an Honours project with Professor Garry King at the University of New South Wales, Sydney, Australia (2004), an APA scholarship with Professor David Craik at the University of Queensland Institute for Molecular Bioscience, Brisbane, Australia (2005-2009) and a NHMRC fellowship with Professor Mingjie Zhang at the Hong Kong University of Science and Technology, Hong Kong, China (2009-2011) and A/Professor Andreas Hofmann at Griffith University Eskitis Institute, Brisbane, Australia (2011-2012). I returned to the University of Queensland in 2012 to join an industry partnership funded by an ARC linkage grant. I currently hold an ARC Future Fellowship and am responsible for a team of research officers, assistants and postgraduate students.
My research output has been recognised by >30 prizes and awards for leadership, research translation and fundamental research excellence, as well as numerous invitations to speak at academic and pharmaceutical conferences. I have over 100 publications and have been cited by researchers from across the world.
Availability
- Associate Professor Conan Wang is:
- Available for supervision
Qualifications
- Bachelor of Engineering, University of New South Wales
- Doctor of Philosophy, The University of Queensland
Research interests
-
Computational design of targeted cancer therapeutics guided by machine learning
The right treatment depends on the right diagnosis. This project aims to engineer advanced agents capable of precisely locating and “painting” every cancer cell in the body, enabling clinicians to detect and treat tumours with unprecedented resolution. The candidate will gain expertise in drug discovery through computational biology and molecular biology. If you’re interested in learning more about drug design or exploring potential projects, please feel free to reach out.
-
Efficient design of drugs using new nanoscale technologies
Powerful technologies have emerged to perform millions of experiments quickly in tiny nanolitre droplets, and have attracted wide interest from major pharmaceutical companies because of the potential to accelerate drug discovery. Research project opportunities are available to investigate these next-generation tools for drug design and learn new skills in one or more areas of nanotechnology and molecular biology.
-
Designing protein drugs for the treatment of drug-resistant cancers
Targeted therapies against kinases are frontline treatments for many cancers. However, drug resistance often emerges within months of initiating therapy. This project aims to develop resilient kinase-targeted drugs with novel mechanisms of action that disrupt growth-promoting signals in cancer cells while reducing the likelihood of resistance. These agents have the potential to more effectively halt cancer progression. Candidates will learn new skills in drug design and characterisation using tools in molecular biology, biochemistry, and structural biology.
Works
Search Professor Conan Wang’s works on UQ eSpace
2026
Journal Article
Minidomains from evolution for scaffold engineering
Devnath, Hiron Saraj, Xie, Jing, Craik, David J. and Wang, Conan K. (2026). Minidomains from evolution for scaffold engineering. Biotechnology Advances, 90 108904, 1-19. doi: 10.1016/j.biotechadv.2026.108904
2026
Journal Article
Applying therapeutic peptide design principles to agricultural peptides
Cobon, Jack H., Craik, David J. and Wang, Conan K. (2026). Applying therapeutic peptide design principles to agricultural peptides. Nature Reviews Bioengineering. doi: 10.1038/s44222-026-00461-3
2026
Journal Article
Enzyme‐assisted synthesis and in vitro characterization of bifunctional PCSK9 inhibitors
Zhang, Yuhui, Wang, Li, Corcilius, Leo, Reji, Amal K., Payne, Richard J., Hong, Bin, Durek, Thomas, Wang, Conan K. and Craik, David J. (2026). Enzyme‐assisted synthesis and in vitro characterization of bifunctional PCSK9 inhibitors. ChemBioChem, 27 (7) e202500972, e202500972. doi: 10.1002/cbic.202500972
2025
Journal Article
Discovery of insecticidal cyclotides from the African plants Allexis batangae and Allexis obanensis
Khatibi, Negin, Eteme, Olivier Ndogo, Wang, Conan K., Gilding, Edward K., Zondegoumba, Ernestine Nkwengoua, Colgrave, Michelle L., Huang, Yen-Hua and Craik, David J. (2025). Discovery of insecticidal cyclotides from the African plants Allexis batangae and Allexis obanensis. Industrial Crops and Products, 237 122073, 1-9. doi: 10.1016/j.indcrop.2025.122073
2025
Journal Article
Disulfide-rich peptides as next-generation radiopharmaceuticals
Dilly, Joshua J., Savage, Benjamin and Wang, Conan K. (2025). Disulfide-rich peptides as next-generation radiopharmaceuticals. Australian Journal of Chemistry, 78 (11) CH25096. doi: 10.1071/ch25096
2025
Journal Article
High-throughput enrichment of functional disulfide-rich peptides by droplet microfluidics
Xie, Jing, Yap, Kuok, de Veer, Simon J., Edwardraja, Selvakumar, Durek, Thomas, Trau, Matt, Craik, David J. and Wang, Conan K. (2025). High-throughput enrichment of functional disulfide-rich peptides by droplet microfluidics. Lab on a Chip, 25 (14), 3525-3536. doi: 10.1039/d5lc00261c
2025
Journal Article
The future of utilising semiochemical pest control methods to manage the destructive crown-of-thorns starfish outbreaks on coral reefs
Harris, Richard J., Barnard, d'Artagnan L., Paxton, Gillian, Lockie, Stewart, Craik, David J., Cummins, Scott F., Wang, Conan K. and Motti, Cherie A. (2025). The future of utilising semiochemical pest control methods to manage the destructive crown-of-thorns starfish outbreaks on coral reefs. Biological Conservation, 302 110984, 110984-302. doi: 10.1016/j.biocon.2025.110984
2025
Journal Article
Yeast as a tool for exploring disulfide-rich peptides
Yap, Kuok, Porth, Owen T, Xie, Jing, Wang, Conan K, Durek, Thomas, Wittrup, K Dane and Craik, David J (2025). Yeast as a tool for exploring disulfide-rich peptides. FEMS Yeast Research, 25 foaf069. doi: 10.1093/femsyr/foaf069
2024
Journal Article
Display technologies for expanding the pharmaceutical applications of cyclotides
Xie, Jing, Kan, Meng‐Wei, de Veer, Simon J., Wang, Conan and Craik, David J. (2024). Display technologies for expanding the pharmaceutical applications of cyclotides. Israel Journal of Chemistry, 64 (8-9) e202400010. doi: 10.1002/ijch.202400010
2024
Journal Article
Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylation
Rehm, Fabian B. H., Tyler, Tristan J., Zhou, Yan, Huang, Yen-Hua, Wang, Conan K., Lawrence, Nicole, Craik, David J. and Durek, Thomas (2024). Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylation. Nature Chemistry, 16 (9), 1565-1565. doi: 10.1038/s41557-024-01625-7
2024
Conference Publication
Site-directed scanning mutagenesis reveals specific residues that enhance both the enduring stability and insecticidal efficacy of the cyclotide kalata B1
Huang, Yen-Hua, Jiang, Zhihao, Yap, Kuok, Bigot, Aurelien, Kaas, Quentin, Wang, Conan and Craik, David (2024). Site-directed scanning mutagenesis reveals specific residues that enhance both the enduring stability and insecticidal efficacy of the cyclotide kalata B1. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons.
2024
Conference Publication
Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide
Zhang, Yuhui, Wang, Li, Tombling, Benjamin, Lammi, Carmen, Huang, Yen-Hua, Yue, Li, Bartolomei, Martina, Hong, Bin, Craik, David and Wang, Conan (2024). Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons.
2024
Journal Article
Structure and activity of reconstructed pseudo‐ancestral cyclotides
Jiang, Zhihao, Huang, Yen-Hua, Kaas, Quentin, Craik, David J. and Wang, Conan K. (2024). Structure and activity of reconstructed pseudo‐ancestral cyclotides. ChemMedChem, 19 (14) e202400124, e202400124. doi: 10.1002/cmdc.202400124
2024
Journal Article
Repurposing a plant peptide cyclase for targeted lysine acylation
Rehm, Fabian B. H., Tyler, Tristan J., Zhou, Yan, Huang, Yen-Hua, Wang, Conan K., Lawrence, Nicole, Craik, David J. and Durek, Thomas (2024). Repurposing a plant peptide cyclase for targeted lysine acylation. Nature Chemistry, 2024 (9), 1-1. doi: 10.1038/s41557-024-01520-1
2024
Journal Article
Isolation and characterization of insecticidal cyclotides from Viola communis
Khatibi, Negin, Huang, Yen-Hua, Wang, Conan K., Durek, Thomas, Gilding, Edward K. and Craik, David J. (2024). Isolation and characterization of insecticidal cyclotides from Viola communis. Journal of Natural Products, 88 (1), 24-35. doi: 10.1021/acs.jnatprod.4c00168
2024
Journal Article
Seasonal tissue-specific gene expression in wild crown-of-thorns starfish reveals reproductive and stress-related transcriptional systems
Morin, Marie, Jönsson, Mathias, Wang, Conan K., Craik, David J., Degnan, Sandie M. and Degnan, Bernard M. (2024). Seasonal tissue-specific gene expression in wild crown-of-thorns starfish reveals reproductive and stress-related transcriptional systems. PLOS Biology, 22 (5) e3002620, e3002620. doi: 10.1371/journal.pbio.3002620
2024
Journal Article
Nucleation of a key beta-turn promotes cyclotide oxidative folding
Tian, Sixin, de Veer, Simon J., Durek, Thomas, Wang, Conan K. and Craik, David J. (2024). Nucleation of a key beta-turn promotes cyclotide oxidative folding. Journal of Biological Chemistry, 300 (4) 107125, 107125. doi: 10.1016/j.jbc.2024.107125
2024
Journal Article
Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1
Huang, Yen-Hua, Jiang, Zhihao, Du, Qingdan, Yap, Kuok, Bigot, Aurélien, Kaas, Quentin, Wang, Conan K. and Craik, David J. (2024). Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1. Journal of Biological Chemistry, 300 (3) 105682, 105682. doi: 10.1016/j.jbc.2024.105682
2024
Journal Article
Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide
Philippe, Grégoire Jean-Baptiste, Huang, Yen-Hua, Mittermeier, Anna, Brown, Christopher J., Kaas, Quentin, Ramlan, Siti Radhiah, Wang, Conan K., Lane, David, Loewer, Alexander, Troeira Henriques, Sónia and Craik, David J. (2024). Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide. Journal of Medicinal Chemistry, 67 (2), 1197-1208. doi: 10.1021/acs.jmedchem.3c01682
2024
Journal Article
The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance
Biswas, Biswajit, Huang, Yen-Hua, Craik, David J. and Wang, Conan K. (2024). The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance. Chemical Science, 15 (33), 13130-13147. doi: 10.1039/d4sc01088d
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Conan Wang is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
A new molecular technology platform for design and production of ultra-stable peptides
Principal Advisor
Other advisors: Professor David Craik
-
Doctor Philosophy
Design and manufacturing of next-generation ultra-stable peptide radiotracers for precision diagnosis and therapy
Principal Advisor
Other advisors: Dr Yen-Hua Crystal Huang
-
Doctor Philosophy
Discovery and Development of Substrate-Based Peptide Kinase Inhibitors
Principal Advisor
Other advisors: Dr Yen-Hua Crystal Huang, Professor David Craik
-
Doctor Philosophy
Patient-friendly peptide tracers for improving immunotherapy outcomes
Principal Advisor
Other advisors: Dr Yen-Hua Crystal Huang
-
Doctor Philosophy
Accelerating design and optimisation of next-generation ecofriendly insecticides in picolitre bioreactors
Principal Advisor
Other advisors: Professor David Craik, Dr Yen-Hua Crystal Huang
-
Doctor Philosophy
Next-generation IL-2 mimics for immunotherapy
Principal Advisor
Other advisors: Professor David Craik, Professor Di Yu
-
Doctor Philosophy
Design and optimisation of a novel compound for theranostic use in cancer
Principal Advisor
Other advisors: Professor David Craik, Dr Yen-Hua Crystal Huang
-
Doctor Philosophy
Design of orally active cholesterol-lowering peptides
Associate Advisor
Other advisors: Professor David Craik
-
Doctor Philosophy
Exploring delivery strategies for cyclotide-based therapeutics
Associate Advisor
Other advisors: Professor David Craik, Dr Yen-Hua Crystal Huang
-
Doctor Philosophy
Development of peptide-based inhibitors for crop protection
Associate Advisor
Other advisors: Professor Brett Collins, Professor David Craik
Completed supervision
-
2021
Doctor Philosophy
The development of peptide-based cholesterol-lowering therapeutics
Principal Advisor
Other advisors: Professor David Craik
-
2026
Doctor Philosophy
Towards population control of a coral reef pest: The crown-of-thorns starfish
Associate Advisor
Other advisors: Professor David Craik, Dr Thomas Durek, Emeritus Professor Linda Lua
-
2025
Doctor Philosophy
Selective modification and chemical synthesis of peptides & proteins for drug discovery applications
Associate Advisor
Other advisors: Professor David Craik, Dr Thomas Durek
-
2024
Doctor Philosophy
Discovery, production, and development of disulfide-rich peptides for drug design and development
Associate Advisor
Other advisors: Professor David Craik, Dr Thomas Durek
-
2023
Doctor Philosophy
Structural Modifications to Optimise the Oxidative Folding and Activity of Cyclotides
Associate Advisor
Other advisors: Dr Simon de Veer, Professor David Craik
-
2023
Doctor Philosophy
Characterising the crown-of-thorns starfish secretome to identify factors for future biocontrol systems
Associate Advisor
Other advisors: Professor Sandie Degnan, Professor Bernard Degnan
-
2022
Doctor Philosophy
Investigating approaches for the design and delivery of disulfide-rich peptide therapeutics
Associate Advisor
Other advisors: Dr Yen-Hua Crystal Huang, Professor David Craik
-
2015
Doctor Philosophy
Structure-activity relationships and development of disulfide-rich cyclic peptides as pharmaceutical templates
Associate Advisor
Other advisors: Professor David Craik
Media
Enquiries
For media enquiries about Associate Professor Conan Wang's areas of expertise, story ideas and help finding experts, contact our Media team: