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Associate Professor Conan Wang
Associate Professor

Conan Wang

Email: 
Phone: 
+61 7 334 62014

Overview

Background

I lead the Technology-Driven Drug Discovery (Tech3D) Group at the Institute for Molecular Bioscience, UQ. We believe that the key to solving some of our world's biggest challenges, whether that be in medicine or agriculture, relies on the ability to precision engineer molecules at will. My group harnesses three technological pillars to engineer peptides and proteins, which are computational biology, molecular libraries, and nanotechnology. We aspire to design better drugs, creating next generation biotechnological agents that have real impact. These could be new cancer drugs that harness the body's immune system or new insecticides that are environmentally friendly. In these pursuits, we value advancement, fun, balance, respect, fairness, and integrity.

I have been involved in peptide and protein research for over two decades, and am highly experienced in bioinformatics, chemistry, structural characterization, biophysics, and biochemistry. I trained with experts in peptide and protein characterization: an Honours project with Professor Garry King at the University of New South Wales, Sydney, Australia (2004), an APA scholarship with Professor David Craik at the University of Queensland Institute for Molecular Bioscience, Brisbane, Australia (2005-2009) and a NHMRC fellowship with Professor Mingjie Zhang at the Hong Kong University of Science and Technology, Hong Kong, China (2009-2011) and A/Professor Andreas Hofmann at Griffith University Eskitis Institute, Brisbane, Australia (2011-2012). I returned to the University of Queensland in 2012 to join an industry partnership funded by an ARC linkage grant. I currently hold an ARC Future Fellowship and am responsible for a team of research officers, assistants and postgraduate students.

My research output has been recognised by >30 prizes and awards for leadership, research translation and fundamental research excellence, as well as numerous invitations to speak at academic and pharmaceutical conferences. I have over 100 publications and have been cited by researchers from across the world.

Availability

Associate Professor Conan Wang is:
Available for supervision

Qualifications

  • Bachelor of Engineering, University of New South Wales
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Computational design of targeted cancer therapeutics guided by machine learning

    The right treatment depends on the right diagnosis. This project aims to engineer advanced agents capable of precisely locating and “painting” every cancer cell in the body, enabling clinicians to detect and treat tumours with unprecedented resolution. The candidate will gain expertise in drug discovery through computational biology and molecular biology. If you’re interested in learning more about drug design or exploring potential projects, please feel free to reach out.

  • Efficient design of drugs using new nanoscale technologies

    Powerful technologies have emerged to perform millions of experiments quickly in tiny nanolitre droplets, and have attracted wide interest from major pharmaceutical companies because of the potential to accelerate drug discovery. Research project opportunities are available to investigate these next-generation tools for drug design and learn new skills in one or more areas of nanotechnology and molecular biology.

  • Designing protein drugs for the treatment of drug-resistant cancers

    Targeted therapies against kinases are frontline treatments for many cancers. However, drug resistance often emerges within months of initiating therapy. This project aims to develop resilient kinase-targeted drugs with novel mechanisms of action that disrupt growth-promoting signals in cancer cells while reducing the likelihood of resistance. These agents have the potential to more effectively halt cancer progression. Candidates will learn new skills in drug design and characterisation using tools in molecular biology, biochemistry, and structural biology.

Works

Search Professor Conan Wang’s works on UQ eSpace

130 works between 2006 and 2026

1 - 20 of 130 works

2026

Journal Article

Minidomains from evolution for scaffold engineering

Devnath, Hiron Saraj, Xie, Jing, Craik, David J. and Wang, Conan K. (2026). Minidomains from evolution for scaffold engineering. Biotechnology Advances, 90 108904, 1-19. doi: 10.1016/j.biotechadv.2026.108904

Minidomains from evolution for scaffold engineering

2026

Journal Article

Applying therapeutic peptide design principles to agricultural peptides

Cobon, Jack H., Craik, David J. and Wang, Conan K. (2026). Applying therapeutic peptide design principles to agricultural peptides. Nature Reviews Bioengineering. doi: 10.1038/s44222-026-00461-3

Applying therapeutic peptide design principles to agricultural peptides

2026

Journal Article

Enzyme‐assisted synthesis and in vitro characterization of bifunctional PCSK9 inhibitors

Zhang, Yuhui, Wang, Li, Corcilius, Leo, Reji, Amal K., Payne, Richard J., Hong, Bin, Durek, Thomas, Wang, Conan K. and Craik, David J. (2026). Enzyme‐assisted synthesis and in vitro characterization of bifunctional PCSK9 inhibitors. ChemBioChem, 27 (7) e202500972, e202500972. doi: 10.1002/cbic.202500972

Enzyme‐assisted synthesis and in vitro characterization of bifunctional PCSK9 inhibitors

2025

Journal Article

Discovery of insecticidal cyclotides from the African plants Allexis batangae and Allexis obanensis

Khatibi, Negin, Eteme, Olivier Ndogo, Wang, Conan K., Gilding, Edward K., Zondegoumba, Ernestine Nkwengoua, Colgrave, Michelle L., Huang, Yen-Hua and Craik, David J. (2025). Discovery of insecticidal cyclotides from the African plants Allexis batangae and Allexis obanensis. Industrial Crops and Products, 237 122073, 1-9. doi: 10.1016/j.indcrop.2025.122073

Discovery of insecticidal cyclotides from the African plants Allexis batangae and Allexis obanensis

2025

Journal Article

Disulfide-rich peptides as next-generation radiopharmaceuticals

Dilly, Joshua J., Savage, Benjamin and Wang, Conan K. (2025). Disulfide-rich peptides as next-generation radiopharmaceuticals. Australian Journal of Chemistry, 78 (11) CH25096. doi: 10.1071/ch25096

Disulfide-rich peptides as next-generation radiopharmaceuticals

2025

Journal Article

High-throughput enrichment of functional disulfide-rich peptides by droplet microfluidics

Xie, Jing, Yap, Kuok, de Veer, Simon J., Edwardraja, Selvakumar, Durek, Thomas, Trau, Matt, Craik, David J. and Wang, Conan K. (2025). High-throughput enrichment of functional disulfide-rich peptides by droplet microfluidics. Lab on a Chip, 25 (14), 3525-3536. doi: 10.1039/d5lc00261c

High-throughput enrichment of functional disulfide-rich peptides by droplet microfluidics

2025

Journal Article

The future of utilising semiochemical pest control methods to manage the destructive crown-of-thorns starfish outbreaks on coral reefs

Harris, Richard J., Barnard, d'Artagnan L., Paxton, Gillian, Lockie, Stewart, Craik, David J., Cummins, Scott F., Wang, Conan K. and Motti, Cherie A. (2025). The future of utilising semiochemical pest control methods to manage the destructive crown-of-thorns starfish outbreaks on coral reefs. Biological Conservation, 302 110984, 110984-302. doi: 10.1016/j.biocon.2025.110984

The future of utilising semiochemical pest control methods to manage the destructive crown-of-thorns starfish outbreaks on coral reefs

2025

Journal Article

Yeast as a tool for exploring disulfide-rich peptides

Yap, Kuok, Porth, Owen T, Xie, Jing, Wang, Conan K, Durek, Thomas, Wittrup, K Dane and Craik, David J (2025). Yeast as a tool for exploring disulfide-rich peptides. FEMS Yeast Research, 25 foaf069. doi: 10.1093/femsyr/foaf069

Yeast as a tool for exploring disulfide-rich peptides

2024

Journal Article

Display technologies for expanding the pharmaceutical applications of cyclotides

Xie, Jing, Kan, Meng‐Wei, de Veer, Simon J., Wang, Conan and Craik, David J. (2024). Display technologies for expanding the pharmaceutical applications of cyclotides. Israel Journal of Chemistry, 64 (8-9) e202400010. doi: 10.1002/ijch.202400010

Display technologies for expanding the pharmaceutical applications of cyclotides

2024

Journal Article

Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylation

Rehm, Fabian B. H., Tyler, Tristan J., Zhou, Yan, Huang, Yen-Hua, Wang, Conan K., Lawrence, Nicole, Craik, David J. and Durek, Thomas (2024). Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylation. Nature Chemistry, 16 (9), 1565-1565. doi: 10.1038/s41557-024-01625-7

Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylation

2024

Conference Publication

Site-directed scanning mutagenesis reveals specific residues that enhance both the enduring stability and insecticidal efficacy of the cyclotide kalata B1

Huang, Yen-Hua, Jiang, Zhihao, Yap, Kuok, Bigot, Aurelien, Kaas, Quentin, Wang, Conan and Craik, David (2024). Site-directed scanning mutagenesis reveals specific residues that enhance both the enduring stability and insecticidal efficacy of the cyclotide kalata B1. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons.

Site-directed scanning mutagenesis reveals specific residues that enhance both the enduring stability and insecticidal efficacy of the cyclotide kalata B1

2024

Conference Publication

Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide

Zhang, Yuhui, Wang, Li, Tombling, Benjamin, Lammi, Carmen, Huang, Yen-Hua, Yue, Li, Bartolomei, Martina, Hong, Bin, Craik, David and Wang, Conan (2024). Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons.

Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide

2024

Journal Article

Structure and activity of reconstructed pseudo‐ancestral cyclotides

Jiang, Zhihao, Huang, Yen-Hua, Kaas, Quentin, Craik, David J. and Wang, Conan K. (2024). Structure and activity of reconstructed pseudo‐ancestral cyclotides. ChemMedChem, 19 (14) e202400124, e202400124. doi: 10.1002/cmdc.202400124

Structure and activity of reconstructed pseudo‐ancestral cyclotides

2024

Journal Article

Repurposing a plant peptide cyclase for targeted lysine acylation

Rehm, Fabian B. H., Tyler, Tristan J., Zhou, Yan, Huang, Yen-Hua, Wang, Conan K., Lawrence, Nicole, Craik, David J. and Durek, Thomas (2024). Repurposing a plant peptide cyclase for targeted lysine acylation. Nature Chemistry, 2024 (9), 1-1. doi: 10.1038/s41557-024-01520-1

Repurposing a plant peptide cyclase for targeted lysine acylation

2024

Journal Article

Isolation and characterization of insecticidal cyclotides from Viola communis

Khatibi, Negin, Huang, Yen-Hua, Wang, Conan K., Durek, Thomas, Gilding, Edward K. and Craik, David J. (2024). Isolation and characterization of insecticidal cyclotides from Viola communis. Journal of Natural Products, 88 (1), 24-35. doi: 10.1021/acs.jnatprod.4c00168

Isolation and characterization of insecticidal cyclotides from Viola communis

2024

Journal Article

Seasonal tissue-specific gene expression in wild crown-of-thorns starfish reveals reproductive and stress-related transcriptional systems

Morin, Marie, Jönsson, Mathias, Wang, Conan K., Craik, David J., Degnan, Sandie M. and Degnan, Bernard M. (2024). Seasonal tissue-specific gene expression in wild crown-of-thorns starfish reveals reproductive and stress-related transcriptional systems. PLOS Biology, 22 (5) e3002620, e3002620. doi: 10.1371/journal.pbio.3002620

Seasonal tissue-specific gene expression in wild crown-of-thorns starfish reveals reproductive and stress-related transcriptional systems

2024

Journal Article

Nucleation of a key beta-turn promotes cyclotide oxidative folding

Tian, Sixin, de Veer, Simon J., Durek, Thomas, Wang, Conan K. and Craik, David J. (2024). Nucleation of a key beta-turn promotes cyclotide oxidative folding. Journal of Biological Chemistry, 300 (4) 107125, 107125. doi: 10.1016/j.jbc.2024.107125

Nucleation of a key beta-turn promotes cyclotide oxidative folding

2024

Journal Article

Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1

Huang, Yen-Hua, Jiang, Zhihao, Du, Qingdan, Yap, Kuok, Bigot, Aurélien, Kaas, Quentin, Wang, Conan K. and Craik, David J. (2024). Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1. Journal of Biological Chemistry, 300 (3) 105682, 105682. doi: 10.1016/j.jbc.2024.105682

Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1

2024

Journal Article

Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide

Philippe, Grégoire Jean-Baptiste, Huang, Yen-Hua, Mittermeier, Anna, Brown, Christopher J., Kaas, Quentin, Ramlan, Siti Radhiah, Wang, Conan K., Lane, David, Loewer, Alexander, Troeira Henriques, Sónia and Craik, David J. (2024). Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide. Journal of Medicinal Chemistry, 67 (2), 1197-1208. doi: 10.1021/acs.jmedchem.3c01682

Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide

2024

Journal Article

The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance

Biswas, Biswajit, Huang, Yen-Hua, Craik, David J. and Wang, Conan K. (2024). The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance. Chemical Science, 15 (33), 13130-13147. doi: 10.1039/d4sc01088d

The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance

Funding

Current funding

  • 2026 - 2028
    All-in-one: enhancing multidimensional vaccine protection through a novel IL-21 agonistic antibody
    UQ - Sanofi Translational Science Hub Partnership Scheme
    Open grant
  • 2025 - 2028
    Robotics & automation for plant-based production of pharmaceutical peptides
    ARC Linkage Projects
    Open grant
  • 2025 - 2028
    Disruptive technologies for targeting tyrosine kinase substrate sites
    NHMRC IDEAS Grants
    Open grant
  • 2025 - 2028
    Unleashing the biocontrol potential of venom peptides with cyclotides
    ARC Linkage Projects
    Open grant
  • 2025 - 2028
    A molecular platform for design and production of next-generation peptides
    ARC Linkage Projects
    Open grant
  • 2024 - 2026
    Developing novel peptide tracers for improving immunotherapy outcomes
    NHMRC Development Grant
    Open grant
  • 2023 - 2026
    A peptide platform to fight pests threatening global food security
    ARC Discovery Projects
    Open grant
  • 2023 - 2028
    ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals
    ARC Industrial Transformation Research Hubs
    Open grant
  • 2023 - 2027
    Peptides and Proteins for Fighting Pests and Protecting the Environment
    ARC Future Fellowships
    Open grant
  • 2020 - 2026
    Crown-of-Thorns Starfish Control Innovation Program
    Great Barrier Reef Foundation
    Open grant

Past funding

  • 2025 - 2026
    A Facility for Accelerated Microbial Phenotyping in Southeast Queensland
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2018 - 2022
    Biocontrol of crown-of-thorns starfish using genomics and proteomics
    ARC Linkage Projects
    Open grant
  • 2016 - 2018
    New drug leads for cholesterol
    NHMRC Project Grant
    Open grant
  • 2014
    Bioengineering stable peptide inhibitors of amyloidosis
    UQ Early Career Researcher
    Open grant
  • 2012 - 2013
    NHMRC Australia-China Exchange Fellowship: Improving the bioavailability of peptide-based therapeutics for the treatment of Multiple Sclerosis
    NHMRC Training (Postdoctoral) Fellowship
    Open grant

Supervision

Availability

Associate Professor Conan Wang is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Media

Enquiries

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