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Dr Conan Wang
Dr

Conan Wang

Email: 
Phone: 
+61 7 334 62014

Overview

Background

I lead the Technology-Driven Drug Discovery (Tech3D) Group at the Institute for Molecular Bioscience, UQ. We believe that the key to solving some of our world's biggest challenges, whether that be in medicine or agriculture, relies on the ability to precision engineer molecules at will. My group harnesses three technological pillars to engineer peptides and proteins, which are computational biology, molecular libraries, and nanotechnology. We aspire to design better drugs, creating next generation biotechnological agents that have real impact. These could be new cancer drugs that harness the body's immune system or new insecticides that are environmentally friendly. In these pursuits, we value advancement, fun, balance, respect, fairness, and integrity.

I have been involved in peptide and protein research for over two decades, and am highly experienced in bioinformatics, chemistry, structural characterization, biophysics, and biochemistry. I trained with experts in peptide and protein characterization: an Honours project with Professor Garry King at the University of New South Wales, Sydney, Australia (2004), an APA scholarship with Professor David Craik at the University of Queensland Institute for Molecular Bioscience, Brisbane, Australia (2005-2009) and a NHMRC fellowship with Professor Mingjie Zhang at the Hong Kong University of Science and Technology, Hong Kong, China (2009-2011) and A/Professor Andreas Hofmann at Griffith University Eskitis Institute, Brisbane, Australia (2011-2012). I returned to the University of Queensland in 2012 to join an industry partnership funded by an ARC linkage grant. I currently hold an ARC Future Fellowship and am responsible for a team of research officers, assistants and postgraduate students.

My research output has been recognised by >30 prizes and awards for leadership, research translation and fundamental research excellence, as well as numerous invitations to speak at academic and pharmaceutical conferences. I have over 100 publications and have been cited by researchers from across the world.

Availability

Dr Conan Wang is:
Available for supervision

Qualifications

  • Bachelor of Engineering, University of New South Wales
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Drug Discovery and Protein/Peptide Engineeering

    My group uses: 1) computational algorithms to predict drug properties with unprecedented accuracy; 2) molecular libraries capable of screening through billions of drug leads to design drugs efficiently; and 3) nano-sized reaction droplets to capture drug activity to make drugs that actually work.

  • Cancer Therapeutics

    My group is interested in developing new cancer therapeutics, particularly those that modulate the immune system or relevant to lung cancer.

Works

Search Professor Conan Wang’s works on UQ eSpace

116 works between 2006 and 2024

21 - 40 of 116 works

2021

Journal Article

An integrated molecular grafting approach for the design of Keap1-targeted peptide inhibitors

Yin, Huawu, Huang, Yen-Hua, Best, Sarah A., Sutherland, Kate D., Craik, David J. and Wang, Conan K. (2021). An integrated molecular grafting approach for the design of Keap1-targeted peptide inhibitors. ACS Chemical Biology, 16 (7) acschembio.1c00388, 1276-1287. doi: 10.1021/acschembio.1c00388

An integrated molecular grafting approach for the design of Keap1-targeted peptide inhibitors

2021

Journal Article

Increased valency improves inhibitory activity of peptides targeting proprotein convertase subtilisin/kexin type 9 (PCSK9)

Tombling, Benjamin J., Lammi, Carmen, Bollati, Carlotta, Anoldi, Anna, Craik, David J. and Wang, Conan K. (2021). Increased valency improves inhibitory activity of peptides targeting proprotein convertase subtilisin/kexin type 9 (PCSK9). ChemBioChem, 22 (12) cbic.202100103, 1-8. doi: 10.1002/cbic.202100103

Increased valency improves inhibitory activity of peptides targeting proprotein convertase subtilisin/kexin type 9 (PCSK9)

2021

Journal Article

Bioactive cyclization optimizes the affinity of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) peptide inhibitor

Tombling, Benjamin J., Lammi, Carmen, Lawrence, Nicole, Gilding, Edward K., Grazioso, Giovanni, Craik, David J. and Wang, Conan K. (2021). Bioactive cyclization optimizes the affinity of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) peptide inhibitor. Journal of Medicinal Chemistry, 64 (5) acs.jmedchem.0c01766, 2523-2533. doi: 10.1021/acs.jmedchem.0c01766

Bioactive cyclization optimizes the affinity of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) peptide inhibitor

2021

Journal Article

Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases

Yap, Kuok, Du, Junqiao, Rehm, Fabian B. H., Tang, Shyn Ric, Zhou, Yan, Xie, Jing, Wang, Conan K., de Veer, Simon J., Lua, Linda H. L., Durek, Thomas and Craik, David J. (2021). Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases. Nature Protocols, 16 (3), 1-23. doi: 10.1038/s41596-020-00483-0

Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases

2021

Journal Article

Engineered EGF-A peptides with improved affinity for proprotein convertase subtilisin/kexin type 9 (PCSK9)

Tombling, Benjamin J., Lammi, Carmen, Lawrence, Nicole, Li, Jianqiang, Arnoldi, Anna, Craik, David J. and Wang, Conan K. (2021). Engineered EGF-A peptides with improved affinity for proprotein convertase subtilisin/kexin type 9 (PCSK9). ACS Chemical Biology, 16 (2) acschembio.0c00991, 429-439. doi: 10.1021/acschembio.0c00991

Engineered EGF-A peptides with improved affinity for proprotein convertase subtilisin/kexin type 9 (PCSK9)

2021

Journal Article

Linking molecular evolution to molecular grafting

Wang, Conan K. and Craik, David J. (2021). Linking molecular evolution to molecular grafting. Journal of Biological Chemistry, 296 100425, 1-11. doi: 10.1016/j.jbc.2021.100425

Linking molecular evolution to molecular grafting

2020

Journal Article

Cyclotide structures revealed by NMR, with a little help from X-ray crystallography

Handley, Thomas N. G., Harvey, Peta J., Wang, Conan K., Lawrence, Nicole and Craik, David (2020). Cyclotide structures revealed by NMR, with a little help from X-ray crystallography. Chembiochem, 21 (24) cbic.202000315, 3463-3475. doi: 10.1002/cbic.202000315

Cyclotide structures revealed by NMR, with a little help from X-ray crystallography

2020

Journal Article

Front Cover: Cyclotide Structures Revealed by NMR, with a Little Help from X‐ray Crystallography (ChemBioChem 24/2020)

Handley, Thomas N. G., Wang, Conan K., Harvey, Peta J., Lawrence, Nicole and Craik, David J. (2020). Front Cover: Cyclotide Structures Revealed by NMR, with a Little Help from X‐ray Crystallography (ChemBioChem 24/2020). ChemBioChem, 21 (24), 3449-3449. doi: 10.1002/cbic.202000778

Front Cover: Cyclotide Structures Revealed by NMR, with a Little Help from X‐ray Crystallography (ChemBioChem 24/2020)

2020

Journal Article

Structure-activity analysis of truncated albumin-binding domains suggests new lead constructs for potential therapeutic delivery

Wang, Conan K., Amiss, Anna S., Weidmann, Joachim and Craik, David J. (2020). Structure-activity analysis of truncated albumin-binding domains suggests new lead constructs for potential therapeutic delivery. Journal of Biological Chemistry, 295 (34), 12143-12152. doi: 10.1074/jbc.ra120.014168

Structure-activity analysis of truncated albumin-binding domains suggests new lead constructs for potential therapeutic delivery

2020

Journal Article

EGF‐artige und andere disulfidreiche Mikrodomänen als therapeutische Molekülgerüste

Tombling, Benjamin J., Wang, Conan K. and Craik, David J. (2020). EGF‐artige und andere disulfidreiche Mikrodomänen als therapeutische Molekülgerüste. Angewandte Chemie, 132 (28) ange.201913809, 11314-11328. doi: 10.1002/ange.201913809

EGF‐artige und andere disulfidreiche Mikrodomänen als therapeutische Molekülgerüste

2020

Journal Article

An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides

Yap, Kuok, Du, Junqiao, Looi, Fong Yang, Tang, Shyn Ric, de Veer, Simon J., Bony, Anuja R., Rehm, Fabian B. H., Xie, Jing, Chan, Lai Yue, Wang, Conan K., Adams, David J., Lua, Linda H. L., Durek, Thomas and Craik, David J. (2020). An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides. Green Chemistry, 22 (15), 5002-5016. doi: 10.1039/d0gc01366h

An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides

2020

Journal Article

Inside Cover: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. Int. Ed. 28/2020)

White, Andrew M., Veer, Simon J., Wu, Guojie, Harvey, Peta J., Yap, Kuok, King, Gordon J., Swedberg, Joakim E., Wang, Conan K., Law, Ruby H. P., Durek, Thomas and Craik, David J. (2020). Inside Cover: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. Int. Ed. 28/2020). Angewandte Chemie International Edition, 59 (28), 11162-11162. doi: 10.1002/anie.202006713

Inside Cover: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. Int. Ed. 28/2020)

2020

Journal Article

Innentitelbild: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. 28/2020)

White, Andrew M., Veer, Simon J., Wu, Guojie, Harvey, Peta J., Yap, Kuok, King, Gordon J., Swedberg, Joakim E., Wang, Conan K., Law, Ruby H. P., Durek, Thomas and Craik, David J. (2020). Innentitelbild: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. 28/2020). Angewandte Chemie, 132 (28), 11258-11258. doi: 10.1002/ange.202006713

Innentitelbild: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. 28/2020)

2020

Journal Article

Application and structural analysis of triazole‐bridged disulfide mimetics in cyclic peptides

White, Andrew M., Veer, Simon J., Wu, Guojie, Harvey, Peta J., Yap, Kuok, King, Gordon J., Swedberg, Joakim E., Wang, Conan K., Law, Ruby H. P., Durek, Thomas and Craik, David J. (2020). Application and structural analysis of triazole‐bridged disulfide mimetics in cyclic peptides. Angewandte Chemie International Edition, 132 (28) anie.202003435, 11369-11373. doi: 10.1002/anie.202003435

Application and structural analysis of triazole‐bridged disulfide mimetics in cyclic peptides

2020

Journal Article

Cellular uptake and cytosolic delivery of a cyclic cystine knot scaffold

Yin, Huawu, Huang, Yen-Hua, Deprey, Kirsten, Condon, Nicholas D., Kritzer, Joshua A., Craik, David J. and Wang, Conan K. (2020). Cellular uptake and cytosolic delivery of a cyclic cystine knot scaffold. ACS Chemical Biology, 15 (6), 1650-1661. doi: 10.1021/acschembio.0c00297

Cellular uptake and cytosolic delivery of a cyclic cystine knot scaffold

2020

Conference Publication

Challenging the chirality paradigm in peptide-lipid interactions

Henriques, Sonia Troeira, Peacock, Hayden, Benfield, Aurelie H., Wang, Conan K. and Craik, David (2020). Challenging the chirality paradigm in peptide-lipid interactions. 64th Annual Meeting of the Biophysical Society, San Diego, CA, United States, 15-19 February 2020. St. Louis, MO, United States: Cell Press. doi: 10.1016/j.bpj.2019.11.1983

Challenging the chirality paradigm in peptide-lipid interactions

2019

Journal Article

Is the mirror image a true reflection? Intrinsic membrane chirality modulates peptide binding

Troeira Henriques, Sónia, Peacock, Hayden, Benfield, Aurelie, Wang, Conan K and Craik, David J (2019). Is the mirror image a true reflection? Intrinsic membrane chirality modulates peptide binding. Journal of the American Chemical Society, 141 (51) jacs.9b11194, 20460-20469. doi: 10.1021/jacs.9b11194

Is the mirror image a true reflection? Intrinsic membrane chirality modulates peptide binding

2019

Journal Article

EGF-like and other disulfide-rich microdomains as therapeutic scaffolds

Tombling, Benjamin J., Wang, Conan K. and Craik, David J. (2019). EGF-like and other disulfide-rich microdomains as therapeutic scaffolds. Angewandte Chemie International Edition, 59 (28), 11218-11232. doi: 10.1002/anie.201913809

EGF-like and other disulfide-rich microdomains as therapeutic scaffolds

2019

Journal Article

Anchor residues guide form and function in grafted peptides

Yin, Huawu, Craik, David J. and Wang, Conan K. (2019). Anchor residues guide form and function in grafted peptides. Angewandte Chemie International Edition, 58 (23), 7652-7656. doi: 10.1002/anie.201901572

Anchor residues guide form and function in grafted peptides

2019

Journal Article

Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor

Chambers, Chris, Cutler, Penny, Huang, Yen-Hua, Goodchild, James A., Blythe, Judith, Wang, Conan K., Bigot, Aurélien, Kaas, Quentin, Craik, David J., Sabbadin, Davide and Earley, Fergus G. (2019). Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor. FEBS Letters, 593 (12) 1873-3468.13435, 1336-1350. doi: 10.1002/1873-3468.13435

Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor

Funding

Current funding

  • 2024 - 2026
    Developing novel peptide tracers for improving immunotherapy outcomes
    NHMRC Development Grant
    Open grant
  • 2023 - 2026
    A peptide platform to fight pests threatening global food security
    ARC Discovery Projects
    Open grant
  • 2023 - 2027
    Peptides and Proteins for Fighting Pests and Protecting the Environment
    ARC Future Fellowships
    Open grant
  • 2020 - 2024
    Crown-of-Thorns Starfish Control Innovation Program
    Great Barrier Reef Foundation
    Open grant

Past funding

  • 2018 - 2022
    Biocontrol of crown-of-thorns starfish using genomics and proteomics
    ARC Linkage Projects
    Open grant
  • 2016 - 2018
    New drug leads for cholesterol
    NHMRC Project Grant
    Open grant
  • 2014
    Bioengineering stable peptide inhibitors of amyloidosis
    UQ Early Career Researcher
    Open grant
  • 2012 - 2013
    NHMRC Australia-China Exchange Fellowship: Improving the bioavailability of peptide-based therapeutics for the treatment of Multiple Sclerosis
    NHMRC Training (Postdoctoral) Fellowship
    Open grant

Supervision

Availability

Dr Conan Wang is:
Available for supervision

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Available projects

Supervision history

Current supervision

Completed supervision

Media

Enquiries

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communications@uq.edu.au