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Associate Professor Conan Wang
Associate Professor

Conan Wang

Email: 
Phone: 
+61 7 334 62014

Overview

Background

I lead the Technology-Driven Drug Discovery (Tech3D) Group at the Institute for Molecular Bioscience, UQ. We believe that the key to solving some of our world's biggest challenges, whether that be in medicine or agriculture, relies on the ability to precision engineer molecules at will. My group harnesses three technological pillars to engineer peptides and proteins, which are computational biology, molecular libraries, and nanotechnology. We aspire to design better drugs, creating next generation biotechnological agents that have real impact. These could be new cancer drugs that harness the body's immune system or new insecticides that are environmentally friendly. In these pursuits, we value advancement, fun, balance, respect, fairness, and integrity.

I have been involved in peptide and protein research for over two decades, and am highly experienced in bioinformatics, chemistry, structural characterization, biophysics, and biochemistry. I trained with experts in peptide and protein characterization: an Honours project with Professor Garry King at the University of New South Wales, Sydney, Australia (2004), an APA scholarship with Professor David Craik at the University of Queensland Institute for Molecular Bioscience, Brisbane, Australia (2005-2009) and a NHMRC fellowship with Professor Mingjie Zhang at the Hong Kong University of Science and Technology, Hong Kong, China (2009-2011) and A/Professor Andreas Hofmann at Griffith University Eskitis Institute, Brisbane, Australia (2011-2012). I returned to the University of Queensland in 2012 to join an industry partnership funded by an ARC linkage grant. I currently hold an ARC Future Fellowship and am responsible for a team of research officers, assistants and postgraduate students.

My research output has been recognised by >30 prizes and awards for leadership, research translation and fundamental research excellence, as well as numerous invitations to speak at academic and pharmaceutical conferences. I have over 100 publications and have been cited by researchers from across the world.

Availability

Associate Professor Conan Wang is:
Available for supervision

Qualifications

  • Bachelor of Engineering, University of New South Wales
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Computational design of targeted cancer therapeutics guided by machine learning

    The right treatment depends on the right diagnosis. This project aims to engineer advanced agents capable of precisely locating and “painting” every cancer cell in the body, enabling clinicians to detect and treat tumours with unprecedented resolution. The candidate will gain expertise in drug discovery through computational biology and molecular biology. If you’re interested in learning more about drug design or exploring potential projects, please feel free to reach out.

  • Efficient design of drugs using new nanoscale technologies

    Powerful technologies have emerged to perform millions of experiments quickly in tiny nanolitre droplets, and have attracted wide interest from major pharmaceutical companies because of the potential to accelerate drug discovery. Research project opportunities are available to investigate these next-generation tools for drug design and learn new skills in one or more areas of nanotechnology and molecular biology.

  • Designing protein drugs for the treatment of drug-resistant cancers

    Targeted therapies against kinases are frontline treatments for many cancers. However, drug resistance often emerges within months of initiating therapy. This project aims to develop resilient kinase-targeted drugs with novel mechanisms of action that disrupt growth-promoting signals in cancer cells while reducing the likelihood of resistance. These agents have the potential to more effectively halt cancer progression. Candidates will learn new skills in drug design and characterisation using tools in molecular biology, biochemistry, and structural biology.

Works

Search Professor Conan Wang’s works on UQ eSpace

131 works between 2006 and 2026

21 - 40 of 131 works

2024

Journal Article

The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance

Biswas, Biswajit, Huang, Yen-Hua, Craik, David J. and Wang, Conan K. (2024). The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance. Chemical Science, 15 (33), 13130-13147. doi: 10.1039/d4sc01088d

The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance

2023

Conference Publication

More contacts, copies, and stability - optimising efficacy of a PCSK9 peptide inhibitor

Wang, Conan (2023). More contacts, copies, and stability - optimising efficacy of a PCSK9 peptide inhibitor. 37th Annual Meeting of The-Protein-Society (TPS), Boston, MA United States, 13-16 July 2023. Hoboken, NJ United States: Wiley-Blackwell Publishing.

More contacts, copies, and stability - optimising efficacy of a PCSK9 peptide inhibitor

Featured

2023

Journal Article

The circular bacteriocin enterocin NKR-5-3B has an improved stability profile over nisin

Wang, Conan K., Huang, Yen-Hua, Shabbir, Fatima, Pham, Huong T., Lawrence, Nicole, Benfield, Aurélie H., van der Donk, Wilfred, Henriques, Sónia T., Turner, Mark S. and Craik, David J. (2023). The circular bacteriocin enterocin NKR-5-3B has an improved stability profile over nisin. Peptides, 167 171049, 171049. doi: 10.1016/j.peptides.2023.171049

The circular bacteriocin enterocin NKR-5-3B has an improved stability profile over nisin

2023

Journal Article

Captivity induces a sweeping and sustained genomic response in a starfish

Morin, Marie, Jönsson, Mathias, Wang, Conan K., Craik, David J., Degnan, Sandie M. and Degnan, Bernard M. (2023). Captivity induces a sweeping and sustained genomic response in a starfish. Molecular Ecology, 32 (13), 3541-3556. doi: 10.1111/mec.16947

Captivity induces a sweeping and sustained genomic response in a starfish

2023

Journal Article

The 2022 Kazuhiko Tatemoto Prize: ACE2-derived peptides for COVID-19 treatment

Wang, Conan K. (2023). The 2022 Kazuhiko Tatemoto Prize: ACE2-derived peptides for COVID-19 treatment. Peptides, 162 170964, 170964. doi: 10.1016/j.peptides.2023.170964

The 2022 Kazuhiko Tatemoto Prize: ACE2-derived peptides for COVID-19 treatment

2023

Journal Article

Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation

Chen, Zhian, Cui, Yanfang, Yao, Yin, Liu, Bo, Yunis, Joseph, Gao, Xin, Wang, Naiqi, Cañete, Pablo F., Tuong, Zewen Kelvin, Sun, Hongjian, Wang, Hao, Yang, Siling, Wang, Runli, Leong, Yew Ann, Simon Davis, David, Qin, Jiahuan, Liang, Kaili, Deng, Jun, Wang, Conan K., Huang, Yen-Hua, Roco, Jonathan A., Nettelfield, Sam, Zhu, Huaming, Xu, Huajun, Yu, Zhijia, Craik, David, Liu, Zheng, Qi, Hai, Parish, Christopher and Yu, Di (2023). Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Science Immunology, 8 (80) eadd1728, 1-17. doi: 10.1126/sciimmunol.add1728

Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation

2022

Journal Article

Sex-specific expression of pheromones and other signals in gravid starfish

Jönsson, Mathias, Morin, Marie, Wang, Conan K., Craik, David J., Degnan, Sandie M. and Degnan, Bernard M. (2022). Sex-specific expression of pheromones and other signals in gravid starfish. BMC Biology, 20 (1) 288, 1-18. doi: 10.1186/s12915-022-01491-0

Sex-specific expression of pheromones and other signals in gravid starfish

2022

Journal Article

Engineering the cyclization loop of MCoTI-II generates targeted cyclotides that potently inhibit factor XIIa

Tian, Sixin, Durek, Thomas, Wang, Conan K., Zdenek, Christina N., Fry, Bryan G., Craik, David J. and de Veer, Simon J. (2022). Engineering the cyclization loop of MCoTI-II generates targeted cyclotides that potently inhibit factor XIIa. Journal of Medicinal Chemistry, 65 (23), 15698-15709. doi: 10.1021/acs.jmedchem.2c01080

Engineering the cyclization loop of MCoTI-II generates targeted cyclotides that potently inhibit factor XIIa

2022

Journal Article

Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide

Zhang, Yuhui, Wang, Li, Tombling, Benjamin J., Lammi, Carmen, Huang, Yen-Hua, Li, Yue, Bartolomei, Martina, Hong, Bin, Craik, David J. and Wang, Conan K. (2022). Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide. Journal of the American Chemical Society, 144 (42), 19485-19498. doi: 10.1021/jacs.2c08029

Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide

2022

Journal Article

CIPPS, an Australian Centre for Peptide and Protein Research, goes live!

Wang, Conan K. and Craik, David J. (2022). CIPPS, an Australian Centre for Peptide and Protein Research, goes live!. Peptides, 155 170835, 1-2. doi: 10.1016/j.peptides.2022.170835

CIPPS, an Australian Centre for Peptide and Protein Research, goes live!

2022

Conference Publication

Activating the p53 pathway with peptide conjugates: synthesis, structure, activity and cellular uptake

Philippe, Gregoire, Huang, Yen-Hua, Mittermeier, Anna, Brown, Christopher, Wang, Conan, Kaas, Quentin, Lawrence, Nicole, Condon, Nicholas, Lane, David, Loewer, Alexander, Craik, David and Henriques, Sonia (2022). Activating the p53 pathway with peptide conjugates: synthesis, structure, activity and cellular uptake. 36th European Peptide Symposium 12th International Peptide Symposium, Barcelona, Spain, 28 August - 2 September 2022. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.3445

Activating the p53 pathway with peptide conjugates: synthesis, structure, activity and cellular uptake

2022

Journal Article

Mutagenesis of bracelet cyclotide hyen D reveals functionally and structurally critical residues for membrane binding and cytotoxicity

Du, Qingdan, Huang, Yen-Hua, Wang, Conan K., Kaas, Quentin and Craik, David J. (2022). Mutagenesis of bracelet cyclotide hyen D reveals functionally and structurally critical residues for membrane binding and cytotoxicity. Journal of Biological Chemistry, 298 (4) 101822, 101822. doi: 10.1016/j.jbc.2022.101822

Mutagenesis of bracelet cyclotide hyen D reveals functionally and structurally critical residues for membrane binding and cytotoxicity

2021

Journal Article

Rational design of potent peptide inhibitors of the PD-1:PD-L1 interaction for cancer immunotherapy

Yin, Huawu, Zhou, Xiuman, Huang, Yen-Hua, King, Gordon J., Collins, Brett M., Gao, Yanfeng, Craik, David J. and Wang, Conan K. (2021). Rational design of potent peptide inhibitors of the PD-1:PD-L1 interaction for cancer immunotherapy. Journal of the American Chemical Society, 143 (44) jacs.1c08132, 18536-18547. doi: 10.1021/jacs.1c08132

Rational design of potent peptide inhibitors of the PD-1:PD-L1 interaction for cancer immunotherapy

2021

Journal Article

Enabling efficient folding and high-resolution crystallographic analysis of bracelet cyclotides

Huang, Yen-Hua, Du, Qingdan, Jiang, Zhihao, King, Gordon J., Collins, Brett M., Wang, Conan K. and Craik, David J. (2021). Enabling efficient folding and high-resolution crystallographic analysis of bracelet cyclotides. Molecules, 26 (18) 5554, 5554. doi: 10.3390/molecules26185554

Enabling efficient folding and high-resolution crystallographic analysis of bracelet cyclotides

2021

Journal Article

The emerging landscape of peptide-based inhibitors of PCSK9

Tombling, Benjamin J., Zhang, Yuhui, Huang, Yen-Hua, Craik, David J. and Wang, Conan K. (2021). The emerging landscape of peptide-based inhibitors of PCSK9. Atherosclerosis, 330, 52-60. doi: 10.1016/j.atherosclerosis.2021.06.903

The emerging landscape of peptide-based inhibitors of PCSK9

2021

Journal Article

An integrated molecular grafting approach for the design of Keap1-targeted peptide inhibitors

Yin, Huawu, Huang, Yen-Hua, Best, Sarah A., Sutherland, Kate D., Craik, David J. and Wang, Conan K. (2021). An integrated molecular grafting approach for the design of Keap1-targeted peptide inhibitors. ACS Chemical Biology, 16 (7) acschembio.1c00388, 1276-1287. doi: 10.1021/acschembio.1c00388

An integrated molecular grafting approach for the design of Keap1-targeted peptide inhibitors

2021

Journal Article

Increased valency improves inhibitory activity of peptides targeting proprotein convertase subtilisin/kexin type 9 (PCSK9)

Tombling, Benjamin J., Lammi, Carmen, Bollati, Carlotta, Anoldi, Anna, Craik, David J. and Wang, Conan K. (2021). Increased valency improves inhibitory activity of peptides targeting proprotein convertase subtilisin/kexin type 9 (PCSK9). ChemBioChem, 22 (12) cbic.202100103, 1-8. doi: 10.1002/cbic.202100103

Increased valency improves inhibitory activity of peptides targeting proprotein convertase subtilisin/kexin type 9 (PCSK9)

2021

Journal Article

Bioactive cyclization optimizes the affinity of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) peptide inhibitor

Tombling, Benjamin J., Lammi, Carmen, Lawrence, Nicole, Gilding, Edward K., Grazioso, Giovanni, Craik, David J. and Wang, Conan K. (2021). Bioactive cyclization optimizes the affinity of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) peptide inhibitor. Journal of Medicinal Chemistry, 64 (5) acs.jmedchem.0c01766, 2523-2533. doi: 10.1021/acs.jmedchem.0c01766

Bioactive cyclization optimizes the affinity of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) peptide inhibitor

2021

Journal Article

Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases

Yap, Kuok, Du, Junqiao, Rehm, Fabian B. H., Tang, Shyn Ric, Zhou, Yan, Xie, Jing, Wang, Conan K., de Veer, Simon J., Lua, Linda H. L., Durek, Thomas and Craik, David J. (2021). Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases. Nature Protocols, 16 (3), 1-23. doi: 10.1038/s41596-020-00483-0

Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases

2021

Journal Article

Engineered EGF-A peptides with improved affinity for proprotein convertase subtilisin/kexin type 9 (PCSK9)

Tombling, Benjamin J., Lammi, Carmen, Lawrence, Nicole, Li, Jianqiang, Arnoldi, Anna, Craik, David J. and Wang, Conan K. (2021). Engineered EGF-A peptides with improved affinity for proprotein convertase subtilisin/kexin type 9 (PCSK9). ACS Chemical Biology, 16 (2) acschembio.0c00991, 429-439. doi: 10.1021/acschembio.0c00991

Engineered EGF-A peptides with improved affinity for proprotein convertase subtilisin/kexin type 9 (PCSK9)

Funding

Current funding

  • 2026 - 2028
    All-in-one: enhancing multidimensional vaccine protection through a novel IL-21 agonistic antibody
    UQ - Sanofi Translational Science Hub Partnership Scheme
    Open grant
  • 2025 - 2028
    Robotics & automation for plant-based production of pharmaceutical peptides
    ARC Linkage Projects
    Open grant
  • 2025 - 2028
    Disruptive technologies for targeting tyrosine kinase substrate sites
    NHMRC IDEAS Grants
    Open grant
  • 2025 - 2028
    Unleashing the biocontrol potential of venom peptides with cyclotides
    ARC Linkage Projects
    Open grant
  • 2025 - 2028
    A molecular platform for design and production of next-generation peptides
    ARC Linkage Projects
    Open grant
  • 2023 - 2026
    A peptide platform to fight pests threatening global food security
    ARC Discovery Projects
    Open grant
  • 2023 - 2028
    ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals
    ARC Industrial Transformation Research Hubs
    Open grant
  • 2023 - 2027
    Peptides and Proteins for Fighting Pests and Protecting the Environment
    ARC Future Fellowships
    Open grant
  • 2020 - 2026
    Crown-of-Thorns Starfish Control Innovation Program
    Great Barrier Reef Foundation
    Open grant

Past funding

  • 2025 - 2026
    A Facility for Accelerated Microbial Phenotyping in Southeast Queensland
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2024 - 2026
    Developing novel peptide tracers for improving immunotherapy outcomes
    NHMRC Development Grant
    Open grant
  • 2018 - 2022
    Biocontrol of crown-of-thorns starfish using genomics and proteomics
    ARC Linkage Projects
    Open grant
  • 2016 - 2018
    New drug leads for cholesterol
    NHMRC Project Grant
    Open grant
  • 2014
    Bioengineering stable peptide inhibitors of amyloidosis
    UQ Early Career Researcher
    Open grant
  • 2012 - 2013
    NHMRC Australia-China Exchange Fellowship: Improving the bioavailability of peptide-based therapeutics for the treatment of Multiple Sclerosis
    NHMRC Training (Postdoctoral) Fellowship
    Open grant

Supervision

Availability

Associate Professor Conan Wang is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Media

Enquiries

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