
Overview
Background
I lead the Technology-Driven Drug Discovery (Tech3D) Group at the Institute for Molecular Bioscience, UQ. We believe that the key to solving some of our world's biggest challenges, whether that be in medicine or agriculture, relies on the ability to precision engineer molecules at will. My group harnesses three technological pillars to engineer peptides and proteins, which are computational biology, molecular libraries, and nanotechnology. We aspire to design better drugs, creating next generation biotechnological agents that have real impact. These could be new cancer drugs that harness the body's immune system or new insecticides that are environmentally friendly. In these pursuits, we value advancement, fun, balance, respect, fairness, and integrity.
I have been involved in peptide and protein research for over two decades, and am highly experienced in bioinformatics, chemistry, structural characterization, biophysics, and biochemistry. I trained with experts in peptide and protein characterization: an Honours project with Professor Garry King at the University of New South Wales, Sydney, Australia (2004), an APA scholarship with Professor David Craik at the University of Queensland Institute for Molecular Bioscience, Brisbane, Australia (2005-2009) and a NHMRC fellowship with Professor Mingjie Zhang at the Hong Kong University of Science and Technology, Hong Kong, China (2009-2011) and A/Professor Andreas Hofmann at Griffith University Eskitis Institute, Brisbane, Australia (2011-2012). I returned to the University of Queensland in 2012 to join an industry partnership funded by an ARC linkage grant. I currently hold an ARC Future Fellowship and am responsible for a team of research officers, assistants and postgraduate students.
My research output has been recognised by >30 prizes and awards for leadership, research translation and fundamental research excellence, as well as numerous invitations to speak at academic and pharmaceutical conferences. I have over 100 publications and have been cited by researchers from across the world.
Availability
- Dr Conan Wang is:
- Available for supervision
Qualifications
- Bachelor of Engineering, University of New South Wales
- Doctor of Philosophy, The University of Queensland
Research interests
-
Drug Discovery and Protein/Peptide Engineeering
My group uses: 1) computational algorithms to predict drug properties with unprecedented accuracy; 2) molecular libraries capable of screening through billions of drug leads to design drugs efficiently; and 3) nano-sized reaction droplets to capture drug activity to make drugs that actually work.
-
Cancer Therapeutics
My group is interested in developing new cancer therapeutics, particularly those that modulate the immune system or relevant to lung cancer.
Works
Search Professor Conan Wang’s works on UQ eSpace
2016
Journal Article
Cyclic peptide oral bioavailability: lessons from the past
Wang, Conan K. and Craik, David J. (2016). Cyclic peptide oral bioavailability: lessons from the past. Biopolymers, 106 (6), 901-909. doi: 10.1002/bip.22878
2016
Journal Article
Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide
Kwon, Soohyun, Bosmans, Frank, Kaas, Quentin, Cheneval, Olivier, Conibear, Anne C., Rosengren, K. Johan, Wang, Conan K., Schroeder, Christina I. and Craik, David J. (2016). Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnology and Bioengineering, 113 (10), 2202-2212. doi: 10.1002/bit.25993
2016
Journal Article
Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold
Wang, Conan K., Stalmans, Sofie, De Spiegeleer, Bart and Craik, David J. (2016). Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold. Journal of Peptide Science, 22 (5), 305-310. doi: 10.1002/psc.2862
2016
Journal Article
Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic properties
Wang, Conan K., King, Gordon J., Conibear, Anne C., Ramos, Mariana C., Chaousis, Stephanie, Henriques, Sonia Troeira and Craik, David J. (2016). Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic properties. Journal of American Chemical Society, 138 (17), 5706-5713. doi: 10.1021/jacs.6b02575
2016
Journal Article
Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold
Wang, Conan K., Northfield, Susan E., Huang, Yen-Hua, Ramos, Mariana C. and Craik, David J. (2016). Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold. European Journal of Medicinal Chemistry, 109, 342-349. doi: 10.1016/j.ejmech.2016.01.006
2016
Journal Article
Chlorotoxin: structure, activity, and potential uses in cancer therapy
Ojeda, Paola G., Wang, Conan K. and Craik, David J. (2016). Chlorotoxin: structure, activity, and potential uses in cancer therapy. Biopolymers - Peptide Science, 106 (1), 25-36. doi: 10.1002/bip.22748
2016
Journal Article
Using the MCoTI-II cyclotide scaffold to design a stable cyclic peptide antagonist of SET, a protein overexpressed in human cancer
D'Souza, Charlotte, Henriques, Sonia Troeira, Wang, Conana K., Cheneval, Olivier, Chan, Lai Yue, Bokil, Nilesh J., Sweet, Matthew J. and Craik, David J. (2016). Using the MCoTI-II cyclotide scaffold to design a stable cyclic peptide antagonist of SET, a protein overexpressed in human cancer. Biochemistry, 55 (2), 396-405. doi: 10.1021/acs.biochem.5b00529
2015
Journal Article
Effects of Cyclization on Peptide Backbone Dynamics
Wang, Conan K., Swedberg, Joakim E., Northfield, Susan E. and Craik, David J. (2015). Effects of Cyclization on Peptide Backbone Dynamics. Journal of Physical Chemistry B, 119 (52), 15821-15830. doi: 10.1021/acs.jpcb.5b11085
2015
Journal Article
Lysine-rich cyclotides: a new subclass of circular knotted proteins from violaceae
Ravipati, Anjaneya S., Henriques, Sónia Troeira, Poth, Aaron G., Kaas, Quentin, Wang, Conan K., Colgrave, Michelle L. and Craik, David J. (2015). Lysine-rich cyclotides: a new subclass of circular knotted proteins from violaceae. ACS Chemical Biology, 10 (11), 2491-2500. doi: 10.1021/acschembio.5b00454
2015
Journal Article
Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library
de Veer, Simon J., Wang, Conan, Harris, Jonathan M., Craik, David J. and Swedberg, Joakim E. (2015). Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library. Journal of Medicinal Chemistry, 58 (20), 8257-8268. doi: 10.1021/acs.jmedchem.5b01148
2015
Journal Article
Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold
Huang, Yen-Hua, Henriques, Sonia T., Wang, Conan K., Thorstholm, Louise, Daly, Norelle L., Kaas, Quentin and Craik, David J. (2015). Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold. Scientific Reports, 5 (1) 12974, 1-15. doi: 10.1038/srep12974
2015
Journal Article
Exploring experimental and computational markers of cyclic peptides: charting islands of permeability
Wang, Conan K., Northfield, Susan Ellen, Swedberg, Joakim E., Colless, Barbara, Chaousis, Stephanie, Price, David A., Liras, Spiros and Craik, David J. (2015). Exploring experimental and computational markers of cyclic peptides: charting islands of permeability. European Journal of Medicinal Chemistry, 97, 202-213. doi: 10.1016/j.ejmech.2015.04.049
2015
Journal Article
An integrated Java tool for generating amino acid sequence alignments with mapped secondary structure elements
Wang, Conan K. and Hofmann, Andreas (2015). An integrated Java tool for generating amino acid sequence alignments with mapped secondary structure elements. 3 Biotech, 5 (1), 87-92. doi: 10.1007/s13205-014-0222-0
2014
Journal Article
Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficients
Wang, Conan K., Northfield, Susan E., Colless, Barbara, Chaousis, Stephanie, Hamernig, Ingrid, Lohman, Rink-Jan, Nielsen, Daniel S., Schroeder, Christina I., Liras, Spiros, Price, David, A., Fairlie, David and Craik, David J. (2014). Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficients. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 111 (49), 17504-17509. doi: 10.1073/pnas.1417611111
2014
Journal Article
Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis
Conibear, Anne C., Wang, Conan K., Bi, Tao, Rosengren, K. Johan, Camarero, Julio A. and Craik, David J. (2014). Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis. Journal of Physical Chemistry B, 118 (49), 14257-14266. doi: 10.1021/jp507754c
2014
Journal Article
Native peptide folding dominates over stereoelectronic effects of prolyl hydroxylation in loop 5 of the macrocyclic peptide kalata B1
Taylor, Carol M., Northfield, Susan E., Wang, Conan K. and Craik, David J. (2014). Native peptide folding dominates over stereoelectronic effects of prolyl hydroxylation in loop 5 of the macrocyclic peptide kalata B1. Tetrahedron, 70 (42), 7669-7674. doi: 10.1016/j.tet.2014.06.058
2014
Journal Article
Racemic and quasi-racemic x-ray structures of cyclic disulfide-rich peptide drug scaffolds
Wang, Conan K., King, Gordon J., Northfield, Susan E., Ojeda, Paola G. and Craik, David J. (2014). Racemic and quasi-racemic x-ray structures of cyclic disulfide-rich peptide drug scaffolds. Angewandte Chemie - International Edition, 53 (42), 11236-11241. doi: 10.1002/anie.201406563
2014
Journal Article
Specific interaction to PIP2 increases the kinetic rate of membrane binding of VILIPs, a subfamily of Neuronal Calcium Sensors (NCS) proteins
Rebaud, Samuel, Wang, Conan K., Sarkis, Joe, Mason, Lyndel, Simon, Anne, Blum, Loic J., Hofmann, Andreas and Girard-Egrot, Agnes P. (2014). Specific interaction to PIP2 increases the kinetic rate of membrane binding of VILIPs, a subfamily of Neuronal Calcium Sensors (NCS) proteins. Biochimica et Biophysica Acta - Biomembranes, 1838 (10), 2698-2707. doi: 10.1016/j.bbamem.2014.06.021
2014
Journal Article
The role of disulfide bonds in structure and activity of chlorotoxin
Ojeda, Paola G., Chan, Lai Y., Poth, Aaron G., Wang, Conan K. and Craik, David J. (2014). The role of disulfide bonds in structure and activity of chlorotoxin. Future Medicinal Chemistry, 6 (15), 1617-1628. doi: 10.4155/FMC.14.93
2014
Journal Article
Translational diffusion of cyclic peptides measured using pulsed-field gradient NMR
Wang, Conan K., Northfield, Susan E., Swedberg, Joakim E., Harvey, Peta J., Mathiowetz, Alan M., Price, David A, Liras, Spiros and Craik, David J. (2014). Translational diffusion of cyclic peptides measured using pulsed-field gradient NMR. Journal of Physical Chemistry B, 118 (38), 11129-11136. doi: 10.1021/jp506678f
Funding
Current funding
Past funding
Supervision
Availability
- Dr Conan Wang is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
Molecular design of drugs for cancer diagnosis, imaging and therapy.
In this industry-linked project, an exceptional opportunity awaits a highly motivated PhD candidate interested in discovery and engineering of peptide drugs to combat cancer.
-
Molecular design of drugs for cancer diagnosis, imaging and therapy.
In this industry-linked project, an exceptional opportunity awaits a highly motivated PhD candidate interested in discovery and engineering of peptide drugs to combat cancer.
-
Design of novel cancer therapeutics to combat drug resistance
Develop a suite of technologies to overcome key challenges in cancer drug resistance.
-
PhD top-up scholarship: Design and manufacturing of next-generation ultra-stable peptide radiotracers for precision diagnosis and therapy
Scholarship + Top-up opportunity for a talented domestic student.
-
PhD top-up scholarship: Technology-driven discovery of sustainable next-generation insecticides
Scholarship + Top-up opportunity for a talented international/domestic student interesting in designing novel ecofriendly insecticides for safeguarding agriculture.
Supervision history
Current supervision
-
Doctor Philosophy
A new molecular technology platform for design and production of ultra-stable peptides
Principal Advisor
Other advisors: Professor David Craik
-
Doctor Philosophy
Patient-friendly peptide tracers for improving immunotherapy outcomes
Principal Advisor
Other advisors: Dr Yen-Hua Crystal Huang
-
Doctor Philosophy
Discovery and Development of Substrate-Based Peptide Kinase Inhibitors
Principal Advisor
Other advisors: Dr Yen-Hua Crystal Huang, Professor David Craik
-
Doctor Philosophy
Next-generation IL-2 mimics for immunotherapy
Principal Advisor
Other advisors: Professor David Craik, Professor Di Yu
-
Doctor Philosophy
Development of commercially viable cyclic peptide production for the protection of the Great Barrier Reef
Associate Advisor
Other advisors: Professor David Craik, Dr Thomas Durek, Professor Linda Lua
-
Doctor Philosophy
Exploring delivery strategies for cyclotide-based therapeutics
Associate Advisor
Other advisors: Dr Yen-Hua Crystal Huang, Professor David Craik
-
Doctor Philosophy
Development of peptide-based inhibitors for crop protection
Associate Advisor
Other advisors: Professor Brett Collins, Professor David Craik
-
Doctor Philosophy
Development of a new class of ligase enzymes for protein engineering and drug development
Associate Advisor
Other advisors: Professor David Craik, Dr Thomas Durek
Completed supervision
-
2021
Doctor Philosophy
The development of peptide-based cholesterol-lowering therapeutics
Principal Advisor
Other advisors: Professor David Craik
-
2024
Doctor Philosophy
Discovery, production, and development of disulfide-rich peptides for drug design and development
Associate Advisor
Other advisors: Professor David Craik, Dr Thomas Durek
-
2023
Doctor Philosophy
Structural Modifications to Optimise the Oxidative Folding and Activity of Cyclotides
Associate Advisor
Other advisors: Dr Simon de Veer, Professor David Craik
-
2023
Doctor Philosophy
Characterising the crown-of-thorns starfish secretome to identify factors for future biocontrol systems
Associate Advisor
Other advisors: Professor Sandie Degnan, Professor Bernard Degnan
-
2022
Doctor Philosophy
Investigating approaches for the design and delivery of disulfide-rich peptide therapeutics
Associate Advisor
Other advisors: Dr Yen-Hua Crystal Huang, Professor David Craik
-
2015
Doctor Philosophy
Structure-activity relationships and development of disulfide-rich cyclic peptides as pharmaceutical templates
Associate Advisor
Other advisors: Professor David Craik
Media
Enquiries
For media enquiries about Dr Conan Wang's areas of expertise, story ideas and help finding experts, contact our Media team: