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Associate Professor Conan Wang
Associate Professor

Conan Wang

Email: 
Phone: 
+61 7 334 62014

Overview

Background

I lead the Technology-Driven Drug Discovery (Tech3D) Group at the Institute for Molecular Bioscience, UQ. We believe that the key to solving some of our world's biggest challenges, whether that be in medicine or agriculture, relies on the ability to precision engineer molecules at will. My group harnesses three technological pillars to engineer peptides and proteins, which are computational biology, molecular libraries, and nanotechnology. We aspire to design better drugs, creating next generation biotechnological agents that have real impact. These could be new cancer drugs that harness the body's immune system or new insecticides that are environmentally friendly. In these pursuits, we value advancement, fun, balance, respect, fairness, and integrity.

I have been involved in peptide and protein research for over two decades, and am highly experienced in bioinformatics, chemistry, structural characterization, biophysics, and biochemistry. I trained with experts in peptide and protein characterization: an Honours project with Professor Garry King at the University of New South Wales, Sydney, Australia (2004), an APA scholarship with Professor David Craik at the University of Queensland Institute for Molecular Bioscience, Brisbane, Australia (2005-2009) and a NHMRC fellowship with Professor Mingjie Zhang at the Hong Kong University of Science and Technology, Hong Kong, China (2009-2011) and A/Professor Andreas Hofmann at Griffith University Eskitis Institute, Brisbane, Australia (2011-2012). I returned to the University of Queensland in 2012 to join an industry partnership funded by an ARC linkage grant. I currently hold an ARC Future Fellowship and am responsible for a team of research officers, assistants and postgraduate students.

My research output has been recognised by >30 prizes and awards for leadership, research translation and fundamental research excellence, as well as numerous invitations to speak at academic and pharmaceutical conferences. I have over 100 publications and have been cited by researchers from across the world.

Availability

Associate Professor Conan Wang is:
Available for supervision

Qualifications

  • Bachelor of Engineering, University of New South Wales
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Computational design of targeted cancer therapeutics guided by machine learning

    The right treatment depends on the right diagnosis. This project aims to engineer advanced agents capable of precisely locating and “painting” every cancer cell in the body, enabling clinicians to detect and treat tumours with unprecedented resolution. The candidate will gain expertise in drug discovery through computational biology and molecular biology. If you’re interested in learning more about drug design or exploring potential projects, please feel free to reach out.

  • Efficient design of drugs using new nanoscale technologies

    Powerful technologies have emerged to perform millions of experiments quickly in tiny nanolitre droplets, and have attracted wide interest from major pharmaceutical companies because of the potential to accelerate drug discovery. Research project opportunities are available to investigate these next-generation tools for drug design and learn new skills in one or more areas of nanotechnology and molecular biology.

  • Designing protein drugs for the treatment of drug-resistant cancers

    Targeted therapies against kinases are frontline treatments for many cancers. However, drug resistance often emerges within months of initiating therapy. This project aims to develop resilient kinase-targeted drugs with novel mechanisms of action that disrupt growth-promoting signals in cancer cells while reducing the likelihood of resistance. These agents have the potential to more effectively halt cancer progression. Candidates will learn new skills in drug design and characterisation using tools in molecular biology, biochemistry, and structural biology.

Works

Search Professor Conan Wang’s works on UQ eSpace

131 works between 2006 and 2026

61 - 80 of 131 works

2018

Journal Article

Conformational Flexibility Is a Determinant of Permeability for Cyclosporin

Wang, Conan K., Swedberg, Joakim E., Harvey, Peta J., Kaas, Quentin and Craik, David J. (2018). Conformational Flexibility Is a Determinant of Permeability for Cyclosporin. The Journal of Physical Chemistry. B, 122 (8), 2261-2276. doi: 10.1021/acs.jpcb.7b12419

Conformational Flexibility Is a Determinant of Permeability for Cyclosporin

2018

Conference Publication

A journey alongside cyclosporin on the road to peptide oral bioavailability

Wang, Conan and Craik, David (2018). A journey alongside cyclosporin on the road to peptide oral bioavailability. 35th European Peptide Symposium, Dublin City University, Ireland, 26-31 August 2018. Oxford, United Kingdom: John Wiley & Sons.

A journey alongside cyclosporin on the road to peptide oral bioavailability

2018

Conference Publication

Targeting the coiled-coil domain of BCR-ABL1 kinase with new weapons

Huang, Yen-Hua, Passioura, Toby, Peacock, Hayden, Henriques, Sonia Troeira, Wang, Conan, Kaas, Quentin, Suga, Hiroaki and Craik, David (2018). Targeting the coiled-coil domain of BCR-ABL1 kinase with new weapons. 35th European Peptide Symposium, Dublin City University, Ireland, 26-31 August 2018. Oxford, United Kingdom: John Wiley & Sons.

Targeting the coiled-coil domain of BCR-ABL1 kinase with new weapons

2018

Book Chapter

NMR relaxation analysis of pharmaceutically active peptides

Wang, Conan K. (2018). NMR relaxation analysis of pharmaceutically active peptides. Modern magnetic resonance. (pp. 1997-2020) edited by Graham A. Webb. Cham, Switzerland: Springer. doi: 10.1007/978-3-319-28388-3_115

NMR relaxation analysis of pharmaceutically active peptides

2018

Conference Publication

Is the mirror image a true reflection? Lipid chirality in the activity of the prototypic cyclotide kalata B1

Henriques, Sonia Troeira, Peacock, Hayden, Benfield, Aurelie H., Wang, Conan and Craik, David (2018). Is the mirror image a true reflection? Lipid chirality in the activity of the prototypic cyclotide kalata B1. 35th European Peptide Symposium, Dublin City University, Ireland, 26-31 August 2018. Oxford, United Kingdom: John Wiley & Sons.

Is the mirror image a true reflection? Lipid chirality in the activity of the prototypic cyclotide kalata B1

2017

Journal Article

Lysine to arginine mutagenesis of chlorotoxin enhances its cellular uptake

Ojeda, Paola G. , Henriques, Sonia Troeira, Pan, Yijun, Nicolazzo, Joseph A., Craik, David J. and Wang, Conan K. (2017). Lysine to arginine mutagenesis of chlorotoxin enhances its cellular uptake. Biopolymers, 108 (5) e23025, e23025. doi: 10.1002/bip.23025

Lysine to arginine mutagenesis of chlorotoxin enhances its cellular uptake

2017

Journal Article

Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer

Wu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin, Harvey, Peta J., Wang, Conan K., Tae, Han-Shen, Adams, David J. and Craik, David J. (2017). Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. Journal of Biological Chemistry, 292 (41), 17101-17112. doi: 10.1074/jbc.M117.808386

Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer

2017

Journal Article

Design of potent and selective cathepsin G inhibitors based on the sunflower trypsin inhibitor-1 scaffold

Swedberg, Joakim E., Li, Choi Yi, De Veer, Simon J., Wang, Conan K. and Craik, David J. (2017). Design of potent and selective cathepsin G inhibitors based on the sunflower trypsin inhibitor-1 scaffold. Journal of Medicinal Chemistry, 60 (2), 658-667. doi: 10.1021/acs.jmedchem.6b01509

Design of potent and selective cathepsin G inhibitors based on the sunflower trypsin inhibitor-1 scaffold

2017

Book Chapter

A practical guide to structural aspects of macrocycles (NMR, x-ray, and modeling)

Craik, David J., Kaas, Quentin and Wang, Conan K. (2017). A practical guide to structural aspects of macrocycles (NMR, x-ray, and modeling). Practical medicinal chemistry with macrocycles: Design, synthesis, and case studies. (pp. 25-57) edited by Eric Marsault and Mark L Peterson. Hoboken, New Jersey, United States: John Wiley & Sons. doi: 10.1002/9781119092599.ch2

A practical guide to structural aspects of macrocycles (NMR, x-ray, and modeling)

2016

Journal Article

Cyclic peptide oral bioavailability: lessons from the past

Wang, Conan K. and Craik, David J. (2016). Cyclic peptide oral bioavailability: lessons from the past. Biopolymers, 106 (6), 901-909. doi: 10.1002/bip.22878

Cyclic peptide oral bioavailability: lessons from the past

2016

Journal Article

Forward for ICCP2015 issue of biopolymers peptide science

Craik, David J. and Wang, Conan K. (2016). Forward for ICCP2015 issue of biopolymers peptide science. Biopolymers, 106 (6), 772-773. doi: 10.1002/bip.22989

Forward for ICCP2015 issue of biopolymers peptide science

2016

Journal Article

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

Kwon, Soohyun, Bosmans, Frank, Kaas, Quentin, Cheneval, Olivier, Conibear, Anne C., Rosengren, K. Johan, Wang, Conan K., Schroeder, Christina I. and Craik, David J. (2016). Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnology and Bioengineering, 113 (10), 2202-2212. doi: 10.1002/bit.25993

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

2016

Journal Article

Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold

Wang, Conan K., Stalmans, Sofie, De Spiegeleer, Bart and Craik, David J. (2016). Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold. Journal of Peptide Science, 22 (5), 305-310. doi: 10.1002/psc.2862

Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold

2016

Journal Article

Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic properties

Wang, Conan K., King, Gordon J., Conibear, Anne C., Ramos, Mariana C., Chaousis, Stephanie, Henriques, Sonia Troeira and Craik, David J. (2016). Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic properties. Journal of American Chemical Society, 138 (17), 5706-5713. doi: 10.1021/jacs.6b02575

Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic properties

2016

Journal Article

Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold

Wang, Conan K., Northfield, Susan E., Huang, Yen-Hua, Ramos, Mariana C. and Craik, David J. (2016). Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold. European Journal of Medicinal Chemistry, 109, 342-349. doi: 10.1016/j.ejmech.2016.01.006

Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold

2016

Journal Article

Chlorotoxin: structure, activity, and potential uses in cancer therapy

Ojeda, Paola G., Wang, Conan K. and Craik, David J. (2016). Chlorotoxin: structure, activity, and potential uses in cancer therapy. Biopolymers - Peptide Science, 106 (1), 25-36. doi: 10.1002/bip.22748

Chlorotoxin: structure, activity, and potential uses in cancer therapy

2016

Journal Article

Using the MCoTI-II cyclotide scaffold to design a stable cyclic peptide antagonist of SET, a protein overexpressed in human cancer

D'Souza, Charlotte, Henriques, Sonia Troeira, Wang, Conana K., Cheneval, Olivier, Chan, Lai Yue, Bokil, Nilesh J., Sweet, Matthew J. and Craik, David J. (2016). Using the MCoTI-II cyclotide scaffold to design a stable cyclic peptide antagonist of SET, a protein overexpressed in human cancer. Biochemistry, 55 (2), 396-405. doi: 10.1021/acs.biochem.5b00529

Using the MCoTI-II cyclotide scaffold to design a stable cyclic peptide antagonist of SET, a protein overexpressed in human cancer

2015

Journal Article

Effects of Cyclization on Peptide Backbone Dynamics

Wang, Conan K., Swedberg, Joakim E., Northfield, Susan E. and Craik, David J. (2015). Effects of Cyclization on Peptide Backbone Dynamics. Journal of Physical Chemistry B, 119 (52), 15821-15830. doi: 10.1021/acs.jpcb.5b11085

Effects of Cyclization on Peptide Backbone Dynamics

2015

Journal Article

Lysine-rich cyclotides: a new subclass of circular knotted proteins from violaceae

Ravipati, Anjaneya S., Henriques, Sónia Troeira, Poth, Aaron G., Kaas, Quentin, Wang, Conan K., Colgrave, Michelle L. and Craik, David J. (2015). Lysine-rich cyclotides: a new subclass of circular knotted proteins from violaceae. ACS Chemical Biology, 10 (11), 2491-2500. doi: 10.1021/acschembio.5b00454

Lysine-rich cyclotides: a new subclass of circular knotted proteins from violaceae

2015

Journal Article

Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library

de Veer, Simon J., Wang, Conan, Harris, Jonathan M., Craik, David J. and Swedberg, Joakim E. (2015). Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library. Journal of Medicinal Chemistry, 58 (20), 8257-8268. doi: 10.1021/acs.jmedchem.5b01148

Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library

Funding

Current funding

  • 2026 - 2028
    All-in-one: enhancing multidimensional vaccine protection through a novel IL-21 agonistic antibody
    UQ - Sanofi Translational Science Hub Partnership Scheme
    Open grant
  • 2025 - 2028
    Robotics & automation for plant-based production of pharmaceutical peptides
    ARC Linkage Projects
    Open grant
  • 2025 - 2028
    Disruptive technologies for targeting tyrosine kinase substrate sites
    NHMRC IDEAS Grants
    Open grant
  • 2025 - 2028
    Unleashing the biocontrol potential of venom peptides with cyclotides
    ARC Linkage Projects
    Open grant
  • 2025 - 2028
    A molecular platform for design and production of next-generation peptides
    ARC Linkage Projects
    Open grant
  • 2023 - 2026
    A peptide platform to fight pests threatening global food security
    ARC Discovery Projects
    Open grant
  • 2023 - 2028
    ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals
    ARC Industrial Transformation Research Hubs
    Open grant
  • 2023 - 2027
    Peptides and Proteins for Fighting Pests and Protecting the Environment
    ARC Future Fellowships
    Open grant
  • 2020 - 2026
    Crown-of-Thorns Starfish Control Innovation Program
    Great Barrier Reef Foundation
    Open grant

Past funding

  • 2025 - 2026
    A Facility for Accelerated Microbial Phenotyping in Southeast Queensland
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2024 - 2026
    Developing novel peptide tracers for improving immunotherapy outcomes
    NHMRC Development Grant
    Open grant
  • 2018 - 2022
    Biocontrol of crown-of-thorns starfish using genomics and proteomics
    ARC Linkage Projects
    Open grant
  • 2016 - 2018
    New drug leads for cholesterol
    NHMRC Project Grant
    Open grant
  • 2014
    Bioengineering stable peptide inhibitors of amyloidosis
    UQ Early Career Researcher
    Open grant
  • 2012 - 2013
    NHMRC Australia-China Exchange Fellowship: Improving the bioavailability of peptide-based therapeutics for the treatment of Multiple Sclerosis
    NHMRC Training (Postdoctoral) Fellowship
    Open grant

Supervision

Availability

Associate Professor Conan Wang is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Media

Enquiries

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communications@uq.edu.au