Overview
Background
I lead the Technology-Driven Drug Discovery (Tech3D) Group at the Institute for Molecular Bioscience, UQ. We believe that the key to solving some of our world's biggest challenges, whether that be in medicine or agriculture, relies on the ability to precision engineer molecules at will. My group harnesses three technological pillars to engineer peptides and proteins, which are computational biology, molecular libraries, and nanotechnology. We aspire to design better drugs, creating next generation biotechnological agents that have real impact. These could be new cancer drugs that harness the body's immune system or new insecticides that are environmentally friendly. In these pursuits, we value advancement, fun, balance, respect, fairness, and integrity.
I have been involved in peptide and protein research for over two decades, and am highly experienced in bioinformatics, chemistry, structural characterization, biophysics, and biochemistry. I trained with experts in peptide and protein characterization: an Honours project with Professor Garry King at the University of New South Wales, Sydney, Australia (2004), an APA scholarship with Professor David Craik at the University of Queensland Institute for Molecular Bioscience, Brisbane, Australia (2005-2009) and a NHMRC fellowship with Professor Mingjie Zhang at the Hong Kong University of Science and Technology, Hong Kong, China (2009-2011) and A/Professor Andreas Hofmann at Griffith University Eskitis Institute, Brisbane, Australia (2011-2012). I returned to the University of Queensland in 2012 to join an industry partnership funded by an ARC linkage grant. I currently hold an ARC Future Fellowship and am responsible for a team of research officers, assistants and postgraduate students.
My research output has been recognised by >30 prizes and awards for leadership, research translation and fundamental research excellence, as well as numerous invitations to speak at academic and pharmaceutical conferences. I have over 100 publications and have been cited by researchers from across the world.
Availability
- Associate Professor Conan Wang is:
- Available for supervision
Qualifications
- Bachelor of Engineering, University of New South Wales
- Doctor of Philosophy, The University of Queensland
Research interests
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Computational design of targeted cancer therapeutics guided by machine learning
The right treatment depends on the right diagnosis. This project aims to engineer advanced agents capable of precisely locating and “painting” every cancer cell in the body, enabling clinicians to detect and treat tumours with unprecedented resolution. The candidate will gain expertise in drug discovery through computational biology and molecular biology. If you’re interested in learning more about drug design or exploring potential projects, please feel free to reach out.
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Efficient design of drugs using new nanoscale technologies
Powerful technologies have emerged to perform millions of experiments quickly in tiny nanolitre droplets, and have attracted wide interest from major pharmaceutical companies because of the potential to accelerate drug discovery. Research project opportunities are available to investigate these next-generation tools for drug design and learn new skills in one or more areas of nanotechnology and molecular biology.
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Designing protein drugs for the treatment of drug-resistant cancers
Targeted therapies against kinases are frontline treatments for many cancers. However, drug resistance often emerges within months of initiating therapy. This project aims to develop resilient kinase-targeted drugs with novel mechanisms of action that disrupt growth-promoting signals in cancer cells while reducing the likelihood of resistance. These agents have the potential to more effectively halt cancer progression. Candidates will learn new skills in drug design and characterisation using tools in molecular biology, biochemistry, and structural biology.
Works
Search Professor Conan Wang’s works on UQ eSpace
2015
Journal Article
Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold
Huang, Yen-Hua, Henriques, Sonia T., Wang, Conan K., Thorstholm, Louise, Daly, Norelle L., Kaas, Quentin and Craik, David J. (2015). Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold. Scientific Reports, 5 (1) 12974, 1-15. doi: 10.1038/srep12974
2015
Journal Article
Exploring experimental and computational markers of cyclic peptides: charting islands of permeability
Wang, Conan K., Northfield, Susan Ellen, Swedberg, Joakim E., Colless, Barbara, Chaousis, Stephanie, Price, David A., Liras, Spiros and Craik, David J. (2015). Exploring experimental and computational markers of cyclic peptides: charting islands of permeability. European Journal of Medicinal Chemistry, 97, 202-213. doi: 10.1016/j.ejmech.2015.04.049
2015
Journal Article
An integrated Java tool for generating amino acid sequence alignments with mapped secondary structure elements
Wang, Conan K. and Hofmann, Andreas (2015). An integrated Java tool for generating amino acid sequence alignments with mapped secondary structure elements. 3 Biotech, 5 (1), 87-92. doi: 10.1007/s13205-014-0222-0
2014
Journal Article
Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficients
Wang, Conan K., Northfield, Susan E., Colless, Barbara, Chaousis, Stephanie, Hamernig, Ingrid, Lohman, Rink-Jan, Nielsen, Daniel S., Schroeder, Christina I., Liras, Spiros, Price, David, A., Fairlie, David and Craik, David J. (2014). Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficients. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 111 (49), 17504-17509. doi: 10.1073/pnas.1417611111
2014
Journal Article
Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis
Conibear, Anne C., Wang, Conan K., Bi, Tao, Rosengren, K. Johan, Camarero, Julio A. and Craik, David J. (2014). Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis. Journal of Physical Chemistry B, 118 (49), 14257-14266. doi: 10.1021/jp507754c
2014
Journal Article
Native peptide folding dominates over stereoelectronic effects of prolyl hydroxylation in loop 5 of the macrocyclic peptide kalata B1
Taylor, Carol M., Northfield, Susan E., Wang, Conan K. and Craik, David J. (2014). Native peptide folding dominates over stereoelectronic effects of prolyl hydroxylation in loop 5 of the macrocyclic peptide kalata B1. Tetrahedron, 70 (42), 7669-7674. doi: 10.1016/j.tet.2014.06.058
2014
Journal Article
Racemic and quasi-racemic x-ray structures of cyclic disulfide-rich peptide drug scaffolds
Wang, Conan K., King, Gordon J., Northfield, Susan E., Ojeda, Paola G. and Craik, David J. (2014). Racemic and quasi-racemic x-ray structures of cyclic disulfide-rich peptide drug scaffolds. Angewandte Chemie - International Edition, 53 (42), 11236-11241. doi: 10.1002/anie.201406563
2014
Journal Article
The role of disulfide bonds in structure and activity of chlorotoxin
Ojeda, Paola G., Chan, Lai Y., Poth, Aaron G., Wang, Conan K. and Craik, David J. (2014). The role of disulfide bonds in structure and activity of chlorotoxin. Future Medicinal Chemistry, 6 (15), 1617-1628. doi: 10.4155/FMC.14.93
2014
Journal Article
Specific interaction to PIP2 increases the kinetic rate of membrane binding of VILIPs, a subfamily of Neuronal Calcium Sensors (NCS) proteins
Rebaud, Samuel, Wang, Conan K., Sarkis, Joe, Mason, Lyndel, Simon, Anne, Blum, Loic J., Hofmann, Andreas and Girard-Egrot, Agnes P. (2014). Specific interaction to PIP2 increases the kinetic rate of membrane binding of VILIPs, a subfamily of Neuronal Calcium Sensors (NCS) proteins. Biochimica et Biophysica Acta - Biomembranes, 1838 (10), 2698-2707. doi: 10.1016/j.bbamem.2014.06.021
2014
Journal Article
Translational diffusion of cyclic peptides measured using pulsed-field gradient NMR
Wang, Conan K., Northfield, Susan E., Swedberg, Joakim E., Harvey, Peta J., Mathiowetz, Alan M., Price, David A, Liras, Spiros and Craik, David J. (2014). Translational diffusion of cyclic peptides measured using pulsed-field gradient NMR. Journal of Physical Chemistry B, 118 (38), 11129-11136. doi: 10.1021/jp506678f
2014
Journal Article
Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting
Henriques, Sonia Troeira, Huang, Yen-Hua, Chaousis, Steph, Wang, Conan and Craik, David J. (2014). Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting. Chembiochem, 15 (13), 1956-1965. doi: 10.1002/cbic.201402144
2014
Journal Article
Structural parameters modulating the cellular uptake of disulfide-rich cyclic cell-penetrating peptides: MCoTI-II and SFTI-1
D'Souza, Charlotte, Troeira Henriques, Sonia, Wang, Conan K. and Craik, David J. (2014). Structural parameters modulating the cellular uptake of disulfide-rich cyclic cell-penetrating peptides: MCoTI-II and SFTI-1. European Journal of Medicinal Chemistry, 88, 10-18. doi: 10.1016/j.ejmech.2014.06.047
2014
Journal Article
Comparison of VILIP-1 and VILIP-3 binding to phospholipid monolayers
Rebaud S., Simon A., Wang C.K., Mason L., Blum L., Hofmann A. and Girard-Egrot A. (2014). Comparison of VILIP-1 and VILIP-3 binding to phospholipid monolayers. PLoS ONE, 9 (4) e93948, e93948.1-e93948.8. doi: 10.1371/journal.pone.0093948
2014
Journal Article
Disulfide-rich macrocyclic peptides as templates in drug design
Northfield, Susan E., Wang, Conan K., Schroeder, Christina I., Durek, Thomas, Kan, Meng-Wei, Swedberg, Joakim E. and Craik, David J. (2014). Disulfide-rich macrocyclic peptides as templates in drug design. European Journal of Medicinal Chemistry, 77 (2), 248-257. doi: 10.1016/j.ejmech.2014.03.011
2014
Journal Article
The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif
Conibear, Anne C., Bochen, Alexander, Rosengren, K. Johan, Stupar, Petar, Wang, Conan, Kessler, Horst and Craik, David J. (2014). The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif. ChemBioChem, 15 (3), 451-459. doi: 10.1002/cbic.201300568
2014
Journal Article
Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis
Wang, Conan K., Gruber, Christian W., Cemazar, Masa, Siatskas, Christopher, Tagore, Prascilla, Payne, Natalie, Sun, Guizhi, Wang, Shunhe, Bernard, Claude C. and Craik, David J. (2014). Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis. ACS Chemical Biology, 9 (1), 156-163. doi: 10.1021/cb400548s
2013
Conference Publication
Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis
Wang, C. K., Gruber, C. W., Cernazar, M., Siatskas, C., Tagore, P., Sun, G., Wang, S., Bernard, C. and Craik, D. J. (2013). Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis. 23rd American Peptide Symposium, Waikoloa, Hawaii, 22-27 June 2013 . Hoboken, NJ, United States : John Wiley & Sons.
2012
Journal Article
Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactions
Wang, Conan K., Wacklin, Hanna P. and Craik, David J. (2012). Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactions. Journal of Biological Chemistry, 287 (52), 43884-43898. doi: 10.1074/jbc.M112.421198
2012
Journal Article
Alpha-1 giardin is an annexin with highly unusual calcium-regulated mechanisms
Weeratunga, Saroja K., Osman, Asiah, Hu, Nien-Jen, Wang, Conan K., Mason, Lyndel, Svard, Staffan, Hope, Greg, Jones, Malcolm K. and Hofmann, Andreas (2012). Alpha-1 giardin is an annexin with highly unusual calcium-regulated mechanisms. Journal of Molecular Biology, 423 (2), 169-181. doi: 10.1016/j.jmb.2012.06.041
2012
Journal Article
Hookworm SCP/TAPS protein structure - A key to understanding host-parasite interactions and developing new interventions
Osman, Asiah, Wang, Conan K., Winter, Anja, Loukas, Alex, Tribolet, Leon, Gasser, Robin B. and Hofmann, Andreas (2012). Hookworm SCP/TAPS protein structure - A key to understanding host-parasite interactions and developing new interventions. Biotechnology Advances, 30 (3), 652-657. doi: 10.1016/j.biotechadv.2011.11.002
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Conan Wang is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Supervision history
Current supervision
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Doctor Philosophy
A new molecular technology platform for design and production of ultra-stable peptides
Principal Advisor
Other advisors: Professor David Craik
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Doctor Philosophy
Design and manufacturing of next-generation ultra-stable peptide radiotracers for precision diagnosis and therapy
Principal Advisor
Other advisors: Dr Yen-Hua Crystal Huang
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Doctor Philosophy
Discovery and Development of Substrate-Based Peptide Kinase Inhibitors
Principal Advisor
Other advisors: Dr Yen-Hua Crystal Huang, Professor David Craik
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Doctor Philosophy
Patient-friendly peptide tracers for improving immunotherapy outcomes
Principal Advisor
Other advisors: Dr Yen-Hua Crystal Huang
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Doctor Philosophy
Accelerating design and optimisation of next-generation ecofriendly insecticides in picolitre bioreactors
Principal Advisor
Other advisors: Professor David Craik, Dr Yen-Hua Crystal Huang
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Doctor Philosophy
Next-generation IL-2 mimics for immunotherapy
Principal Advisor
Other advisors: Professor David Craik, Professor Di Yu
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Doctor Philosophy
Design and optimisation of a novel compound for theranostic use in cancer
Principal Advisor
Other advisors: Professor David Craik, Dr Yen-Hua Crystal Huang
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Doctor Philosophy
Design of orally active cholesterol-lowering peptides
Associate Advisor
Other advisors: Professor David Craik
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Doctor Philosophy
Exploring delivery strategies for cyclotide-based therapeutics
Associate Advisor
Other advisors: Professor David Craik, Dr Yen-Hua Crystal Huang
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Doctor Philosophy
Development of peptide-based inhibitors for crop protection
Associate Advisor
Other advisors: Professor Brett Collins, Professor David Craik
Completed supervision
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2021
Doctor Philosophy
The development of peptide-based cholesterol-lowering therapeutics
Principal Advisor
Other advisors: Professor David Craik
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2026
Doctor Philosophy
Towards population control of a coral reef pest: The crown-of-thorns starfish
Associate Advisor
Other advisors: Professor David Craik, Dr Thomas Durek, Emeritus Professor Linda Lua
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2025
Doctor Philosophy
Selective modification and chemical synthesis of peptides & proteins for drug discovery applications
Associate Advisor
Other advisors: Professor David Craik, Dr Thomas Durek
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2024
Doctor Philosophy
Discovery, production, and development of disulfide-rich peptides for drug design and development
Associate Advisor
Other advisors: Professor David Craik, Dr Thomas Durek
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2023
Doctor Philosophy
Structural Modifications to Optimise the Oxidative Folding and Activity of Cyclotides
Associate Advisor
Other advisors: Dr Simon de Veer, Professor David Craik
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2023
Doctor Philosophy
Characterising the crown-of-thorns starfish secretome to identify factors for future biocontrol systems
Associate Advisor
Other advisors: Professor Sandie Degnan, Professor Bernard Degnan
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2022
Doctor Philosophy
Investigating approaches for the design and delivery of disulfide-rich peptide therapeutics
Associate Advisor
Other advisors: Dr Yen-Hua Crystal Huang, Professor David Craik
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2015
Doctor Philosophy
Structure-activity relationships and development of disulfide-rich cyclic peptides as pharmaceutical templates
Associate Advisor
Other advisors: Professor David Craik
Media
Enquiries
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