Skip to menu Skip to content Skip to footer
Associate Professor Conan Wang
Associate Professor

Conan Wang

Email: 
Phone: 
+61 7 334 62014

Overview

Background

I lead the Technology-Driven Drug Discovery (Tech3D) Group at the Institute for Molecular Bioscience, UQ. We believe that the key to solving some of our world's biggest challenges, whether that be in medicine or agriculture, relies on the ability to precision engineer molecules at will. My group harnesses three technological pillars to engineer peptides and proteins, which are computational biology, molecular libraries, and nanotechnology. We aspire to design better drugs, creating next generation biotechnological agents that have real impact. These could be new cancer drugs that harness the body's immune system or new insecticides that are environmentally friendly. In these pursuits, we value advancement, fun, balance, respect, fairness, and integrity.

I have been involved in peptide and protein research for over two decades, and am highly experienced in bioinformatics, chemistry, structural characterization, biophysics, and biochemistry. I trained with experts in peptide and protein characterization: an Honours project with Professor Garry King at the University of New South Wales, Sydney, Australia (2004), an APA scholarship with Professor David Craik at the University of Queensland Institute for Molecular Bioscience, Brisbane, Australia (2005-2009) and a NHMRC fellowship with Professor Mingjie Zhang at the Hong Kong University of Science and Technology, Hong Kong, China (2009-2011) and A/Professor Andreas Hofmann at Griffith University Eskitis Institute, Brisbane, Australia (2011-2012). I returned to the University of Queensland in 2012 to join an industry partnership funded by an ARC linkage grant. I currently hold an ARC Future Fellowship and am responsible for a team of research officers, assistants and postgraduate students.

My research output has been recognised by >30 prizes and awards for leadership, research translation and fundamental research excellence, as well as numerous invitations to speak at academic and pharmaceutical conferences. I have over 100 publications and have been cited by researchers from across the world.

Availability

Associate Professor Conan Wang is:
Available for supervision

Qualifications

  • Bachelor of Engineering, University of New South Wales
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Computational design of targeted cancer therapeutics guided by machine learning

    The right treatment depends on the right diagnosis. This project aims to engineer advanced agents capable of precisely locating and “painting” every cancer cell in the body, enabling clinicians to detect and treat tumours with unprecedented resolution. The candidate will gain expertise in drug discovery through computational biology and molecular biology. If you’re interested in learning more about drug design or exploring potential projects, please feel free to reach out.

  • Efficient design of drugs using new nanoscale technologies

    Powerful technologies have emerged to perform millions of experiments quickly in tiny nanolitre droplets, and have attracted wide interest from major pharmaceutical companies because of the potential to accelerate drug discovery. Research project opportunities are available to investigate these next-generation tools for drug design and learn new skills in one or more areas of nanotechnology and molecular biology.

  • Designing protein drugs for the treatment of drug-resistant cancers

    Targeted therapies against kinases are frontline treatments for many cancers. However, drug resistance often emerges within months of initiating therapy. This project aims to develop resilient kinase-targeted drugs with novel mechanisms of action that disrupt growth-promoting signals in cancer cells while reducing the likelihood of resistance. These agents have the potential to more effectively halt cancer progression. Candidates will learn new skills in drug design and characterisation using tools in molecular biology, biochemistry, and structural biology.

Works

Search Professor Conan Wang’s works on UQ eSpace

131 works between 2006 and 2026

101 - 120 of 131 works

2012

Journal Article

SBAL: A practical tool to generate and edit structure-based amino acid sequence alignments

Wang, Conan K., Broder, Ursula, Weeratunga, Saroja K., Gasser, Robin B., Loukas, Alex and Hofmann, Andreas (2012). SBAL: A practical tool to generate and edit structure-based amino acid sequence alignments. Bioinformatics, 28 (7) bts035, 1026-1027. doi: 10.1093/bioinformatics/bts035

SBAL: A practical tool to generate and edit structure-based amino acid sequence alignments

2012

Journal Article

Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration

Xavier, Charles-Peter, Rastetter, Raphael H., Blomacher, Margit, Stumpf, Maria, Himmel, Mirko, Morgan, Reginald O., Fernandez, Maria-Pilar, Wang, Conan, Osman, Asiah, Miyata, Yoshihiko, Gjerset, Ruth A., Eichinger, Ludwig, Hofmann, Andreas, Linder, Stefan, Noegel, Angelika A. and Clemen, Christoph S. (2012). Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration. Scientific Reports, 2 (1) 241. doi: 10.1038/srep00241

Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration

2012

Book Chapter

Cyclotide isolation and characterization

Craik, David J., Henriques, Sonia Troeira, Mylne, Joshua S. and Wang, Conan K. (2012). Cyclotide isolation and characterization. Natural product biosynthesis by microorganisms and plants, part B. (pp. 37-62) edited by David A. Hopwood. Burlington, USA: Elsevier. doi: 10.1016/B978-0-12-394291-3.00024-1

Cyclotide isolation and characterization

2011

Journal Article

DMAN: a java tool for analysis of multi-well differential scanning fluorimetry experiments

Wang, Conan K., Weeratunga, Saroja K., Pacheco, Chris M. and Hofmann, Andreas (2011). DMAN: a java tool for analysis of multi-well differential scanning fluorimetry experiments. Bioinformatics, 28 (3) btr664, 439-440. doi: 10.1093/bioinformatics/btr664

DMAN: a java tool for analysis of multi-well differential scanning fluorimetry experiments

2011

Journal Article

Promiscuity of carbonic anhydrase II: Unexpected ester hydrolysis of carbohydrate-based sulfamate inhibitors

Lopez, Marie, Vu. Hoan, Wang, Conan K., Wolf, Maarten G., Groenhof, Gerrit, Innocentis, Alessio, Supuran, Claudiu T. and Poulsen, Sally-Ann (2011). Promiscuity of carbonic anhydrase II: Unexpected ester hydrolysis of carbohydrate-based sulfamate inhibitors. Journal of The American Chemical Society, 133 (45), 18452-18462. doi: 10.1021/ja207855c

Promiscuity of carbonic anhydrase II: Unexpected ester hydrolysis of carbohydrate-based sulfamate inhibitors

2011

Journal Article

Divalent cations and Redox conditions regulate the molecular structure and function of visinin-like protein-1

Wang, Conan K., Simon, Anne, Jessen, Christian M., Oliveira, Cristiano L. P., Mack, Lynsey, Braunewell, Karl-Heinz, Ames, James B., Pedersen, Jan Skov and Hofmann, Andreas (2011). Divalent cations and Redox conditions regulate the molecular structure and function of visinin-like protein-1. PLoS One, 6 (11) e26793, e26793.1-e26793.10. doi: 10.1371/journal.pone.0026793

Divalent cations and Redox conditions regulate the molecular structure and function of visinin-like protein-1

2011

Journal Article

Insights into the membrane interactions of the saposin-like proteins Na-SLP-1 and Ac-SLP-1 from human and dog hookworm

Willis, Charlene, Wang, Conan K., Osman, Asiah, Simon, Anne, Pickering, Darren, Mulvenna, Jason, Riboldi-Tunicliffe, Alan, Jones, Malcolm K., Loukas, Alex and Hofmann, Andreas (2011). Insights into the membrane interactions of the saposin-like proteins Na-SLP-1 and Ac-SLP-1 from human and dog hookworm. PLoS One, 6 (10) e25369, e25369.1-e25369.10. doi: 10.1371/journal.pone.0025369

Insights into the membrane interactions of the saposin-like proteins Na-SLP-1 and Ac-SLP-1 from human and dog hookworm

2011

Journal Article

The role of conserved Glu residue on cyclotide stability and activity: A structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant

Wang, Conan K. L., Clark, Richard J., Harvey, Peta J., Rosengren, K. Johan, Cemazar, Masa and Craik, David J. (2011). The role of conserved Glu residue on cyclotide stability and activity: A structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant. Biochemistry, 50 (19), 4077-4086. doi: 10.1021/bi2004153

The role of conserved Glu residue on cyclotide stability and activity: A structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant

2011

Journal Article

Atypical (RIO) protein kinases from Haemonchus contortus-promise as new targets for nematocidal drugs

Campbell, Bronwyn E., Boag, Peter R., Hofmann, Andreas, Cantacessi, Cinzia, Wang, Conan K., Taylor, Paul, Hu, Min, Sindhu, Zia-ud-Din, Loukas, Alex, Sternberg, Paul W. and Gasser, Robin B. (2011). Atypical (RIO) protein kinases from Haemonchus contortus-promise as new targets for nematocidal drugs. Biotechnology Advances, 29 (3), 338-350. doi: 10.1016/j.biotechadv.2011.01.006

Atypical (RIO) protein kinases from Haemonchus contortus-promise as new targets for nematocidal drugs

2010

Journal Article

Isolation and characterization of Bioactive Cyclotides from Viola labrilorica

Tang, Jun, Wang, Conan K., Pan, Xulin, Yan, He, Zeng, Guangzhi, Xu, Wenyan, He, Wenjun, Daly, Norelle L., Craik, David J. and Tan, Ninghua (2010). Isolation and characterization of Bioactive Cyclotides from Viola labrilorica. Helvetica Chimica Acta, 93 (11), 2287-2295. doi: 10.1002/hlca.201000115

Isolation and characterization of Bioactive Cyclotides from Viola labrilorica

2010

Journal Article

Merging structural biology with chemical biology: Structural Chemistry at Eskitis

Hofmann, Andreas, Wang, Con, Osman, Asiah and Camp, David (2010). Merging structural biology with chemical biology: Structural Chemistry at Eskitis. Structural Chemistry, 21 (5), 1117-1129. doi: 10.1007/s11224-010-9654-2

Merging structural biology with chemical biology: Structural Chemistry at Eskitis

2010

Journal Article

Extensions of PDZ domains as important structural and functional elements

Wang, Conan K., Pan, Lifeng, Chen, Jia and Zhang, Mingjie (2010). Extensions of PDZ domains as important structural and functional elements. Protein & Cell, 1 (8), 737-751. doi: 10.1007/s13238-010-0099-6

Extensions of PDZ domains as important structural and functional elements

2010

Journal Article

Isolation and characterization of cytotoxic cyclotides from Viola tricolor

Tang, Jun, Wang, Conan K., Pan, Xulin, Yan, He, Zeng, Guangzhi, Xu, Wenyan, He, Wenjun, Daly, Norelle L., Craik, David J. and Tan, Ninghua (2010). Isolation and characterization of cytotoxic cyclotides from Viola tricolor. Peptides, 31 (8), 1434-1440. doi: 10.1016/j.peptides.2010.05.004

Isolation and characterization of cytotoxic cyclotides from Viola tricolor

2010

Journal Article

Cyclotides are a component of the innate defense of Oldenlandia affinis

Mylne, Joshua S, Wang, Conan K, van der Weerden, Nicole L and Craik, David J (2010). Cyclotides are a component of the innate defense of Oldenlandia affinis. Biopolymers, 94 (5), 635-646. doi: 10.1002/bip.21419

Cyclotides are a component of the innate defense of Oldenlandia affinis

2010

Conference Publication

Cyclotides are a component of the innate defense of Oldenlandia affinis

Mylne, Joshua S., Wang, Conan K., van der Weerden, Nicole L. and Craik, David J. (2010). Cyclotides are a component of the innate defense of Oldenlandia affinis. 1st International Conference on Circular Proteins, Heron Island, Qld, Australia, 18-21 October, 2009. Hoboken, NJ, United States: Wiley. doi: 10.1002/bip.21419

Cyclotides are a component of the innate defense of Oldenlandia affinis

2010

Book Chapter

Membrane binding of cyclotides

Wang, Conan K., Huang, Yen-Hua, Greenwood, Kathryn and Craik, David J. (2010). Membrane binding of cyclotides. Membrane-active peptides: Methods and results on structure and function. (pp. 597-672) edited by Miguel A.R.B. Castanho. La Jolla, CA, U.S.A.: International University Line.

Membrane binding of cyclotides

2009

Journal Article

Despite a conserved cystine knot motif, different cyclotides have different membrane binding modes

Wang, C. K., Colgrave, M. L., Ireland, D. C., Kaas, Q and Craik, D. J. (2009). Despite a conserved cystine knot motif, different cyclotides have different membrane binding modes. Biophysical Journal, 97 (5), 1471-1481. doi: 10.1016/j.bpj.2009.06.032

Despite a conserved cystine knot motif, different cyclotides have different membrane binding modes

2009

Journal Article

Isolation and characterization of peptides from momordica cochinchinensis seeds

Chan, L. Y., Wang, C. K., Major, J. M., Greenwood, K. P., Lewis, R. J., Craik, D. J. and Daly, N. L. (2009). Isolation and characterization of peptides from momordica cochinchinensis seeds. JOURNAL OF NATURAL PRODUCTS, 72 (8), 1453-1458. doi: 10.1021/np900174n

Isolation and characterization of peptides from momordica cochinchinensis seeds

2009

Journal Article

Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold

Wang, C. K., Hu, S. H., Martin, J. L., Sjogren, T, Hajdu, J, Bohlin, L, Claeson, P, Goransson, U, Rosengren, K. J., Tang, J, Tan, N. H. and Craik, D. J. (2009). Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. Journal of Biological Chemistry, 284 (16), 10672-10683. doi: 10.1074/jbc.M900021200

Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold

2008

Journal Article

NMRDyn: a program for NMR relaxation studies of protein association

Wang, Conan K., Schirra, Horst Joachim and Craik, David J. (2008). NMRDyn: a program for NMR relaxation studies of protein association. PLoS One, 3 (11) e3820, e3820-1-e3820-7. doi: 10.1371/journal.pone.0003820

NMRDyn: a program for NMR relaxation studies of protein association

Funding

Current funding

  • 2026 - 2028
    All-in-one: enhancing multidimensional vaccine protection through a novel IL-21 agonistic antibody
    UQ - Sanofi Translational Science Hub Partnership Scheme
    Open grant
  • 2025 - 2028
    Robotics & automation for plant-based production of pharmaceutical peptides
    ARC Linkage Projects
    Open grant
  • 2025 - 2028
    Disruptive technologies for targeting tyrosine kinase substrate sites
    NHMRC IDEAS Grants
    Open grant
  • 2025 - 2028
    Unleashing the biocontrol potential of venom peptides with cyclotides
    ARC Linkage Projects
    Open grant
  • 2025 - 2028
    A molecular platform for design and production of next-generation peptides
    ARC Linkage Projects
    Open grant
  • 2024 - 2026
    Developing novel peptide tracers for improving immunotherapy outcomes
    NHMRC Development Grant
    Open grant
  • 2023 - 2026
    A peptide platform to fight pests threatening global food security
    ARC Discovery Projects
    Open grant
  • 2023 - 2028
    ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals
    ARC Industrial Transformation Research Hubs
    Open grant
  • 2023 - 2027
    Peptides and Proteins for Fighting Pests and Protecting the Environment
    ARC Future Fellowships
    Open grant
  • 2020 - 2026
    Crown-of-Thorns Starfish Control Innovation Program
    Great Barrier Reef Foundation
    Open grant

Past funding

  • 2025 - 2026
    A Facility for Accelerated Microbial Phenotyping in Southeast Queensland
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2018 - 2022
    Biocontrol of crown-of-thorns starfish using genomics and proteomics
    ARC Linkage Projects
    Open grant
  • 2016 - 2018
    New drug leads for cholesterol
    NHMRC Project Grant
    Open grant
  • 2014
    Bioengineering stable peptide inhibitors of amyloidosis
    UQ Early Career Researcher
    Open grant
  • 2012 - 2013
    NHMRC Australia-China Exchange Fellowship: Improving the bioavailability of peptide-based therapeutics for the treatment of Multiple Sclerosis
    NHMRC Training (Postdoctoral) Fellowship
    Open grant

Supervision

Availability

Associate Professor Conan Wang is:
Available for supervision

Looking for a supervisor? Read our advice on how to choose a supervisor.

Supervision history

Current supervision

Completed supervision

Media

Enquiries

For media enquiries about Associate Professor Conan Wang's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au