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Dr Conan Wang
Dr

Conan Wang

Email: 
Phone: 
+61 7 334 62014

Overview

Background

I lead the Technology-Driven Drug Discovery (Tech3D) Group at the Institute for Molecular Bioscience, UQ. We believe that the key to solving some of our world's biggest challenges, whether that be in medicine or agriculture, relies on the ability to precision engineer molecules at will. My group harnesses three technological pillars to engineer peptides and proteins, which are computational biology, molecular libraries, and nanotechnology. We aspire to design better drugs, creating next generation biotechnological agents that have real impact. These could be new cancer drugs that harness the body's immune system or new insecticides that are environmentally friendly. In these pursuits, we value advancement, fun, balance, respect, fairness, and integrity.

I have been involved in peptide and protein research for over two decades, and am highly experienced in bioinformatics, chemistry, structural characterization, biophysics, and biochemistry. I trained with experts in peptide and protein characterization: an Honours project with Professor Garry King at the University of New South Wales, Sydney, Australia (2004), an APA scholarship with Professor David Craik at the University of Queensland Institute for Molecular Bioscience, Brisbane, Australia (2005-2009) and a NHMRC fellowship with Professor Mingjie Zhang at the Hong Kong University of Science and Technology, Hong Kong, China (2009-2011) and A/Professor Andreas Hofmann at Griffith University Eskitis Institute, Brisbane, Australia (2011-2012). I returned to the University of Queensland in 2012 to join an industry partnership funded by an ARC linkage grant. I currently hold an ARC Future Fellowship and am responsible for a team of research officers, assistants and postgraduate students.

My research output has been recognised by >30 prizes and awards for leadership, research translation and fundamental research excellence, as well as numerous invitations to speak at academic and pharmaceutical conferences. I have over 100 publications and have been cited by researchers from across the world.

Availability

Dr Conan Wang is:
Available for supervision

Qualifications

  • Bachelor of Engineering, University of New South Wales
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Drug Discovery and Protein/Peptide Engineeering

    My group uses: 1) computational algorithms to predict drug properties with unprecedented accuracy; 2) molecular libraries capable of screening through billions of drug leads to design drugs efficiently; and 3) nano-sized reaction droplets to capture drug activity to make drugs that actually work.

  • Cancer Therapeutics

    My group is interested in developing new cancer therapeutics, particularly those that modulate the immune system or relevant to lung cancer.

Works

Search Professor Conan Wang’s works on UQ eSpace

117 works between 2006 and 2024

101 - 117 of 117 works

2010

Book Chapter

Membrane binding of cyclotides

Wang, Conan K., Huang, Yen-Hua, Greenwood, Kathryn and Craik, David J. (2010). Membrane binding of cyclotides. Membrane-active peptides: Methods and results on structure and function. (pp. 597-672) edited by Miguel A.R.B. Castanho. La Jolla, CA, U.S.A.: International University Line.

Membrane binding of cyclotides

2010

Journal Article

Cyclotides are a component of the innate defense of Oldenlandia affinis

Mylne, Joshua S, Wang, Conan K, van der Weerden, Nicole L and Craik, David J (2010). Cyclotides are a component of the innate defense of Oldenlandia affinis. Biopolymers, 94 (5), 635-646. doi: 10.1002/bip.21419

Cyclotides are a component of the innate defense of Oldenlandia affinis

2009

Journal Article

Despite a conserved cystine knot motif, different cyclotides have different membrane binding modes

Wang, C. K., Colgrave, M. L., Ireland, D. C., Kaas, Q and Craik, D. J. (2009). Despite a conserved cystine knot motif, different cyclotides have different membrane binding modes. Biophysical Journal, 97 (5), 1471-1481. doi: 10.1016/j.bpj.2009.06.032

Despite a conserved cystine knot motif, different cyclotides have different membrane binding modes

2009

Journal Article

Isolation and characterization of peptides from momordica cochinchinensis seeds

Chan, L. Y., Wang, C. K., Major, J. M., Greenwood, K. P., Lewis, R. J., Craik, D. J. and Daly, N. L. (2009). Isolation and characterization of peptides from momordica cochinchinensis seeds. JOURNAL OF NATURAL PRODUCTS, 72 (8), 1453-1458. doi: 10.1021/np900174n

Isolation and characterization of peptides from momordica cochinchinensis seeds

2009

Journal Article

Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold

Wang, C. K., Hu, S. H., Martin, J. L., Sjogren, T, Hajdu, J, Bohlin, L, Claeson, P, Goransson, U, Rosengren, K. J., Tang, J, Tan, N. H. and Craik, D. J. (2009). Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. Journal of Biological Chemistry, 284 (16), 10672-10683. doi: 10.1074/jbc.M900021200

Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold

2008

Journal Article

NMRDyn: a program for NMR relaxation studies of protein association

Wang, Conan K., Schirra, Horst Joachim and Craik, David J. (2008). NMRDyn: a program for NMR relaxation studies of protein association. PLoS One, 3 (11) e3820, e3820-1-e3820-7. doi: 10.1371/journal.pone.0003820

NMRDyn: a program for NMR relaxation studies of protein association

2008

Journal Article

CyBase: a database of cyclic protein sequences and structures, with application in protein discovery and engineering

Wang, C. K., Kaas, Q., Chiche, L. and Craik, D. J. (2008). CyBase: a database of cyclic protein sequences and structures, with application in protein discovery and engineering. Nucleic Acids Research, 36 (SUPPL. 1), D206-D210. doi: 10.1093/nar/gkm953

CyBase: a database of cyclic protein sequences and structures, with application in protein discovery and engineering

2008

Journal Article

Distribution and evolution of circular miniproteins in flowering plants

Gruber, Christian W., Elliott, Alysha G., Ireland, David C., Delprete, Piero G., Dessein, Steven, Goransson, Ulf, Trabi, Manuela, Wang, Conan K., Kinghorn, Andrew B., Robbrecht, Elmar and Craik, David J. (2008). Distribution and evolution of circular miniproteins in flowering plants. The Plant Cell, 20 (9), 2471-2483. doi: 10.1105/tpc.108.062331

Distribution and evolution of circular miniproteins in flowering plants

2008

Journal Article

The anthelmintic activity of the cyclotides: Natural variants with enhanced activity

Colgrave, Michelle L., Kotze, Andrew C., Ireland, David C., Wang, Conan K. and Craik, David J. (2008). The anthelmintic activity of the cyclotides: Natural variants with enhanced activity. ChemBioChem, 9 (12), 1939-1945. doi: 10.1002/cbic.200800174

The anthelmintic activity of the cyclotides: Natural variants with enhanced activity

2008

Other Outputs

Structural and functional studies of cyclotides

Wang, Conan (2008). Structural and functional studies of cyclotides. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/174289

Structural and functional studies of cyclotides

2008

Journal Article

Alanine Scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity

Simonsen, S. M., Sando, L., Rosengren, K. J., Wang, C. K., Colgrave, M. L., Daly, N. L. and Craik, D. J. (2008). Alanine Scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity. Journal of Biological Chemistry, 283 (15), 9805-9813. doi: 10.1074/jbc.M709303200

Alanine Scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity

2008

Journal Article

ConoServer, a database for conopeptide sequences and structures

Kaas, Quentin, Westermann, Jan, Halai, Reena, Wang, Conan and Craik, David J. (2008). ConoServer, a database for conopeptide sequences and structures. Bioinformatics, 24 (3), 445-446. doi: 10.1093/bioinformatics/btm596

ConoServer, a database for conopeptide sequences and structures

2008

Journal Article

Anti-HIV Cyclotides from the Chinese Medicinal Herb Viola yedonensis

Wang, Conan K. L., Colgrave, Michelle L., Gustafson, Kirk R., Ireland, David C., Goransson, Ulf and Craik, David J. (2008). Anti-HIV Cyclotides from the Chinese Medicinal Herb Viola yedonensis. Journal of Natural Products, 71 (1), 47-52. doi: 10.1021/np070393g

Anti-HIV Cyclotides from the Chinese Medicinal Herb Viola yedonensis

2008

Journal Article

Cyclotides as natural anti-HIV agents

Ireland, David C., Wang, Conan K., Wilson, Jennifer A., Gustafson, Kirk R. and Craik, David J. (2008). Cyclotides as natural anti-HIV agents. Biopolymers: Peptide Science, 90 (1), 51-60. doi: 10.1002/bip.20886

Cyclotides as natural anti-HIV agents

2006

Journal Article

CyBase: a database of cyclic protein sequence and structure

Mulvenna, J. P., Wang, C. and Craik, D. J. (2006). CyBase: a database of cyclic protein sequence and structure. Nucleic Acids Research, 34 (Sp. Iss. SI), D192-D194. doi: 10.1093/nar/gkj005

CyBase: a database of cyclic protein sequence and structure

2006

Journal Article

The cyclotide family of circular miniproteins: Nature's combinatorial peptide template

Craik, D. J., Cemazar, M., Wang, C. K. L. and Daly, N. L. (2006). The cyclotide family of circular miniproteins: Nature's combinatorial peptide template. Biopolymers, 84 (3), 250-266. doi: 10.1002/hip.20451

The cyclotide family of circular miniproteins: Nature's combinatorial peptide template

2006

Journal Article

Cycloviolacin H4, a hydrophobic cyclotide from Viola hederaceae

Chen, B., Colgrave, M. L., Wang, C. N. and Craik, D. J. (2006). Cycloviolacin H4, a hydrophobic cyclotide from Viola hederaceae. Journal of Natural Products, 69 (1), 23-28. doi: 10.1021/np050317i

Cycloviolacin H4, a hydrophobic cyclotide from Viola hederaceae

Funding

Current funding

  • 2024 - 2026
    Developing novel peptide tracers for improving immunotherapy outcomes
    NHMRC Development Grant
    Open grant
  • 2023 - 2026
    A peptide platform to fight pests threatening global food security
    ARC Discovery Projects
    Open grant
  • 2023 - 2028
    ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals
    ARC Industrial Transformation Research Hubs
    Open grant
  • 2023 - 2027
    Peptides and Proteins for Fighting Pests and Protecting the Environment
    ARC Future Fellowships
    Open grant
  • 2020 - 2025
    Crown-of-Thorns Starfish Control Innovation Program
    Great Barrier Reef Foundation
    Open grant

Past funding

  • 2018 - 2022
    Biocontrol of crown-of-thorns starfish using genomics and proteomics
    ARC Linkage Projects
    Open grant
  • 2016 - 2018
    New drug leads for cholesterol
    NHMRC Project Grant
    Open grant
  • 2014
    Bioengineering stable peptide inhibitors of amyloidosis
    UQ Early Career Researcher
    Open grant
  • 2012 - 2013
    NHMRC Australia-China Exchange Fellowship: Improving the bioavailability of peptide-based therapeutics for the treatment of Multiple Sclerosis
    NHMRC Training (Postdoctoral) Fellowship
    Open grant

Supervision

Availability

Dr Conan Wang is:
Available for supervision

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Available projects

Supervision history

Current supervision

Completed supervision

Media

Enquiries

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