Overview
Background
I lead the Technology-Driven Drug Discovery (Tech3D) Group at the Institute for Molecular Bioscience, UQ. We believe that the key to solving some of our world's biggest challenges, whether that be in medicine or agriculture, relies on the ability to precision engineer molecules at will. My group harnesses three technological pillars to engineer peptides and proteins, which are computational biology, molecular libraries, and nanotechnology. We aspire to design better drugs, creating next generation biotechnological agents that have real impact. These could be new cancer drugs that harness the body's immune system or new insecticides that are environmentally friendly. In these pursuits, we value advancement, fun, balance, respect, fairness, and integrity.
I have been involved in peptide and protein research for over two decades, and am highly experienced in bioinformatics, chemistry, structural characterization, biophysics, and biochemistry. I trained with experts in peptide and protein characterization: an Honours project with Professor Garry King at the University of New South Wales, Sydney, Australia (2004), an APA scholarship with Professor David Craik at the University of Queensland Institute for Molecular Bioscience, Brisbane, Australia (2005-2009) and a NHMRC fellowship with Professor Mingjie Zhang at the Hong Kong University of Science and Technology, Hong Kong, China (2009-2011) and A/Professor Andreas Hofmann at Griffith University Eskitis Institute, Brisbane, Australia (2011-2012). I returned to the University of Queensland in 2012 to join an industry partnership funded by an ARC linkage grant. I currently hold an ARC Future Fellowship and am responsible for a team of research officers, assistants and postgraduate students.
My research output has been recognised by >30 prizes and awards for leadership, research translation and fundamental research excellence, as well as numerous invitations to speak at academic and pharmaceutical conferences. I have over 100 publications and have been cited by researchers from across the world.
Availability
- Associate Professor Conan Wang is:
- Available for supervision
Qualifications
- Bachelor of Engineering, University of New South Wales
- Doctor of Philosophy, The University of Queensland
Research interests
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Computational design of targeted cancer therapeutics guided by machine learning
The right treatment depends on the right diagnosis. This project aims to engineer advanced agents capable of precisely locating and “painting” every cancer cell in the body, enabling clinicians to detect and treat tumours with unprecedented resolution. The candidate will gain expertise in drug discovery through computational biology and molecular biology. If you’re interested in learning more about drug design or exploring potential projects, please feel free to reach out.
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Efficient design of drugs using new nanoscale technologies
Powerful technologies have emerged to perform millions of experiments quickly in tiny nanolitre droplets, and have attracted wide interest from major pharmaceutical companies because of the potential to accelerate drug discovery. Research project opportunities are available to investigate these next-generation tools for drug design and learn new skills in one or more areas of nanotechnology and molecular biology.
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Designing protein drugs for the treatment of drug-resistant cancers
Targeted therapies against kinases are frontline treatments for many cancers. However, drug resistance often emerges within months of initiating therapy. This project aims to develop resilient kinase-targeted drugs with novel mechanisms of action that disrupt growth-promoting signals in cancer cells while reducing the likelihood of resistance. These agents have the potential to more effectively halt cancer progression. Candidates will learn new skills in drug design and characterisation using tools in molecular biology, biochemistry, and structural biology.
Works
Search Professor Conan Wang’s works on UQ eSpace
2012
Journal Article
SBAL: A practical tool to generate and edit structure-based amino acid sequence alignments
Wang, Conan K., Broder, Ursula, Weeratunga, Saroja K., Gasser, Robin B., Loukas, Alex and Hofmann, Andreas (2012). SBAL: A practical tool to generate and edit structure-based amino acid sequence alignments. Bioinformatics, 28 (7) bts035, 1026-1027. doi: 10.1093/bioinformatics/bts035
2012
Journal Article
Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration
Xavier, Charles-Peter, Rastetter, Raphael H., Blomacher, Margit, Stumpf, Maria, Himmel, Mirko, Morgan, Reginald O., Fernandez, Maria-Pilar, Wang, Conan, Osman, Asiah, Miyata, Yoshihiko, Gjerset, Ruth A., Eichinger, Ludwig, Hofmann, Andreas, Linder, Stefan, Noegel, Angelika A. and Clemen, Christoph S. (2012). Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration. Scientific Reports, 2 (1) 241. doi: 10.1038/srep00241
2012
Book Chapter
Cyclotide isolation and characterization
Craik, David J., Henriques, Sonia Troeira, Mylne, Joshua S. and Wang, Conan K. (2012). Cyclotide isolation and characterization. Natural product biosynthesis by microorganisms and plants, part B. (pp. 37-62) edited by David A. Hopwood. Burlington, USA: Elsevier. doi: 10.1016/B978-0-12-394291-3.00024-1
2011
Journal Article
DMAN: a java tool for analysis of multi-well differential scanning fluorimetry experiments
Wang, Conan K., Weeratunga, Saroja K., Pacheco, Chris M. and Hofmann, Andreas (2011). DMAN: a java tool for analysis of multi-well differential scanning fluorimetry experiments. Bioinformatics, 28 (3) btr664, 439-440. doi: 10.1093/bioinformatics/btr664
2011
Journal Article
Promiscuity of carbonic anhydrase II: Unexpected ester hydrolysis of carbohydrate-based sulfamate inhibitors
Lopez, Marie, Vu. Hoan, Wang, Conan K., Wolf, Maarten G., Groenhof, Gerrit, Innocentis, Alessio, Supuran, Claudiu T. and Poulsen, Sally-Ann (2011). Promiscuity of carbonic anhydrase II: Unexpected ester hydrolysis of carbohydrate-based sulfamate inhibitors. Journal of The American Chemical Society, 133 (45), 18452-18462. doi: 10.1021/ja207855c
2011
Journal Article
Divalent cations and Redox conditions regulate the molecular structure and function of visinin-like protein-1
Wang, Conan K., Simon, Anne, Jessen, Christian M., Oliveira, Cristiano L. P., Mack, Lynsey, Braunewell, Karl-Heinz, Ames, James B., Pedersen, Jan Skov and Hofmann, Andreas (2011). Divalent cations and Redox conditions regulate the molecular structure and function of visinin-like protein-1. PLoS One, 6 (11) e26793, e26793.1-e26793.10. doi: 10.1371/journal.pone.0026793
2011
Journal Article
Insights into the membrane interactions of the saposin-like proteins Na-SLP-1 and Ac-SLP-1 from human and dog hookworm
Willis, Charlene, Wang, Conan K., Osman, Asiah, Simon, Anne, Pickering, Darren, Mulvenna, Jason, Riboldi-Tunicliffe, Alan, Jones, Malcolm K., Loukas, Alex and Hofmann, Andreas (2011). Insights into the membrane interactions of the saposin-like proteins Na-SLP-1 and Ac-SLP-1 from human and dog hookworm. PLoS One, 6 (10) e25369, e25369.1-e25369.10. doi: 10.1371/journal.pone.0025369
2011
Journal Article
The role of conserved Glu residue on cyclotide stability and activity: A structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant
Wang, Conan K. L., Clark, Richard J., Harvey, Peta J., Rosengren, K. Johan, Cemazar, Masa and Craik, David J. (2011). The role of conserved Glu residue on cyclotide stability and activity: A structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant. Biochemistry, 50 (19), 4077-4086. doi: 10.1021/bi2004153
2011
Journal Article
Atypical (RIO) protein kinases from Haemonchus contortus-promise as new targets for nematocidal drugs
Campbell, Bronwyn E., Boag, Peter R., Hofmann, Andreas, Cantacessi, Cinzia, Wang, Conan K., Taylor, Paul, Hu, Min, Sindhu, Zia-ud-Din, Loukas, Alex, Sternberg, Paul W. and Gasser, Robin B. (2011). Atypical (RIO) protein kinases from Haemonchus contortus-promise as new targets for nematocidal drugs. Biotechnology Advances, 29 (3), 338-350. doi: 10.1016/j.biotechadv.2011.01.006
2010
Journal Article
Isolation and characterization of Bioactive Cyclotides from Viola labrilorica
Tang, Jun, Wang, Conan K., Pan, Xulin, Yan, He, Zeng, Guangzhi, Xu, Wenyan, He, Wenjun, Daly, Norelle L., Craik, David J. and Tan, Ninghua (2010). Isolation and characterization of Bioactive Cyclotides from Viola labrilorica. Helvetica Chimica Acta, 93 (11), 2287-2295. doi: 10.1002/hlca.201000115
2010
Journal Article
Merging structural biology with chemical biology: Structural Chemistry at Eskitis
Hofmann, Andreas, Wang, Con, Osman, Asiah and Camp, David (2010). Merging structural biology with chemical biology: Structural Chemistry at Eskitis. Structural Chemistry, 21 (5), 1117-1129. doi: 10.1007/s11224-010-9654-2
2010
Journal Article
Extensions of PDZ domains as important structural and functional elements
Wang, Conan K., Pan, Lifeng, Chen, Jia and Zhang, Mingjie (2010). Extensions of PDZ domains as important structural and functional elements. Protein & Cell, 1 (8), 737-751. doi: 10.1007/s13238-010-0099-6
2010
Journal Article
Isolation and characterization of cytotoxic cyclotides from Viola tricolor
Tang, Jun, Wang, Conan K., Pan, Xulin, Yan, He, Zeng, Guangzhi, Xu, Wenyan, He, Wenjun, Daly, Norelle L., Craik, David J. and Tan, Ninghua (2010). Isolation and characterization of cytotoxic cyclotides from Viola tricolor. Peptides, 31 (8), 1434-1440. doi: 10.1016/j.peptides.2010.05.004
2010
Journal Article
Cyclotides are a component of the innate defense of Oldenlandia affinis
Mylne, Joshua S, Wang, Conan K, van der Weerden, Nicole L and Craik, David J (2010). Cyclotides are a component of the innate defense of Oldenlandia affinis. Biopolymers, 94 (5), 635-646. doi: 10.1002/bip.21419
2010
Conference Publication
Cyclotides are a component of the innate defense of Oldenlandia affinis
Mylne, Joshua S., Wang, Conan K., van der Weerden, Nicole L. and Craik, David J. (2010). Cyclotides are a component of the innate defense of Oldenlandia affinis. 1st International Conference on Circular Proteins, Heron Island, Qld, Australia, 18-21 October, 2009. Hoboken, NJ, United States: Wiley. doi: 10.1002/bip.21419
2010
Book Chapter
Membrane binding of cyclotides
Wang, Conan K., Huang, Yen-Hua, Greenwood, Kathryn and Craik, David J. (2010). Membrane binding of cyclotides. Membrane-active peptides: Methods and results on structure and function. (pp. 597-672) edited by Miguel A.R.B. Castanho. La Jolla, CA, U.S.A.: International University Line.
2009
Journal Article
Despite a conserved cystine knot motif, different cyclotides have different membrane binding modes
Wang, C. K., Colgrave, M. L., Ireland, D. C., Kaas, Q and Craik, D. J. (2009). Despite a conserved cystine knot motif, different cyclotides have different membrane binding modes. Biophysical Journal, 97 (5), 1471-1481. doi: 10.1016/j.bpj.2009.06.032
2009
Journal Article
Isolation and characterization of peptides from momordica cochinchinensis seeds
Chan, L. Y., Wang, C. K., Major, J. M., Greenwood, K. P., Lewis, R. J., Craik, D. J. and Daly, N. L. (2009). Isolation and characterization of peptides from momordica cochinchinensis seeds. JOURNAL OF NATURAL PRODUCTS, 72 (8), 1453-1458. doi: 10.1021/np900174n
2009
Journal Article
Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold
Wang, C. K., Hu, S. H., Martin, J. L., Sjogren, T, Hajdu, J, Bohlin, L, Claeson, P, Goransson, U, Rosengren, K. J., Tang, J, Tan, N. H. and Craik, D. J. (2009). Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. Journal of Biological Chemistry, 284 (16), 10672-10683. doi: 10.1074/jbc.M900021200
2008
Journal Article
NMRDyn: a program for NMR relaxation studies of protein association
Wang, Conan K., Schirra, Horst Joachim and Craik, David J. (2008). NMRDyn: a program for NMR relaxation studies of protein association. PLoS One, 3 (11) e3820, e3820-1-e3820-7. doi: 10.1371/journal.pone.0003820
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Conan Wang is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Supervision history
Current supervision
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Doctor Philosophy
Accelerating design and optimisation of next-generation ecofriendly insecticides in picolitre bioreactors
Principal Advisor
Other advisors: Professor David Craik, Dr Yen-Hua Crystal Huang
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Doctor Philosophy
Next-generation IL-2 mimics for immunotherapy
Principal Advisor
Other advisors: Professor David Craik, Professor Di Yu
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Doctor Philosophy
Design and optimisation of a novel compound for theranostic use in cancer
Principal Advisor
Other advisors: Professor David Craik, Dr Yen-Hua Crystal Huang
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Doctor Philosophy
A new molecular technology platform for design and production of ultra-stable peptides
Principal Advisor
Other advisors: Professor David Craik
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Doctor Philosophy
Design and manufacturing of next-generation ultra-stable peptide radiotracers for precision diagnosis and therapy
Principal Advisor
Other advisors: Dr Yen-Hua Crystal Huang
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Doctor Philosophy
Discovery and Development of Substrate-Based Peptide Kinase Inhibitors
Principal Advisor
Other advisors: Dr Yen-Hua Crystal Huang, Professor David Craik
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Doctor Philosophy
Patient-friendly peptide tracers for improving immunotherapy outcomes
Principal Advisor
Other advisors: Dr Yen-Hua Crystal Huang
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Doctor Philosophy
Design of orally active cholesterol-lowering peptides
Associate Advisor
Other advisors: Professor David Craik
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Doctor Philosophy
Exploring delivery strategies for cyclotide-based therapeutics
Associate Advisor
Other advisors: Professor David Craik, Dr Yen-Hua Crystal Huang
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Doctor Philosophy
Development of peptide-based inhibitors for crop protection
Associate Advisor
Other advisors: Professor Brett Collins, Professor David Craik
Completed supervision
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2021
Doctor Philosophy
The development of peptide-based cholesterol-lowering therapeutics
Principal Advisor
Other advisors: Professor David Craik
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2026
Doctor Philosophy
Towards population control of a coral reef pest: The crown-of-thorns starfish
Associate Advisor
Other advisors: Professor David Craik, Dr Thomas Durek, Emeritus Professor Linda Lua
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2025
Doctor Philosophy
Selective modification and chemical synthesis of peptides & proteins for drug discovery applications
Associate Advisor
Other advisors: Professor David Craik, Dr Thomas Durek
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2024
Doctor Philosophy
Discovery, production, and development of disulfide-rich peptides for drug design and development
Associate Advisor
Other advisors: Professor David Craik, Dr Thomas Durek
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2023
Doctor Philosophy
Structural Modifications to Optimise the Oxidative Folding and Activity of Cyclotides
Associate Advisor
Other advisors: Dr Simon de Veer, Professor David Craik
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2023
Doctor Philosophy
Characterising the crown-of-thorns starfish secretome to identify factors for future biocontrol systems
Associate Advisor
Other advisors: Professor Sandie Degnan, Professor Bernard Degnan
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2022
Doctor Philosophy
Investigating approaches for the design and delivery of disulfide-rich peptide therapeutics
Associate Advisor
Other advisors: Dr Yen-Hua Crystal Huang, Professor David Craik
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2015
Doctor Philosophy
Structure-activity relationships and development of disulfide-rich cyclic peptides as pharmaceutical templates
Associate Advisor
Other advisors: Professor David Craik
Media
Enquiries
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