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2024 Journal Article Repurposing a plant peptide cyclase for targeted lysine acylationRehm, Fabian B. H., Tyler, Tristan J., Zhou, Yan, Huang, Yen-Hua, Wang, Conan K., Lawrence, Nicole, Craik, David J. and Durek, Thomas (2024). Repurposing a plant peptide cyclase for targeted lysine acylation. Nature Chemistry, 2024, 1-1. doi: 10.1038/s41557-024-01520-1 |
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2024 Journal Article Isolation and Characterization of Insecticidal Cyclotides from <i>Viola communis</i>Khatibi, Negin, Huang, Yen-Hua, Wang, Conan K., Durek, Thomas, Gilding, Edward K. and Craik, David J. (2024). Isolation and Characterization of Insecticidal Cyclotides from Viola communis. Journal of Natural Products. doi: 10.1021/acs.jnatprod.4c00168 |
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2024 Journal Article Seasonal tissue-specific gene expression in wild crown-of-thorns starfish reveals reproductive and stress-related transcriptional systemsMorin, Marie, Jönsson, Mathias, Wang, Conan K., Craik, David J., Degnan, Sandie M. and Degnan, Bernard M. (2024). Seasonal tissue-specific gene expression in wild crown-of-thorns starfish reveals reproductive and stress-related transcriptional systems. PLOS Biology, 22 (5) e3002620, e3002620. doi: 10.1371/journal.pbio.3002620 |
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2024 Journal Article Display technologies for expanding the pharmaceutical applications of cyclotidesXie, Jing, Kan, Meng‐Wei, de Veer, Simon J., Wang, Conan and Craik, David J. (2024). Display technologies for expanding the pharmaceutical applications of cyclotides. Israel Journal of Chemistry. doi: 10.1002/ijch.202400010 |
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2024 Journal Article Structure and Activity of Reconstructed Pseudo‐Ancestral CyclotidesJiang, Zhihao, Huang, Yen-Hua, Kaas, Quentin, Craik, David J. and Wang, Conan K. (2024). Structure and Activity of Reconstructed Pseudo‐Ancestral Cyclotides. ChemMedChem, 19 (14), e202400124. doi: 10.1002/cmdc.202400124 |
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2024 Journal Article Nucleation of a key beta-turn promotes cyclotide oxidative foldingTian, Sixin, de Veer, Simon J., Durek, Thomas, Wang, Conan K. and Craik, David J. (2024). Nucleation of a key beta-turn promotes cyclotide oxidative folding. Journal of Biological Chemistry, 300 (4) 107125, 107125. doi: 10.1016/j.jbc.2024.107125 |
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2024 Journal Article Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating PeptidePhilippe, Grégoire Jean-Baptiste, Huang, Yen-Hua, Mittermeier, Anna, Brown, Christopher J., Kaas, Quentin, Ramlan, Siti Radhiah, Wang, Conan K., Lane, David, Loewer, Alexander, Troeira Henriques, Sónia and Craik, David J. (2024). Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide. Journal of Medicinal Chemistry, 67 (2), 1197-1208. doi: 10.1021/acs.jmedchem.3c01682 |
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2024 Journal Article The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistanceBiswas, Biswajit, Huang, Yen-Hua, Craik, David J. and Wang, Conan K. (2024). The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance. Chemical Science, 15 (33), 13130-13147. doi: 10.1039/d4sc01088d |
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2023 Journal Article The circular bacteriocin enterocin NKR-5-3B has an improved stability profile over nisinWang, Conan K., Huang, Yen-Hua, Shabbir, Fatima, Pham, Huong T., Lawrence, Nicole, Benfield, Aurélie H., van der Donk, Wilfred, Henriques, Sónia T., Turner, Mark S. and Craik, David J. (2023). The circular bacteriocin enterocin NKR-5-3B has an improved stability profile over nisin. Peptides, 167 171049, 171049. doi: 10.1016/j.peptides.2023.171049 |
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2023 Journal Article Captivity induces a sweeping and sustained genomic response in a starfishMorin, Marie, Jönsson, Mathias, Wang, Conan K., Craik, David J., Degnan, Sandie M. and Degnan, Bernard M. (2023). Captivity induces a sweeping and sustained genomic response in a starfish. Molecular Ecology, 32 (13), 3541-3556. doi: 10.1111/mec.16947 |
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2023 Journal Article The 2022 Kazuhiko Tatemoto Prize: ACE2-derived peptides for COVID-19 treatmentWang, Conan K. (2023). The 2022 Kazuhiko Tatemoto Prize: ACE2-derived peptides for COVID-19 treatment. Peptides, 162 170964, 170964. doi: 10.1016/j.peptides.2023.170964 |
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2023 Journal Article Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiationChen, Zhian, Cui, Yanfang, Yao, Yin, Liu, Bo, Yunis, Joseph, Gao, Xin, Wang, Naiqi, Cañete, Pablo F., Tuong, Zewen Kelvin, Sun, Hongjian, Wang, Hao, Yang, Siling, Wang, Runli, Leong, Yew Ann, Simon Davis, David, Qin, Jiahuan, Liang, Kaili, Deng, Jun, Wang, Conan K., Huang, Yen-Hua, Roco, Jonathan A., Nettelfield, Sam, Zhu, Huaming, Xu, Huajun, Yu, Zhijia, Craik, David, Liu, Zheng, Qi, Hai, Parish, Christopher and Yu, Di (2023). Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Science immunology, 8 (80) eadd1728, 1-17. doi: 10.1126/sciimmunol.add1728 |
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2022 Journal Article Sex-specific expression of pheromones and other signals in gravid starfishJönsson, Mathias, Morin, Marie, Wang, Conan K., Craik, David J., Degnan, Sandie M. and Degnan, Bernard M. (2022). Sex-specific expression of pheromones and other signals in gravid starfish. BMC Biology, 20 (1) 288, 1-18. doi: 10.1186/s12915-022-01491-0 |
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2022 Journal Article Engineering the cyclization loop of MCoTI-II generates targeted cyclotides that potently inhibit factor XIIaTian, Sixin, Durek, Thomas, Wang, Conan K., Zdenek, Christina N., Fry, Bryan G., Craik, David J. and de Veer, Simon J. (2022). Engineering the cyclization loop of MCoTI-II generates targeted cyclotides that potently inhibit factor XIIa. Journal of Medicinal Chemistry, 65 (23), 15698-15709. doi: 10.1021/acs.jmedchem.2c01080 |
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2022 Journal Article Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptideZhang, Yuhui, Wang, Li, Tombling, Benjamin J., Lammi, Carmen, Huang, Yen-Hua, Li, Yue, Bartolomei, Martina, Hong, Bin, Craik, David J. and Wang, Conan K. (2022). Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide. Journal of the American Chemical Society, 144 (42), 19485-19498. doi: 10.1021/jacs.2c08029 |
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2022 Journal Article CIPPS, an Australian Centre for Peptide and Protein Research, goes live!Wang, Conan K. and Craik, David J. (2022). CIPPS, an Australian Centre for Peptide and Protein Research, goes live!. Peptides, 155 170835, 1-2. doi: 10.1016/j.peptides.2022.170835 |
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2022 Journal Article Mutagenesis of bracelet cyclotide hyen D reveals functionally and structurally critical residues for membrane binding and cytotoxicityDu, Qingdan, Huang, Yen-Hua, Wang, Conan K., Kaas, Quentin and Craik, David J. (2022). Mutagenesis of bracelet cyclotide hyen D reveals functionally and structurally critical residues for membrane binding and cytotoxicity. Journal of Biological Chemistry, 298 (4) 101822, 101822. doi: 10.1016/j.jbc.2022.101822 |
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2021 Journal Article Rational design of potent peptide inhibitors of the PD-1:PD-L1 interaction for cancer immunotherapyYin, Huawu, Zhou, Xiuman, Huang, Yen-Hua, King, Gordon J., Collins, Brett M., Gao, Yanfeng, Craik, David J. and Wang, Conan K. (2021). Rational design of potent peptide inhibitors of the PD-1:PD-L1 interaction for cancer immunotherapy. Journal of the American Chemical Society, 143 (44) jacs.1c08132, 18536-18547. doi: 10.1021/jacs.1c08132 |
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2021 Journal Article Enabling efficient folding and high-resolution crystallographic analysis of bracelet cyclotidesHuang, Yen-Hua, Du, Qingdan, Jiang, Zhihao, King, Gordon J., Collins, Brett M., Wang, Conan K. and Craik, David J. (2021). Enabling efficient folding and high-resolution crystallographic analysis of bracelet cyclotides. Molecules, 26 (18) 5554, 5554. doi: 10.3390/molecules26185554 |
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2021 Journal Article The emerging landscape of peptide-based inhibitors of PCSK9Tombling, Benjamin J., Zhang, Yuhui, Huang, Yen-Hua, Craik, David J. and Wang, Conan K. (2021). The emerging landscape of peptide-based inhibitors of PCSK9. Atherosclerosis, 330, 52-60. doi: 10.1016/j.atherosclerosis.2021.06.903 |
