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2019 Journal Article Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptorChambers, Chris, Cutler, Penny, Huang, Yen-Hua, Goodchild, James A., Blythe, Judith, Wang, Conan K., Bigot, Aurélien, Kaas, Quentin, Craik, David J., Sabbadin, Davide and Earley, Fergus G. (2019). Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor. FEBS Letters, 593 (12) 1873-3468.13435, 1336-1350. doi: 10.1002/1873-3468.13435 |
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2019 Journal Article Anchor residues guide form and function in grafted peptidesYin, Huawu, Craik, David J. and Wang, Conan K. (2019). Anchor residues guide form and function in grafted peptides. Angewandte Chemie, 131 (23), 7734-7738. doi: 10.1002/ange.201901572 |
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2019 Journal Article Toward structure determination of disulfide-rich peptides using chemical shift-based methodsWang, Conan K. and Craik, David J. (2019). Toward structure determination of disulfide-rich peptides using chemical shift-based methods. The Journal of Physical Chemistry B, 123 (9) acs.jpcb.8b10649, 1903-1912. doi: 10.1021/acs.jpcb.8b10649 |
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2018 Journal Article Synthesis, racemic x-ray crystallographic, and permeability studies of bioactive orbitides from Jatropha speciesRamalho, Suelem D., Wang, Conan K., King, Gordon J., Byriel, Karl A., Huang, Yen-Hua, Bolzani, Vanderlan S. and Craik, David J. (2018). Synthesis, racemic x-ray crystallographic, and permeability studies of bioactive orbitides from Jatropha species. Journal of Natural Products, 81 (11) acs.jnatprod.8b00447, 2436-2445. doi: 10.1021/acs.jnatprod.8b00447 |
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2018 Journal Article Calcium-mediated allostery of the EGF foldWang, Conan K., Ghani, Hafiza Abdul, Bundock, Anna, Weidmann, Joachim, Harvey, Peta J., Edwards, Ingrid A., Schroeder, Christina I., Swedberg, Joakim E. and Craik, David J. (2018). Calcium-mediated allostery of the EGF fold. ACS Chemical Biology, 13 (6), 1659-1667. doi: 10.1021/acschembio.8b00291 |
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2018 Journal Article Designing macrocyclic disulfide-rich peptides for biotechnological applicationsWang, Conan K. and Craik, David J. (2018). Designing macrocyclic disulfide-rich peptides for biotechnological applications. Nature Chemical Biology, 14 (5), 417-427. doi: 10.1038/s41589-018-0039-y |
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2018 Journal Article Conformational Flexibility Is a Determinant of Permeability for CyclosporinWang, Conan K., Swedberg, Joakim E., Harvey, Peta J., Kaas, Quentin and Craik, David J. (2018). Conformational Flexibility Is a Determinant of Permeability for Cyclosporin. The Journal of Physical Chemistry. B, 122 (8), 2261-2276. doi: 10.1021/acs.jpcb.7b12419 |
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2018 Book Chapter NMR relaxation analysis of pharmaceutically active peptidesWang, Conan K. (2018). NMR relaxation analysis of pharmaceutically active peptides. Modern magnetic resonance. (pp. 1997-2020) edited by Graham A. Webb. Cham, Switzerland: Springer. doi: 10.1007/978-3-319-28388-3_115 |
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2018 Conference Publication Is the mirror image a true reflection? Lipid chirality in the activity of the prototypic cyclotide kalata B1Henriques, Sonia Troeira, Peacock, Hayden, Benfield, Aurelie H., Wang, Conan and Craik, David (2018). Is the mirror image a true reflection? Lipid chirality in the activity of the prototypic cyclotide kalata B1. 35th European Peptide Symposium, Dublin City University, Ireland, 26-31 August 2018. Oxford, United Kingdom: John Wiley & Sons. |
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2018 Conference Publication A journey alongside cyclosporin on the road to peptide oral bioavailabilityWang, Conan and Craik, David (2018). A journey alongside cyclosporin on the road to peptide oral bioavailability. 35th European Peptide Symposium, Dublin City University, Ireland, 26-31 August 2018. Oxford, United Kingdom: John Wiley & Sons. |
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2018 Conference Publication Targeting the coiled-coil domain of BCR-ABL1 kinase with new weaponsHuang, Yen-Hua, Passioura, Toby, Peacock, Hayden, Henriques, Sonia Troeira, Wang, Conan, Kaas, Quentin, Suga, Hiroaki and Craik, David (2018). Targeting the coiled-coil domain of BCR-ABL1 kinase with new weapons. 35th European Peptide Symposium, Dublin City University, Ireland, 26-31 August 2018. Oxford, United Kingdom: John Wiley & Sons. |
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2017 Journal Article Lysine to arginine mutagenesis of chlorotoxin enhances its cellular uptakeOjeda, Paola G. , Henriques, Sonia Troeira, Pan, Yijun, Nicolazzo, Joseph A., Craik, David J. and Wang, Conan K. (2017). Lysine to arginine mutagenesis of chlorotoxin enhances its cellular uptake. Biopolymers, 108 (5) e23025, e23025. doi: 10.1002/bip.23025 |
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2017 Journal Article Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomerWu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin, Harvey, Peta J., Wang, Conan K., Tae, Han-Shen, Adams, David J. and Craik, David J. (2017). Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. Journal of Biological Chemistry, 292 (41), 17101-17112. doi: 10.1074/jbc.M117.808386 |
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2017 Journal Article Design of potent and selective cathepsin G inhibitors based on the sunflower trypsin inhibitor-1 scaffoldSwedberg, Joakim E., Li, Choi Yi, De Veer, Simon J., Wang, Conan K. and Craik, David J. (2017). Design of potent and selective cathepsin G inhibitors based on the sunflower trypsin inhibitor-1 scaffold. Journal of Medicinal Chemistry, 60 (2), 658-667. doi: 10.1021/acs.jmedchem.6b01509 |
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2017 Book Chapter A practical guide to structural aspects of macrocycles (NMR, x-ray, and modeling)Craik, David J., Kaas, Quentin and Wang, Conan K. (2017). A practical guide to structural aspects of macrocycles (NMR, x-ray, and modeling). Practical medicinal chemistry with macrocycles: Design, synthesis, and case studies. (pp. 25-57) edited by Eric Marsault and Mark L Peterson. Hoboken, New Jersey, United States: John Wiley & Sons. doi: 10.1002/9781119092599.ch2 |
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2016 Journal Article Cyclic peptide oral bioavailability: lessons from the pastWang, Conan K. and Craik, David J. (2016). Cyclic peptide oral bioavailability: lessons from the past. Biopolymers, 106 (6), 901-909. doi: 10.1002/bip.22878 |
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2016 Journal Article Forward for ICCP2015 issue of biopolymers peptide scienceCraik, David J. and Wang, Conan K. (2016). Forward for ICCP2015 issue of biopolymers peptide science. Biopolymers, 106 (6), 772-773. doi: 10.1002/bip.22989 |
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2016 Journal Article Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptideKwon, Soohyun, Bosmans, Frank, Kaas, Quentin, Cheneval, Olivier, Conibear, Anne C., Rosengren, K. Johan, Wang, Conan K., Schroeder, Christina I. and Craik, David J. (2016). Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnology and Bioengineering, 113 (10), 2202-2212. doi: 10.1002/bit.25993 |
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2016 Journal Article Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffoldWang, Conan K., Stalmans, Sofie, De Spiegeleer, Bart and Craik, David J. (2016). Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold. Journal of Peptide Science, 22 (5), 305-310. doi: 10.1002/psc.2862 |
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2016 Journal Article Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic propertiesWang, Conan K., King, Gordon J., Conibear, Anne C., Ramos, Mariana C., Chaousis, Stephanie, Henriques, Sonia Troeira and Craik, David J. (2016). Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic properties. Journal of American Chemical Society, 138 (17), 5706-5713. doi: 10.1021/jacs.6b02575 |
