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2022 Conference Publication Activating the p53 pathway with peptide conjugates: synthesis, structure, activity and cellular uptakePhilippe, Gregoire, Huang, Yen-Hua, Mittermeier, Anna, Brown, Christopher, Wang, Conan, Kaas, Quentin, Lawrence, Nicole, Condon, Nicholas, Lane, David, Loewer, Alexander, Craik, David and Henriques, Sonia (2022). Activating the p53 pathway with peptide conjugates: synthesis, structure, activity and cellular uptake. 36th European Peptide Symposium 12th International Peptide Symposium, Barcelona, Spain, 28 August - 2 September 2022. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.3445 |
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2022 Journal Article Mutagenesis of bracelet cyclotide hyen D reveals functionally and structurally critical residues for membrane binding and cytotoxicityDu, Qingdan, Huang, Yen-Hua, Wang, Conan K., Kaas, Quentin and Craik, David J. (2022). Mutagenesis of bracelet cyclotide hyen D reveals functionally and structurally critical residues for membrane binding and cytotoxicity. Journal of Biological Chemistry, 298 (4) 101822, 101822. doi: 10.1016/j.jbc.2022.101822 |
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2021 Journal Article Rational design of potent peptide inhibitors of the PD-1:PD-L1 interaction for cancer immunotherapyYin, Huawu, Zhou, Xiuman, Huang, Yen-Hua, King, Gordon J., Collins, Brett M., Gao, Yanfeng, Craik, David J. and Wang, Conan K. (2021). Rational design of potent peptide inhibitors of the PD-1:PD-L1 interaction for cancer immunotherapy. Journal of the American Chemical Society, 143 (44) jacs.1c08132, 18536-18547. doi: 10.1021/jacs.1c08132 |
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2021 Journal Article Enabling efficient folding and high-resolution crystallographic analysis of bracelet cyclotidesHuang, Yen-Hua, Du, Qingdan, Jiang, Zhihao, King, Gordon J., Collins, Brett M., Wang, Conan K. and Craik, David J. (2021). Enabling efficient folding and high-resolution crystallographic analysis of bracelet cyclotides. Molecules, 26 (18) 5554, 5554. doi: 10.3390/molecules26185554 |
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2021 Journal Article The emerging landscape of peptide-based inhibitors of PCSK9Tombling, Benjamin J., Zhang, Yuhui, Huang, Yen-Hua, Craik, David J. and Wang, Conan K. (2021). The emerging landscape of peptide-based inhibitors of PCSK9. Atherosclerosis, 330, 52-60. doi: 10.1016/j.atherosclerosis.2021.06.903 |
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2021 Journal Article An integrated molecular grafting approach for the design of Keap1-targeted peptide inhibitorsYin, Huawu, Huang, Yen-Hua, Best, Sarah A., Sutherland, Kate D., Craik, David J. and Wang, Conan K. (2021). An integrated molecular grafting approach for the design of Keap1-targeted peptide inhibitors. ACS Chemical Biology, 16 (7) acschembio.1c00388, 1276-1287. doi: 10.1021/acschembio.1c00388 |
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2021 Journal Article Increased valency improves inhibitory activity of peptides targeting proprotein convertase subtilisin/kexin type 9 (PCSK9)Tombling, Benjamin J., Lammi, Carmen, Bollati, Carlotta, Anoldi, Anna, Craik, David J. and Wang, Conan K. (2021). Increased valency improves inhibitory activity of peptides targeting proprotein convertase subtilisin/kexin type 9 (PCSK9). ChemBioChem, 22 (12) cbic.202100103, 1-8. doi: 10.1002/cbic.202100103 |
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2021 Journal Article Bioactive cyclization optimizes the affinity of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) peptide inhibitorTombling, Benjamin J., Lammi, Carmen, Lawrence, Nicole, Gilding, Edward K., Grazioso, Giovanni, Craik, David J. and Wang, Conan K. (2021). Bioactive cyclization optimizes the affinity of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) peptide inhibitor. Journal of Medicinal Chemistry, 64 (5) acs.jmedchem.0c01766, 2523-2533. doi: 10.1021/acs.jmedchem.0c01766 |
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2021 Journal Article Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidasesYap, Kuok, Du, Junqiao, Rehm, Fabian B. H., Tang, Shyn Ric, Zhou, Yan, Xie, Jing, Wang, Conan K., de Veer, Simon J., Lua, Linda H. L., Durek, Thomas and Craik, David J. (2021). Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases. Nature Protocols, 16 (3), 1-23. doi: 10.1038/s41596-020-00483-0 |
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2021 Journal Article Engineered EGF-A peptides with improved affinity for proprotein convertase subtilisin/kexin type 9 (PCSK9)Tombling, Benjamin J., Lammi, Carmen, Lawrence, Nicole, Li, Jianqiang, Arnoldi, Anna, Craik, David J. and Wang, Conan K. (2021). Engineered EGF-A peptides with improved affinity for proprotein convertase subtilisin/kexin type 9 (PCSK9). ACS Chemical Biology, 16 (2) acschembio.0c00991, 429-439. doi: 10.1021/acschembio.0c00991 |
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2021 Journal Article Linking molecular evolution to molecular graftingWang, Conan K. and Craik, David J. (2021). Linking molecular evolution to molecular grafting. Journal of Biological Chemistry, 296 100425, 1-11. doi: 10.1016/j.jbc.2021.100425 |
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2020 Journal Article Cyclotide structures revealed by NMR, with a little help from X-ray crystallographyHandley, Thomas N. G., Harvey, Peta J., Wang, Conan K., Lawrence, Nicole and Craik, David (2020). Cyclotide structures revealed by NMR, with a little help from X-ray crystallography. Chembiochem, 21 (24) cbic.202000315, 3463-3475. doi: 10.1002/cbic.202000315 |
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2020 Journal Article Front Cover: Cyclotide Structures Revealed by NMR, with a Little Help from X‐ray Crystallography (ChemBioChem 24/2020)Handley, Thomas N. G., Wang, Conan K., Harvey, Peta J., Lawrence, Nicole and Craik, David J. (2020). Front Cover: Cyclotide Structures Revealed by NMR, with a Little Help from X‐ray Crystallography (ChemBioChem 24/2020). ChemBioChem, 21 (24), 3449-3449. doi: 10.1002/cbic.202000778 |
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2020 Journal Article Structure-activity analysis of truncated albumin-binding domains suggests new lead constructs for potential therapeutic deliveryWang, Conan K., Amiss, Anna S., Weidmann, Joachim and Craik, David J. (2020). Structure-activity analysis of truncated albumin-binding domains suggests new lead constructs for potential therapeutic delivery. Journal of Biological Chemistry, 295 (34), 12143-12152. doi: 10.1074/jbc.ra120.014168 |
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2020 Journal Article EGF‐artige und andere disulfidreiche Mikrodomänen als therapeutische MolekülgerüsteTombling, Benjamin J., Wang, Conan K. and Craik, David J. (2020). EGF‐artige und andere disulfidreiche Mikrodomänen als therapeutische Molekülgerüste. Angewandte Chemie, 132 (28) ange.201913809, 11314-11328. doi: 10.1002/ange.201913809 |
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2020 Journal Article An environmentally sustainable biomimetic production of cyclic disulfide-rich peptidesYap, Kuok, Du, Junqiao, Looi, Fong Yang, Tang, Shyn Ric, de Veer, Simon J., Bony, Anuja R., Rehm, Fabian B. H., Xie, Jing, Chan, Lai Yue, Wang, Conan K., Adams, David J., Lua, Linda H. L., Durek, Thomas and Craik, David J. (2020). An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides. Green Chemistry, 22 (15), 5002-5016. doi: 10.1039/d0gc01366h |
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2020 Journal Article Innentitelbild: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. 28/2020)White, Andrew M., Veer, Simon J., Wu, Guojie, Harvey, Peta J., Yap, Kuok, King, Gordon J., Swedberg, Joakim E., Wang, Conan K., Law, Ruby H. P., Durek, Thomas and Craik, David J. (2020). Innentitelbild: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. 28/2020). Angewandte Chemie, 132 (28), 11258-11258. doi: 10.1002/ange.202006713 |
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2020 Journal Article Inside Cover: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. Int. Ed. 28/2020)White, Andrew M., Veer, Simon J., Wu, Guojie, Harvey, Peta J., Yap, Kuok, King, Gordon J., Swedberg, Joakim E., Wang, Conan K., Law, Ruby H. P., Durek, Thomas and Craik, David J. (2020). Inside Cover: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. Int. Ed. 28/2020). Angewandte Chemie International Edition, 59 (28), 11162-11162. doi: 10.1002/anie.202006713 |
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2020 Journal Article Application and structural analysis of triazole‐bridged disulfide mimetics in cyclic peptidesWhite, Andrew M., Veer, Simon J., Wu, Guojie, Harvey, Peta J., Yap, Kuok, King, Gordon J., Swedberg, Joakim E., Wang, Conan K., Law, Ruby H. P., Durek, Thomas and Craik, David J. (2020). Application and structural analysis of triazole‐bridged disulfide mimetics in cyclic peptides. Angewandte Chemie International Edition, 132 (28) anie.202003435, 11369-11373. doi: 10.1002/anie.202003435 |
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2020 Journal Article Cellular uptake and cytosolic delivery of a cyclic cystine knot scaffoldYin, Huawu, Huang, Yen-Hua, Deprey, Kirsten, Condon, Nicholas D., Kritzer, Joshua A., Craik, David J. and Wang, Conan K. (2020). Cellular uptake and cytosolic delivery of a cyclic cystine knot scaffold. ACS Chemical Biology, 15 (6), 1650-1661. doi: 10.1021/acschembio.0c00297 |
