Overview
Background
I lead the Technology-Driven Drug Discovery (Tech3D) Group at the Institute for Molecular Bioscience, UQ. We believe that the key to solving some of our world's biggest challenges, whether that be in medicine or agriculture, relies on the ability to precision engineer molecules at will. My group harnesses three technological pillars to engineer peptides and proteins, which are computational biology, molecular libraries, and nanotechnology. We aspire to design better drugs, creating next generation biotechnological agents that have real impact. These could be new cancer drugs that harness the body's immune system or new insecticides that are environmentally friendly. In these pursuits, we value advancement, fun, balance, respect, fairness, and integrity.
I have been involved in peptide and protein research for over two decades, and am highly experienced in bioinformatics, chemistry, structural characterization, biophysics, and biochemistry. I trained with experts in peptide and protein characterization: an Honours project with Professor Garry King at the University of New South Wales, Sydney, Australia (2004), an APA scholarship with Professor David Craik at the University of Queensland Institute for Molecular Bioscience, Brisbane, Australia (2005-2009) and a NHMRC fellowship with Professor Mingjie Zhang at the Hong Kong University of Science and Technology, Hong Kong, China (2009-2011) and A/Professor Andreas Hofmann at Griffith University Eskitis Institute, Brisbane, Australia (2011-2012). I returned to the University of Queensland in 2012 to join an industry partnership funded by an ARC linkage grant. I currently hold an ARC Future Fellowship and am responsible for a team of research officers, assistants and postgraduate students.
My research output has been recognised by >30 prizes and awards for leadership, research translation and fundamental research excellence, as well as numerous invitations to speak at academic and pharmaceutical conferences. I have over 100 publications and have been cited by researchers from across the world.
Availability
- Associate Professor Conan Wang is:
- Available for supervision
Qualifications
- Bachelor of Engineering, University of New South Wales
- Doctor of Philosophy, The University of Queensland
Research interests
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Computational design of targeted cancer therapeutics guided by machine learning
The right treatment depends on the right diagnosis. This project aims to engineer advanced agents capable of precisely locating and “painting” every cancer cell in the body, enabling clinicians to detect and treat tumours with unprecedented resolution. The candidate will gain expertise in drug discovery through computational biology and molecular biology. If you’re interested in learning more about drug design or exploring potential projects, please feel free to reach out.
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Efficient design of drugs using new nanoscale technologies
Powerful technologies have emerged to perform millions of experiments quickly in tiny nanolitre droplets, and have attracted wide interest from major pharmaceutical companies because of the potential to accelerate drug discovery. Research project opportunities are available to investigate these next-generation tools for drug design and learn new skills in one or more areas of nanotechnology and molecular biology.
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Designing protein drugs for the treatment of drug-resistant cancers
Targeted therapies against kinases are frontline treatments for many cancers. However, drug resistance often emerges within months of initiating therapy. This project aims to develop resilient kinase-targeted drugs with novel mechanisms of action that disrupt growth-promoting signals in cancer cells while reducing the likelihood of resistance. These agents have the potential to more effectively halt cancer progression. Candidates will learn new skills in drug design and characterisation using tools in molecular biology, biochemistry, and structural biology.
Works
Search Professor Conan Wang’s works on UQ eSpace
2008
Journal Article
CyBase: a database of cyclic protein sequences and structures, with application in protein discovery and engineering
Wang, C. K., Kaas, Q., Chiche, L. and Craik, D. J. (2008). CyBase: a database of cyclic protein sequences and structures, with application in protein discovery and engineering. Nucleic Acids Research, 36 (SUPPL. 1), D206-D210. doi: 10.1093/nar/gkm953
2008
Journal Article
Distribution and evolution of circular miniproteins in flowering plants
Gruber, Christian W., Elliott, Alysha G., Ireland, David C., Delprete, Piero G., Dessein, Steven, Goransson, Ulf, Trabi, Manuela, Wang, Conan K., Kinghorn, Andrew B., Robbrecht, Elmar and Craik, David J. (2008). Distribution and evolution of circular miniproteins in flowering plants. The Plant Cell, 20 (9), 2471-2483. doi: 10.1105/tpc.108.062331
2008
Journal Article
The anthelmintic activity of the cyclotides: Natural variants with enhanced activity
Colgrave, Michelle L., Kotze, Andrew C., Ireland, David C., Wang, Conan K. and Craik, David J. (2008). The anthelmintic activity of the cyclotides: Natural variants with enhanced activity. ChemBioChem, 9 (12), 1939-1945. doi: 10.1002/cbic.200800174
2008
Other Outputs
Structural and functional studies of cyclotides
Wang, Conan (2008). Structural and functional studies of cyclotides. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/174289
2008
Journal Article
Alanine Scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity
Simonsen, S. M., Sando, L., Rosengren, K. J., Wang, C. K., Colgrave, M. L., Daly, N. L. and Craik, D. J. (2008). Alanine Scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity. Journal of Biological Chemistry, 283 (15), 9805-9813. doi: 10.1074/jbc.M709303200
2008
Journal Article
ConoServer, a database for conopeptide sequences and structures
Kaas, Quentin, Westermann, Jan, Halai, Reena, Wang, Conan and Craik, David J. (2008). ConoServer, a database for conopeptide sequences and structures. Bioinformatics, 24 (3), 445-446. doi: 10.1093/bioinformatics/btm596
2008
Journal Article
Anti-HIV Cyclotides from the Chinese Medicinal Herb Viola yedonensis
Wang, Conan K. L., Colgrave, Michelle L., Gustafson, Kirk R., Ireland, David C., Goransson, Ulf and Craik, David J. (2008). Anti-HIV Cyclotides from the Chinese Medicinal Herb Viola yedonensis. Journal of Natural Products, 71 (1), 47-52. doi: 10.1021/np070393g
2008
Journal Article
Cyclotides as natural anti-HIV agents
Ireland, David C., Wang, Conan K., Wilson, Jennifer A., Gustafson, Kirk R. and Craik, David J. (2008). Cyclotides as natural anti-HIV agents. Biopolymers: Peptide Science, 90 (1), 51-60. doi: 10.1002/bip.20886
2006
Journal Article
CyBase: a database of cyclic protein sequence and structure
Mulvenna, J. P., Wang, C. and Craik, D. J. (2006). CyBase: a database of cyclic protein sequence and structure. Nucleic Acids Research, 34 (Sp. Iss. SI), D192-D194. doi: 10.1093/nar/gkj005
2006
Journal Article
The cyclotide family of circular miniproteins: Nature's combinatorial peptide template
Craik, D. J., Cemazar, M., Wang, C. K. L. and Daly, N. L. (2006). The cyclotide family of circular miniproteins: Nature's combinatorial peptide template. Biopolymers, 84 (3), 250-266. doi: 10.1002/hip.20451
2006
Journal Article
Cycloviolacin H4, a hydrophobic cyclotide from Viola hederaceae
Chen, B., Colgrave, M. L., Wang, C. N. and Craik, D. J. (2006). Cycloviolacin H4, a hydrophobic cyclotide from Viola hederaceae. Journal of Natural Products, 69 (1), 23-28. doi: 10.1021/np050317i
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Conan Wang is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Supervision history
Current supervision
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Doctor Philosophy
A new molecular technology platform for design and production of ultra-stable peptides
Principal Advisor
Other advisors: Professor David Craik
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Doctor Philosophy
Design and manufacturing of next-generation ultra-stable peptide radiotracers for precision diagnosis and therapy
Principal Advisor
Other advisors: Dr Yen-Hua Crystal Huang
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Doctor Philosophy
Discovery and Development of Substrate-Based Peptide Kinase Inhibitors
Principal Advisor
Other advisors: Dr Yen-Hua Crystal Huang, Professor David Craik
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Doctor Philosophy
Patient-friendly peptide tracers for improving immunotherapy outcomes
Principal Advisor
Other advisors: Dr Yen-Hua Crystal Huang
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Doctor Philosophy
Accelerating design and optimisation of next-generation ecofriendly insecticides in picolitre bioreactors
Principal Advisor
Other advisors: Professor David Craik, Dr Yen-Hua Crystal Huang
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Doctor Philosophy
Next-generation IL-2 mimics for immunotherapy
Principal Advisor
Other advisors: Professor David Craik, Professor Di Yu
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Doctor Philosophy
Design and optimisation of a novel compound for theranostic use in cancer
Principal Advisor
Other advisors: Professor David Craik, Dr Yen-Hua Crystal Huang
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Doctor Philosophy
Design of orally active cholesterol-lowering peptides
Associate Advisor
Other advisors: Professor David Craik
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Doctor Philosophy
Exploring delivery strategies for cyclotide-based therapeutics
Associate Advisor
Other advisors: Professor David Craik, Dr Yen-Hua Crystal Huang
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Doctor Philosophy
Development of peptide-based inhibitors for crop protection
Associate Advisor
Other advisors: Professor Brett Collins, Professor David Craik
Completed supervision
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2021
Doctor Philosophy
The development of peptide-based cholesterol-lowering therapeutics
Principal Advisor
Other advisors: Professor David Craik
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2026
Doctor Philosophy
Towards population control of a coral reef pest: The crown-of-thorns starfish
Associate Advisor
Other advisors: Professor David Craik, Dr Thomas Durek, Emeritus Professor Linda Lua
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2025
Doctor Philosophy
Selective modification and chemical synthesis of peptides & proteins for drug discovery applications
Associate Advisor
Other advisors: Professor David Craik, Dr Thomas Durek
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2024
Doctor Philosophy
Discovery, production, and development of disulfide-rich peptides for drug design and development
Associate Advisor
Other advisors: Professor David Craik, Dr Thomas Durek
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2023
Doctor Philosophy
Structural Modifications to Optimise the Oxidative Folding and Activity of Cyclotides
Associate Advisor
Other advisors: Dr Simon de Veer, Professor David Craik
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2023
Doctor Philosophy
Characterising the crown-of-thorns starfish secretome to identify factors for future biocontrol systems
Associate Advisor
Other advisors: Professor Sandie Degnan, Professor Bernard Degnan
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2022
Doctor Philosophy
Investigating approaches for the design and delivery of disulfide-rich peptide therapeutics
Associate Advisor
Other advisors: Dr Yen-Hua Crystal Huang, Professor David Craik
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2015
Doctor Philosophy
Structure-activity relationships and development of disulfide-rich cyclic peptides as pharmaceutical templates
Associate Advisor
Other advisors: Professor David Craik
Media
Enquiries
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