Dr

Thomas Durek

Email: 
Phone: 
+61 7 334 62021

Availability

Dr Thomas Durek is:
Available for supervision

Fields of research

Biological Sciences Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy, TU Dortmund University

Search Professor Thomas Durek’s works on UQ eSpace

94 works between 2002 and 2024
All (94) Journal Article (90) Conference Publication (4)

1 - 20 of 94 works

2024

Journal Article

Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants

Cristofori-Armstrong, Ben, Budusan, Elena, Smith, Jennifer J., Reynaud, Steve, Voll, Kerstin, Chassagnon, Irène R., Durek, Thomas and Rash, Lachlan D. (2024). Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants. Cellular and Molecular Life Sciences, 81 (1) 266, 266. doi: 10.1007/s00018-024-05276-2

Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants

2024

Journal Article

Repurposing a plant peptide cyclase for targeted lysine acylation

Rehm, Fabian B. H., Tyler, Tristan J., Zhou, Yan, Huang, Yen-Hua, Wang, Conan K., Lawrence, Nicole, Craik, David J. and Durek, Thomas (2024). Repurposing a plant peptide cyclase for targeted lysine acylation. Nature Chemistry, 2024, 1-1. doi: 10.1038/s41557-024-01520-1

Repurposing a plant peptide cyclase for targeted lysine acylation

2024

Journal Article

Isolation and Characterization of Insecticidal Cyclotides from <i>Viola communis</i>

Khatibi, Negin, Huang, Yen-Hua, Wang, Conan K., Durek, Thomas, Gilding, Edward K. and Craik, David J. (2024). Isolation and Characterization of Insecticidal Cyclotides from Viola communis. Journal of Natural Products. doi: 10.1021/acs.jnatprod.4c00168

Isolation and Characterization of Insecticidal Cyclotides from <i>Viola communis</i>

2024

Journal Article

Nucleation of a key beta-turn promotes cyclotide oxidative folding

Tian, Sixin, de Veer, Simon J., Durek, Thomas, Wang, Conan K. and Craik, David J. (2024). Nucleation of a key beta-turn promotes cyclotide oxidative folding. Journal of Biological Chemistry, 300 (4) 107125, 107125. doi: 10.1016/j.jbc.2024.107125

Nucleation of a key beta-turn promotes cyclotide oxidative folding

2024

Journal Article

Tertiary amide bond formation by an engineered asparaginyl ligase

de Veer, Simon J., Zhou, Yan, Durek, Thomas, Craik, David J. and Rehm, Fabian B. H. (2024). Tertiary amide bond formation by an engineered asparaginyl ligase. Chemical Science, 15 (14) 06352, 5248-5255. doi: 10.1039/d3sc06352f

Tertiary amide bond formation by an engineered asparaginyl ligase

2024

Journal Article

Sortase‐Catalyzed Protein Domain Inversion

Zhou, Yan, Durek, Thomas, Craik, David J. and Rehm, Fabian B. H. (2024). Sortase‐Catalyzed Protein Domain Inversion. Angewandte Chemie, 136 (14). doi: 10.1002/ange.202316777

Sortase‐Catalyzed Protein Domain Inversion

2024

Journal Article

Sortase‐Catalyzed Protein Domain Inversion

Zhou, Yan, Durek, Thomas, Craik, David J. and Rehm, Fabian B. H. (2024). Sortase‐Catalyzed Protein Domain Inversion. Angewandte Chemie International Edition, 63 (14) e202316777, 1-7. doi: 10.1002/anie.202316777

Sortase‐Catalyzed Protein Domain Inversion

2024

Journal Article

Chemical synthesis of grafted cyclotides using a “plug and play” approach

Koehbach, Johannes, Muratspahić, Edin, Ahmed, Zakaria M, White, Andrew M, Tomašević, Nataša, Durek, Thomas, Clark, Richard J, Gruber, Christian W and Craik, David J (2024). Chemical synthesis of grafted cyclotides using a “plug and play” approach. RSC Chemical Biology, 5 (6), 567-571. doi: 10.1039/d4cb00008k

Chemical synthesis of grafted cyclotides using a “plug and play” approach

2023

Journal Article

Development of melanocortin 4 receptor agonists by exploiting animal-derived macrocyclic, disulfide-rich peptide scaffolds

Muratspahić, Edin, Aslanoglou, Despoina, White, Andrew M., Draxler, Claudia, Kozisek, Xaver, Farooq, Zara, Craik, David J., McCormick, Peter J., Durek, Thomas and Gruber, Christian W. (2023). Development of melanocortin 4 receptor agonists by exploiting animal-derived macrocyclic, disulfide-rich peptide scaffolds. ACS Pharmacology and Translational Science, 6 (10), 1373-1381. doi: 10.1021/acsptsci.3c00090

Development of melanocortin 4 receptor agonists by exploiting animal-derived macrocyclic, disulfide-rich peptide scaffolds

2023

Journal Article

A chemoenzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide)

Zhou, Yan, Harvey, Peta J., Koehbach, Johannes, Chan, Lai Yue, Jones, Alun, Andersson, Åsa, Vetter, Irina, Durek, Thomas and Craik, David J. (2023). A chemoenzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide). Angewandte Chemie, 135 (29) e202302812, 1-5. doi: 10.1002/ange.202302812

A chemoenzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide)

2023

Journal Article

A chemo-enzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide)

Zhou, Yan, Harvey, Peta J., Koehbach, Johannes, Chan, Lai Yue, Jones, Alun, Andersson, Åsa, Vetter, Irina, Durek, Thomas and Craik, David J. (2023). A chemo-enzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide). Angewandte Chemie, 62 (29) e202302812, e202302812. doi: 10.1002/anie.202302812

A chemo-enzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide)

2023

Journal Article

Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function

Jami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N. ... Vetter, Irina (2023). Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nature Communications, 14 (1) 2442. doi: 10.1038/s41467-023-37963-2

Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function

2023

Journal Article

Native and engineered cyclic disulfide-rich peptides as drug leads

Tyler, Tristan J., Durek, Thomas and Craik, David J. (2023). Native and engineered cyclic disulfide-rich peptides as drug leads. Molecules, 28 (7) 3189, 1-22. doi: 10.3390/molecules28073189

Native and engineered cyclic disulfide-rich peptides as drug leads

2022

Journal Article

Engineering the cyclization loop of MCoTI-II generates targeted cyclotides that potently inhibit factor XIIa

Tian, Sixin, Durek, Thomas, Wang, Conan K., Zdenek, Christina N., Fry, Bryan G., Craik, David J. and de Veer, Simon J. (2022). Engineering the cyclization loop of MCoTI-II generates targeted cyclotides that potently inhibit factor XIIa. Journal of Medicinal Chemistry, 65 (23), 15698-15709. doi: 10.1021/acs.jmedchem.2c01080

Engineering the cyclization loop of MCoTI-II generates targeted cyclotides that potently inhibit factor XIIa

2022

Journal Article

Late-stage functionalization with cysteine staples generates potent and selective melanocortin receptor-1 agonists

White, Andrew M., Dellsén, Anita, Larsson, Niklas, Kaas, Quentin, Jansen, Frank, Plowright, Alleyn T., Knerr, Laurent, Durek, Thomas and Craik, David J. (2022). Late-stage functionalization with cysteine staples generates potent and selective melanocortin receptor-1 agonists. Journal of Medicinal Chemistry, 65 (19), 12956-12969. doi: 10.1021/acs.jmedchem.2c00793

Late-stage functionalization with cysteine staples generates potent and selective melanocortin receptor-1 agonists

2022

Journal Article

Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox

Xie, Jing, Robinson, Samuel D., Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Rehm, Fabian B.H., Yap, Kuok, Ragnarsson, Lotten, Chan, Lai Yue, Hamilton, Brett R., Harvey, Peta J., Craik, David J., Vetter, Irina and Durek, Thomas (2022). Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox. Journal of Biological Chemistry, 298 (8) 102218, 1-12. doi: 10.1016/j.jbc.2022.102218

Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox

2022

Journal Article

Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation

Klasfauseweh, Tabea, Israel, Mathilde R., Ragnarsson, Lotten, Cox, James J., Durek, Thomas, Carter, David A., Leffler, Andreas, Vetter, Irina and Deuis, Jennifer R. (2022). Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation. European Journal of Pharmacology, 925 175013, 175013. doi: 10.1016/j.ejphar.2022.175013

Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation

2022

Journal Article

Cystine knot peptides with tuneable activity and mechanism

Li, Choi Yi, Rehm, Fabian B. H., Yap, Kuok, Zdenek, Christina N., Harding, Maxim D., Fry, Bryan G., Durek, Thomas, Craik, David J. and Veer, Simon J. (2022). Cystine knot peptides with tuneable activity and mechanism. Angewandte Chemie, 61 (19) e202200951, e202200951. doi: 10.1002/ange.202200951

Cystine knot peptides with tuneable activity and mechanism

2022

Journal Article

Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA

Jakob, Valentin, Zoller, Ben G. E., Rinkes, Julia, Wu, Yingwen, Kiefer, Alexander F., Hust, Michael, Polten, Saskia, White, Andrew M., Harvey, Peta J., Durek, Thomas, Craik, David J., Siebert, Andreas, Kazmaier, Uli and Empting, Martin (2022). Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA. European Journal of Medicinal Chemistry, 231 114148, 114148. doi: 10.1016/j.ejmech.2022.114148

Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA

2022

Journal Article

Enzymatic C‐to‐C Protein Ligation

Rehm, Fabian B. H., Tyler, Tristan J., Veer, Simon J., Craik, David J. and Durek, Thomas (2022). Enzymatic C‐to‐C Protein Ligation. Angewandte Chemie International Edition, 134 (11) e202116672, e202116672. doi: 10.1002/anie.202116672

Enzymatic C‐to‐C Protein Ligation

Past funding

  • 2020 - 2024
    Understanding the mechanisms of peptide cyclisation
    ARC Discovery Projects
    Open grant
  • 2020 - 2022
    Peptide ligands as tools to decipher receptor biology
    NHMRC IDEAS Grants
    Open grant
  • 2020 - 2022
    Toxins from Down Under: Novel tools to understand and modulate ion channels
    ARC Discovery Projects
    Open grant
  • 2015 - 2017
    Development of selective melanocortin receptor agonists and antagonists
    NHMRC Project Grant
    Open grant
  • 2015 - 2019
    The chemistry and biology of circular proteins
    ARC Discovery Projects
    Open grant
  • 2011 - 2012
    Novel strategies for site-specific labelling of cysteine-rich peptides and proteins
    UQ Early Career Researcher
    Open grant
  • 2008 - 2010
    Synthesis of microprotein analogs for studying the biochemical and pharmacological properties of ion channels
    UQ Postdoctoral Research Fellowship
    Open grant

Availability

Dr Thomas Durek is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Development of a new class of ligase enzymes for protein engineering and drug development

    Principal Advisor

    Other advisors: Dr Conan Wang, Professor David Craik

  • Doctor Philosophy

    New Toxin Tools for Dissecting Pain

    Associate Advisor

    Other advisors: Professor Irina Vetter, Dr Sam Robinson

  • Doctor Philosophy

    Ultra-stable Miniproteins for Treating Gastrointestinal Disorders

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    Using plants as factories for producing next generation peptide-based pharmaceuticals

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    Development of commercially viable cyclic peptide production for the protection of the Great Barrier Reef

    Associate Advisor

    Other advisors: Dr Conan Wang, Professor David Craik, Professor Linda Lua

  • Doctor Philosophy

    Gut inflammation: model systems and the development of anti-inflammatory peptide drugs.

    Associate Advisor

    Other advisors: Professor Jennifer Stow

Completed supervision

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