Overview
Availability
- Dr Thomas Durek is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, TU Dortmund University
Works
Search Professor Thomas Durek’s works on UQ eSpace
2024
Journal Article
Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants
Cristofori-Armstrong, Ben, Budusan, Elena, Smith, Jennifer J., Reynaud, Steve, Voll, Kerstin, Chassagnon, Irène R., Durek, Thomas and Rash, Lachlan D. (2024). Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants. Cellular and Molecular Life Sciences, 81 (1) 266, 266. doi: 10.1007/s00018-024-05276-2
2024
Journal Article
Repurposing a plant peptide cyclase for targeted lysine acylation
Rehm, Fabian B. H., Tyler, Tristan J., Zhou, Yan, Huang, Yen-Hua, Wang, Conan K., Lawrence, Nicole, Craik, David J. and Durek, Thomas (2024). Repurposing a plant peptide cyclase for targeted lysine acylation. Nature Chemistry, 2024, 1-1. doi: 10.1038/s41557-024-01520-1
2024
Journal Article
Isolation and Characterization of Insecticidal Cyclotides from <i>Viola communis</i>
Khatibi, Negin, Huang, Yen-Hua, Wang, Conan K., Durek, Thomas, Gilding, Edward K. and Craik, David J. (2024). Isolation and Characterization of Insecticidal Cyclotides from Viola communis. Journal of Natural Products. doi: 10.1021/acs.jnatprod.4c00168
2024
Journal Article
Nucleation of a key beta-turn promotes cyclotide oxidative folding
Tian, Sixin, de Veer, Simon J., Durek, Thomas, Wang, Conan K. and Craik, David J. (2024). Nucleation of a key beta-turn promotes cyclotide oxidative folding. Journal of Biological Chemistry, 300 (4) 107125, 107125. doi: 10.1016/j.jbc.2024.107125
2024
Journal Article
Tertiary amide bond formation by an engineered asparaginyl ligase
de Veer, Simon J., Zhou, Yan, Durek, Thomas, Craik, David J. and Rehm, Fabian B. H. (2024). Tertiary amide bond formation by an engineered asparaginyl ligase. Chemical Science, 15 (14) 06352, 5248-5255. doi: 10.1039/d3sc06352f
2024
Journal Article
Sortase‐Catalyzed Protein Domain Inversion
Zhou, Yan, Durek, Thomas, Craik, David J. and Rehm, Fabian B. H. (2024). Sortase‐Catalyzed Protein Domain Inversion. Angewandte Chemie, 136 (14). doi: 10.1002/ange.202316777
2024
Journal Article
Sortase‐Catalyzed Protein Domain Inversion
Zhou, Yan, Durek, Thomas, Craik, David J. and Rehm, Fabian B. H. (2024). Sortase‐Catalyzed Protein Domain Inversion. Angewandte Chemie International Edition, 63 (14) e202316777, 1-7. doi: 10.1002/anie.202316777
2024
Journal Article
Chemical synthesis of grafted cyclotides using a “plug and play” approach
Koehbach, Johannes, Muratspahić, Edin, Ahmed, Zakaria M, White, Andrew M, Tomašević, Nataša, Durek, Thomas, Clark, Richard J, Gruber, Christian W and Craik, David J (2024). Chemical synthesis of grafted cyclotides using a “plug and play” approach. RSC Chemical Biology, 5 (6), 567-571. doi: 10.1039/d4cb00008k
2023
Journal Article
Development of melanocortin 4 receptor agonists by exploiting animal-derived macrocyclic, disulfide-rich peptide scaffolds
Muratspahić, Edin, Aslanoglou, Despoina, White, Andrew M., Draxler, Claudia, Kozisek, Xaver, Farooq, Zara, Craik, David J., McCormick, Peter J., Durek, Thomas and Gruber, Christian W. (2023). Development of melanocortin 4 receptor agonists by exploiting animal-derived macrocyclic, disulfide-rich peptide scaffolds. ACS Pharmacology and Translational Science, 6 (10), 1373-1381. doi: 10.1021/acsptsci.3c00090
2023
Journal Article
A chemoenzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide)
Zhou, Yan, Harvey, Peta J., Koehbach, Johannes, Chan, Lai Yue, Jones, Alun, Andersson, Åsa, Vetter, Irina, Durek, Thomas and Craik, David J. (2023). A chemoenzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide). Angewandte Chemie, 135 (29) e202302812, 1-5. doi: 10.1002/ange.202302812
2023
Journal Article
A chemo-enzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide)
Zhou, Yan, Harvey, Peta J., Koehbach, Johannes, Chan, Lai Yue, Jones, Alun, Andersson, Åsa, Vetter, Irina, Durek, Thomas and Craik, David J. (2023). A chemo-enzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide). Angewandte Chemie, 62 (29) e202302812, e202302812. doi: 10.1002/anie.202302812
2023
Journal Article
Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function
Jami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N. ... Vetter, Irina (2023). Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nature Communications, 14 (1) 2442. doi: 10.1038/s41467-023-37963-2
2023
Journal Article
Native and engineered cyclic disulfide-rich peptides as drug leads
Tyler, Tristan J., Durek, Thomas and Craik, David J. (2023). Native and engineered cyclic disulfide-rich peptides as drug leads. Molecules, 28 (7) 3189, 1-22. doi: 10.3390/molecules28073189
2022
Journal Article
Engineering the cyclization loop of MCoTI-II generates targeted cyclotides that potently inhibit factor XIIa
Tian, Sixin, Durek, Thomas, Wang, Conan K., Zdenek, Christina N., Fry, Bryan G., Craik, David J. and de Veer, Simon J. (2022). Engineering the cyclization loop of MCoTI-II generates targeted cyclotides that potently inhibit factor XIIa. Journal of Medicinal Chemistry, 65 (23), 15698-15709. doi: 10.1021/acs.jmedchem.2c01080
2022
Journal Article
Late-stage functionalization with cysteine staples generates potent and selective melanocortin receptor-1 agonists
White, Andrew M., Dellsén, Anita, Larsson, Niklas, Kaas, Quentin, Jansen, Frank, Plowright, Alleyn T., Knerr, Laurent, Durek, Thomas and Craik, David J. (2022). Late-stage functionalization with cysteine staples generates potent and selective melanocortin receptor-1 agonists. Journal of Medicinal Chemistry, 65 (19), 12956-12969. doi: 10.1021/acs.jmedchem.2c00793
2022
Journal Article
Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox
Xie, Jing, Robinson, Samuel D., Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Rehm, Fabian B.H., Yap, Kuok, Ragnarsson, Lotten, Chan, Lai Yue, Hamilton, Brett R., Harvey, Peta J., Craik, David J., Vetter, Irina and Durek, Thomas (2022). Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox. Journal of Biological Chemistry, 298 (8) 102218, 1-12. doi: 10.1016/j.jbc.2022.102218
2022
Journal Article
Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation
Klasfauseweh, Tabea, Israel, Mathilde R., Ragnarsson, Lotten, Cox, James J., Durek, Thomas, Carter, David A., Leffler, Andreas, Vetter, Irina and Deuis, Jennifer R. (2022). Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation. European Journal of Pharmacology, 925 175013, 175013. doi: 10.1016/j.ejphar.2022.175013
2022
Journal Article
Cystine knot peptides with tuneable activity and mechanism
Li, Choi Yi, Rehm, Fabian B. H., Yap, Kuok, Zdenek, Christina N., Harding, Maxim D., Fry, Bryan G., Durek, Thomas, Craik, David J. and Veer, Simon J. (2022). Cystine knot peptides with tuneable activity and mechanism. Angewandte Chemie, 61 (19) e202200951, e202200951. doi: 10.1002/ange.202200951
2022
Journal Article
Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA
Jakob, Valentin, Zoller, Ben G. E., Rinkes, Julia, Wu, Yingwen, Kiefer, Alexander F., Hust, Michael, Polten, Saskia, White, Andrew M., Harvey, Peta J., Durek, Thomas, Craik, David J., Siebert, Andreas, Kazmaier, Uli and Empting, Martin (2022). Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA. European Journal of Medicinal Chemistry, 231 114148, 114148. doi: 10.1016/j.ejmech.2022.114148
2022
Journal Article
Enzymatic C‐to‐C Protein Ligation
Rehm, Fabian B. H., Tyler, Tristan J., Veer, Simon J., Craik, David J. and Durek, Thomas (2022). Enzymatic C‐to‐C Protein Ligation. Angewandte Chemie International Edition, 134 (11) e202116672, e202116672. doi: 10.1002/anie.202116672
Funding
Past funding
Supervision
Availability
- Dr Thomas Durek is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Development of a new class of ligase enzymes for protein engineering and drug development
Principal Advisor
Other advisors: Dr Conan Wang, Professor David Craik
-
Doctor Philosophy
New Toxin Tools for Dissecting Pain
Associate Advisor
Other advisors: Professor Irina Vetter, Dr Sam Robinson
-
Doctor Philosophy
Ultra-stable Miniproteins for Treating Gastrointestinal Disorders
Associate Advisor
Other advisors: Professor David Craik
-
Doctor Philosophy
Using plants as factories for producing next generation peptide-based pharmaceuticals
Associate Advisor
Other advisors: Professor David Craik
-
Doctor Philosophy
Development of commercially viable cyclic peptide production for the protection of the Great Barrier Reef
Associate Advisor
Other advisors: Dr Conan Wang, Professor David Craik, Professor Linda Lua
-
Doctor Philosophy
Gut inflammation: model systems and the development of anti-inflammatory peptide drugs.
Associate Advisor
Other advisors: Professor Jennifer Stow
Completed supervision
-
2024
Doctor Philosophy
Discovery, production, and development of disulfide-rich peptides for drug design and development
Principal Advisor
Other advisors: Dr Conan Wang, Professor David Craik
-
2024
Doctor Philosophy
Molecular tools for peptide and protein engineering
Associate Advisor
Other advisors: Professor David Craik
-
2021
Doctor Philosophy
Enzymes that make-or-break peptide bonds in cyclotide biosynthesis
Associate Advisor
Other advisors: Professor David Craik
-
2020
Doctor Philosophy
The Effect of Naturally Derived Peptides on Animal Behaviour
Associate Advisor
Other advisors: Professor David Craik
-
2020
Doctor Philosophy
Engineering of Cyclic Disulfide-Rich Peptides for Applications in Drug Design
Associate Advisor
Other advisors: Professor David Craik
-
2019
Doctor Philosophy
Elucidating the role of NaV1.6 in peripheral sensory neurons
Associate Advisor
Other advisors: Professor Irina Vetter
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