Dr

Thomas Durek

Email: 
Phone: 
+61 7 334 62021

Availability

Dr Thomas Durek is:
Available for supervision

Fields of research

Biological Sciences Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy, TU Dortmund University

Search Professor Thomas Durek’s works on UQ eSpace

99 works between 2002 and 2025
All (99) Journal Article (94) Conference Publication (4) Book Chapter (1)

21 - 40 of 99 works

2022

Journal Article

Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox

Xie, Jing, Robinson, Samuel D., Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Rehm, Fabian B.H., Yap, Kuok, Ragnarsson, Lotten, Chan, Lai Yue, Hamilton, Brett R., Harvey, Peta J., Craik, David J., Vetter, Irina and Durek, Thomas (2022). Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox. Journal of Biological Chemistry, 298 (8) 102218, 1-12. doi: 10.1016/j.jbc.2022.102218

Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox

2022

Journal Article

Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation

Klasfauseweh, Tabea, Israel, Mathilde R., Ragnarsson, Lotten, Cox, James J., Durek, Thomas, Carter, David A., Leffler, Andreas, Vetter, Irina and Deuis, Jennifer R. (2022). Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation. European Journal of Pharmacology, 925 175013, 175013. doi: 10.1016/j.ejphar.2022.175013

Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation

2022

Journal Article

Cystine knot peptides with tuneable activity and mechanism

Li, Choi Yi, Rehm, Fabian B. H., Yap, Kuok, Zdenek, Christina N., Harding, Maxim D., Fry, Bryan G., Durek, Thomas, Craik, David J. and Veer, Simon J. (2022). Cystine knot peptides with tuneable activity and mechanism. Angewandte Chemie, 61 (19) e202200951, e202200951. doi: 10.1002/ange.202200951

Cystine knot peptides with tuneable activity and mechanism

2022

Journal Article

Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA

Jakob, Valentin, Zoller, Ben G. E., Rinkes, Julia, Wu, Yingwen, Kiefer, Alexander F., Hust, Michael, Polten, Saskia, White, Andrew M., Harvey, Peta J., Durek, Thomas, Craik, David J., Siebert, Andreas, Kazmaier, Uli and Empting, Martin (2022). Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA. European Journal of Medicinal Chemistry, 231 114148, 114148. doi: 10.1016/j.ejmech.2022.114148

Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA

2022

Journal Article

Enzymatic C‐to‐C Protein Ligation

Rehm, Fabian B. H., Tyler, Tristan J., Veer, Simon J., Craik, David J. and Durek, Thomas (2022). Enzymatic C‐to‐C Protein Ligation. Angewandte Chemie International Edition, 134 (11) e202116672, e202116672. doi: 10.1002/anie.202116672

Enzymatic C‐to‐C Protein Ligation

2021

Journal Article

Enzymatic C-terminal protein engineering with amines

Rehm, Fabian B. H., Tyler, Tristan J., Yap, Kuok, de Veer, Simon J., Craik, David J. and Durek, Thomas (2021). Enzymatic C-terminal protein engineering with amines. Journal of the American Chemical Society, 143 (46) jacs.1c08976, 19498-19504. doi: 10.1021/jacs.1c08976

Enzymatic C-terminal protein engineering with amines

2021

Journal Article

Melanocortin 1 receptor agonists based on a bivalent, bicyclic peptide framework

Durek, Thomas, Kaas, Quentin, White, Andrew M., Weidmann, Joachim, Fuaad, Abdullah Ahmad, Cheneval, Olivier, Schroeder, Christina I., de Veer, Simon J., Dellsén, Anita, Österlund, Torben, Larsson, Niklas, Knerr, Laurent, Bauer, Udo, Plowright, Alleyn T. and Craik, David J. (2021). Melanocortin 1 receptor agonists based on a bivalent, bicyclic peptide framework. Journal of Medicinal Chemistry, 64 (14) acs.jmedchem.1c00095, 9906-9915. doi: 10.1021/acs.jmedchem.1c00095

Melanocortin 1 receptor agonists based on a bivalent, bicyclic peptide framework

2021

Journal Article

Asparaginyl ligases: new enzymes for the protein engineer's toolbox

Rehm, Fabian B. H., Tyler, Tristan J., Xie, Jing, Yap, Kuok, Durek, Thomas and Craik, David J. (2021). Asparaginyl ligases: new enzymes for the protein engineer's toolbox. ChemBioChem, 22 (12), 2079-2086. doi: 10.1002/cbic.202100071

Asparaginyl ligases: new enzymes for the protein engineer's toolbox

2021

Journal Article

Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1

Poth, Aaron G., Chiu, Francis C.K., Stalmans, Sofie, Hamilton, Brett R., Huang, Yen-Hua, Shackleford, David M., Patil, Rahul, Le, Thao T., Kan, Meng-Wei, Durek, Thomas, Wynendaele, Evelien, De Spiegeleer, Bart, Powell, Andrew K., Venter, Deon J., Clark, Richard J., Charman, Susan A. and Craik, David J. (2021). Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1. Medicine in Drug Discovery, 10 100087, 1-10. doi: 10.1016/j.medidd.2021.100087

Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1

2021

Journal Article

Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases

Yap, Kuok, Du, Junqiao, Rehm, Fabian B. H., Tang, Shyn Ric, Zhou, Yan, Xie, Jing, Wang, Conan K., de Veer, Simon J., Lua, Linda H. L., Durek, Thomas and Craik, David J. (2021). Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases. Nature Protocols, 16 (3), 1-23. doi: 10.1038/s41596-020-00483-0

Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases

2020

Journal Article

Improved asparaginyl‐ligase‐catalyzed transpeptidation via selective nucleophile quenching

Rehm, Fabian B. H., Tyler, Tristan J., Yap, Kuok, Durek, Thomas and Craik, David J. (2020). Improved asparaginyl‐ligase‐catalyzed transpeptidation via selective nucleophile quenching. Angewandte Chemie, 133 (8) ange.202013584, 4050-4054. doi: 10.1002/ange.202013584

Improved asparaginyl‐ligase‐catalyzed transpeptidation via selective nucleophile quenching

2020

Journal Article

Make it or break it: plant AEPs on stage in biotechnology

Jackson, Mark A., Nguyen, Linh T. T., Gilding, Edward K., Durek, Thomas and Craik, David J. (2020). Make it or break it: plant AEPs on stage in biotechnology. Biotechnology Advances, 45 107651, 107651. doi: 10.1016/j.biotechadv.2020.107651

Make it or break it: plant AEPs on stage in biotechnology

2020

Journal Article

Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otency

Peschel, Alicia, Cardoso, Fernanda C., Walker, Andrew A., Durek, Thomas, Stone, M Rhia L., Braga Emidio, Nayara, Dawson, Philip E., Muttenthaler, Markus and King, Glenn F. (2020). Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otency. Journal of Medicinal Chemistry, 63 (21), 12773-12785. doi: 10.1021/acs.jmedchem.0c01107

Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otency

2020

Journal Article

Neurotoxic peptides from the venom of the giant Australian stinging tree

Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Israel, Mathilde R., Harvey, Peta J., Poth, Aaron G., Rehm, Fabian B. H., Stow, Jennifer L., Robinson, Samuel D., Yap, Kuok, Brown, Darren L., Hamilton, Brett R., Andersson, David, Craik, David J., Vetter, Irina and Durek, Thomas (2020). Neurotoxic peptides from the venom of the giant Australian stinging tree. Science Advances, 6 (38) eabb8828, 1-10. doi: 10.1126/sciadv.abb8828

Neurotoxic peptides from the venom of the giant Australian stinging tree

2020

Journal Article

An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides

Yap, Kuok, Du, Junqiao, Looi, Fong Yang, Tang, Shyn Ric, de Veer, Simon J., Bony, Anuja R., Rehm, Fabian B. H., Xie, Jing, Chan, Lai Yue, Wang, Conan K., Adams, David J., Lua, Linda H. L., Durek, Thomas and Craik, David J. (2020). An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides. Green Chemistry, 22 (15), 5002-5016. doi: 10.1039/d0gc01366h

An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides

2020

Journal Article

Characterization of synthetic Tf2 as a NaV1.3 selective pharmacological probe

Israel, Mathilde R., Dash, Thomas S., Bothe, Stefanie N., Robinson, Samuel D., Deuis, Jennifer R., Craik, David J., Lampert, Angelika, Vetter, Irina and Durek, Thomas (2020). Characterization of synthetic Tf2 as a NaV1.3 selective pharmacological probe. Biomedicines, 8 (6) 155, 155. doi: 10.3390/biomedicines8060155

Characterization of synthetic Tf2 as a NaV1.3 selective pharmacological probe

2020

Journal Article

Inside Cover: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. Int. Ed. 28/2020)

White, Andrew M., Veer, Simon J., Wu, Guojie, Harvey, Peta J., Yap, Kuok, King, Gordon J., Swedberg, Joakim E., Wang, Conan K., Law, Ruby H. P., Durek, Thomas and Craik, David J. (2020). Inside Cover: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. Int. Ed. 28/2020). Angewandte Chemie International Edition, 59 (28), 11162-11162. doi: 10.1002/anie.202006713

Inside Cover: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. Int. Ed. 28/2020)

2020

Journal Article

Innentitelbild: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. 28/2020)

White, Andrew M., Veer, Simon J., Wu, Guojie, Harvey, Peta J., Yap, Kuok, King, Gordon J., Swedberg, Joakim E., Wang, Conan K., Law, Ruby H. P., Durek, Thomas and Craik, David J. (2020). Innentitelbild: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. 28/2020). Angewandte Chemie, 132 (28), 11258-11258. doi: 10.1002/ange.202006713

Innentitelbild: Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides (Angew. Chem. 28/2020)

2020

Journal Article

Application and structural analysis of triazole‐bridged disulfide mimetics in cyclic peptides

White, Andrew M., Veer, Simon J., Wu, Guojie, Harvey, Peta J., Yap, Kuok, King, Gordon J., Swedberg, Joakim E., Wang, Conan K., Law, Ruby H. P., Durek, Thomas and Craik, David J. (2020). Application and structural analysis of triazole‐bridged disulfide mimetics in cyclic peptides. Angewandte Chemie International Edition, 132 (28) anie.202003435, 11369-11373. doi: 10.1002/anie.202003435

Application and structural analysis of triazole‐bridged disulfide mimetics in cyclic peptides

2020

Journal Article

A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors

Du, Junqiao, Yap, Kuok, Chan, Lai Yue, Rehm, Fabian B. H., Looi, Fong Yang, Poth, Aaron G., Gilding, Edward K., Kaas, Quentin, Durek, Thomas and Craik, David J. (2020). A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors. Nature Communications, 11 (1) 1575, 1-11. doi: 10.1038/s41467-020-15418-2

A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors

Past funding

  • 2020 - 2024
    Understanding the mechanisms of peptide cyclisation
    ARC Discovery Projects
    Open grant
  • 2020 - 2022
    Peptide ligands as tools to decipher receptor biology
    NHMRC IDEAS Grants
    Open grant
  • 2020 - 2022
    Toxins from Down Under: Novel tools to understand and modulate ion channels
    ARC Discovery Projects
    Open grant
  • 2015 - 2017
    Development of selective melanocortin receptor agonists and antagonists
    NHMRC Project Grant
    Open grant
  • 2015 - 2019
    The chemistry and biology of circular proteins
    ARC Discovery Projects
    Open grant
  • 2011 - 2012
    Novel strategies for site-specific labelling of cysteine-rich peptides and proteins
    UQ Early Career Researcher
    Open grant
  • 2008 - 2010
    Synthesis of microprotein analogs for studying the biochemical and pharmacological properties of ion channels
    UQ Postdoctoral Research Fellowship
    Open grant

Availability

Dr Thomas Durek is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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