Dr

Thomas Durek

Email: 
Phone: 
+61 7 334 62021

Availability

Dr Thomas Durek is:
Available for supervision

Fields of research

Biological Sciences Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy, TU Dortmund University

Search Professor Thomas Durek’s works on UQ eSpace

95 works between 2002 and 2024
All (95) Journal Article (91) Conference Publication (4)

41 - 60 of 95 works

2019

Journal Article

NaV1.6 regulates excitability of mechanosensitive sensory neurons

Israel, Mathilde R., Tanaka, Brian S., Castro, Joel, Thongyoo, Panumart, Robinson, Samuel D., Zhao, Peng, Deuis, Jennifer R., Craik, David J., Durek, Thomas, Brierley, Stuart M., Waxman, Stephen G, Dib-Hajj, Sulayman D. and Vetter, Irina (2019). NaV1.6 regulates excitability of mechanosensitive sensory neurons. Journal of Physiology, 597 (14), 3751-3768. doi: 10.1113/JP278148

NaV1.6 regulates excitability of mechanosensitive sensory neurons

2019

Journal Article

Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization

Rehm, Fabian B. H., Jackson, Mark A., De Geyter, Ewout, Yap, Kuok, Gilding, Edward K., Durek, Thomas and Craik, David J. (2019). Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization. Proceedings of the National Academy of Sciences, 116 (16), 7831-7836. doi: 10.1073/pnas.1901807116

Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization

2019

Journal Article

A centipede toxin family defines an ancient class of CSαβ defensins

Dash, Thomas S., Shafee, Thomas, Harvey, Peta J., Zhang, Chuchu, Peigneur, Steve, Deuis, Jennifer R., Vetter, Irina, Tytgat, Jan, Anderson, Marilyn A., Craik, David J., Durek, Thomas and Undheim, Eivind A. B. (2019). A centipede toxin family defines an ancient class of CSαβ defensins. Structure, 27 (2), 315-326. doi: 10.1016/j.str.2018.10.022

A centipede toxin family defines an ancient class of CSαβ defensins

2019

Journal Article

Highly potent and selective plasmin inhibitors based on the sunflower trypsin inhibitor-1 scaffold attenuate fibrinolysis in plasma

Swedberg, Joakim E., Wu, Guojie, Mahatmanto, Tunjung, Durek, Thomas, Caradoc-Davies, Tom T., Whisstock, James C., Law, Ruby H. P. and Craik, David J. (2019). Highly potent and selective plasmin inhibitors based on the sunflower trypsin inhibitor-1 scaffold attenuate fibrinolysis in plasma. Journal of Medicinal Chemistry, 62 (2), 552-560. doi: 10.1021/acs.jmedchem.8b01139

Highly potent and selective plasmin inhibitors based on the sunflower trypsin inhibitor-1 scaffold attenuate fibrinolysis in plasma

2018

Journal Article

NMR structure of µ-conotoxin GIIIC: Leucine 18 induces local repacking of the N-terminus resulting in reduced Nav channel potency

Harvey, Peta J., Kurniawan, Nyoman D., Finol-Urdaneta, Rocio K., McArthur, Jeffrey R., Van Lysebetten, Dorien, Dash, Thomas S., Hill, Justine M., Adams, David J., Durek, Thomas and Craik, David J. (2018). NMR structure of µ-conotoxin GIIIC: Leucine 18 induces local repacking of the N-terminus resulting in reduced Nav channel potency. Molecules, 23 (10) molecules23102715, 2715. doi: 10.3390/molecules23102715

NMR structure of µ-conotoxin GIIIC: Leucine 18 induces local repacking of the N-terminus resulting in reduced Nav channel potency

2018

Journal Article

Targeted delivery of cyclotides via conjugation to a nanobody

Kwon, Soohyun, Duarte, Joao N., Li, Zeyang, Ling, Jingjing J., Cheneval, Olivier, Durek, Thomas, Schroeder, Christina I., Craik, David J. and Ploegh, Hidde L. (2018). Targeted delivery of cyclotides via conjugation to a nanobody. ACS Chemical Biology, 13 (10), 2973-2980. doi: 10.1021/acschembio.8b00653

Targeted delivery of cyclotides via conjugation to a nanobody

2018

Conference Publication

Chemical synthesis and applications of a novel fluorescent probe for human complement C3a receptor

Wu, Chongyang, de Araujo, Aline, Wu, Kai-Chen, Reid, Robert, Durek, Thomas, Lim, Junxian and Fairlie, David (2018). Chemical synthesis and applications of a novel fluorescent probe for human complement C3a receptor. 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond, Boston Ma, Aug 19-23, 2018. WASHINGTON: AMER CHEMICAL SOC.

Chemical synthesis and applications of a novel fluorescent probe for human complement C3a receptor

2018

Journal Article

Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases

Jackson, M. A., Gilding, E. K., Shafee, T., Harris, K. S., Kaas, Q., Poon, S., Yap, K., Jia, H., Guarino, R., Chan, L. Y., Durek, T., Anderson, M. A. and Craik, D. J. (2018). Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases. Nature Communications, 9 (1) 2411, 2411. doi: 10.1038/s41467-018-04669-9

Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases

2018

Journal Article

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1

Durek, Thomas, Cromm, Philipp M., White, Andrew M., Schroeder, Christina I., Kaas, Quentin, Weidmann, Joachim, Ahmad Fuaad, Abdullah, Cheneval, Olivier, Harvey, Peta J., Daly, Norelle L., Zhou, Yang, Dellsén, Anita, Österlund, Torben, Larsson, Niklas, Knerr, Laurent, Bauer, Udo, Kessler, Horst, Cai, Minying, Hruby, Victor J., Plowright, Alleyn T. and Craik, David J. (2018). Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1. Journal of Medicinal Chemistry, 61 (8), 3674-3684. doi: 10.1021/acs.jmedchem.8b00170

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1

2018

Journal Article

The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6

Israel, Mathilde R., Thongyoo, Panumart, Deuis, Jennifer R., Craik, David J., Vetter, Irina and Durek, Thomas (2018). The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6. Journal of Medicinal Chemistry, 61 (4), 1730-1736. doi: 10.1021/acs.jmedchem.7b01609

The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6

2018

Conference Publication

Development of serine protease inhibitors using the 1,2,3-triazole motif as a disulfide mimetic in the cyclic peptide sunflower trypsin inhibitor-1

White, Andrew, Deveer, Simon, Swedberg, Joakim, Durek, Thomas and Craik, David (2018). Development of serine protease inhibitors using the 1,2,3-triazole motif as a disulfide mimetic in the cyclic peptide sunflower trypsin inhibitor-1. 35th European Peptide Symposium, Dublin City University, Ireland, 26-31 August 2018. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.3127

Development of serine protease inhibitors using the 1,2,3-triazole motif as a disulfide mimetic in the cyclic peptide sunflower trypsin inhibitor-1

2017

Journal Article

Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta

Poon, Simon, Harris, Karen S, Jackson, Mark A, McCorkelle, Owen C, Gilding, Edward K, Durek, Thomas, van der Weerden, Nicole L, Craik, David J and Anderson, Marilyn A (2017). Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta. Journal of experimental botany, 69 (3), 633-641. doi: 10.1093/jxb/erx422

Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta

2017

Journal Article

Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors

Durek, Thomas, Shelukhina, Irina V., Tae, Han-Shen, Thongyoo, Panumart, Spirova, Ekaterina N., Kudryavtsev, Denis S., Kasheverov, Igor E., Faure, Grazyna, Corringer, Pierre-Jean, Craik, David J., Adams, David J. and Tsetlin, Victor I. (2017). Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors. Scientific Reports, 7 (1) 16606, 16606. doi: 10.1038/s41598-017-16809-0

Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors

2017

Journal Article

Europium-labeled synthetic C3a protein as a novel fluorescent probe for human complement C3a receptor

Dantas de Araujo, Aline, Wu, Chongyang, Wu, Kai-Chen, Reid, Robert C., Durek, Thomas, Lim, Junxian and Fairlie, David P. (2017). Europium-labeled synthetic C3a protein as a novel fluorescent probe for human complement C3a receptor. Bioconjugate Chemistry, 28 (6), 1669-1676. doi: 10.1021/acs.bioconjchem.7b00132

Europium-labeled synthetic C3a protein as a novel fluorescent probe for human complement C3a receptor

2017

Journal Article

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Wingerd, Joshua S., Mozar, Christine A., Ussing, Christine A., Murali, Swetha S., Chin, Yanni K. -Y., Cristofori-Armstrong, Ben, Durek, Thomas, Gilchrist, John, Vaughan, Christopher W., Bosmans, Frank, Adams, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Christie, Macdonald J. and Rash, Lachlan D. (2017). The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.. Scientific Reports, 7 (1) 974, 974. doi: 10.1038/s41598-017-01129-0

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

2017

Journal Article

Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET

Kubota, Tomoya, Durek, Thomas, Dang, Bobo, Finol-Urdaneta, Rocio K., Craik, David J., Kent, Stephen B. H., French, Robert J., Bezanilla, Francisco and Correa, Ana M. (2017). Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET. Proceedings of the National Academy of Sciences, 114 (10), E1857-E1865. doi: 10.1073/pnas.1700453114

Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET

2017

Journal Article

Synthesis and protein engineering applications of cyclotides

Qu, Haiou, Smithies, Bronwyn J. , Durek, Thomas and Craik, David J. (2017). Synthesis and protein engineering applications of cyclotides. Australian Journal of Chemistry, 70 (2), 152-161. doi: 10.1071/CH16589

Synthesis and protein engineering applications of cyclotides

2016

Journal Article

Combining sense and nonsense codon reassignment for site-selective protein modification with unnatural amino acids

Cui, Zhenling, Mureev, Sergey, Polinkovsky, Mark E., Tnimov, Zakir, Guo, Zhong, Durek, Thomas, Jones, Alun and Alexandrov, Kirill (2016). Combining sense and nonsense codon reassignment for site-selective protein modification with unnatural amino acids. ACS Synthetic Biology, 6 (3), 535-544. doi: 10.1021/acssynbio.6b00245

Combining sense and nonsense codon reassignment for site-selective protein modification with unnatural amino acids

2016

Journal Article

Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix

Ikonomopoulou, Maria P., Smith, Jennifer J., Herzig, Volker, Pineda, Sandy S., Dziemborowicz, Sławomir, Er, Sing-Yan, Durek, Thomas, Gilchrist, John, Alewood, Paul F., Nicholson, Graham M., Bosmans, Frank and King, Glenn F. (2016). Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix. Toxicon, 123, 62-70. doi: 10.1016/j.toxicon.2016.10.013

Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix

2016

Journal Article

Nicotiana alata defensin chimeras reveal differences in the mechanism of fungal and tumor cell killing and an enhanced antifungal variant

Bleackley, Mark R., Payne, Jennifer A. E., Hayes, Brigitte M. E, Durek, Thomas, Craik, David J., Shafee, Thomas M. A., Poon, Ivan K. H., Hulett, Mark D., Van Der Weerden, Nicole L. and Anderson, Marilyn A. (2016). Nicotiana alata defensin chimeras reveal differences in the mechanism of fungal and tumor cell killing and an enhanced antifungal variant. Antimicrobial Agents and Chemotherapy, 60 (10), 6302-6312. doi: 10.1128/AAC.01479-16

Nicotiana alata defensin chimeras reveal differences in the mechanism of fungal and tumor cell killing and an enhanced antifungal variant

Past funding

  • 2020 - 2024
    Understanding the mechanisms of peptide cyclisation
    ARC Discovery Projects
    Open grant
  • 2020 - 2022
    Peptide ligands as tools to decipher receptor biology
    NHMRC IDEAS Grants
    Open grant
  • 2020 - 2022
    Toxins from Down Under: Novel tools to understand and modulate ion channels
    ARC Discovery Projects
    Open grant
  • 2015 - 2017
    Development of selective melanocortin receptor agonists and antagonists
    NHMRC Project Grant
    Open grant
  • 2015 - 2019
    The chemistry and biology of circular proteins
    ARC Discovery Projects
    Open grant
  • 2011 - 2012
    Novel strategies for site-specific labelling of cysteine-rich peptides and proteins
    UQ Early Career Researcher
    Open grant
  • 2008 - 2010
    Synthesis of microprotein analogs for studying the biochemical and pharmacological properties of ion channels
    UQ Postdoctoral Research Fellowship
    Open grant

Availability

Dr Thomas Durek is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Development of a new class of ligase enzymes for protein engineering and drug development

    Principal Advisor

    Other advisors: Dr Conan Wang, Professor David Craik

  • Doctor Philosophy

    New Toxin Tools for Dissecting Pain

    Associate Advisor

    Other advisors: Professor Irina Vetter, Dr Sam Robinson

  • Doctor Philosophy

    Development of novel peptide based drug leads for chronic myeloid leukaemia

    Associate Advisor

    Other advisors: Dr Simon de Veer, Professor David Craik

  • Doctor Philosophy

    Application of transpeptidases for peptide and protein engineering

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    Development of commercially viable cyclic peptide production for the protection of the Great Barrier Reef

    Associate Advisor

    Other advisors: Dr Conan Wang, Professor David Craik, Professor Linda Lua

  • Doctor Philosophy

    Accessing structurally elusive states of sodium channels as novel analgesic targets

    Associate Advisor

    Other advisors: Professor Irina Vetter, Professor Mehdi Mobli

  • Doctor Philosophy

    Application of transpeptidases for peptide and protein engineering

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    Gut inflammation: model systems and the development of anti-inflammatory peptide drugs.

    Associate Advisor

    Other advisors: Professor Jennifer Stow

  • Doctor Philosophy

    Using plants as factories for producing next generation peptide-based pharmaceuticals

    Associate Advisor

    Other advisors: Dr Paul Visendi Muhindira, Professor David Craik

  • Doctor Philosophy

    Application of transpeptidases for peptide and protein engineering

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    Ultra-stable Miniproteins for Treating Gastrointestinal Disorders

    Associate Advisor

    Other advisors: Professor David Craik

Completed supervision

Enquiries

For media enquiries about Dr Thomas Durek's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au