Dr

Thomas Durek

Email: 
Phone: 
+61 7 334 62021

Availability

Dr Thomas Durek is:
Available for supervision

Fields of research

Biological Sciences Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy, TU Dortmund University

Search Professor Thomas Durek’s works on UQ eSpace

95 works between 2002 and 2024
All (95) Journal Article (91) Conference Publication (4)

61 - 80 of 95 works

2016

Journal Article

Constrained cyclic peptides as immunomodulatory inhibitors of the CD2:CD58 protein-protein interaction

Sable, Rushikesh, Durek, Thomas, Taneja, Veena, Craik, David J., Pallerla, Sandeep, Gauthier, Ted and Jois, Seetharama (2016). Constrained cyclic peptides as immunomodulatory inhibitors of the CD2:CD58 protein-protein interaction. ACS Chemical Biology, 11 (8), 2366-2374. doi: 10.1021/acschembio.6b00486

Constrained cyclic peptides as immunomodulatory inhibitors of the CD2:CD58 protein-protein interaction

2016

Journal Article

Analgesic effects of GpTx-1, PF-04856264 and CNV1014802 in a mouse model of NaV1.7-Mediated pain

Deuis, Jennifer R., Wingerd, Joshua S., Winter, Zoltan, Durek, Thomas, Dekan, Zoltan, Sousa, Silmara R., Zimmermann, Katharina, Hoffmann, Tali, Weidner, Christian, Nassar, Mohammed A., Alewood, Paul F., Lewis, Richard J. and Vetter, Irina (2016). Analgesic effects of GpTx-1, PF-04856264 and CNV1014802 in a mouse model of NaV1.7-Mediated pain. Toxins, 8 (3) 78, 78. doi: 10.3390/toxins8030078

Analgesic effects of GpTx-1, PF-04856264 and CNV1014802 in a mouse model of NaV1.7-Mediated pain

2016

Journal Article

Modulation of human Nav1.7 channel gating by synthetic alpha-scorpion toxin OD1 and its analogs

Motin, Leonid, Durek, Thomas and Adams, David J. (2016). Modulation of human Nav1.7 channel gating by synthetic alpha-scorpion toxin OD1 and its analogs. Channels, 10 (2), 139-147. doi: 10.1080/19336950.2015.1120392

Modulation of human Nav1.7 channel gating by synthetic alpha-scorpion toxin OD1 and its analogs

2016

Journal Article

Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization

Conibear, Anne C., Chaousis, Stephanie, Durek, Thomas, Rosengren, K. Johan, Craik, David J. and Schroeder, Christina I. (2016). Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization. Biopolymers, 106 (1), 89-100. doi: 10.1002/bip.22767

Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization

2016

Conference Publication

Probing voltage-dependent structural changes of the VSD in mammalian Nav with LRET

Kubota, Tomoya, Durek, Thomas, Finol-Urdaneta, Rocio K., Craik, David J., French, Robert J., Bezanilla, Francisco and Correa, Ana M. (2016). Probing voltage-dependent structural changes of the VSD in mammalian Nav with LRET. 60th Annual Meeting of the Biophysical Society, Los Angeles, United States, Feb 27-Mar 02, 2016. St. Louis, United States: Cell Press. doi: 10.1016/j.bpj.2015.11.665

Probing voltage-dependent structural changes of the VSD in mammalian Nav with LRET

2015

Journal Article

Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase

Harris, Karen S., Durek, Thomas, Kaas, Quentin, Poth, Aaron G., Gilding, Edward K., Conlan, Brendon F., Saska, Ivana, Daly, Norelle L., Van Der Weerden, Nicole L., Craik, David J. and Anderson, Marilyn A. (2015). Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase. Nature Communications, 6 (10199) 10199, 10199. doi: 10.1038/ncomms10199

Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase

2015

Journal Article

Potent complement C3a receptor agonists derived from oxazole amino acids: structure-activity relationships

Singh, Ranee, Reed, Anthony N., Chu, Peifei, Scully, Conor C. G., Yau, Mei-Kwan, Suen, Jacky Y., Durek, Thomas, Reid, Robert C. and Fairlie, David P. (2015). Potent complement C3a receptor agonists derived from oxazole amino acids: structure-activity relationships. Bioorganic and Medicinal Chemistry Letters, 25 (23), 5604-5608. doi: 10.1016/j.bmcl.2015.10.038

Potent complement C3a receptor agonists derived from oxazole amino acids: structure-activity relationships

2015

Journal Article

Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists

Swedberg, Joakim E., Schroeder, Christina I., Mitchell, Justin M., Durek, Thomas, Fairlie, David P., Edmonds, David J., Griffith, David A., Ruggeri, Roger B., Derksen, David R., Loria, Paula M., Liras, Spiros, Price, David A. and Craik, David J. (2015). Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists. European Journal of Medicinal Chemistry, 103, 175-184. doi: 10.1016/j.ejmech.2015.08.046

Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists

2015

Journal Article

Therapeutic conotoxins: a US patent literature survey

Durek, Thomas and Craik, David J. (2015). Therapeutic conotoxins: a US patent literature survey. Expert Opinion in Therapeutic Patents, 25 (10), 1159-1173. doi: 10.1517/13543776.2015.1054095

Therapeutic conotoxins: a US patent literature survey

2014

Journal Article

Fmoc-based synthesis of disulfide-rich cyclic peptides

Cheneval, Olivier, Schroeder, Christina I., Durek, Thomas, Walsh, Phillip, Huang, Yen-Hua, Liras, Spiros, Price, David A. and Craik, David J. (2014). Fmoc-based synthesis of disulfide-rich cyclic peptides. Journal of Organic Chemistry, 79 (12), 5538-5544. doi: 10.1021/jo500699m

Fmoc-based synthesis of disulfide-rich cyclic peptides

2014

Journal Article

Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom

Wang, Ching-I Anderson, Reeks, Timothy, Vetter, Irina, Vergara, Irene, Kovtun, Oleksiy, Lewis, Richard J., Alewood, Paul F. and Durek, Thomas (2014). Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom. Biochemistry, 53 (23), 3758-3766. doi: 10.1021/bi5004475

Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom

2014

Journal Article

Isolation, synthesis and characterization of omega-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels

Klint, Julie K., Berecki, Géza, Durek, Thomas, Mobli, Mehdi, Knapp, Oliver, King, Glenn F., Adams, David J., Alewood, Paul F. and Rash, Lachlan D. (2014). Isolation, synthesis and characterization of omega-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels. Biochemical Pharmacology, 89 (2), 276-286. doi: 10.1016/j.bcp.2014.02.008

Isolation, synthesis and characterization of omega-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels

2014

Journal Article

Disulfide-rich macrocyclic peptides as templates in drug design

Northfield, Susan E., Wang, Conan K., Schroeder, Christina I., Durek, Thomas, Kan, Meng-Wei, Swedberg, Joakim E. and Craik, David J. (2014). Disulfide-rich macrocyclic peptides as templates in drug design. European Journal of Medicinal Chemistry, 77 (2), 248-257. doi: 10.1016/j.ejmech.2014.03.011

Disulfide-rich macrocyclic peptides as templates in drug design

2014

Journal Article

Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2

Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2. Angewandte Chemie International Edition, 53 (4), 1017-1020. doi: 10.1002/anie.201308898

Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2

2014

Journal Article

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2. Angewandte Chemie, 126 (4), 1035-1038. doi: 10.1002/ange.201308898

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

2013

Journal Article

Chemical engineering and structural and pharmacological characterization of the alpha-scorpion toxin OD1

Durek, Thomas, Vetter, Irina, Wang, Ching-I Anderson, Motin, Leonid, Knapp, Oliver, Adams, David J., Lewis, Richard J. and Alewood, Paul F. (2013). Chemical engineering and structural and pharmacological characterization of the alpha-scorpion toxin OD1. ACS Chemical Biology, 8 (6), 1215-1222. doi: 10.1021/cb400012k

Chemical engineering and structural and pharmacological characterization of the alpha-scorpion toxin OD1

2013

Journal Article

Solid phase synthesis of peptide-selenoesters

Ghassemian, Artin, Vila-Farres, Xavier, Alewood, Paul F. and Durek, Thomas (2013). Solid phase synthesis of peptide-selenoesters. Bioorganic and Medicinal Chemistry, 21 (12), 3473-3478. doi: 10.1016/j.bmc.2013.03.076

Solid phase synthesis of peptide-selenoesters

2013

Journal Article

Efficient chemical synthesis of human complement protein C3a

Ghassemian, Artin, Wang, Ching-I Anderson, Yau, Mei-Kwan, Reid, Robert C., Lewis, Richard J., Fairlie, David P., Alewood, Paul F. and Durek, Thomas (2013). Efficient chemical synthesis of human complement protein C3a. Chemical Communications, 49 (23), 2356-2358. doi: 10.1039/c3cc40537k

Efficient chemical synthesis of human complement protein C3a

2012

Journal Article

Characterisation of Na-v types endogenously expressed in human SH-SY5Y neuroblastoma cells

Vetter, Irina, Mozar, Christine A., Durek, Thomas, Wingerd, Joshua S., Alewood, Paul F., Christie, Macdonald J. and Lewis, Richard J. (2012). Characterisation of Na-v types endogenously expressed in human SH-SY5Y neuroblastoma cells. Biochemical Pharmacology, 83 (11), 1562-1571. doi: 10.1016/j.bcp.2012.02.022

Characterisation of Na-v types endogenously expressed in human SH-SY5Y neuroblastoma cells

2011

Journal Article

Preformed selenoesters enable rapid native chemical ligation at intractable sites

Durek, Thomas and Alewood, Paul F. (2011). Preformed selenoesters enable rapid native chemical ligation at intractable sites. Angewandte Chemie International Edition, 50 (50), 12042-12045. doi: 10.1002/anie.201105512

Preformed selenoesters enable rapid native chemical ligation at intractable sites

Past funding

  • 2020 - 2024
    Understanding the mechanisms of peptide cyclisation
    ARC Discovery Projects
    Open grant
  • 2020 - 2022
    Peptide ligands as tools to decipher receptor biology
    NHMRC IDEAS Grants
    Open grant
  • 2020 - 2022
    Toxins from Down Under: Novel tools to understand and modulate ion channels
    ARC Discovery Projects
    Open grant
  • 2015 - 2017
    Development of selective melanocortin receptor agonists and antagonists
    NHMRC Project Grant
    Open grant
  • 2015 - 2019
    The chemistry and biology of circular proteins
    ARC Discovery Projects
    Open grant
  • 2011 - 2012
    Novel strategies for site-specific labelling of cysteine-rich peptides and proteins
    UQ Early Career Researcher
    Open grant
  • 2008 - 2010
    Synthesis of microprotein analogs for studying the biochemical and pharmacological properties of ion channels
    UQ Postdoctoral Research Fellowship
    Open grant

Availability

Dr Thomas Durek is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Development of a new class of ligase enzymes for protein engineering and drug development

    Principal Advisor

    Other advisors: Dr Conan Wang, Professor David Craik

  • Doctor Philosophy

    Using plants as factories for producing next generation peptide-based pharmaceuticals

    Associate Advisor

    Other advisors: Dr Paul Visendi Muhindira, Professor David Craik

  • Doctor Philosophy

    Application of transpeptidases for peptide and protein engineering

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    Ultra-stable Miniproteins for Treating Gastrointestinal Disorders

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    New Toxin Tools for Dissecting Pain

    Associate Advisor

    Other advisors: Professor Irina Vetter, Dr Sam Robinson

  • Doctor Philosophy

    Development of novel peptide based drug leads for chronic myeloid leukaemia

    Associate Advisor

    Other advisors: Dr Simon de Veer, Professor David Craik

  • Doctor Philosophy

    Application of transpeptidases for peptide and protein engineering

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    Development of commercially viable cyclic peptide production for the protection of the Great Barrier Reef

    Associate Advisor

    Other advisors: Dr Conan Wang, Professor David Craik, Professor Linda Lua

  • Doctor Philosophy

    Accessing structurally elusive states of sodium channels as novel analgesic targets

    Associate Advisor

    Other advisors: Professor Irina Vetter, Professor Mehdi Mobli

  • Doctor Philosophy

    Application of transpeptidases for peptide and protein engineering

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    Gut inflammation: model systems and the development of anti-inflammatory peptide drugs.

    Associate Advisor

    Other advisors: Professor Jennifer Stow

Completed supervision

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