Dr

Thomas Durek

Email: 
Phone: 
+61 7 334 62021

Availability

Dr Thomas Durek is:
Available for supervision

Fields of research

Biological Sciences Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy, TU Dortmund University

Search Professor Thomas Durek’s works on UQ eSpace

95 works between 2002 and 2024
All (95) Journal Article (91) Conference Publication (4)

81 - 95 of 95 works

2010

Journal Article

Chemical synthesis and structure of the prokineticin Bv8

Morales, Rodrigo A. V., Daly, Norelle L., Vetter, Irina, Mobli, Mehdi, Napier, Ian A., Craik, David J., Lewis, Richard J., Christie, MacDonald J., King, Glenn F., Alewood, Paul F. and Durek, Thomas (2010). Chemical synthesis and structure of the prokineticin Bv8. ChemBioChem, 11 (13), 1882-1888. doi: 10.1002/cbic.201000330

Chemical synthesis and structure of the prokineticin Bv8

2009

Journal Article

Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3

Jensen, J. E., Durek, T, Alewood, P. F., Adams, D. J., King, G. F. and Rash, L. D. (2009). Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3. TOXICON, 54 (1), 56-61. doi: 10.1016/j.toxicon.2009.03.014

Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3

2007

Journal Article

Synthesis of photoactive analogues of a cystine knot trypsin inhibitor protein

Durek, Thomas, Zhang, Junliang, He, Chuan and Kent, Stephen B.H. (2007). Synthesis of photoactive analogues of a cystine knot trypsin inhibitor protein. Organic Letters, 9 (26), 5497-5500. doi: 10.1021/ol702461z

Synthesis of photoactive analogues of a cystine knot trypsin inhibitor protein

2007

Journal Article

Convergent chemical synthesis and high-resolution x-ray structure of human lysozyme

Durek, Thomas, Torbeev, Vladimir Yu and Kent, Stephen B. H. (2007). Convergent chemical synthesis and high-resolution x-ray structure of human lysozyme. Proceedings of the National Academy of Sciences of the United States of America, 104 (2), 4846-4851. doi: 10.1073/pnas.0610630104

Convergent chemical synthesis and high-resolution x-ray structure of human lysozyme

2006

Journal Article

Total Chemical Synthesis, Folding, and Assay of a Small Protein on a Water-Compatible Solid Support

Johnson, Erik C. B., Durek, Thomas and Kent, Stephen B. H. (2006). Total Chemical Synthesis, Folding, and Assay of a Small Protein on a Water-Compatible Solid Support. Angewandte Chemie International Edition, 45 (20), 3283-3287. doi: 10.1002/anie.200600381

Total Chemical Synthesis, Folding, and Assay of a Small Protein on a Water-Compatible Solid Support

2006

Journal Article

Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling

Pylypenko, Olena, Rak, Alexey, Durek, Thomas, Kushnir, Susanna, Dursina, Beatrice E., Thomae, Nicolas H., Constantinescu, Alexandru T., Brunsveld, Luc, Watzke, Anja, Waldmann, Herbert, Goody, Roger S. and Alexandrov, Kirill (2006). Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling. The EMBO Journal, 25 (1), 13-23. doi: 10.1038/sj.emboj.7600921

Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling

2005

Journal Article

Synthesis of functionalized Rab GTPases by a combination of solution- or solid-phase lipopeptide synthesis with expressed protein ligation

Brunsveld, Luc, Watzke, Anja, Durek, Thomas, Alexandrov, Kirill, Goody, Roger S. and Waldmann, Herbert (2005). Synthesis of functionalized Rab GTPases by a combination of solution- or solid-phase lipopeptide synthesis with expressed protein ligation. Chemistry: A European Journal, 11 (9), 2756-2772. doi: 10.1002/chem.200401041

Synthesis of functionalized Rab GTPases by a combination of solution- or solid-phase lipopeptide synthesis with expressed protein ligation

2005

Journal Article

Chemical biology of protein lipidation: Semi-synthesis and structure elucidation of prenylated RabGTPases

Watzke, Anja, Brunsveld, Luc, Durek, Thomas, Alexandrov, Kirill, Rak, Alexey, Goody, Roger S. and Waldmann, Herbert (2005). Chemical biology of protein lipidation: Semi-synthesis and structure elucidation of prenylated RabGTPases. Organic and Biomolecular Chemistry, 3 (7), 1157-1164. doi: 10.1039/b417573e

Chemical biology of protein lipidation: Semi-synthesis and structure elucidation of prenylated RabGTPases

2005

Conference Publication

Protein semi-synthesis and its application to studies of structure and function of GTPases

Rak, A, Pylypenko, O, Durek, T, Watzke, A, Waldmann, H, Goody, RS and Alexandrov, K (2005). Protein semi-synthesis and its application to studies of structure and function of GTPases. 19th American Peptide Symposium, San Diego, U.S., 18-23 June 2005. Hoboken, U.S.: Wiley Interscience.

Protein semi-synthesis and its application to studies of structure and function of GTPases

2005

Journal Article

Protein semi-synthesis: new proteins for functional and structural studies

Durek, Thomas and Becker, Christian F. W. (2005). Protein semi-synthesis: new proteins for functional and structural studies. Biomolecular Engineering, 22 (5-6), 153-172. doi: 10.1016/j.bioeng.2005.07.004

Protein semi-synthesis: new proteins for functional and structural studies

2005

Journal Article

Application of protein semisynthesis for the construction of functionalized posttranslationally modified Rab GTPases

Goody, Roger S., Durek, Thomas, Waldmann, Herbert, Brunsveld, Lucas and Alexandrov, Kirill (2005). Application of protein semisynthesis for the construction of functionalized posttranslationally modified Rab GTPases. Methods in Enzymology, 403 4, 29-42. doi: 10.1016/S0076-6879(05)03004-1

Application of protein semisynthesis for the construction of functionalized posttranslationally modified Rab GTPases

2004

Journal Article

Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase

Durek, Thomas, Alexandrov, Kirill, Goody, Roger S., Hildebrand, Alexandra, Heinemann, Ines and Waldmann, Herbert (2004). Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase. Journal of American Chemical Society, 126 (50), 16368-16378. doi: 10.1021/ja046164n

Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase

2004

Journal Article

In vitro semi-synthesis and applications of C-terminally modified Rab proteins

Durek, Thomas, Goody, Roger S. and Alexandrov, Kirill (2004). In vitro semi-synthesis and applications of C-terminally modified Rab proteins. Methods in Molecular Biology, 283, 233-244. doi: 10.1385/1-59259-813-7:233

In vitro semi-synthesis and applications of C-terminally modified Rab proteins

2003

Journal Article

Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase

Rak, A., Pylypenko, O., Durek, T., Watzke, A., Kushnir, S., Brunsveld, L., Waldmann, H., Goody, R. S. and Alexandrov, K. (2003). Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase. Science, 302 (5645), 646-650. doi: 10.1126/science.1087761

Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase

2002

Journal Article

Intein-Mediated Synthesis of Geranylgeranylated Rab7 Protein in Vitro

Alexandrov, Kirill, Heinemann, Ines, Durek, Thomas, Sidorovitch, Vadim, Goody, Roger S. and Waldmann, Herbert (2002). Intein-Mediated Synthesis of Geranylgeranylated Rab7 Protein in Vitro. Journal of the American Chemical Society, 124 (20), 5648-5649. doi: 10.1021/ja017799e

Intein-Mediated Synthesis of Geranylgeranylated Rab7 Protein in Vitro

Past funding

  • 2020 - 2024
    Understanding the mechanisms of peptide cyclisation
    ARC Discovery Projects
    Open grant
  • 2020 - 2022
    Peptide ligands as tools to decipher receptor biology
    NHMRC IDEAS Grants
    Open grant
  • 2020 - 2022
    Toxins from Down Under: Novel tools to understand and modulate ion channels
    ARC Discovery Projects
    Open grant
  • 2015 - 2017
    Development of selective melanocortin receptor agonists and antagonists
    NHMRC Project Grant
    Open grant
  • 2015 - 2019
    The chemistry and biology of circular proteins
    ARC Discovery Projects
    Open grant
  • 2011 - 2012
    Novel strategies for site-specific labelling of cysteine-rich peptides and proteins
    UQ Early Career Researcher
    Open grant
  • 2008 - 2010
    Synthesis of microprotein analogs for studying the biochemical and pharmacological properties of ion channels
    UQ Postdoctoral Research Fellowship
    Open grant

Availability

Dr Thomas Durek is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Development of a new class of ligase enzymes for protein engineering and drug development

    Principal Advisor

    Other advisors: Dr Conan Wang, Professor David Craik

  • Doctor Philosophy

    New Toxin Tools for Dissecting Pain

    Associate Advisor

    Other advisors: Professor Irina Vetter, Dr Sam Robinson

  • Doctor Philosophy

    Development of novel peptide based drug leads for chronic myeloid leukaemia

    Associate Advisor

    Other advisors: Dr Simon de Veer, Professor David Craik

  • Doctor Philosophy

    Application of transpeptidases for peptide and protein engineering

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    Development of commercially viable cyclic peptide production for the protection of the Great Barrier Reef

    Associate Advisor

    Other advisors: Dr Conan Wang, Professor David Craik, Professor Linda Lua

  • Doctor Philosophy

    Accessing structurally elusive states of sodium channels as novel analgesic targets

    Associate Advisor

    Other advisors: Professor Irina Vetter, Professor Mehdi Mobli

  • Doctor Philosophy

    Application of transpeptidases for peptide and protein engineering

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    Gut inflammation: model systems and the development of anti-inflammatory peptide drugs.

    Associate Advisor

    Other advisors: Professor Jennifer Stow

  • Doctor Philosophy

    Using plants as factories for producing next generation peptide-based pharmaceuticals

    Associate Advisor

    Other advisors: Dr Paul Visendi Muhindira, Professor David Craik

  • Doctor Philosophy

    Application of transpeptidases for peptide and protein engineering

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    Ultra-stable Miniproteins for Treating Gastrointestinal Disorders

    Associate Advisor

    Other advisors: Professor David Craik

Completed supervision

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