Dr Yen-Hua Crystal Huang
Dr

Yen-Hua Crystal Huang

Email: 
Phone: 
+61 7 334 62020

Availability

Dr Yen-Hua Crystal Huang is:
Available for supervision

Fields of research

Agricultural, Veterinary and Food Sciences Analytical chemistry Biological Sciences Chemical Sciences Crop and pasture production Medicinal and biomolecular chemistry

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Yen-Hua Crystal Huang’s works on UQ eSpace

89 works between 2008 and 2024
All (89) Journal Article (73) Book Chapter (2) Conference Publication (13) Other Outputs (1)

41 - 60 of 89 works

2019

Conference Publication

Spider toxins as novel allosteric modulators of insect nicotinic receptors

Earley, Fergus, Chambers, Chris, Cutler, Penny, Huang, Yen-Hua and Craik, David (2019). Spider toxins as novel allosteric modulators of insect nicotinic receptors. ACS Fall National Meeting and Exposition, San Diego, CA, United States, 25-29 August, 2019. Washington, DC United States: American Chemical Society.

Spider toxins as novel allosteric modulators of insect nicotinic receptors

2019

Journal Article

Cell membrane composition drives selectivity and toxicity of designed cyclic helix-loop-helix peptides with cell penetrating and tumor suppressor properties

Philippe, Grégoire J. -B., Gaspar, Diana, Sheng, Caibin, Huang, Yen-Hua, Benfield, Aurélie H., Condon, Nicholas D., Weidmann, Joachim, Lawrence, Nicole, Löwer, Alexander, Castanho, Miguel A. R. B., Craik, David J. and Troeira Henriques, Sónia (2019). Cell membrane composition drives selectivity and toxicity of designed cyclic helix-loop-helix peptides with cell penetrating and tumor suppressor properties. ACS Chemical Biology, 14 (9), 2071-2087. doi: 10.1021/acschembio.9b00593

Cell membrane composition drives selectivity and toxicity of designed cyclic helix-loop-helix peptides with cell penetrating and tumor suppressor properties

2019

Journal Article

Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold

Poth, Aaron G., Huang, Yen-Hua, Le, Thao T., Kan, Meng-Wei and Craik, David J. (2019). Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold. International Journal of Pharmaceutics, 565, 437-446. doi: 10.1016/j.ijpharm.2019.05.001

Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold

2019

Journal Article

Efficient enzymatic cyclization of disulfide-rich peptides by using peptide ligases

Schmidt, Marcel, Huang, Yen-Hua, de Oliveira, Eduardo F. Texeira, Toplak, Ana, Wijma, Hein J., Janssen, Dick B., van Maarseveen, Jan H., Craik, David J. and Nuijens, Timo (2019). Efficient enzymatic cyclization of disulfide-rich peptides by using peptide ligases. ChemBioChem, 20 (12) cbic.201900033, 1524-1529. doi: 10.1002/cbic.201900033

Efficient enzymatic cyclization of disulfide-rich peptides by using peptide ligases

2019

Journal Article

Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor

Chambers, Chris, Cutler, Penny, Huang, Yen-Hua, Goodchild, James A., Blythe, Judith, Wang, Conan K., Bigot, Aurélien, Kaas, Quentin, Craik, David J., Sabbadin, Davide and Earley, Fergus G. (2019). Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor. FEBS Letters, 593 (12) 1873-3468.13435, 1336-1350. doi: 10.1002/1873-3468.13435

Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor

2018

Journal Article

Synthesis, racemic x-ray crystallographic, and permeability studies of bioactive orbitides from Jatropha species

Ramalho, Suelem D., Wang, Conan K., King, Gordon J., Byriel, Karl A., Huang, Yen-Hua, Bolzani, Vanderlan S. and Craik, David J. (2018). Synthesis, racemic x-ray crystallographic, and permeability studies of bioactive orbitides from Jatropha species. Journal of Natural Products, 81 (11) acs.jnatprod.8b00447, 2436-2445. doi: 10.1021/acs.jnatprod.8b00447

Synthesis, racemic x-ray crystallographic, and permeability studies of bioactive orbitides from Jatropha species

2018

Journal Article

Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB

Wu, Xiaosa, Tae, Han-Shen, Huang, Yen-Hua, Adams, David J., Craik, David J. and Kaas, Quentin (2018). Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB. Biochemical Pharmacology, 155, 288-297. doi: 10.1016/j.bcp.2018.07.007

Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB

2018

Conference Publication

Targeting the coiled-coil domain of BCR-ABL1 kinase with new weapons

Huang, Yen-Hua, Passioura, Toby, Peacock, Hayden, Henriques, Sonia Troeira, Wang, Conan, Kaas, Quentin, Suga, Hiroaki and Craik, David (2018). Targeting the coiled-coil domain of BCR-ABL1 kinase with new weapons. 35th European Peptide Symposium, Dublin City University, Ireland, 26-31 August 2018. Oxford, United Kingdom: John Wiley & Sons.

Targeting the coiled-coil domain of BCR-ABL1 kinase with new weapons

2018

Conference Publication

Inhibition of nicotinic acetylcholine receptor subtypes by the ribbon isomers of alpha-conotoxins

Kaas, Quentin, Wu, Xiaosa, Tae, Han-Shen, Huang, Yen-Hua, Adams, David J. and Craik, David (2018). Inhibition of nicotinic acetylcholine receptor subtypes by the ribbon isomers of alpha-conotoxins. 35th European Peptide Symposium, Dublin City University, Ireland, 26-31 August 2018. Oxford, United Kingdom: John Wiley & Sons.

Inhibition of nicotinic acetylcholine receptor subtypes by the ribbon isomers of alpha-conotoxins

2017

Journal Article

Redesigned spider peptide with improved antimicrobial and anticancer properties

Henriques, Sónia Troeira, Lawrence, Nicole, Chaousis, Stephanie, Ravipati, Anjaneya S., Cheneval, Olivier, Benfield, Aurélie H., Elliott, Alysha G., Kavanagh, Angela Maria, Cooper, Matthew A., Chan, Lai Yue, Huang, Yen-Hua and Craik, David J. (2017). Redesigned spider peptide with improved antimicrobial and anticancer properties. ACS Chemical Biology, 12 (9), 2324-2334. doi: 10.1021/acschembio.7b00459

Redesigned spider peptide with improved antimicrobial and anticancer properties

2017

Journal Article

Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer

Wu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin, Harvey, Peta J., Wang, Conan K., Tae, Han-Shen, Adams, David J. and Craik, David J. (2017). Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. Journal of Biological Chemistry, 292 (41), 17101-17112. doi: 10.1074/jbc.M117.808386

Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer

2017

Journal Article

Lengths of the C-terminus and interconnecting loops impact stability of spider-derived gating modifier toxins

Agwa, Akello J., Huang, Yen-Hua, Craik, David J., Henriques, Sonia T. and Schroeder, Christina I. (2017). Lengths of the C-terminus and interconnecting loops impact stability of spider-derived gating modifier toxins. Toxins, 9 (8) 248, 248. doi: 10.3390/toxins9080248

Lengths of the C-terminus and interconnecting loops impact stability of spider-derived gating modifier toxins

2017

Journal Article

Understanding the diversity and distribution of cyclotides from plants of varied genetic origin

Ravipati, Anjaneya S., Poth, Aaron G., Henriques, Sonia Troeira, Bhandari, Murari, Huang, Yen-Hua, Nino, Jaime, Colgrave, Michelle L. and Craik, David J. (2017). Understanding the diversity and distribution of cyclotides from plants of varied genetic origin. Journal of Natural Products, 80 (5), 1522-1530. doi: 10.1021/acs.jnatprod.7b00061

Understanding the diversity and distribution of cyclotides from plants of varied genetic origin

2017

Journal Article

Structural and functional characterization of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies

Abdul Ghani, Hafiza, Henriques, Sonia Troeira, Huang, Yen-Hua, Swedberg, Joakim E. , Schroeder, Christina I. and Craik, David J. (2017). Structural and functional characterization of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies. Biopolymers, 108 (1) e22927, e22927. doi: 10.1002/bip.22927

Structural and functional characterization of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies

2016

Journal Article

Front Cover: Cyclisation of Disulfide-Rich Conotoxins in Drug Design Applications (Eur. J. Org. Chem. 21/2016)

Wu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2016). Front Cover: Cyclisation of Disulfide-Rich Conotoxins in Drug Design Applications (Eur. J. Org. Chem. 21/2016). European Journal of Organic Chemistry, 2016 (21), 3457-3457. doi: 10.1002/ejoc.201670211

Front Cover: Cyclisation of Disulfide-Rich Conotoxins in Drug Design Applications (Eur. J. Org. Chem. 21/2016)

2016

Journal Article

Cyclisation of disulfide-rich conotoxins in drug design applications

Wu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2016). Cyclisation of disulfide-rich conotoxins in drug design applications. European Journal of Organic Chemistry, 2016 (21), 3462-3472. doi: 10.1002/ejoc.201600402

Cyclisation of disulfide-rich conotoxins in drug design applications

2016

Journal Article

Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold

Wang, Conan K., Northfield, Susan E., Huang, Yen-Hua, Ramos, Mariana C. and Craik, David J. (2016). Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold. European Journal of Medicinal Chemistry, 109, 342-349. doi: 10.1016/j.ejmech.2016.01.006

Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold

2016

Journal Article

Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions

Philippe, Gregoire, Huang, Yen-Hua, Cheneval, Olivier, Lawrence, Nicole, Zhang, Zhen, Fairlie, David P., Craik, David J., Dantas De Araujo, Aline and Troeira Henriques, Sonia (2016). Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions. Biopolymers - Peptide Science, 106 (6), 853-863. doi: 10.1002/bip.22893

Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions

2016

Conference Publication

Inhibitory Effects of Substrate-Based Bcr-Abl1 Kinase Inhibitors On the Growth of Chronic Myeloid Leukemia Cell Line K562

Huang, Y. -H., Henriques, S. Troeira, Lawrence, N., Kaas, Q. and Craik, D. J. (2016). Inhibitory Effects of Substrate-Based Bcr-Abl1 Kinase Inhibitors On the Growth of Chronic Myeloid Leukemia Cell Line K562. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2950

Inhibitory Effects of Substrate-Based Bcr-Abl1 Kinase Inhibitors On the Growth of Chronic Myeloid Leukemia Cell Line K562

2016

Conference Publication

Cyclotides, stable drug scaffolds and delivery systems to target intracellular cancer pathways

Henriques, S. Troeira, Huang, Y. -H. and Craik, D. (2016). Cyclotides, stable drug scaffolds and delivery systems to target intracellular cancer pathways. 34th European Peptide Symposium, Leipzig, Germany, 4-9 September 2016. Oxford, United Kingdom: John Wiley & Sons.

Cyclotides, stable drug scaffolds and delivery systems to target intracellular cancer pathways

Current funding

  • 2024 - 2026
    Developing novel peptide tracers for improving immunotherapy outcomes
    NHMRC Development Grant
    Open grant

Past funding

  • 2021 - 2024
    Plant cyclotides as novel sustainable tools for crop protection
    ARC Linkage Projects
    Open grant

Availability

Dr Yen-Hua Crystal Huang is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Patient-friendly peptide tracers for improving immunotherapy outcomes

    Associate Advisor

    Other advisors: Dr Conan Wang

  • Doctor Philosophy

    Novel peptide-based drug leads for targeting leukaemia.

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    Discovery and Development of Substrate-Based Peptide Kinase Inhibitors

    Associate Advisor

    Other advisors: Professor David Craik, Dr Conan Wang

  • Doctor Philosophy

    Applications of cyclic peptides in drug design

    Associate Advisor

    Other advisors: Professor David Craik

Completed supervision

Enquiries

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