Dr Yen-Hua Crystal Huang
Dr

Yen-Hua Crystal Huang

Email: 
Phone: 
+61 7 334 62020

Availability

Dr Yen-Hua Crystal Huang is:
Available for supervision

Fields of research

Agricultural, Veterinary and Food Sciences Analytical chemistry Biological Sciences Chemical Sciences Crop and pasture production Medicinal and biomolecular chemistry

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Yen-Hua Crystal Huang’s works on UQ eSpace

86 works between 2008 and 2024
All (86) Journal Article (71) Book Chapter (2) Conference Publication (12) Other Outputs (1)

61 - 80 of 86 works

2015

Conference Publication

Cyclotides, stable drug scaffolds that enter cells after binding to PE-phospholipids

Henriques, S. T., Huang, Y. -H., Chaouis, S., Sani, M. -A., Poth, A. G., Separovic, F. and Craik, D. J. (2015). Cyclotides, stable drug scaffolds that enter cells after binding to PE-phospholipids. 10th European Biophysical Societies Association (EBSA) European Biophysics Congress, Dresden, Germany, Jul 18-22, 2015. Heidelberg, Germany: Springer.

Cyclotides, stable drug scaffolds that enter cells after binding to PE-phospholipids

2014

Journal Article

Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting

Henriques, Sonia Troeira, Huang, Yen-Hua, Chaousis, Steph, Wang, Conan and Craik, David J. (2014). Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting. Chembiochem, 15 (13), 1956-1965. doi: 10.1002/cbic.201402144

Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting

2014

Journal Article

Effects of arginine 10 to lysine substitution on omega-conotoxin CVIE and CVIF block of Ca(v)2.2 channels

Berecki, G., Daly, N. L., Huang, Y. H., Vink, S., Craik, D. J., Alewood, P. F. and Adams, D. J. (2014). Effects of arginine 10 to lysine substitution on omega-conotoxin CVIE and CVIF block of Ca(v)2.2 channels. British Journal of Pharmacology, 171 (13), 3313-3327. doi: 10.1111/bph.12686

Effects of arginine 10 to lysine substitution on omega-conotoxin CVIE and CVIF block of Ca(v)2.2 channels

2014

Journal Article

Fmoc-based synthesis of disulfide-rich cyclic peptides

Cheneval, Olivier, Schroeder, Christina I., Durek, Thomas, Walsh, Phillip, Huang, Yen-Hua, Liras, Spiros, Price, David A. and Craik, David J. (2014). Fmoc-based synthesis of disulfide-rich cyclic peptides. Journal of Organic Chemistry, 79 (12), 5538-5544. doi: 10.1021/jo500699m

Fmoc-based synthesis of disulfide-rich cyclic peptides

2014

Journal Article

Semienzymatic cyclization of disulfide-rich peptides using sortase A

Jia, Xinying, Kwon, Soohyun, Wang, Ching-I Anderson, Huang, Yen-Hua, Chan, Lai Y., Tan, Chia Chia, Rosengren, K. Johan, Mulvenna, Jason P., Schroeder, Christina I. and Craik, David J. (2014). Semienzymatic cyclization of disulfide-rich peptides using sortase A. Journal of Biological Chemistry, Papers in Press (10), 1-25. doi: 10.1074/jbc.M113.539262

Semienzymatic cyclization of disulfide-rich peptides using sortase A

2014

Conference Publication

Cyclotides use specific lipids as a switch to internalize inside cells

Henriques, S. T., Huang, Y-H., Chaousis, S. and Craik, D. J. (2014). Cyclotides use specific lipids as a switch to internalize inside cells. IUPAB Congress 2014, Brisbane, QLD, Australia, 3-7 August 2014. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2687

Cyclotides use specific lipids as a switch to internalize inside cells

2013

Journal Article

A novel quantitative kinase assay using bacterial surface display and flow cytometry

Henriques, Sónia Troeira, Thorstholm, Louise, Huang, Yen-Hua, Getz, Jennifer A., Daugherty, Patrick S. and Craik, David J. (2013). A novel quantitative kinase assay using bacterial surface display and flow cytometry. PloS One, 8 (11) e80474, e80474.1-e80474.7. doi: 10.1371/journal.pone.0080474

A novel quantitative kinase assay using bacterial surface display and flow cytometry

2013

Journal Article

The Antimicrobial Activity of Sub3 is Dependent on Membrane Binding and Cell-Penetrating Ability

Torcato, Ines M., Huang, Yen-Hua, Franquelim, Henri G., Gaspar, Diana D., Craik, David J., Castanho, Miguel A. R. B. and Henriques, Sonia Troeira (2013). The Antimicrobial Activity of Sub3 is Dependent on Membrane Binding and Cell-Penetrating Ability. Chembiochem, 14 (15), 2013-2022. doi: 10.1002/cbic.201300274

The Antimicrobial Activity of Sub3 is Dependent on Membrane Binding and Cell-Penetrating Ability

2013

Journal Article

Cyclotides suppress human T-Lymphocyte proliferation by an interleukin 2-dependent mechanism

Gruendemann, Carsten, Thell, Kathrin, Lengen, Karin, Garcia-Kaeufer, Manuel, Huang, Yen-Hua, Huber, Roman, Craik, David J., Schabbauer, Gernot and Gruber, Christian W. (2013). Cyclotides suppress human T-Lymphocyte proliferation by an interleukin 2-dependent mechanism. Plos One, 8 (6) e68016, e68016.1-e68016.12. doi: 10.1371/journal.pone.0068016

Cyclotides suppress human T-Lymphocyte proliferation by an interleukin 2-dependent mechanism

2013

Journal Article

High-affinity cyclic peptide matriptase inhibitors

Quimbar, Pedro, Malik, Uru, Sommerhoff, Christian P., Kaas, Quentin, Chan, Lai Y., Huang, Yen-Hua, Grundhuber, Maresa, Dunse, Kerry, Craik, David J., Anderson, Marilyn A. and Daly, Norelle L. (2013). High-affinity cyclic peptide matriptase inhibitors. Journal of Biological Chemistry, 288 (19), 13885-13896. doi: 10.1074/jbc.M113.460030

High-affinity cyclic peptide matriptase inhibitors

2013

Journal Article

Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria

Torcato, Inês M., Huang, Yen-Hua, Franquelim, Henri G., Gaspar, Diana, Craik, David J., Castanho, Miguel A. R. B. and Henriques, Sonia Troeira (2013). Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria. Biochimica et Biophysica Acta, 1828 (3), 944-955. doi: 10.1016/j.bbamem.2012.12.002

Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria

2013

Journal Article

Cyclization of the antimicrobial peptide gomesin with native chemical ligation: influences on stability and bioactivity

Chan, Lai Yue, Zhang, Veronica M., Huang, Yen-hua, Waters, Norman C., Bansal, Paramjit S., Craik, David J. and Daly, Norelle L. (2013). Cyclization of the antimicrobial peptide gomesin with native chemical ligation: influences on stability and bioactivity. Chembiochem, 14 (5), 617-624. doi: 10.1002/cbic.201300034

Cyclization of the antimicrobial peptide gomesin with native chemical ligation: influences on stability and bioactivity

2012

Journal Article

Phosphatidylethanolamine-binding is a conserved feature of cyclotide-membrane interactions

Henriques, Sonia Troeira, Huang, Yen-Hua, Castanho, Miguel A. R. B., Bagatolli, Luis A., Sonza, Secondo, Tachedjan, Gilda, Daly, Norelle L. and Craik, David J. (2012). Phosphatidylethanolamine-binding is a conserved feature of cyclotide-membrane interactions. Journal of Biological Chemistry, 287 (40), 33629-33643. doi: 10.1074/jbc.M112.372011

Phosphatidylethanolamine-binding is a conserved feature of cyclotide-membrane interactions

2012

Conference Publication

The Importance of the cell membrane on the mechanism of action of cyclotides

Henriques, S. T., Huang, Y. -H., Castanho, M. A. R. B., Daly, N. L. and Craik, D. J. (2012). The Importance of the cell membrane on the mechanism of action of cyclotides. 32nd European Peptide Symposium "Peptides 2012", Athens, Greece, 02-07 September 2012. West Sussex, United Kingdom: John Wiley and Sons. doi: 10.1002/psc.2449

The Importance of the cell membrane on the mechanism of action of cyclotides

2011

Journal Article

Decoding the membrane activity of the cyclotide kalata B1: The importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities

Henriques, Sónia Troeira, Huang, Yen-Hua, Rosengren, K. Johan, Franquelim, Henri G., Carvalho, Filomena A., Johnson, Adam, Sonza, Secondo, Tachedjian, Gilda, Castanho, Miguel A. R. B., Daly, Norelle L. and Craik, David J. (2011). Decoding the membrane activity of the cyclotide kalata B1: The importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities. Journal of Biological Chemistry, 286 (27), 24231-24241. doi: 10.1074/jbc.M111.253393

Decoding the membrane activity of the cyclotide kalata B1: The importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities

2011

Journal Article

Identification and characterization of a new family of cell penetrating peptides: Cyclic cell penetrating peptides

Cascales, Laura, Henriques, Sónia T., Kerr, Markus C., Huang, Yen-Hua, Sweet, Matthew J., Daly, Norelle L. and Craik, David J. (2011). Identification and characterization of a new family of cell penetrating peptides: Cyclic cell penetrating peptides. Journal of Biological Chemistry, Epub ahead of print (42), 36932-36943. doi: 10.1074/jbc.M111.264424

Identification and characterization of a new family of cell penetrating peptides: Cyclic cell penetrating peptides

2011

Conference Publication

Differences in bactericidal, hemolytic and anti-HIV efficiencies of the cyclotide kalata B1 are explained by distinct cell membrane compositions

Henriques, Sonia Troeira, Huang, Yen-Boa, Rosengren, K. Johan, Franquelim, Henri G., Carvalho, Filomena A., Johnson, Adam, Sonza, Second, Tachedjian, Gilda, Castanho, Miguel A. R. B., Daly, Norelle L. and Craik, I. David J. (2011). Differences in bactericidal, hemolytic and anti-HIV efficiencies of the cyclotide kalata B1 are explained by distinct cell membrane compositions. 22nd American Peptide Symposium, San Diego, California, 25-30 June 2011 . Hoboken, NJ, United States: John Wiley & Sons.

Differences in bactericidal, hemolytic and anti-HIV efficiencies of the cyclotide kalata B1 are explained by distinct cell membrane compositions

2010

Journal Article

Cyclotide interactions with the nematode external surface

Colgrave, Michelle L., Huang, Yen-Hua, Craik, David J. and Kotze, Andrew C. (2010). Cyclotide interactions with the nematode external surface. Antimicrobial Agents and Chemotherapy, 54 (5), 2160-2166. doi: 10.1128/AAC.01306-09

Cyclotide interactions with the nematode external surface

2010

Other Outputs

The mode of action of cyclotides: Functional studies of the prototypic cyclotide kalata B1

Yen-Hua Huang (2010). The mode of action of cyclotides: Functional studies of the prototypic cyclotide kalata B1. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland.

The mode of action of cyclotides: Functional studies of the prototypic cyclotide kalata B1

2010

Journal Article

Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity

Huang, Yen-Hua (黃彥華), Colgrave, Michelle L., Clark, Richard J., Kotze, Andrew C. and Craik, David J. (2010). Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity. Journal of Biological Chemistry, 285 (14), 10797-10805. doi: 10.1074/jbc.M109.089854

Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity

Current funding

  • 2024 - 2026
    Developing novel peptide tracers for improving immunotherapy outcomes
    NHMRC Development Grant
    Open grant
  • 2021 - 2024
    Plant cyclotides as novel sustainable tools for crop protection
    ARC Linkage Projects
    Open grant

Availability

Dr Yen-Hua Crystal Huang is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Applications of cyclic peptides in drug design

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    Patient-friendly peptide tracers for improving immunotherapy outcomes

    Associate Advisor

    Other advisors: Dr Conan Wang

  • Doctor Philosophy

    Novel peptide-based drug leads for targeting leukaemia.

    Associate Advisor

    Other advisors: Professor David Craik

  • Doctor Philosophy

    Discovery and Development of Substrate-Based Peptide Kinase Inhibitors

    Associate Advisor

    Other advisors: Professor David Craik, Dr Conan Wang

  • Doctor Philosophy

    Development of novel peptide based drug leads for chronic myeloid leukaemia

    Associate Advisor

    Other advisors: Professor David Craik

Completed supervision

Enquiries

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