Overview
Background
Keith is Molecular Virologist and group leader with a dual appointment within the Australian Bioengineering and Nanotechnology Institute and the School of Chemistry and Molecular Biosciences. His research is focused on vaccine development and the understanding of medically and environmentally significant viruses. Keith is one of the inventors of a UQ’s molecular clamp platform and is the co-leader of a program to produce a vaccine for COVID-19 at UQ. Keith has played a leading role in designing and implementing an epidemic response vaccine pipeline which enabled the progression of UQ’s COVID-19 vaccine candidate from sequence information to clinical trial dosing within 6 months.
Keith completed his PhD at the University of Queensland in 2007 on the structure and function of flavivirus NS3 protease. Subsequently, he spent three years (2007-2010) as a post-doctoral researcher at one of Spain’s most respected research institutes, Instituto Salud Carlos III, where I conducted research on the fusion protein of Respiratory Syncytial viurs as a target for conformationally specific neutralizing antibodies. Keith returned to UQ in 2011 and his research has focused on understanding of many medically and environmentally important viruses and bacteria, particularly focussing on Influenza, Respiratory Syncytial virus (RSV), SARS-CoV-2, Koala Retrovirus and Streptococcus pneumoniae.
Availability
- Professor Keith Chappell is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research impacts
Keith is the co-leader of UQ's COVID-19 vaccine program, which produced one of the first vaccines to eneter clinical trials, in just 6 months after the pandemic was announced. In phase I clinical trials, UQ's COVID-19 vaccine was shown to be safe and produce a strong neutralising immune response, however the initial version was not progressed due to the induction of response that interfered with some HIV diagnostic tests. The outcome of UQ's COVID-19 vaccine program represents an important proof of principle finding for the molecular clamp technology and the team are now re-engineering the platform to aleviate the potential for diagnostic interferance.
Keith is the co-creator of the molecular clamp platform technology, which has potential to produce vaccines for many medically significant viral pathogens. This technology has received a total of over $30 million in investment from Australian competitive grant schemes, international funders and philanthropic organisations and Keith now leads a team of 12 researchers.
Keith also works on Koala retrovirus (KoRV), which is a signficant cause of disease amongst koala populations in QLD and NSW. This work has received research support from the ARC improved our understanding of KoRV genetic diversity, mode of transmission and the fundamental process of genome immunity which mitigates against disease.
Works
Search Professor Keith Chappell’s works on UQ eSpace
2024
Journal Article
HTLV-1 reverse transcriptase homology model provides structural basis for sensitivity to existing nucleoside/nucleotide reverse transcriptase inhibitors
Tardiota, Nicolas, Jaberolansar, Noushin, Lackenby, Julia A., Chappell, Keith J. and O’Donnell, Jake S. (2024). HTLV-1 reverse transcriptase homology model provides structural basis for sensitivity to existing nucleoside/nucleotide reverse transcriptase inhibitors. Virology Journal, 21 (1) 14. doi: 10.1186/s12985-024-02288-z
2024
Journal Article
Human T-lymphotropic virus type 1 and antiretroviral therapy: practical considerations for pre-exposure and post-exposure prophylaxis, transmission prevention, and mitigation of severe disease
O’Donnell, Jake S., Jaberolansar, Noushin and Chappell, Keith J. (2024). Human T-lymphotropic virus type 1 and antiretroviral therapy: practical considerations for pre-exposure and post-exposure prophylaxis, transmission prevention, and mitigation of severe disease. The Lancet Microbe, 5 (4), e400-e408. doi: 10.1016/s2666-5247(23)00359-2
2023
Journal Article
The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 gamma variant
Pegg, Cassandra L., Modhiran, Naphak, Parry, Rhys H., Liang, Benjamin, Amarilla, Alberto A., Khromykh, Alexander A., Burr, Lucy, Young, Paul R., Chappell, Keith, Schulz, Benjamin L. and Watterson, Daniel (2023). The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 gamma variant. Glycobiology, 34 (2) cwad097, 1-13. doi: 10.1093/glycob/cwad097
2023
Journal Article
Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial
Chappell, Keith J., Mordant, Francesca L., Amarilla, Alberto A., Modhiran, Naphak, Liang, Benjamin, Li, Zheyi, Wijesundara, Danushka K., Lackenby, Julia A., Griffin, Paul, Bennet, Jillian K., Hensen, Luca, Zhang, Wuji, Nguyen, Thi H.O., Tran, Mai H., Tapley, Peter, Barnes, James, Reading, Patrick C., Kedzierska, Katherine, Ranasinghe, Charani, Subbarao, Kanta, Watterson, Daniel, Young, Paul R. and Munro, Trent P. (2023). Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial. eBioMedicine, 97 104842. doi: 10.1016/j.ebiom.2023.104842
2023
Journal Article
Broad protection from SARS-CoV-2 variants without antigen matching
Chappell, Keith (2023). Broad protection from SARS-CoV-2 variants without antigen matching. The Lancet Respiratory Medicine, 11 (11), 947-948. doi: 10.1016/S2213-2600(23)00290-4
2023
Journal Article
A nanobody recognizes a unique conserved epitope and potently neutralizes against the SARS-CoV-2 omicron variants
Modhiran, Naphak, Lauer, Simon Malte, Amarilla, Alberto A., Hewins, Peter, Lopes van den Broek, Sara Irene, Low, Yu Shang, Thakur, Nazia, Liang, Benjamin, Nieto, Guillermo Valenzuela, Jung, James, Paramitha, Devina, Isaacs, Ariel, Sng, Julian D. J., Song, David, Jørgensen, Jesper Tranekjær, Cheuquemilla, Yorka, Bürger, Jörg, Andersen, Ida Vang, Himelreichs, Johanna, Jara, Ronald, MacLoughlin, Ronan, Miranda-Chacon, Zaray, Chana-Cuevas, Pedro, Kramer, Vasko, Spahn, Christian M. T., Mielke, Thorsten, Khromykh, Alexander A., Munro, Trent, Jones, Martina L. ... Watterson, Daniel (2023). A nanobody recognizes a unique conserved epitope and potently neutralizes against the SARS-CoV-2 omicron variants. iScience, 26 (7) 107085, 107085. doi: 10.1016/j.isci.2023.107085
2023
Journal Article
Integrated molecular and immunological features of human T-lymphotropic virus type 1 infection and disease progression to adult T-cell leukaemia or lymphoma
O'Donnell, Jake S., Hunt, Stewart K. and Chappell, Keith J. (2023). Integrated molecular and immunological features of human T-lymphotropic virus type 1 infection and disease progression to adult T-cell leukaemia or lymphoma. The Lancet Haematology, 10 (7), e539-e548. doi: 10.1016/S2352-3026(23)00087-X
2023
Journal Article
Structure and antigenicity of divergent Henipavirus fusion glycoproteins
Isaacs, Ariel, Low, Yu Shang, Macauslane, Kyle L., Seitanidou, Joy, Pegg, Cassandra L., Cheung, Stacey T. M., Liang, Benjamin, Scott, Connor A. P., Landsberg, Michael J., Schulz, Benjamin L., Chappell, Keith J., Modhiran, Naphak and Watterson, Daniel (2023). Structure and antigenicity of divergent Henipavirus fusion glycoproteins. Nature Communications, 14 (1) 3577, 1-10. doi: 10.1038/s41467-023-39278-8
2023
Journal Article
Erratum: Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions (Proc. Natl. Acad. Sci. U.S.A. (2022) 119 (e2122680119) DOI: 10.1073/pnas.2122680119)
Blyton, Michaela D. J., Young, Paul R., Moore, Ben D. and Chappell, Keith J. (2023). Erratum: Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions (Proc. Natl. Acad. Sci. U.S.A. (2022) 119 (e2122680119) DOI: 10.1073/pnas.2122680119). Proceedings of the National Academy of Sciences of the United States of America, 120 (1) e2220541120. doi: 10.1073/pnas.2220541120
2023
Journal Article
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein
Albornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2023). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 2878-2893. doi: 10.1038/s41380-022-01831-0
2022
Journal Article
Diversity and transmission of koala retrovirus: a case study in three captive koala populations
Joyce, Briony A., Blyton, Michaela D. J., Johnston, Stephen D., Meikle, William D., Vinette Herrin, Kimberly, Madden, Claire, Young, Paul R. and Chappell, Keith J. (2022). Diversity and transmission of koala retrovirus: a case study in three captive koala populations. Scientific Reports, 12 (1) 15787, 1-8. doi: 10.1038/s41598-022-18939-6
2022
Journal Article
Characterization and comparison of novel adjuvants for a prefusion clamped MERS vaccine
O’Donnell, Jake S., Isaacs, Ariel, Jakob, Virginie, Lebas, Celia, Barnes, James B., Reading, Patrick C., Young, Paul R., Watterson, Daniel, Dubois, Patrice M., Collin, Nicolas and Chappell, Keith J. (2022). Characterization and comparison of novel adjuvants for a prefusion clamped MERS vaccine. Frontiers in Immunology, 13 976968, 976968. doi: 10.3389/fimmu.2022.976968
2022
Journal Article
Editorial: Emerging and re-emerging viral zoonoses
Kumar, Naveen, Uversky, Vladimir N., Tomar, Shailly, Li, Kenneth S. M., Chappell, Keith and Lau, Susanna K. P. (2022). Editorial: Emerging and re-emerging viral zoonoses. Frontiers in Microbiology, 13 978259, 978259. doi: 10.3389/fmicb.2022.978259
2022
Journal Article
A platform technology for generating subunit vaccines against diverse viral pathogens
Young, Andrew, Isaacs, Ariel, Scott, Connor A. P., Modhiran, Naphak, McMillan, Christopher L. D., Cheung, Stacey T. M., Barr, Jennifer, Marsh, Glenn, Thakur, Nazia, Bailey, Dalan, Li, Kenneth S. M., Luk, Hayes K. H., Kok, Kin-Hang, Lau, Susanna K. P., Woo, Patrick C. Y., Furuyama, Wakako, Marzi, Andrea, Young, Paul R., Chappell, Keith J. and Watterson, Daniel (2022). A platform technology for generating subunit vaccines against diverse viral pathogens. Frontiers in Immunology, 13 963023, 1-16. doi: 10.3389/fimmu.2022.963023
2022
Journal Article
Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions
Blyton, Michaela D. J., Young, Paul R., Moore, Ben D., Chappell, Keith J. and Goff, Stephen (2022). Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions. Proceedings of the National Academy of Sciences of the United States of America, 119 (33) e2122680119, 1-11. doi: 10.1073/pnas.2122680119
2022
Journal Article
Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions
Blyton, Michaela D. J., Young, Paul R., Moore, Ben D. and Chappell, Keith J. (2022). Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions. Proceedings of the National Academy of Sciences, 119 (33) e2122680119, 1-11. doi: 10.1073/pnas.2122680119
2022
Journal Article
Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variants
Isaacs, Ariel, Amarilla, Alberto A., Aguado, Julio, Modhiran, Naphak, Albornoz, Eduardo A., Baradar, Alireza A., McMillan, Christopher L. D., Choo, Jovin J. Y., Idris, Adi, Supramaniam, Aroon, McMillan, Nigel A. J., Muller, David A., Young, Paul R., Woodruff, Trent M., Wolvetang, Ernst J., Chappell, Keith J. and Watterson, Daniel (2022). Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variants. Frontiers in Immunology, 13 926262, 926262. doi: 10.3389/fimmu.2022.926262
2022
Journal Article
Koala retrovirus load and non-A subtypes are associated with secondary disease among wild northern koalas
Blyton, Michaela D. J., Pyne, Michael, Young, Paul and Chappell, Keith (2022). Koala retrovirus load and non-A subtypes are associated with secondary disease among wild northern koalas. PLoS Pathogens, 18 (5) e1010513, 1-20. doi: 10.1371/journal.ppat.1010513
2022
Journal Article
Peptide-based vaccine against SARS-CoV-2: peptide antigen discovery and screening of adjuvant systems
Shalash, Ahmed O., Azuar, Armira, Madge, Harrison Y. R., Modhiran, Naphak, Amarilla, Alberto A., Liang, Benjamin, Khromykh, Alexander A., Hussein, Waleed M., Chappell, Keith J., Watterson, Daniel, Young, Paul R., Skwarczynski, Mariusz and Toth, Istvan (2022). Peptide-based vaccine against SARS-CoV-2: peptide antigen discovery and screening of adjuvant systems. Pharmaceutics, 14 (4) 856, 856. doi: 10.3390/pharmaceutics14040856
2022
Journal Article
Author Correction: Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses
McMillan, Christopher L. D., Cheung, Stacey T. M., Modhiran, Naphak, Barnes, James, Amarilla, Alberto A., Bielefeldt-Ohmann, Helle, Lee, Leo Yi Yang, Guilfoyle, Kate, van Amerongen, Geert, Stittelaar, Koert, Jakob, Virginie, Lebas, Celia, Reading, Patrick, Short, Kirsty R., Young, Paul R., Watterson, Daniel and Chappell, Keith J. (2022). Author Correction: Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses. npj Vaccines, 7 (1) 3, 3. doi: 10.1038/s41541-021-00428-y
Funding
Current funding
Supervision
Availability
- Professor Keith Chappell is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Silencing of fusion-gene expression in cancer with synthetic long-noncoding RNA therapies
Principal Advisor
-
Doctor Philosophy
Understanding vaccine-intrinsic factors which influence immunological memory and protection from disease
Principal Advisor
Other advisors: Dr Jake O'Donnell, Dr Noushin Jaberolansar
-
Doctor Philosophy
Preclinical development and clinical testing of a Human T lymphotropic virus type 1 (HTLV-1)-specific vaccine
Associate Advisor
Other advisors: Dr Jake O'Donnell, Dr Noushin Jaberolansar
Completed supervision
-
2023
Doctor Philosophy
Understanding the koala retrovirus epidemic: genetic diversity, transmission and immunogenicity
Principal Advisor
Other advisors: Associate Professor Steve Johnston, Professor Paul Young
-
2019
Doctor Philosophy
Rational design of a recombinant subunit influenza vaccine
Principal Advisor
Other advisors: Professor Daniel Watterson, Professor Paul Young
-
2023
Doctor Philosophy
Structure-guided vaccine and therapeutic design for emerging viruses
Associate Advisor
Other advisors: Professor Paul Young, Professor Daniel Watterson
-
2021
Doctor Philosophy
Broad-Spectrum Vaccines & Therapeutics for Henipaviruses
Associate Advisor
Other advisors: Professor Paul Young, Professor Daniel Watterson
-
2020
Doctor Philosophy
The Filovirus glycoprotein as applied to rational vaccine design and diagnostics
Associate Advisor
Other advisors: Professor Daniel Watterson, Professor Paul Young
-
2018
Doctor Philosophy
Epitope-focused vaccines against respiratory syncytial virus
Associate Advisor
Other advisors: Professor Daniel Watterson, Professor Istvan Toth, Associate Professor Mariusz Skwarczynski, Professor Paul Young
-
2018
Doctor Philosophy
Structural and functional studies of the respiratory syncytial virus F protein
Associate Advisor
Other advisors: Professor Daniel Watterson, Professor Paul Young
-
2017
Doctor Philosophy
Dengue virus NS2B-NS3protease as a target for inhibitor-drugs
Associate Advisor
Other advisors: Professor Paul Young
-
2017
Doctor Philosophy
Viral/bacterial respiratory tract co-infections in children
Associate Advisor
Other advisors: Professor Phil Hugenholtz, Professor Paul Young
Media
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