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Professor Keith Chappell
Professor

Keith Chappell

Email: 
Phone: 
+61 7 344 32597

Overview

Background

Keith is Molecular Virologist and group leader with a dual appointment within the Australian Bioengineering and Nanotechnology Institute and the School of Chemistry and Molecular Biosciences. His research is focused on vaccine development and the understanding of medically and environmentally significant viruses. Keith is one of the inventors of a UQ’s molecular clamp platform and is the co-leader of a program to produce a vaccine for COVID-19 at UQ. Keith has played a leading role in designing and implementing an epidemic response vaccine pipeline which enabled the progression of UQ’s COVID-19 vaccine candidate from sequence information to clinical trial dosing within 6 months.

Keith completed his PhD at the University of Queensland in 2007 on the structure and function of flavivirus NS3 protease. Subsequently, he spent three years (2007-2010) as a post-doctoral researcher at one of Spain’s most respected research institutes, Instituto Salud Carlos III, where I conducted research on the fusion protein of Respiratory Syncytial viurs as a target for conformationally specific neutralizing antibodies. Keith returned to UQ in 2011 and his research has focused on understanding of many medically and environmentally important viruses and bacteria, particularly focussing on Influenza, Respiratory Syncytial virus (RSV), SARS-CoV-2, Koala Retrovirus and Streptococcus pneumoniae.

Availability

Professor Keith Chappell is:
Available for supervision

Qualifications

  • Bachelor of Science, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research impacts

Keith is the co-leader of UQ's COVID-19 vaccine program, which produced one of the first vaccines to eneter clinical trials, in just 6 months after the pandemic was announced. In phase I clinical trials, UQ's COVID-19 vaccine was shown to be safe and produce a strong neutralising immune response, however the initial version was not progressed due to the induction of response that interfered with some HIV diagnostic tests. The outcome of UQ's COVID-19 vaccine program represents an important proof of principle finding for the molecular clamp technology and the team are now re-engineering the platform to aleviate the potential for diagnostic interferance.

Keith is the co-creator of the molecular clamp platform technology, which has potential to produce vaccines for many medically significant viral pathogens. This technology has received a total of over $30 million in investment from Australian competitive grant schemes, international funders and philanthropic organisations and Keith now leads a team of 12 researchers.

Keith also works on Koala retrovirus (KoRV), which is a signficant cause of disease amongst koala populations in QLD and NSW. This work has received research support from the ARC improved our understanding of KoRV genetic diversity, mode of transmission and the fundamental process of genome immunity which mitigates against disease.

Works

Search Professor Keith Chappell’s works on UQ eSpace

79 works between 2004 and 2025

21 - 40 of 79 works

2021

Journal Article

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

Selva, Kevin J., van de Sandt, Carolien E., Lemke, Melissa M., Lee, Christina Y., Shoffner, Suzanne K., Chua, Brendon Y., Davis, Samantha K., Nguyen, Thi H. O., Rowntree, Louise C., Hensen, Luca, Koutsakos, Marios, Wong, Chinn Yi, Mordant, Francesca, Jackson, David C., Flanagan, Katie L., Crowe, Jane, Tosif, Shidan, Neeland, Melanie R., Sutton, Philip, Licciardi, Paul V., Crawford, Nigel W., Cheng, Allen C., Doolan, Denise L., Amanat, Fatima, Krammer, Florian, Chappell, Keith, Modhiran, Naphak, Watterson, Daniel, Young, Paul ... Chung, Amy W. (2021). Systems serology detects functionally distinct coronavirus antibody features in children and elderly. Nature Communications, 12 (1) 2037, 2037. doi: 10.1038/s41467-021-22236-7

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

2021

Journal Article

Retroviral integrations contribute to elevated host cancer rates during germline invasion

McEwen, Gayle K., Alquezar-Planas, David E., Dayaram, Anisha, Gillett, Amber, Tarlinton, Rachael, Mongan, Nigel, Chappell, Keith J., Henning, Joerg, Tan, Milton, Timms, Peter, Young, Paul R., Roca, Alfred L. and Greenwood, Alex D. (2021). Retroviral integrations contribute to elevated host cancer rates during germline invasion. Nature Communications, 12 (1) 1316, 1-13. doi: 10.1038/s41467-021-21612-7

Retroviral integrations contribute to elevated host cancer rates during germline invasion

2021

Journal Article

Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses

McMillan, Christopher L. D., Cheung, Stacey T. M., Modhiran, Naphak, Barnes, James, Amarilla, Alberto A., Bielefeldt-Ohmann, Helle, Lee, Leo Yi Yang, Guilfoyle, Kate, van Amerongen, Geert, Stittelaar, Koert, Jakob, Virginie, Lebas, Celia, Reading, Patrick, Short, Kirsty R., Young, Paul R., Watterson, Daniel and Chappell, Keith J. (2021). Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses. npj Vaccines, 6 (1) 135, 135. doi: 10.1038/s41541-021-00395-4

Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses

2021

Journal Article

Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial

Chappell, Keith J., Mordant, Francesca L., Li, Zheyi, Wijesundara, Danushka K., Ellenberg, Paula, Lackenby, Julia A., Cheung, Stacey T. M., Modhiran, Naphak, Avumegah, Michael S., Henderson, Christina L., Hoger, Kym, Griffin, Paul, Bennet, Jillian, Hensen, Luca, Zhang, Wuji, Nguyen, Thi H. O., Marrero-Hernandez, Sara, Selva, Kevin J., Chung, Amy W., Tran, Mai H., Tapley, Peter, Barnes, James, Reading, Patrick C., Nicholson, Suellen, Corby, Stavroula, Holgate, Thomas, Wines, Bruce D., Hogarth, P Mark, Kedzierska, Katherine ... Munro, Trent P. (2021). Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial. The Lancet Infectious Diseases, 21 (10), 1383-1394. doi: 10.1016/S1473-3099(21)00200-0

Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial

2021

Journal Article

Combinatorial F-G Immunogens as Nipah and Respiratory Syncytial Virus Vaccine Candidates

Isaacs, Ariel, Cheung, Stacey T. M., Thakur, Nazia, Jaberolansar, Noushin, Young, Andrew, Modhiran, Naphak, Bailey, Dalan, Graham, Simon P., Young, Paul R., Chappell, Keith J. and Watterson, Daniel (2021). Combinatorial F-G Immunogens as Nipah and Respiratory Syncytial Virus Vaccine Candidates. Viruses, 13 (10) 1942, 1942. doi: 10.3390/v13101942

Combinatorial F-G Immunogens as Nipah and Respiratory Syncytial Virus Vaccine Candidates

2021

Journal Article

Cord‐blood respiratory syncytial virus antibodies and respiratory health in first 5‐years of life

Takashima, Mari D., Grimwood, Keith, Sly, Peter D., Lambert, Stephen B., Chappell, Keith J., Watterson, Daniel, Young, Paul, Kusel, Merci, Holt, Barbara, Holt, Patrick and Ware, Robert S. (2021). Cord‐blood respiratory syncytial virus antibodies and respiratory health in first 5‐years of life. Pediatric Pulmonology, 56 (12), 3942-3951. doi: 10.1002/ppul.25688

Cord‐blood respiratory syncytial virus antibodies and respiratory health in first 5‐years of life

2021

Journal Article

Koala retrovirus genetic diversity and transmission dynamics within captive koala populations

Joyce, Briony A., Blyton, Michaela D. J., Johnston, Stephen D., Young, Paul R. and Chappell, Keith J. (2021). Koala retrovirus genetic diversity and transmission dynamics within captive koala populations. National Academy of Sciences. Proceedings, 118 (38) e2024021118, e2024021118. doi: 10.1073/pnas.2024021118

Koala retrovirus genetic diversity and transmission dynamics within captive koala populations

2021

Journal Article

Implications of dengue virus maturation on vaccine induced humoral immunity in mice

Scott, Connor A. P., Amarilla, Alberto A., Bibby, Summa, Newton, Natalee D., Hall, Roy A., Hobson-Peters, Jody, Muller, David A., Chappell, Keith J., Young, Paul R., Modhiran, Naphak and Watterson, Daniel (2021). Implications of dengue virus maturation on vaccine induced humoral immunity in mice. Viruses, 13 (9) 1843, 1843. doi: 10.3390/v13091843

Implications of dengue virus maturation on vaccine induced humoral immunity in mice

2021

Journal Article

Chronic SARS-CoV-2, a cause of post-acute COVID-19 sequelae (Long-COVID)?

O’Donnell, Jake S. and Chappell, Keith J. (2021). Chronic SARS-CoV-2, a cause of post-acute COVID-19 sequelae (Long-COVID)?. Frontiers in Microbiology, 12 724654, 1-4. doi: 10.3389/fmicb.2021.724654

Chronic SARS-CoV-2, a cause of post-acute COVID-19 sequelae (Long-COVID)?

2021

Journal Article

Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2

Watterson, Daniel, Wijesundara, Danushka K., Modhiran, Naphak, Mordant, Francesca L., Li, Zheyi, Avumegah, Michael S., McMillan, Christopher L. D., Lackenby, Julia, Guilfoyle, Kate, van Amerongen, Geert, Stittelaar, Koert, Cheung, Stacey T. M., Bibby, Summa, Daleris, Mallory, Hoger, Kym, Gillard, Marianne, Radunz, Eve, Jones, Martina L., Hughes, Karen, Hughes, Ben, Goh, Justin, Edwards, David, Scoble, Judith, Pearce, Lesley, Kowalczyk, Lukasz, Phan, Tram, La, Mylinh, Lu, Louis, Pham, Tam ... Chappell, Keith J. (2021). Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2. Clinical & Translational Immunology, 10 (4) e1269, e1269. doi: 10.1002/cti2.1269

Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2

2021

Journal Article

Epidemiology of respiratory syncytial virus in a community birth cohort of infants in the first 2 years of life

Takashima, Mari D., Grimwood, Keith, Sly, Peter D., Lambert, Stephen B., Chappell, Keith J., Watterson, Daniel and Ware, Robert S. (2021). Epidemiology of respiratory syncytial virus in a community birth cohort of infants in the first 2 years of life. European Journal of Pediatrics, 180 (7), 2125-2135. doi: 10.1007/s00431-021-03998-0

Epidemiology of respiratory syncytial virus in a community birth cohort of infants in the first 2 years of life

2021

Journal Article

An optimized high-throughput immuno-plaque assay for SARS-CoV-2

Amarilla, Alberto A., Modhiran, Naphak, Setoh, Yin Xiang, Peng, Nias Y. G., Sng, Julian D. J., Liang, Benjamin, McMillan, Christopher L. D., Freney, Morgan E, Cheung, Stacey T. M., Chappell, Keith J., Khromykh, Alexander A., Young, Paul R. and Watterson, Daniel (2021). An optimized high-throughput immuno-plaque assay for SARS-CoV-2. Frontiers in Microbiology, 12 625136, 625136. doi: 10.3389/fmicb.2021.625136

An optimized high-throughput immuno-plaque assay for SARS-CoV-2

2021

Journal Article

Adjuvant selection for influenza and RSV prefusion subunit vaccines

Isaacs, Ariel, Li, Zheyi, Cheung, Stacey T. M., Wijesundara, Danushka K., McMillan, Christopher L. D., Modhiran, Naphak, Young, Paul R., Ranasinghe, Charani, Watterson, Daniel and Chappell, Keith J. (2021). Adjuvant selection for influenza and RSV prefusion subunit vaccines. Vaccines, 9 (2) 71, 1-14. doi: 10.3390/vaccines9020071

Adjuvant selection for influenza and RSV prefusion subunit vaccines

2021

Journal Article

A broadly protective antibody that targets the flavivirus NS1 protein

Modhiran, Naphak, Song, Hao, Liu, Lidong, Bletchly, Cheryl, Brillault, Lou, Amarilla, Alberto A., Xu, Xiaoying, Qi, Jianxun, Chai, Yan, Cheung, Stacey T. M., Traves, Renee, Setoh, Yin Xiang, Bibby, Summa, Scott, Connor A. P., Freney, Morgan E., Newton, Natalee D., Khromykh, Alexander A., Chappell, Keith J., Muller, David A., Stacey, Katryn J., Landsberg, Michael J., Shi, Yi, Gao, George F., Young, Paul R. and Watterson, Daniel (2021). A broadly protective antibody that targets the flavivirus NS1 protein. Science, 371 (6525), 190-194. doi: 10.1126/science.abb9425

A broadly protective antibody that targets the flavivirus NS1 protein

2021

Journal Article

First report of a phase 1 randomised trial of molecular clamp-stabilised spike protein-based and MF59-adjuvanted vaccine for SARS-CoV-2

Chappell, Keith Joseph, Mordant, Francesca L., Li, Zheyi, Wijesundara, Danushka K., Ellenberg, Paula, Lackenby, Julia, Cheung, Stacey, Modhiran, Naphak, Avumegah, Michael S., Henderson, Christina L., Hoger, Kym, Bennet, Jillian, Hensen, Luca, Nguyen, Thi H. O., Marrero-Hernandez, Sara, Selva, Kevin J., AW, Chung, Tran, Mai H., Tapley, Peter, Reading, Patrick, Nicholson, Suellen, Corby, Stavroula, Holgate, Thomas, Wines, Bruce D., Hogarth, P. Mark, Kedzierska, Katherine, Purcell, Damian, Ranasinghe, Charani, Subbarao, Kanta ... Munro, Trent P. (2021). First report of a phase 1 randomised trial of molecular clamp-stabilised spike protein-based and MF59-adjuvanted vaccine for SARS-CoV-2. SSRN Electronic Journal. doi: 10.2139/ssrn.3769210

First report of a phase 1 randomised trial of molecular clamp-stabilised spike protein-based and MF59-adjuvanted vaccine for SARS-CoV-2

2021

Journal Article

The next generation of influenza vaccines: towards a universal solution

McMillan, Christopher L. D., Young, Paul R., Watterson, Daniel and Chappell, Keith J. (2021). The next generation of influenza vaccines: towards a universal solution. Vaccines, 9 (1) 26, 1-20. doi: 10.3390/vaccines9010026

The next generation of influenza vaccines: towards a universal solution

2020

Journal Article

Rapid response subunit vaccine design in the absence of structural information

Wijesundara, Danushka K., Avumegah, Michael S., Lackenby, Julia, Modhiran, Naphak, Isaacs, Ariel, Young, Paul R., Watterson, Daniel and Chappell, Keith J. (2020). Rapid response subunit vaccine design in the absence of structural information. Frontiers in Immunology, 11 592370, 592370. doi: 10.3389/fimmu.2020.592370

Rapid response subunit vaccine design in the absence of structural information

2020

Journal Article

Micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell–cell fusion

Thakur, Nazia, Conceicao, Carina, Isaacs, Ariel, Human, Stacey, Modhiran, Naphak, McLean, Rebecca K., Pedrera, Miriam, Tan, Tiong Kit, Rijal, Pramila, Townsend, Alain, Taylor, Geraldine, Young, Paul R., Watterson, Daniel, Chappell, Keith J., Graham, Simon P. and Bailey, Dalan (2020). Micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell–cell fusion. Journal of General Virology, 102 (1) 001506. doi: 10.1099/jgv.0.001506

Micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell–cell fusion

2020

Journal Article

Bacterial colonization dynamics associated with respiratory syncytial virus during early childhood

Brealey, Jaelle C., Young, Paul R., Sloots, Theo P., Ware, Robert S., Lambert, Stephen B., Sly, Peter D., Grimwood, Keith and Chappell, Keith J. (2020). Bacterial colonization dynamics associated with respiratory syncytial virus during early childhood. Pediatric Pulmonology, 55 (5) ppul.24715, 1237-1245. doi: 10.1002/ppul.24715

Bacterial colonization dynamics associated with respiratory syncytial virus during early childhood

2020

Journal Article

Bovine herpesvirus-4-vectored delivery of nipah virus glycoproteins enhances T cell immunogenicity in pigs

Pedrera, Miriam, Macchi, Francesca, McLean, Rebecca K., Franceschi, Valentina, Thakur, Nazia, Russo, Luca, Medfai, Lobna, Todd, Shawn, Tchilian, Elma Z., Audonnet, Jean-Christophe, Chappell, Keith, Isaacs, Ariel, Watterson, Daniel, Young, Paul R., Marsh, Glenn A., Bailey, Dalan, Graham, Simon P. and Donofrio, Gaetano (2020). Bovine herpesvirus-4-vectored delivery of nipah virus glycoproteins enhances T cell immunogenicity in pigs. Vaccines, 8 (1) 115, 115. doi: 10.3390/vaccines8010115

Bovine herpesvirus-4-vectored delivery of nipah virus glycoproteins enhances T cell immunogenicity in pigs

Funding

Current funding

  • 2024 - 2025
    Determination of koala retrovirus subtypes and load for Koala Conservation Australia's breeding program
    Koala Conservation Australia Limited
    Open grant
  • 2024 - 2027
    Hyperactive endogenous retroviruses and their impact on the koala genome
    ARC Discovery Projects
    Open grant
  • 2023 - 2025
    A reengineered Molecular Clamp platform to safeguard Australia against novel viral threats
    Golden Casket Lottery Corporation Ltd
    Open grant
  • 2020 - 2028
    COVID-19 Vaccine Research (CEPI)
    The a2 Milk Company (Australia) Pty Ltd
    Open grant

Past funding

  • 2024
    Koala retrovirus subtyping for Symbio Wildlife Park
    J.M.R PTY Limited
    Open grant
  • 2024
    Determination of koala retrovirus subtypes and load at potential koala breeding program release sites
    Taronga Conservation Society Australia trading as Taronga Zoo
    Open grant
  • 2022 - 2024
    Do environmental stressors increase retrovirus activity and exacerbate disease in koalas?
    New South Wales Department of Planning and Environment
    Open grant
  • 2021 - 2022
    Molecular Clamp Stabilised HTLV-1 Envelope Glycoprotein for Vaccination and Immunotherapy
    Australian Centre for HIV and Hepatitis Virology Research (ACH2)
    Open grant
  • 2020 - 2024
    Rapid Acceleration of the UQ COVID-19 vaccine in Conjunction Program
    Queensland Department of State Development, Tourism and Innovation
    Open grant
  • 2020 - 2022
    Molecular Clamp Stabilized Spike Vaccine for Rapid Response
    NHMRC MRFF EPCDR - Novel Coronavirus Vaccine Development
    Open grant
  • 2020 - 2023
    Rapid Acceleration of the UQ COVID-19 Vaccine Program
    NHMRC MRFF Coronavirus Research Response
    Open grant
  • 2019 - 2021
    Clamp stabilized vaccines to provide broad spectrum protection against influenza
    NHMRC Development Grant
    Open grant
  • 2018 - 2022
    Koala retrovirus epidemic: genetic diversity, genome invasion and disease
    ARC Discovery Projects
    Open grant
  • 2018 - 2021
    Virus vaccines that ensure preparedness against future public health emergencies
    NHMRC Project Grant
    Open grant

Supervision

Availability

Professor Keith Chappell is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Silencing of fusion-gene expression in cancer with synthetic long-noncoding RNA therapies

    Principal Advisor

  • Doctor Philosophy

    Understanding vaccine-intrinsic factors which influence immunological memory and protection from disease

    Principal Advisor

    Other advisors: Dr Jake O'Donnell, Dr Noushin Jaberolansar

  • Doctor Philosophy

    Preclinical development and clinical testing of a Human T lymphotropic virus type 1 (HTLV-1)-specific vaccine

    Associate Advisor

    Other advisors: Dr Jake O'Donnell, Dr Noushin Jaberolansar

Completed supervision

Media

Enquiries

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communications@uq.edu.au