Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

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Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

1 - 20 of 683 works

Featured

2011

Journal Article

Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation

Deng, Zhou J., Liang, Mingtao, Monteiro, Michael, Toth, Istvan and Minchin, Rodney F. (2011). Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation. Nature Nanotechnology, 6 (1), 39-44. doi: 10.1038/NNANO.2010.250

Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation

Featured

2010

Journal Article

Polyacrylate dendrimer nanoparticles: A self-adjuvanting vaccine delivery system

Skwarczynski, Mariusz, Zaman, Mehfuz, Urbani, Carl N., Lin, I-Chun, Jia, Zhongfan, Batzloff, Michael R., Good, Michael F., Monteiro, Michael J. and Toth, Istvan (2010). Polyacrylate dendrimer nanoparticles: A self-adjuvanting vaccine delivery system. Angewandte Chemie (International Edition), 49 (33), 5742-5745. doi: 10.1002/anie.201002221

Polyacrylate dendrimer nanoparticles: A self-adjuvanting vaccine delivery system

Featured

2010

Journal Article

Cellular uptake of densely packed polymer coatings on gold nanoparticles

Liang, Mingtao, Lin, I-Chun, Whittaker, Michael R., Minchin, Rodney F., Monteiro, Michael J. and Toth, Istvan (2010). Cellular uptake of densely packed polymer coatings on gold nanoparticles. ACS Nano, 4 (1), 403-413. doi: 10.1021/nn9011237

Cellular uptake of densely packed polymer coatings on gold nanoparticles

2025

Journal Article

Influence of component structural arrangement on cholesterol-antigen conjugate immunogenicity and antisera bactericidal activity against group A Streptococcus

Skwarczynski, Mariusz, Alharbi, Nedaa, Nahar, Ummey J., Shalash, Ahmed O., Azuar, Armira, Koirala, Prashamsa, Khisty, Shefali J., Wang, Jingwen, Marasini, Nirmal, Hussein, Waleed M., Khalil, Zeinab G. and Toth, Istvan (2025). Influence of component structural arrangement on cholesterol-antigen conjugate immunogenicity and antisera bactericidal activity against group A Streptococcus. Bioorganic Chemistry, 157 108248, 108248-157. doi: 10.1016/j.bioorg.2025.108248

Influence of component structural arrangement on cholesterol-antigen conjugate immunogenicity and antisera bactericidal activity against group A Streptococcus

2025

Journal Article

A synthetic cyclic peptide for promoting antigen presentation and immune activation

Zhang, Jiahui, Madge, Harrison Y. R., Mahmoud, Asmaa, Lu, Lantian, Wang, Wanyi, Huang, Wenbin, Koirala, Prashamsa, Gonzalez Cruz, Jazmina L., Kong, Wei Yang, Bashiri, Sahra, Shalash, Ahmed O., Hussein, Waleed M., Khalil, Zeinab G., Wells, James W., Toth, Istvan and Stephenson, Rachel J. (2025). A synthetic cyclic peptide for promoting antigen presentation and immune activation. NPJ Vaccines, 10 (1) 9, 9-1. doi: 10.1038/s41541-024-01050-4

A synthetic cyclic peptide for promoting antigen presentation and immune activation

2025

Journal Article

A Modular Self-Assembling and Self-Adjuvanting Multiepitope Peptide Nanoparticle Vaccine Platform to Improve the Efficacy and Immunogenicity of BCG

Zhao, Guangzu, Sathkumara, Harindra D., Miranda-Hernandez, Socorro, Seifert, Julia, Valencia-Hernandez, Ana Maria, Puri, Munish, Huang, Wenbin, Toth, Istvan, Daly, Norelle, Skwarczynski, Mariusz and Kupz, Andreas (2025). A Modular Self-Assembling and Self-Adjuvanting Multiepitope Peptide Nanoparticle Vaccine Platform to Improve the Efficacy and Immunogenicity of BCG. Small, 21 (7) 2406874, e2406874. doi: 10.1002/smll.202406874

A Modular Self-Assembling and Self-Adjuvanting Multiepitope Peptide Nanoparticle Vaccine Platform to Improve the Efficacy and Immunogenicity of BCG

2024

Journal Article

Self-assembled monovalent lipidated mannose ligand as a standalone nanoadjuvant

Nahar, Ummey J., Wang, Jingwen, Shalash, Ahmed O., Lu, Lantian, Islam, Md. T., Alharbi, Nedaa, Koirala, Prashamsa, Khalil, Zeinab G., Capon, Robert J., Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2024). Self-assembled monovalent lipidated mannose ligand as a standalone nanoadjuvant. Vaccine, 42 (23) 126060. doi: 10.1016/j.vaccine.2024.06.027

Self-assembled monovalent lipidated mannose ligand as a standalone nanoadjuvant

2024

Journal Article

Self-assembling peptides for vaccine adjuvant discovery

Fan, Jingyi, Toth, Istvan and Stephenson, Rachel J. (2024). Self-assembling peptides for vaccine adjuvant discovery. Immuno, 4 (4), 325-343. doi: 10.3390/immuno4040021

Self-assembling peptides for vaccine adjuvant discovery

2024

Conference Publication

Synthetic anti-cocaine nano-vaccine successfully prevents cocaine-induced hyperlocomotion

Madge, Harrison, Alexander, Suzy, Azuar, Armira, Zhang, Jiahui, Koirala, Prashamsa, Burne, Thomas, Toth, Istvan and Stephenson, Rachel (2024). Synthetic anti-cocaine nano-vaccine successfully prevents cocaine-induced hyperlocomotion. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons.

Synthetic anti-cocaine nano-vaccine successfully prevents cocaine-induced hyperlocomotion

2024

Journal Article

Cyclic Peptide Conjugate Vaccines and Physically Mixed Cyclic Peptide Vaccines for Subcutaneous Immunization

Huang, Wenbin, Madge, Harrison Y. R., Toth, Istvan and Stephenson, Rachel J. (2024). Cyclic Peptide Conjugate Vaccines and Physically Mixed Cyclic Peptide Vaccines for Subcutaneous Immunization. Methods in Molecular Biology, 2821, 111-127. doi: 10.1007/978-1-0716-3914-6_9

Cyclic Peptide Conjugate Vaccines and Physically Mixed Cyclic Peptide Vaccines for Subcutaneous Immunization

2024

Journal Article

Cholesterol as an inbuilt immunoadjuvant for a lipopeptide vaccine against group A Streptococcus infection

Alharbi, Nedaa, Shalash, Ahmed O., Koirala, Prashamsa, Boer, Jennifer C., Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Plebanski, Magdalena, Toth, Istvan and Skwarczynski, Mariusz (2024). Cholesterol as an inbuilt immunoadjuvant for a lipopeptide vaccine against group A Streptococcus infection. Journal of Colloid and Interface Science, 663, 43-52. doi: 10.1016/j.jcis.2024.02.134

Cholesterol as an inbuilt immunoadjuvant for a lipopeptide vaccine against group A Streptococcus infection

2024

Journal Article

COVID-19 variants and vaccine development

Zhao, Ziyao, Bashiri, Sahra, Ziora, Zyta M., Toth, Istvan and Skwarczynski, Mariusz (2024). COVID-19 variants and vaccine development. Viruses, 16 (5) 757, 757. doi: 10.3390/v16050757

COVID-19 variants and vaccine development

2024

Journal Article

Efficacy of alum-adjuvanted peptide and carbohydrate conjugate vaccine candidates against Group A Streptococcus pharyngeal infection in a non-human primate model

Rivera-Hernandez, Tania, Carnathan, Diane G., Richter, Johanna, Marchant, Patrick, Cork, Amanda J., Elangovan, Gayathiri, Henningham, Anna, Cole, Jason N., Choudhury, Biswa, Moyle, Peter M., Toth, Istvan, Batzloff, Michael R., Good, Michael F., Agarwal, Paresh, Kapoor, Neeraj, Nizet, Victor, Silvestri, Guido and Walker, Mark J. (2024). Efficacy of alum-adjuvanted peptide and carbohydrate conjugate vaccine candidates against Group A Streptococcus pharyngeal infection in a non-human primate model. Vaccines, 12 (4) 382, 1-10. doi: 10.3390/vaccines12040382

Efficacy of alum-adjuvanted peptide and carbohydrate conjugate vaccine candidates against Group A Streptococcus pharyngeal infection in a non-human primate model

2024

Journal Article

Recent scientific advancements towards a vaccine against Group A Streptococcus

Fan, Jingyi, Toth, Istvan and Stephenson, Rachel J. (2024). Recent scientific advancements towards a vaccine against Group A Streptococcus. Vaccines, 12 (3) 272, 1-20. doi: 10.3390/vaccines12030272

Recent scientific advancements towards a vaccine against Group A Streptococcus

2024

Journal Article

Unravelling the relationship between employment, social transfers and income poverty: policy and measurement

Gábos, András, Binder, Barbara, Branyiczki, Réka and Tóth, István György (2024). Unravelling the relationship between employment, social transfers and income poverty: policy and measurement. Journal of European Social Policy, 34 (3), 289-308. doi: 10.1177/09589287241232272

Unravelling the relationship between employment, social transfers and income poverty: policy and measurement

2024

Journal Article

Utilizing murine dendritic cell line DC2.4 to evaluate the immunogenicity of subunit vaccines in vitro

Lu, Lantian, Kong, Wei Yang, Zhang, Jiahui, Firdaus, Farrhana, Wells, James W., Stephenson, Rachel J., Toth, Istvan, Skwarczynski, Mariusz and Cruz, Jazmina L. Gonzalez (2024). Utilizing murine dendritic cell line DC2.4 to evaluate the immunogenicity of subunit vaccines in vitro. Frontiers in Immunology, 15 1298721, 1-13. doi: 10.3389/fimmu.2024.1298721

Utilizing murine dendritic cell line DC2.4 to evaluate the immunogenicity of subunit vaccines in vitro

2024

Journal Article

Polymeric nanoparticles as oral and intranasal peptide vaccine delivery systems: the role of shape and conjugation

Koirala, Prashamsa, Shalash, Ahmed O., Chen, Sung-Po R., Faruck, Mohammad O., Wang, Jingwen, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2024). Polymeric nanoparticles as oral and intranasal peptide vaccine delivery systems: the role of shape and conjugation. Vaccines, 12 (2) 198, 1-14. doi: 10.3390/vaccines12020198

Polymeric nanoparticles as oral and intranasal peptide vaccine delivery systems: the role of shape and conjugation

2024

Book Chapter

An analytical protocol for detecting antibody titer levels in serum/saliva by indirect Enzyme-Linked Immunosorbent Assay (ELISA)

Wang, Jingwen, Bashiri, Sahra, Toth, Istvan and Skwarczynski, Mariusz (2024). An analytical protocol for detecting antibody titer levels in serum/saliva by indirect Enzyme-Linked Immunosorbent Assay (ELISA). Peptide antibodies: methods and protocols. (pp. 205-216) edited by Gunnar Houen. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-3914-6_16

An analytical protocol for detecting antibody titer levels in serum/saliva by indirect Enzyme-Linked Immunosorbent Assay (ELISA)

2024

Book Chapter

A foglalkoztatás és a szegénység alakulásának összefüggései az Európai Unió országaiban és Magyarországon

Gábos, András and Tóth, István György (2024). A foglalkoztatás és a szegénység alakulásának összefüggései az Európai Unió országaiban és Magyarországon. Társadalmi Riport. (pp. 135-156) TÁRKI Társadalomkutatási Intézet Zrt.. doi: 10.61501/trip.2024.6

A foglalkoztatás és a szegénység alakulásának összefüggései az Európai Unió országaiban és Magyarországon

2024

Book Chapter

Társadalmi konvergencia a kelet-közép-európai országok és referenciaországaik között

Tóth, István György and Csathó, Ábel (2024). Társadalmi konvergencia a kelet-közép-európai országok és referenciaországaik között. Társadalmi Riport. (pp. 45-67) TÁRKI Társadalomkutatási Intézet Zrt.. doi: 10.61501/trip.2024.2

Társadalmi konvergencia a kelet-közép-európai országok és referenciaországaik között

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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