Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

Email: 

Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

684 works between 1972 and 2025
All (684) Journal Article (482) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (5) Edited Outputs (1)

41 - 60 of 684 works

2022

Journal Article

Advances in infectious disease vaccine adjuvants

Fan, Jingyi, Jin, Shengbin, Gilmartin, Lachlan, Toth, Istvan, Hussein, Waleed M. and Stephenson, Rachel J. (2022). Advances in infectious disease vaccine adjuvants. Vaccines, 10 (7) 1120, 1-62. doi: 10.3390/vaccines10071120

Advances in infectious disease vaccine adjuvants

2022

Journal Article

Development of a peptide vaccine against hookworm infection: immunogenicity, efficacy, and immune correlates of protection

Shalash, Ahmed O., Becker, Luke, Yang, Jieru, Giacomin, Paul, Pearson, Mark, Hussein, Waleed M., Loukas, Alex, Toth, Istvan and Skwarczynski, Mariusz (2022). Development of a peptide vaccine against hookworm infection: immunogenicity, efficacy, and immune correlates of protection. Journal of Allergy and Clinical Immunology, 150 (1), 157-169.e10. doi: 10.1016/j.jaci.2022.02.020

Development of a peptide vaccine against hookworm infection: immunogenicity, efficacy, and immune correlates of protection

2022

Journal Article

The potential of developing a protective peptide‐based vaccines against SARS‐CoV‐2

Shalash, Ahmed O., Toth, Istvan and Skwarczynski, Mariusz (2022). The potential of developing a protective peptide‐based vaccines against SARS‐CoV‐2. Drug Development Research, 83 (6), 1251-1256. doi: 10.1002/ddr.21969

The potential of developing a protective peptide‐based vaccines against SARS‐CoV‐2

2022

Other Outputs

New peptide comprising specified amino acid sequence useful for treating or preventing inflammatory or autoimmune condition including inflammatory bowel disease, asthma, rheumatoid arthritis and celiac disease.

Cobos, C., Daly, N., Loukas, A., Bansal, P., Toth, I. and Skwarczynski, M. (2022). New peptide comprising specified amino acid sequence useful for treating or preventing inflammatory or autoimmune condition including inflammatory bowel disease, asthma, rheumatoid arthritis and celiac disease. . WO2022120423.

New peptide comprising specified amino acid sequence useful for treating or preventing inflammatory or autoimmune condition including inflammatory bowel disease, asthma, rheumatoid arthritis and celiac disease.

2022

Journal Article

Peptide-based vaccine against SARS-CoV-2: peptide antigen discovery and screening of adjuvant systems

Shalash, Ahmed O., Azuar, Armira, Madge, Harrison Y. R., Modhiran, Naphak, Amarilla, Alberto A., Liang, Benjamin, Khromykh, Alexander A., Hussein, Waleed M., Chappell, Keith J., Watterson, Daniel, Young, Paul R., Skwarczynski, Mariusz and Toth, Istvan (2022). Peptide-based vaccine against SARS-CoV-2: peptide antigen discovery and screening of adjuvant systems. Pharmaceutics, 14 (4) 856, 856. doi: 10.3390/pharmaceutics14040856

Peptide-based vaccine against SARS-CoV-2: peptide antigen discovery and screening of adjuvant systems

2022

Journal Article

Structure-activity relationship of lipid, cyclic peptide and antigen rearrangement of physically mixed vaccines

Huang, Wenbin, Madge, Harrison Y. R., Zhang, Jiahui, Gilmartin, Lachlan, Hussein, Waleed M., Khalil, Zeinab G., Koirala, Prashamsa, Capon, Robert J., Toth, Istvan and Stephenson, Rachel J. (2022). Structure-activity relationship of lipid, cyclic peptide and antigen rearrangement of physically mixed vaccines. International Journal of Pharmaceutics, 617 121614, 1-12. doi: 10.1016/j.ijpharm.2022.121614

Structure-activity relationship of lipid, cyclic peptide and antigen rearrangement of physically mixed vaccines

2022

Journal Article

Antimicrobial activity enhancers: towards smart delivery of antimicrobial agents

Skwarczynski, Mariusz, Bashiri, Sahra, Yuan, Ye, Ziora, Zyta M., Nabil, Osama, Masuda, Keita, Khongkow, Mattaka, Rimsueb, Natchanon, Cabral, Horacio, Ruktanonchai, Uracha, Blaskovich, Mark A. T. and Toth, Istvan (2022). Antimicrobial activity enhancers: towards smart delivery of antimicrobial agents. Antibiotics, 11 (3) 412, 412. doi: 10.3390/antibiotics11030412

Antimicrobial activity enhancers: towards smart delivery of antimicrobial agents

2022

Journal Article

Investigation of liposomal self-adjuvanting peptide epitopes derived from conserved blood-stage Plasmodium antigens

Islam, Md. Tanjir, Ho, Mei-Fong, Nahar, Ummey J., Shalash, Ahmed O., Koirala, Prashamsa, Hussein, Waleed M., Stanisic, Danielle I., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2022). Investigation of liposomal self-adjuvanting peptide epitopes derived from conserved blood-stage Plasmodium antigens. PLoS One, 17 (3) e0264961, e0264961. doi: 10.1371/journal.pone.0264961

Investigation of liposomal self-adjuvanting peptide epitopes derived from conserved blood-stage Plasmodium antigens

2022

Journal Article

Developing an effective glycan‐based vaccine for Streptococcus pyogenes

Mahmoud, Asmaa, Toth, Istvan and Stephenson, Rachel (2022). Developing an effective glycan‐based vaccine for Streptococcus pyogenes. Angewandte Chemie International Edition, 61 (11) e202115342, 1-21. doi: 10.1002/anie.202115342

Developing an effective glycan‐based vaccine for Streptococcus pyogenes

2022

Journal Article

Peptide-based nanovaccines in the treatment of cervical cancer: a review of recent advances

Zhang, Jiahui, Fan, Jingyi, Skwarczynski, Mariusz, Stephenson, Rachel J, Toth, Istvan and Hussein, Waleed M (2022). Peptide-based nanovaccines in the treatment of cervical cancer: a review of recent advances. International Journal of Nanomedicine, 17, 869-900. doi: 10.2147/ijn.s269986

Peptide-based nanovaccines in the treatment of cervical cancer: a review of recent advances

2022

Journal Article

Physical mixture of a cyclic lipopeptide vaccine induced high titres of opsonic IgG antibodies against group A streptococcus

Madge, Harrison Y. R., Huang, Wenbin, Gilmartin, Lachlan, Rigau-Planella, Berta, Hussein, Waleed M., Khalil, Zeinab G., Koirala, Prashamsa, Santiago, Viviene S., Capon, Robert J., Toth, Istvan and Stephenson, Rachel J. (2022). Physical mixture of a cyclic lipopeptide vaccine induced high titres of opsonic IgG antibodies against group A streptococcus. Biomaterials Science, 10 (1), 281-293. doi: 10.1039/d1bm01333e

Physical mixture of a cyclic lipopeptide vaccine induced high titres of opsonic IgG antibodies against group A streptococcus

2022

Book Chapter

Liposomes for the delivery of lipopeptide vaccines

Yang, Jieru, Azuar, Armira, Toth, Istvan and Skwarczynski, Mariusz (2022). Liposomes for the delivery of lipopeptide vaccines. Methods in Molecular Biology. (pp. 295-307) New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1892-9_15

Liposomes for the delivery of lipopeptide vaccines

2022

Book Chapter

Preparation of Trimethyl Chitosan-Based Polyelectrolyte Complexes for Peptide Subunit Vaccine Delivery

Zhao, Lili, Bashiri, Sahra, Toth, Istvan and Skwarczynski, Mariusz (2022). Preparation of Trimethyl Chitosan-Based Polyelectrolyte Complexes for Peptide Subunit Vaccine Delivery. Methods in Molecular Biology. (pp. 141-149) New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-1900-1_9

Preparation of Trimethyl Chitosan-Based Polyelectrolyte Complexes for Peptide Subunit Vaccine Delivery

2022

Book Chapter

Current Prospects in Peptide-Based Subunit Nanovaccines

Koirala, Prashamsa, Bashiri, Sahra, Toth, Istvan and Skwarczynski, Mariusz (2022). Current Prospects in Peptide-Based Subunit Nanovaccines. Methods in Molecular Biology. (pp. 309-338) New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-1892-9_16

Current Prospects in Peptide-Based Subunit Nanovaccines

2022

Book Chapter

Kompország lakói 2022-ben: Az USA, az EU, Oroszország és Kína megítélése a magyar közvéleményben

Tóth, István György (2022). Kompország lakói 2022-ben: Az USA, az EU, Oroszország és Kína megítélése a magyar közvéleményben. Társadalmi Riport 2022. (pp. 431-453) Budapest, Hungary: TÁRKI Társadalomkutatási Intézet. doi: 10.61501/trip.2022.22

Kompország lakói 2022-ben: Az USA, az EU, Oroszország és Kína megítélése a magyar közvéleményben

2022

Book Chapter

Polymer–Peptide Conjugate Vaccine for Oral Immunization

Faruck, Mohammad Omer, Skwarczynski, Mariusz and Toth, Istvan (2022). Polymer–Peptide Conjugate Vaccine for Oral Immunization. Methods in Molecular Biology. (pp. 35-44) New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-1892-9_3

Polymer–Peptide Conjugate Vaccine for Oral Immunization

2022

Journal Article

Dendrimers in vaccine delivery: recent progress and advances

Chowdhury, Silvia, Toth, Istvan and Stephenson, Rachel J. (2022). Dendrimers in vaccine delivery: recent progress and advances. Biomaterials, 280 121303, 121303. doi: 10.1016/j.biomaterials.2021.121303

Dendrimers in vaccine delivery: recent progress and advances

2022

Journal Article

Development of a hyperbranched polymer-based methotrexate nanomedicine for rheumatoid arthritis

Marasini, Nirmal, Er, Gerald, Fu, Changkui, Subasic, Christopher N., Ibrahim, Jibriil, Skwarczynski, Mariusz, Toth, Istvan, Whittaker, Andrew K. and Kaminskas, Lisa M. (2022). Development of a hyperbranched polymer-based methotrexate nanomedicine for rheumatoid arthritis. Acta Biomaterialia, 142, 298-307. doi: 10.1016/j.actbio.2022.01.054

Development of a hyperbranched polymer-based methotrexate nanomedicine for rheumatoid arthritis

2022

Book Chapter

Developments in vaccine adjuvants

Firdaus, Farrhana Ziana, Skwarczynski, Mariusz and Toth, Istvan (2022). Developments in vaccine adjuvants. Vaccine Design: Methods and Protocols, Volume 3: Resources for Vaccine Development. (pp. 145-178) edited by Sunil Thomas. New York, United States: Humana Press. doi: 10.1007/978-1-0716-1892-9_8

Developments in vaccine adjuvants

2021

Journal Article

Detection and quantification of SARS-CoV-2 receptor binding domain neutralization by a sensitive competitive ELISA assay

Shalash, Ahmed O., Azuar, Armira, Madge, Harrison Y. R., Modhiran, Naphak, Amarilla, Alberto A., Liang, Benjamin, Khromykh, Alexander A., Watterson, Daniel, Young, Paul R., Toth, Istvan and Skwarczynski, Mariusz (2021). Detection and quantification of SARS-CoV-2 receptor binding domain neutralization by a sensitive competitive ELISA assay. Vaccines, 9 (12) 1493, 1-21. doi: 10.3390/vaccines9121493

Detection and quantification of SARS-CoV-2 receptor binding domain neutralization by a sensitive competitive ELISA assay

Current funding

  • 2024 - 2027
    A nanovaccine against Invasive Group A Streptococcus and Rheumatic Heart Disease
    NHMRC IDEAS Grants
    Open grant
  • 2024 - 2027
    Paving the way for a Clinical Vaccine Candidate against Hookworm Infection
    NHMRC IDEAS Grants
    Open grant
  • 2024 - 2025
    Single-shot anti-fertility vaccine in pigs
    Australia's Economic Accelerator Seed Grants
    Open grant

Past funding

  • 2023 - 2024
    The evaluation of a self-adjuvanting oral GnRH vaccine in feral pigs (wild boar)
    Istituto Zooprofilattico Sperimentale del Mezzogiorno
    Open grant
  • 2021 - 2024
    Poly(amino acids) as immune stimulators
    ARC Discovery Projects
    Open grant
  • 2021 - 2025
    A single-shot anti-fertility vaccine in female cattle
    Meat & Livestock Australia
    Open grant
  • 2020 - 2024
    Developing a multicomponent platform for targeted gene delivery
    ARC Discovery Projects
    Open grant
  • 2020 - 2021
    Hookworm peptide therapeutic for oral treatment of IBD (NHMRC Development Grant administered by James Cook University)
    James Cook University
    Open grant
  • 2018 - 2022
    Tropical diseases: Translating discoveries into better health (NHMRC Program Grant administered by UniMelb)
    University of Melbourne
    Open grant
  • 2017 - 2019
    Understanding the myometrial transition at term and preterm labour to guide tocolysis (NHMRC Project Grant led by the University of Newcastle)
    University of Newcastle
    Open grant
  • 2016 - 2017
    Evaluation of immunological efficacy and safety parameters of experimental GAS vaccines in non-human primates
    Queensland Emory Development Alliance
    Open grant
  • 2016
    Establishing a High-Throughput, Microwave-Assisted Automated Peptide Synthesis Facility at PACE
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Exosome and Bio/Nanoparticle Characterisation Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    A state-of-the-art spinning disc confocal microscope for high speed imaging of live cells and super resolution microscopy
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2015
    The insulin receptor: an Achilles' heel target for successful schistosome vaccine development (AID UQ-QIMR seed grant administered by QIMR)
    Queensland Institute of Medical Research
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Non-human primate studies of group A streptococcal vaccine candidates
    NHMRC Development Grant
    Open grant
  • 2013 - 2016
    Development of a multicomponent delivery system for oligonucleotides
    ARC Discovery Projects
    Open grant
  • 2013 - 2017
    Tropical disease - immunity, pathogenesis and vaccine development: global translation (NHMRC Program Grant administered by Griffith University)
    Griffith University
    Open grant
  • 2011
    Travel grant for Mr Mehfuz Zaman, PhD Candidate, to attend the 22nd American Peptide Symposium, June 25-30 2011 at San Diego, U.S.
    National Heart Foundation of Australia
    Open grant
  • 2011
    Cell culture facilities for studying host-pathogen interactions and immune function
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2015
    Liposaccharide based peptide and vaccine delivery systems: Improving the bioavailability and immunogenicity of Luteinizing Hormone-Releasing Hormone
    ARC Discovery Projects
    Open grant
  • 2010 - 2013
    Lipid and Carbohydrate Based Systems to Target and Deliver Peptide Drug Candidates to Specific Cells
    ARC Discovery Projects
    Open grant
  • 2010
    Cost effective acquisition of an LC-MS/MS system to support CIPDD organics analysis and preclinical and clinical operations
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    UQ Travel Awards Category 1, Francis Szoka
    UQ Travel Grants Scheme
    Open grant
  • 2009
    Robotics Instrumentation for High Throughput Sample preparation for Increased Productivity of the CIPDD/TetraQ's HPLC-MS/MS Systems for Quantitative Analysis of Organics in a Quality Systems NATA-Acc
    UQ Faculty Co-Funding
    Open grant
  • 2008 - 2010
    New neuropathic pain drugs
    NHMRC Development Grant
    Open grant
  • 2008 - 2009
    Analytical and preparative enantioselective chromatography
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2008 - 2013
    Immunity and pathogenesis in Tropical and Infectious Diseases: Implications for Vaccines and Drug Development (Program Grant Administered by NHMRC)
    Queensland Institute of Medical Research
    Open grant
  • 2008 - 2010
    Synthesis, Biological Interactions and Toxicity Studies of Precisely Engineered Nanoparticles
    ARC Discovery Projects
    Open grant
  • 2007 - 2008
    An X-Ray Diffraction Facility for Molecular Structure Determination
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2007 - 2009
    Two-photon microscopy of albumin handling by the intact kidney
    NHMRC Project Grant
    Open grant
  • 2006
    A high resolution, high-throughput chromatographic system for separation and characterisation of complex samples
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005 - 2007
    Charged Liposaccharide Based Drug Delivery System
    ARC Discovery Projects
    Open grant
  • 2005
    NHMRC_Equipment Grant = DSI Telemetry System
    NHMRC Equipment Grant
    Open grant
  • 2004 - 2009
    Global GAS vaccine based on the M-protein
    Queensland Institute of Medical Research
    Open grant
  • 2004 - 2009
    Global GAS vaccine based on the M-protein
    Queensland Institute of Medical Research
    Open grant
  • 2004 - 2005
    Biological membrane transporters:  Delivery of an oligonucleotide inhibitor of vascular endothelial growth factor (VEGF)
    NHMRC Development Grant
    Open grant
  • 2004 - 2008
    NHMRC PROGRAM GRANT: Tropical infectious diseases - pathogenesis and vaccine research
    Queensland Institute of Medical Research
    Open grant
  • 2004 - 2005
    NHMRC_Equipment Grant_HLTH_Pharmacy
    NHMRC Equipment Grant
    Open grant
  • 2004 - 2006
    Synthesis Of Glycopeptide CNS Drug Candidates Applying Chemical And Chemo-Enzymatic Methods
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2003 - 2006
    A combinatorial approach to creation of new epitopes with biological activity
    ARC Linkage Projects
    Open grant
  • 2003
    A Multiple Antigen Lipophilic Adjuvant Carrier (MALAC) System
    NHMRC Project Grant
    Open grant
  • 2003
    Delivery Technologies For Novel Sub-Unit Antigens
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2003
    Delivery Technologies for Novel Synthetic Peptide Antigens
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2003
    Malvern Zetasizer 3000HS
    NHMRC Equipment Grant
    Open grant
  • 2002 - 2005
    Development of Liposaccharide Peptide Conjugates for Peptide Drug Delivery.
    ARC Linkage Projects
    Open grant
  • 2001 - 2002
    NHMRC Equipment Grant 2000
    NHMRC Equipment Grant
    Open grant
  • 2001 - 2002
    Travel grant for travel on Scientific Visits to Europe
    Australian Academy of Science
    Open grant
  • 2001 - 2003
    Application of Saccharides in Immunology - Immunoadjuvants and Vaccines
    Alchemia Pty Ltd
    Open grant
  • 2001 - 2003
    Charged Liposaccharides for Drug Delivery
    Alchemia Pty Ltd
    Open grant
  • 2001 - 2004
    Lipid and liposaccharide based drug delivery systems
    Wellcome Trust
    Open grant
  • 2001
    A biohazard laminar flow hood for neuronal cell cultures:partial cost recovery from emergency purchase
    Brain Research Fund
    Open grant
  • 2001 - 2003
    Charged Lipophilic Dendrimers: Delivery of Oligonucleotides with Therapeutic Potential
    NHMRC Project Grant
    Open grant
  • 2000 - 2002
    A novel lipidic adjuvant carrier system for vaccination including vaccintation via the oral route
    NHMRC Project Grant
    Open grant
  • 2000 - 2002
    Targeting alpha-conotoxin MII to inhibit neuronal nicotinic acetycholine alpha3beta2 receptors of the central nervous system
    NHMRC Project Grant
    Open grant
  • 1999 - 2002
    A novel liposaccharide based system for drug/peptide delivery
    Wellcome Trust
    Open grant
  • 1999 - 2001
    Development of synthetic methods for the commercial production of sialic acid containing carbohydrates
    Alchemia Pty Ltd
    Open grant
  • 1999 - 2001
    Development of synthetic methods for the commercial production of sialic acid containing carbohydrates
    ARC Collaborative Grant (SPIRT)
    Open grant
  • 1999
    Lipidic peptides
    Cortecs International
    Open grant

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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