Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

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Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

61 - 80 of 683 works

2021

Journal Article

Cyclic dipeptides: the biological and structural landscape with special focus on the anti-cancer proline-based scaffold

Bojarska, Joanna, Mieczkowski, Adam, Ziora, Zyta, Skwarczynski, Mariusz, Toth, Istvan, Shalash, Ahmed O., Parang, Keykavous, El-Mowafi, Shaima A., Mohammed, Eman H. M., Elnagdy, Sherif, AlKhazindar, Maha and Wolf, Wojciech M. (2021). Cyclic dipeptides: the biological and structural landscape with special focus on the anti-cancer proline-based scaffold. Biomolecules, 11 (10) 1515, 1515. doi: 10.3390/biom11101515

Cyclic dipeptides: the biological and structural landscape with special focus on the anti-cancer proline-based scaffold

2021

Journal Article

Oral peptide vaccine against hookworm infection: correlation of antibody titers with protective efficacy

Shalash, Ahmed O., Becker, Luke, Yang, Jieru, Giacomin, Paul, Pearson, Mark, Hussein, Waleed M., Loukas, Alex, Skwarczynski, Mariusz and Toth, Istvan (2021). Oral peptide vaccine against hookworm infection: correlation of antibody titers with protective efficacy. Vaccines, 9 (9) 1034, 1034. doi: 10.3390/vaccines9091034

Oral peptide vaccine against hookworm infection: correlation of antibody titers with protective efficacy

2021

Journal Article

Poly(hydrophobic amino acid) conjugates for the delivery of multiepitope vaccine against Group A Streptococcus

Azuar, Armira, Shibu, Mohini A., Adilbish, Nomin, Marasini, Nirmal, Hung, Hong, Yang, Jieru, Luo, Yacheng, Khalil, Zeinab G., Capon, Robert J., Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2021). Poly(hydrophobic amino acid) conjugates for the delivery of multiepitope vaccine against Group A Streptococcus. Bioconjugate Chemistry, 32 (11) acs.bioconjchem.1c00333, 2307-2317. doi: 10.1021/acs.bioconjchem.1c00333

Poly(hydrophobic amino acid) conjugates for the delivery of multiepitope vaccine against Group A Streptococcus

2021

Journal Article

Polyacrylate-GnRH peptide conjugate as an oral contraceptive vaccine candidate

Faruck, Mohammad O., Koirala, Prashamsa, Yang, Jieru, D’Occhio, Michael J., Skwarczynski, Mariusz and Toth, Istvan (2021). Polyacrylate-GnRH peptide conjugate as an oral contraceptive vaccine candidate. Pharmaceutics, 13 (7) 1081, 1-15. doi: 10.3390/pharmaceutics13071081

Polyacrylate-GnRH peptide conjugate as an oral contraceptive vaccine candidate

2021

Other Outputs

Detection and Quantification of SARS-CoV-2 Receptor Binding Domain Neutralization by a Sensitive Competitive ELISA Assay

Shalash, Ahmed O., Azuar, Armira, Madge, Harrison Y. R., Modhiran, Naphak, Amarilla, Alberto A., Liang, Benjamin, Khromykh, Alexander, Watterson, Daniel, Young, Paul R., Toth, Istvan and Skwarczynski, Mariusz (2021). Detection and Quantification of SARS-CoV-2 Receptor Binding Domain Neutralization by a Sensitive Competitive ELISA Assay. doi: 10.21203/rs.3.pex-1559/v1

Detection and Quantification of SARS-CoV-2 Receptor Binding Domain Neutralization by a Sensitive Competitive ELISA Assay

2021

Journal Article

Key considerations for the development of safe and effective SARS‐CoV‐2 subunit vaccine: a peptide‐based vaccine alternative

Shalash, Ahmed O., Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2021). Key considerations for the development of safe and effective SARS‐CoV‐2 subunit vaccine: a peptide‐based vaccine alternative. Advanced Science, 8 (16) 2100985, 1-35. doi: 10.1002/advs.202100985

Key considerations for the development of safe and effective SARS‐CoV‐2 subunit vaccine: a peptide‐based vaccine alternative

2021

Journal Article

Pre-clinical evaluation of a whole-parasite vaccine to control human babesiosis

Al-Nazal, Hanan A., Cooper, Emily, Ho, Mei Fong, Eskandari, Sharareh, Majam, Victoria, Giddam, Ashwini Kumar, Hussein, Waleed M., Islam, Md Tanjir, Skwarczynski, Mariusz, Toth, Istvan, Kumar, Sanjai, Zaid, Ali, Batzloff, Michael, Stanisic, Danielle I. and Good, Michael F. (2021). Pre-clinical evaluation of a whole-parasite vaccine to control human babesiosis. Cell Host and Microbe, 29 (6), 894-903. doi: 10.1016/j.chom.2021.04.008

Pre-clinical evaluation of a whole-parasite vaccine to control human babesiosis

2021

Journal Article

Chemical conjugation strategies for the development of protein-based subunit nanovaccines

Lu, Lantian, Duong, Viet Tram, Shalash, Ahmed O., Skwarczynski, Mariusz and Toth, Istvan (2021). Chemical conjugation strategies for the development of protein-based subunit nanovaccines. Vaccines, 9 (6) 563, 1-24. doi: 10.3390/vaccines9060563

Chemical conjugation strategies for the development of protein-based subunit nanovaccines

2021

Journal Article

Polyethylenimine quantity and molecular weight influence its adjuvanting properties in liposomal peptide vaccines

Dai, Charles C., Huang, Wenbin, Yang, Jieru, Hussein, Waleed M., Wang, Jingwen, Khalil, Zeinab G., Capon, Robert J., Toth, Istvan and Stephenson, Rachel J. (2021). Polyethylenimine quantity and molecular weight influence its adjuvanting properties in liposomal peptide vaccines. Bioorganic and Medicinal Chemistry Letters, 40 127920, 1-7. doi: 10.1016/j.bmcl.2021.127920

Polyethylenimine quantity and molecular weight influence its adjuvanting properties in liposomal peptide vaccines

2021

Journal Article

Cell-penetrating peptides-based liposomal delivery system enhanced immunogenicity of peptide-based vaccine against group A streptococcus

Yang, Jieru, Firdaus, Farrhana, Azuar, Armira, Khalil, Zeinab G., Marasini, Nirmal, Capon, Robert J., Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2021). Cell-penetrating peptides-based liposomal delivery system enhanced immunogenicity of peptide-based vaccine against group A streptococcus. Vaccines, 9 (5) 499, 499. doi: 10.3390/vaccines9050499

Cell-penetrating peptides-based liposomal delivery system enhanced immunogenicity of peptide-based vaccine against group A streptococcus

2021

Journal Article

Immunogenicity assessment of cell wall carbohydrates of Group A Streptococcus via self-adjuvanted glyco-lipopeptides

Khatun, Farjana, Dai, Charles C., Rivera-Hernandez, Tania, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Toth, Istvan and Stephenson, Rachel J. (2021). Immunogenicity assessment of cell wall carbohydrates of Group A Streptococcus via self-adjuvanted glyco-lipopeptides. ACS Infectious Diseases, 7 (2) acsinfecdis.0c00722, 390-405. doi: 10.1021/acsinfecdis.0c00722

Immunogenicity assessment of cell wall carbohydrates of Group A Streptococcus via self-adjuvanted glyco-lipopeptides

2021

Journal Article

Poly(hydrophobic amino acid)-based self-adjuvanting nanoparticles for Group A Streptococcus vaccine delivery

Azuar, Armira, Li, Zhuoqing, Shibu, Mohini A., Zhao, Lili, Luo, Yacheng, Shalash, Ahmed O., Khalil, Zeinab G., Capon, Robert J., Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2021). Poly(hydrophobic amino acid)-based self-adjuvanting nanoparticles for Group A Streptococcus vaccine delivery. Journal of Medicinal Chemistry, 64 (5) acs.jmedchem.0c01660, 2648-2658. doi: 10.1021/acs.jmedchem.0c01660

Poly(hydrophobic amino acid)-based self-adjuvanting nanoparticles for Group A Streptococcus vaccine delivery

2021

Journal Article

A global review on short peptides: frontiers and perspectives

Apostolopoulos, Vasso, Bojarska, Joanna, Chai, Tsun-Thai, Elnagdy, Sherif, Kaczmarek, Krzysztof, Matsoukas, John, New, Roger, Parang, Keykavous, Lopez, Octavio Paredes, Parhiz, Hamideh, Perera, Conrad O., Pickholz, Monica, Remko, Milan, Saviano, Michele, Skwarczynski, Mariusz, Tang, Yefeng, Wolf, Wojciech M., Yoshiya, Taku, Zabrocki, Janusz, Zielenkiewicz, Piotr, AlKhazindar, Maha, Barriga, Vanessa, Kelaidonis, Konstantinos, Sarasia, Elham Mousavinezhad and Toth, Istvan (2021). A global review on short peptides: frontiers and perspectives. Molecules, 26 (2) 430, 430. doi: 10.3390/molecules26020430

A global review on short peptides: frontiers and perspectives

2021

Book Chapter

Peptide-pegylated lipid conjugation via copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition

Hussein, Waleed M. and Toth, Istvan (2021). Peptide-pegylated lipid conjugation via copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition. Peptide conjugation: methods and protocols. (pp. 57-64) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-1617-8_6

Peptide-pegylated lipid conjugation via copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition

2021

Journal Article

A potent vaccine delivery system

Zhao, Guangzu, Azuar, Armira, Toth, Istvan and Skwarczynski, Mariusz (2021). A potent vaccine delivery system. Bio-protocol, 11 (7) e3973, e3973. doi: 10.21769/bioprotoc.3973

A potent vaccine delivery system

2021

Journal Article

Antibodies to neutralising epitopes synergistically block the interaction of the receptor-binding domain of SARS-CoV-2 to ACE 2

Pandey, Manisha, Ozberk, Victoria, Eskandari, Sharareh, Shalash, Ahmed O., Joyce, Michael A., Saffran, Holly A., Day, Christopher J., Lepletier, Ailin, Spillings, Belinda L., Mills, Jamie-Lee, Calcutt, Ainslie, Fan, Fan, Williams, James T., Stanisic, Danielle I., Hattingh, Laetitia, Gerrard, John, Skwarczynski, Mariusz, Mak, Johnson, Jennings, Michael P., Toth, Istvan, Tyrrell, D. Lorne and Good, Michael F. (2021). Antibodies to neutralising epitopes synergistically block the interaction of the receptor-binding domain of SARS-CoV-2 to ACE 2. Clinical and Translational Immunology, 10 (3) e1260, e1260. doi: 10.1002/cti2.1260

Antibodies to neutralising epitopes synergistically block the interaction of the receptor-binding domain of SARS-CoV-2 to ACE 2

2021

Book Chapter

Peptide-Polymer Conjugation Via Copper-Catalyzed Alkyne-Azide 1,3-Dipolar Cycloaddition

Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2021). Peptide-Polymer Conjugation Via Copper-Catalyzed Alkyne-Azide 1,3-Dipolar Cycloaddition. Methods in Molecular Biology. (pp. 1-7) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-1617-8_1

Peptide-Polymer Conjugation Via Copper-Catalyzed Alkyne-Azide 1,3-Dipolar Cycloaddition

2021

Book

Peptide Conjugation : Methods and Protocols

Hussein, Waleed M., Stephenson, Rachel J. and Toth, Istvan eds. (2021). Peptide Conjugation : Methods and Protocols. Methods in Molecular Biology, New York, NY United States: Springer. doi: 10.1007/978-1-0716-1617-8

Peptide Conjugation : Methods and Protocols

2021

Book Chapter

Double conjugation using mercapto-acryloyl and alkyne-azide reactions for the synthesis of branched multiantigenic vaccine candidates

Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2021). Double conjugation using mercapto-acryloyl and alkyne-azide reactions for the synthesis of branched multiantigenic vaccine candidates. Peptide conjugation: methods and protocols. (pp. 141-150) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-1617-8_13

Double conjugation using mercapto-acryloyl and alkyne-azide reactions for the synthesis of branched multiantigenic vaccine candidates

2021

Book Chapter

Nanocarrier-based vaccine delivery systems for synthetic peptide vaccines

Madge, Harrison Y.R., Stephenson, Rachel J. and Toth, Istvan (2021). Nanocarrier-based vaccine delivery systems for synthetic peptide vaccines. Handbook of nanotechnology applications: environment, energy, agriculture and medicine. (pp. 509-535) edited by Woei Jye Lau, Kajornsak Faungnawakij, Kuakoon Piyachomkwan and Uracha Rungsardthong Ruktanonchai. Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-12-821506-7.00020-x

Nanocarrier-based vaccine delivery systems for synthetic peptide vaccines

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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