Analytical and preparative enantioselective chromatography (2008-2009)
Abstract
The facility will allow analysis of enantiomeric mixtures and the preparative separation of such mixtures 100g scale). It utilises HPLC equipment with two important, costly additions. The column is composed of enantiopure, chiral material and provides the only method for direct separation of enantiomers without prior chemical modification. A laser polarimeter detector concomitantly allows sensitive, specific detection of chiral molecules and determines their optical rotation (uniquely associated with their three dimensional structure). Enantiomer separation is vital in drug development as one enatiomer may be active and the other inactive or even toxic. This equipment is currently unavailable in Australia.
