
Overview
Background
Mariusz Skwarczynski completed his Ph.D. in Chemistry in 1999 at Wroclaw University of Technology (Poland). His postdoctoral training began at Tokushima Bunri University (Japan) under the direction of late Professor M. Nishizawa, where he studied the biomimetic total synthesis of anticancer agent paclitaxel. He then joined the laboratory of Professor Yoshiaki Kiso at Kyoto Pharmaceutical University (Japan) to study prodrugs of paclitaxel. In 2004 he was awarded with Japanese fellowship (Japan Society for the Promotion of Science postdoctoral fellowship) and research grant to conduct further research on paclitaxel. He developed novel classes of paclitaxel prodrugs: isotaxoids and phototaxels. He also co-developed an epimerization-free method for the synthesis of novel building blocks (isodipeptides) for solid phase peptide synthesis and these units have been commercialized by Merck-Novabiochem.
In 2008 he joined Professor Istvan Toth group at University of Queensland (Australia) to work on vaccine delivery strategies. Since then, he research is mainly focused on nanotechnology-based peptide vaccine delivery approaches. In 2010 he was awarded with University of Queensland Strategic Fund Research Fellowship. In Australia, he is involved in a wide range of collaborative research projects, both nationally and internationally, to develop vaccines against GAS, HIV, hookworm infections, malaria and cancer, along with antibiotics against multidrug resistant bacteria.
Availability
- Associate Professor Mariusz Skwarczynski is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Masters (Coursework) of Science, Wroclaw University of Technology
- Doctor of Philosophy, Wroclaw University of Technology
- Member, Australian Infectious Diseases Research Centre, Australian Infectious Diseases Research Centre
- Journal Editorial Board Member, Current Drug Delivery, Current Drug Delivery
- Journal Editorial Board Member, Frontiers in Pharmacology (Associate Editor), Frontiers in Pharmacology (Associate Editor)
- Journal Editorial Board Member, Medicinal Chemistry, Medicinal Chemistry
- Member, Royal Australian Chemical Institute, Royal Australian Chemical Institute
- Member, The Japan Society for the Promotion of Science Alumni Association in Australia, The Japan Society for the Promotion of Science Alumni Association in Australia
- Journal Editorial Board Member, Vaccines (Regional Editor of Australia), Vaccines (Regional Editor of Australia)
Research interests
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Vaccines and Nanomedicine
Vaccine Desing, Nanotechnology, Peptide Chemistry, Medicinal Chemistry, Vaccine/Drug Delivery, Antimicrobial Agents, Macromolecules, Adjuvants, Immunology
Research impacts
Mariusz Skwarczynski has over 180 publications, including peer-reviewed journals, book chapters (Wiley, Springer Nature, Nova Science, Elsevier), and two edited book (Elsevier, Springer Nature) – as of 2023. Among these publications, 16 are in journals with an impact factor of 10-30. He was ranked 3rd in the world in the Subunit Vaccines field (2012-2022) by Expertscape's PubMed-based scheme and placed among the top 0.1% (0.022% of 18,308 published authors) of scholars writing about Subunit Vaccines over the past 10 years: https://expertscape.com/ex/vaccines%2C+subunit. He is an inventor on three patents that attracted interest from the industry including Meat & Livestock Australia Ltd, Vet-Agro Sp. z o.o., Paragen Bio, and Brandon Capital. He co-developed an epimerization-free method for the synthesis of novel building blocks (isodipeptides) for solid-phase peptide synthesis; these units have been commercialised by Merck-Novabiochem. Recently, he has been actively engaged in several projects aimed at the commercialisation of veterinary vaccines (mostly targeting domestic and wild animals’ fertility control) in Australia and Italy.
He is very active in a collaborative initiative between universities, on projects to develop vaccines against Group A Streptococcus, tuberculosis, hookworm, malaria, porcine circovirus, babesia and cancer, as well as other drug delivery systems. He is an Associate Editor in Frontiers in Pharmacology, (2016 – current) and Regional Editor of Australia in Vaccines (2018 – current). In addition to grants from the ARC and NHMRC, he is also the recipient of industry-specific grants (Economic Accelerator Launch Programme 2023 and Meat & Livestock Australia Limited grant 2021). He regularly communicates with the public (locally and internationally) on issues related to vaccine development and safety. His recent publication on the oral hookworm vaccine has attracted wide media interest from all over the world (Australia, India, China, Kenya, New Zealand, Hungary, Pakistan, etc.). He is often invited to present at international conferences, and recently he organised and chaired Micro and Nanoparticles in Drug and Vaccine Delivery Symposium, Brisbane, 2021.
He has served as a primary supervisor of four PhD students (two ongoings, two theses awarded) and co-supervisor of 23 PhD students in the medicinal chemistry, biotechnology, and vaccine development fields. All his former students have successfully found jobs, many of which are in the fields of biology or chemistry, across industry and academia, in Australia and abroad. Some notable examples of current employers of his past students include Harvard T.H. Chan School of Public Health, National University of Malaysia, The Translational Research Institute, Griffith University, Miltenyi Biotec Australia, James Cook University, Procter & Gamble, Woolcock Institute of Medical Research, WuXi Biologics, and Endologix California.
Works
Search Professor Mariusz Skwarczynski’s works on UQ eSpace
2025
Journal Article
Development of an efficacious oral peptide vaccine against infection with the carcinogenic liver fluke Opisthorchis viverrini
Phumrattanaprapin, Wuttipong, Shalash, Ahmed O., Skwarczynski, Mariusz, Smout, Michael J., Laha, Thewarach, Toth, Istvan and Loukas, Alex (2025). Development of an efficacious oral peptide vaccine against infection with the carcinogenic liver fluke Opisthorchis viverrini. Vaccine, 61 127400, 127400-61. doi: 10.1016/j.vaccine.2025.127400
2025
Journal Article
Evaluation of Peptide-Based Vaccines Against Group A Streptococcus in Staphylococcus aureus-Infected Mice
Shalash, Ahmed O., Sun, Haolan, Cui, Yiru, Wang, Jingwen, Arnts, Barb, Bauer, Jannah, Hussein, Waleed M., Khalil, Zeinab G., Skwarczynski, Mariusz and Toth, Istvan (2025). Evaluation of Peptide-Based Vaccines Against Group A Streptococcus in Staphylococcus aureus-Infected Mice. Vaccines, 13 (6) 632, 632-6. doi: 10.3390/vaccines13060632
2025
Journal Article
Evaluation of novel single-dose vaccine candidates against gonadotropin-releasing hormone (GnRH) in mice
Shalash, Ahmed O., Wang, Wanyi, Xia, Yihui, Hussein, Waleed M., Bashiri, Sahra, D'Occhio, Michael J., Stephenson, Rachel J., Skwarczynski, Mariusz and Toth, Istvan (2025). Evaluation of novel single-dose vaccine candidates against gonadotropin-releasing hormone (GnRH) in mice. Vaccine, 53 127092, 127092-53. doi: 10.1016/j.vaccine.2025.127092
2025
Journal Article
Influence of component structural arrangement on cholesterol-antigen conjugate immunogenicity and antisera bactericidal activity against group A Streptococcus
Skwarczynski, Mariusz, Alharbi, Nedaa, Nahar, Ummey J., Shalash, Ahmed O., Azuar, Armira, Koirala, Prashamsa, Khisty, Shefali J., Wang, Jingwen, Marasini, Nirmal, Hussein, Waleed M., Khalil, Zeinab G. and Toth, Istvan (2025). Influence of component structural arrangement on cholesterol-antigen conjugate immunogenicity and antisera bactericidal activity against group A Streptococcus. Bioorganic Chemistry, 157 108248, 108248-157. doi: 10.1016/j.bioorg.2025.108248
2025
Journal Article
Tumor‐Derived Autophagosomes Coated With Nanodots as Future Personalized Cancer Vaccines
Lu, Lantian and Skwarczynski, Mariusz (2025). Tumor‐Derived Autophagosomes Coated With Nanodots as Future Personalized Cancer Vaccines. MedComm – Future Medicine, 4 (1) e70015. doi: 10.1002/mef2.70015
2025
Journal Article
A Modular Self-Assembling and Self-Adjuvanting Multiepitope Peptide Nanoparticle Vaccine Platform to Improve the Efficacy and Immunogenicity of BCG
Zhao, Guangzu, Sathkumara, Harindra D., Miranda-Hernandez, Socorro, Seifert, Julia, Valencia-Hernandez, Ana Maria, Puri, Munish, Huang, Wenbin, Toth, Istvan, Daly, Norelle, Skwarczynski, Mariusz and Kupz, Andreas (2025). A Modular Self-Assembling and Self-Adjuvanting Multiepitope Peptide Nanoparticle Vaccine Platform to Improve the Efficacy and Immunogenicity of BCG. Small, 21 (7) 2406874, e2406874. doi: 10.1002/smll.202406874
2025
Book Chapter
Automated Synthesis and Purification of Hydrophobic Peptides
Huang, Wenbin, Toth, Istvan and Skwarczynski, Mariusz (2025). Automated Synthesis and Purification of Hydrophobic Peptides. Methods in Molecular Biology. (pp. 343-354) New York, NY: Springer US. doi: 10.1007/978-1-0716-4562-8_26
2025
Journal Article
Preface
Hussein, Waleed W. and Skwarczynski, Mariusz (2025). Preface. Methods in Molecular Biology, 2931.
2024
Journal Article
Editorial: Peptides against infectious diseases: from antimicrobial peptides to vaccines
Bojarska, Joanna, Wang, Xiumin and Skwarczynski, Mariusz (2024). Editorial: Peptides against infectious diseases: from antimicrobial peptides to vaccines. Frontiers in Pharmacology, 15 1522148, 1522148. doi: 10.3389/fphar.2024.1522148
2024
Journal Article
Self-assembled monovalent lipidated mannose ligand as a standalone nanoadjuvant
Nahar, Ummey J., Wang, Jingwen, Shalash, Ahmed O., Lu, Lantian, Islam, Md. T., Alharbi, Nedaa, Koirala, Prashamsa, Khalil, Zeinab G., Capon, Robert J., Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2024). Self-assembled monovalent lipidated mannose ligand as a standalone nanoadjuvant. Vaccine, 42 (23) 126060, 126060. doi: 10.1016/j.vaccine.2024.06.027
2024
Journal Article
Cholesterol as an inbuilt immunoadjuvant for a lipopeptide vaccine against group A Streptococcus infection
Alharbi, Nedaa, Shalash, Ahmed O., Koirala, Prashamsa, Boer, Jennifer C., Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Plebanski, Magdalena, Toth, Istvan and Skwarczynski, Mariusz (2024). Cholesterol as an inbuilt immunoadjuvant for a lipopeptide vaccine against group A Streptococcus infection. Journal of Colloid and Interface Science, 663, 43-52. doi: 10.1016/j.jcis.2024.02.134
2024
Journal Article
COVID-19 variants and vaccine development
Zhao, Ziyao, Bashiri, Sahra, Ziora, Zyta M., Toth, Istvan and Skwarczynski, Mariusz (2024). COVID-19 variants and vaccine development. Viruses, 16 (5) 757, 757. doi: 10.3390/v16050757
2024
Journal Article
Utilizing murine dendritic cell line DC2.4 to evaluate the immunogenicity of subunit vaccines in vitro
Lu, Lantian, Kong, Wei Yang, Zhang, Jiahui, Firdaus, Farrhana, Wells, James W., Stephenson, Rachel J., Toth, Istvan, Skwarczynski, Mariusz and Cruz, Jazmina L. Gonzalez (2024). Utilizing murine dendritic cell line DC2.4 to evaluate the immunogenicity of subunit vaccines in vitro. Frontiers in Immunology, 15 1298721, 1-13. doi: 10.3389/fimmu.2024.1298721
2024
Journal Article
Polymeric nanoparticles as oral and intranasal peptide vaccine delivery systems: the role of shape and conjugation
Koirala, Prashamsa, Shalash, Ahmed O., Chen, Sung-Po R., Faruck, Mohammad O., Wang, Jingwen, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2024). Polymeric nanoparticles as oral and intranasal peptide vaccine delivery systems: the role of shape and conjugation. Vaccines, 12 (2) 198, 1-14. doi: 10.3390/vaccines12020198
2024
Book Chapter
An analytical protocol for detecting antibody titer levels in serum/saliva by indirect Enzyme-Linked Immunosorbent Assay (ELISA)
Wang, Jingwen, Bashiri, Sahra, Toth, Istvan and Skwarczynski, Mariusz (2024). An analytical protocol for detecting antibody titer levels in serum/saliva by indirect Enzyme-Linked Immunosorbent Assay (ELISA). Peptide antibodies: methods and protocols. (pp. 205-216) edited by Gunnar Houen. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-3914-6_16
2023
Journal Article
Activity relationship of poly(ethylenimine)-based liposomes as group A Streptococcus vaccine delivery systems
Jin, Shengbin, Zhang, Jiahui, Nahar, Ummey J., Huang, Wenbin, Alharbi, Nedaa A., Shalash, Ahmed O., Koirala, Prashamsa, Yang, Jieru, Kiong, Jolynn J. E., Khalil, Zeinab G., Capon, Robert J., Stephenson, Rachel J., Skwarczynski, Mariusz, Toth, Istvan and Hussein, Waleed M. (2023). Activity relationship of poly(ethylenimine)-based liposomes as group A Streptococcus vaccine delivery systems. ACS Infectious Diseases, 9 (8), 1570-1581. doi: 10.1021/acsinfecdis.3c00159
2023
Journal Article
Towards the development of subunit vaccines against tuberculosis: The key role of adjuvant
Duong, Viet Tram, Skwarczynski, Mariusz and Toth, Istvan (2023). Towards the development of subunit vaccines against tuberculosis: The key role of adjuvant. Tuberculosis, 139 102307, 1-15. doi: 10.1016/j.tube.2023.102307
2023
Journal Article
Multiepitope subunit peptide-based nanovaccine against porcine circovirus type 2 (PCV2) elicited high antibody titers in vaccinated mice
Duong, Viet Tram, Koirala, Prashamsa, Chen, Sung-Po R., Monteiro, Michael J., Skwarczynski, Mariusz and Toth, Istvan (2023). Multiepitope subunit peptide-based nanovaccine against porcine circovirus type 2 (PCV2) elicited high antibody titers in vaccinated mice. Molecules, 28 (5) 2248, 1-15. doi: 10.3390/molecules28052248
2023
Journal Article
Liposomal formulations of a polyleucine–antigen conjugate as therapeutic vaccines against cervical cancer
Firdaus, Farrhana Z., Bartlett, Stacey, Hussein, Waleed M., Lu, Lantian, Wright, Quentin, Huang, Wenbin, Nahar, Ummey J., Yang, Jieru, Khongkow, Mattaka, Veitch, Margaret, Koirala, Prashamsa, Ruktanonchai, Uracha R., Monteiro, Michael J., Gonzalez Cruz, Jazmina L., Stephenson, Rachel J., Wells, James W., Toth, Istvan and Skwarczynski, Mariusz (2023). Liposomal formulations of a polyleucine–antigen conjugate as therapeutic vaccines against cervical cancer. Pharmaceutics, 15 (2) 602, 1-15. doi: 10.3390/pharmaceutics15020602
2023
Journal Article
The development of surface-modified liposomes as an intranasal delivery system for group A Streptococcus vaccines
Yang, Jieru, Boer, Jennifer C., Khongkow, Mattaka, Phunpee, Sarunya, Khalil, Zeinab G., Bashiri, Sahra, Deceneux, Cyril, Goodchild, Georgia, Hussein, Waleed M., Capon, Robert J., Ruktanonchai, Uracha, Plebanski, Magdalena, Toth, Istvan and Skwarczynski, Mariusz (2023). The development of surface-modified liposomes as an intranasal delivery system for group A Streptococcus vaccines. Vaccines, 11 (2) 305. doi: 10.3390/vaccines11020305
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Mariusz Skwarczynski is:
- Available for supervision
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Available projects
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A nanonaccine against Invasive Group A Streptococcus and Rheumatic Heart Disease
The major challenge in any vaccine development is its formulation/delivery once the target antigens are identified. The main aim of this project is to adopt and further develop our immune-stimulating delivery systems to produce a multicomponent synthetic (poly)peptide vaccine candidate against Group A Streptococcus (GAS), the major causative agent of deadly diseases such as rheumatic heart disease (RHD) and invasive GAS infection. Notably, a variety of vaccines against GAS infection have reached clinical trials in the past decades; however, these vaccines have limited efficacy due to the high variability of GAS strains. We hypothesise that the incorporation of three conserved peptide antigens from GAS proteins into our newly developed nanoparticles-based vaccine delivery systems will overcome the above obstacles and produce an efficient and universal vaccine candidate against GAS. The project will deliver preclinical vaccine candidates against Group A Streptococcus, which after oral dosing will be able to induce robust opsonic antibody production against a wide range of GAS strains, without triggering adverse effects and off-target immune responses. We will employ peptide antigens from the highly conserved region of M-protein, cell envelope proteinase and fibronectin-binding protein 1. The optimised vaccine delivery system will be easily adaptable for the development of vaccines against other diseases.
Supervision history
Current supervision
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Doctor Philosophy
Development of silver nanoparticles as novel adjuvants in vaccine
Principal Advisor
Other advisors: Emeritus Professor Istvan Toth
-
Doctor Philosophy
L-Rhamnose-based nanovaccine derived from poly-rhamnose backbone of Group A Carbohydrate (GAC) against Invasive Group A Streptococcus and Rheumatic Heart Disease
Principal Advisor
Other advisors: Emeritus Professor Istvan Toth
-
Doctor Philosophy
Combating cervical cancer through a combination of anticancer therapy and vaccinations.
Principal Advisor
Other advisors: Dr Zyta M Ziora
-
Doctor Philosophy
A nanovaccine against Invasive Group A Streptococcus and Rheumatic Heart Disease
Principal Advisor
Other advisors: Dr Rachel Stephenson, Emeritus Professor Istvan Toth
-
Doctor Philosophy
Development of mannose receptor ligands as novel immune adjuvants
Principal Advisor
Other advisors: Emeritus Professor Istvan Toth
-
Doctor Philosophy
Hookworm vaccine: vaccine development toward clinical trials
Principal Advisor
Other advisors: Emeritus Professor Istvan Toth
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Doctor Philosophy
Novel Vaccine Designs of Adjuvants and Delivery Systems against Infectious Diseases
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth, Dr Rachel Stephenson
Completed supervision
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2022
Doctor Philosophy
Development of a new peptide-based self-adjuvanting delivery system for vaccine against Group A Streptococcus (GAS)
Principal Advisor
Other advisors: Emeritus Professor Istvan Toth
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2022
Doctor Philosophy
Delivery of a peptide-based vaccine against group A streptococcus with the help of cell-penetrating peptides
Principal Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2025
Doctor Philosophy
Development of poly(hydrophobic amino acids)-based immunopotentiators for subunit vaccines against infectious diseases
Associate Advisor
Other advisors: Dr Jazmina Gonzalez Cruz, Emeritus Professor Istvan Toth
-
2023
Doctor Philosophy
Polymers as a nanoparticulate adjuvant and vaccine delivery system
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2023
Doctor Philosophy
Lipophilic Peptides as Immune Stimulants
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2023
Doctor Philosophy
The role of shape in vaccine delivery: Polymeric nanoparticles-based peptide vaccine against Group A Streptococci (GAS) infection
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2023
Doctor Philosophy
Cholesterol-based Vaccine Delivery Systems against Group A Streptococcal Infection
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2023
Doctor Philosophy
Development of Peptide-based Vaccines against Infectious Diseases: Hookworm, Liver fluke, and SARS-CoV-2 virus
Associate Advisor
Other advisors: Dr Waleed Hussein, Emeritus Professor Istvan Toth
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2022
Doctor Philosophy
Targeting lectin receptors for vaccine delivery against group A streptococcus
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2022
Doctor Philosophy
Development of polyacrylate-based delivery systems for peptide vaccines
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2022
Doctor Philosophy
Development of an effective prophylactic and therapeutic treatment for malaria
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
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2020
Doctor Philosophy
Design and evaluation of polysaccharide-based nanoparticles for mucosal vaccine delivery
Associate Advisor
Other advisors: Dr Waleed Hussein, Emeritus Professor Istvan Toth
-
2020
Doctor Philosophy
Hydrophobic amino acid-based vaccine delivery systems to induce cellular and humoral immunity
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2019
Doctor Philosophy
Development of novel nanoparticulate polymeric delivery system for peptide vaccines against group A streptococcus
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2018
Doctor Philosophy
Peptide-Based Self-Assembling Delivery System for Development of Group A Streptococcus Vaccine
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2018
Doctor Philosophy
Epitope-focused vaccines against respiratory syncytial virus
Associate Advisor
Other advisors: Professor Keith Chappell, Professor Daniel Watterson, Emeritus Professor Istvan Toth
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2017
Doctor Philosophy
Development of novel nanoparticle-based mucosal delivery systems for lipopeptide vaccine against group A streptococcus
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2016
Doctor Philosophy
Liposome-based delivery system for the development of malaria vaccine
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2016
Doctor Philosophy
Development of Peptide-Based Vaccines Against Group A Streptococcus (GAS) and Malaria
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2016
Doctor Philosophy
Therapeutic and Preventive Potential of Synthetic Lipopeptides against Bacterial Infections
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2016
Doctor Philosophy
Development of Novel Strategies for Delivery of Vaccine Candidates Against Group A Streptococcus
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth, Dr Waleed Hussein
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2015
Doctor Philosophy
The Development of Peptide-Based Subunit Vaccines against Streptococcus pyogenes, Necator americanus and Schistosome mansoni.
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2015
Doctor Philosophy
Self-assembling and self-adjuvanting polymer-peptide conjugates as therapeutic vaccines against cervical cancer
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
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2010
Doctor Philosophy
Lipopeptide-Carbohydrate-Antigen Platforms for Synthetic Vaccine Development
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2010
Doctor Philosophy
The synthesis and characterization of peptide-based carriers for gene delivery and peptide therapeutics
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
Media
Enquiries
Contact Associate Professor Mariusz Skwarczynski directly for media enquiries about:
- fertility control
- group A streptococcus
- hookworm
- immune adjuvants
- nanovaccines
- peptide vaccines
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