Dr Waleed Hussein
Dr

Waleed Hussein

Email: 
Phone: 
+61 7 344 36285

Availability

Dr Waleed Hussein is:
Available for supervision

Fields of research

Chemical Sciences Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Bachelor of Pharmacy, Cairo University
  • Masters (Research), Helwan University
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Peptide-based vaccines

    I focus on the development of peptide-based vaccines against infectious diseases and cancer. This includes (1) synthesis of adjuvanting moieties for stimulation of immune system; (2) applying different methods for conjugation of peptides and lipids; (3) determination of the size, shape and charge of the self-assembled vaccine particles; (4) investigate the biological efficiency of vaccines in both in vitro and in vivo.

  • Gene delivery

    Currently, I am working on the development of targeted nanoparticle delivery system to deliver the siRNA to cytoplasm. This delivery system includes peptide-based, micelles and/or liposome formulations.

Search Professor Waleed Hussein’s works on UQ eSpace

113 works between 2009 and 2025
All (113) Journal Article (99) Book Chapter (6) Conference Publication (5) Book (2) Other Outputs (1)

1 - 20 of 113 works

2025

Journal Article

A synthetic cyclic peptide for promoting antigen presentation and immune activation

Zhang, Jiahui, Madge, Harrison Y. R., Mahmoud, Asmaa, Lu, Lantian, Wang, Wanyi, Huang, Wenbin, Koirala, Prashamsa, Gonzalez Cruz, Jazmina L., Kong, Wei Yang, Bashiri, Sahra, Shalash, Ahmed O., Hussein, Waleed M., Khalil, Zeinab G., Wells, James W., Toth, Istvan and Stephenson, Rachel J. (2025). A synthetic cyclic peptide for promoting antigen presentation and immune activation. NPJ Vaccines, 10 (1) 9. doi: 10.1038/s41541-024-01050-4

A synthetic cyclic peptide for promoting antigen presentation and immune activation

2024

Journal Article

Total Synthesis of Talarolide A and atrop-Talarolide A: Hydroxamate H-Bond Bridge Stabilization of Cyclic Peptide Conformers Invokes Non-Canonical Atropisomerism

Hussein, Waleed M., Zhu, Yuxuan, Salim, Angela A. and Capon, Robert J. (2024). Total Synthesis of Talarolide A and atrop-Talarolide A: Hydroxamate H-Bond Bridge Stabilization of Cyclic Peptide Conformers Invokes Non-Canonical Atropisomerism. Marine Drugs, 22 (10) 454, 454. doi: 10.3390/md22100454

Total Synthesis of Talarolide A and atrop-Talarolide A: Hydroxamate H-Bond Bridge Stabilization of Cyclic Peptide Conformers Invokes Non-Canonical Atropisomerism

2024

Journal Article

Australian Marine and Terrestrial Streptomyces-Derived Surugamides, and Synthetic Analogs, and Their Ability to Inhibit Dirofilaria immitis (Heartworm) Motility

Wu, Taizong, Hussein, Waleed M., Samarasekera, Kaumadi, Zhu, Yuxuan, Khalil, Zeinab G., Jin, Shengbin, Bruhn, David F., Moreno, Yovany, Salim, Angela A. and Capon, Robert J. (2024). Australian Marine and Terrestrial Streptomyces-Derived Surugamides, and Synthetic Analogs, and Their Ability to Inhibit Dirofilaria immitis (Heartworm) Motility. Marine Drugs, 22 (7) 312, 312. doi: 10.3390/md22070312

Australian Marine and Terrestrial Streptomyces-Derived Surugamides, and Synthetic Analogs, and Their Ability to Inhibit Dirofilaria immitis (Heartworm) Motility

2024

Journal Article

Cholesterol as an inbuilt immunoadjuvant for a lipopeptide vaccine against group A Streptococcus infection

Alharbi, Nedaa, Shalash, Ahmed O., Koirala, Prashamsa, Boer, Jennifer C., Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Plebanski, Magdalena, Toth, Istvan and Skwarczynski, Mariusz (2024). Cholesterol as an inbuilt immunoadjuvant for a lipopeptide vaccine against group A Streptococcus infection. Journal of Colloid and Interface Science, 663, 43-52. doi: 10.1016/j.jcis.2024.02.134

Cholesterol as an inbuilt immunoadjuvant for a lipopeptide vaccine against group A Streptococcus infection

2024

Journal Article

Self-assembled monovalent lipidated mannose ligand as a standalone nanoadjuvant

Nahar, Ummey J., Wang, Jingwen, Shalash, Ahmed O., Lu, Lantian, Islam, Md. T., Alharbi, Nedaa, Koirala, Prashamsa, Khalil, Zeinab G., Capon, Robert J., Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2024). Self-assembled monovalent lipidated mannose ligand as a standalone nanoadjuvant. Vaccine, 42 (23) 126060, 126060. doi: 10.1016/j.vaccine.2024.06.027

Self-assembled monovalent lipidated mannose ligand as a standalone nanoadjuvant

2024

Journal Article

Pullenvalenes A–D: Nitric oxide-mediated transcriptional activation (NOMETA) enables discovery of triterpene aminoglycosides from Australian Termite nest-derived fungi

Dewa, Amila Agampodi, Khalil, Zeinab G., Hussein, Waleed M., Jin, Shengbin, Wang, Yanan, Cruz-Morales, Pablo and Capon, Robert J. (2024). Pullenvalenes A–D: Nitric oxide-mediated transcriptional activation (NOMETA) enables discovery of triterpene aminoglycosides from Australian Termite nest-derived fungi. Journal of Natural Products, 87 (4), 935-947. doi: 10.1021/acs.jnatprod.3c01233

Pullenvalenes A–D: Nitric oxide-mediated transcriptional activation (NOMETA) enables discovery of triterpene aminoglycosides from Australian Termite nest-derived fungi

2024

Conference Publication

Regulation of 20a-hydroxysteroid dehydrogenase expression in term pregnant human myometrium

Paul, Marina, Barreda, Anna Paredes, Gregson, Amy, Kahl, Richard, King, Madeline, Hussein, Waleed M., Walker, Frederick R., Smith, Roger, Zakar, Tamas and Paul, Jonathan W. (2024). Regulation of 20a-hydroxysteroid dehydrogenase expression in term pregnant human myometrium. 71st Annual Meeting of the Society for Reproductive Investigation (SRI), Vancouver, BC, Canada, 12-16 March 2024. Heidelberg, Germany: Springer.

Regulation of 20a-hydroxysteroid dehydrogenase expression in term pregnant human myometrium

2024

Journal Article

Polymeric nanoparticles as oral and intranasal peptide vaccine delivery systems: the role of shape and conjugation

Koirala, Prashamsa, Shalash, Ahmed O., Chen, Sung-Po R., Faruck, Mohammad O., Wang, Jingwen, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Monteiro, Michael J., Toth, Istvan and Skwarczynski, Mariusz (2024). Polymeric nanoparticles as oral and intranasal peptide vaccine delivery systems: the role of shape and conjugation. Vaccines, 12 (2) 198, 1-14. doi: 10.3390/vaccines12020198

Polymeric nanoparticles as oral and intranasal peptide vaccine delivery systems: the role of shape and conjugation

2023

Journal Article

Talarolides Revisited: Cyclic Heptapeptides from an Australian Marine Tunicate-Associated Fungus, Talaromyces sp. CMB-TU011

Salim, Angela A., Hussein, Waleed M., Dewapriya, Pradeep, Hoang, Huy N., Zhou, Yahao, Samarasekera, Kaumadi, Khalil, Zeinab G., Fairlie, David P. and Capon, Robert J. (2023). Talarolides Revisited: Cyclic Heptapeptides from an Australian Marine Tunicate-Associated Fungus, Talaromyces sp. CMB-TU011. Marine Drugs, 21 (9) 487, 1-17. doi: 10.3390/md21090487

Talarolides Revisited: Cyclic Heptapeptides from an Australian Marine Tunicate-Associated Fungus, Talaromyces sp. CMB-TU011

2023

Journal Article

Regulation of 20α-hydroxysteroid dehydrogenase expression in term pregnant human myometrium ex vivo

Paul, Marina, Barreda, Anna Paredes, Gregson, Amy, Kahl, Richard, King, Madeline, Hussein, Waleed M., Walker, Frederick R., Smith, Roger, Zakar, Tamas and Paul, Jonathan W. (2023). Regulation of 20α-hydroxysteroid dehydrogenase expression in term pregnant human myometrium ex vivo. Reproductive Sciences, 31 (1), 1-12. doi: 10.1007/s43032-023-01333-6

Regulation of 20α-hydroxysteroid dehydrogenase expression in term pregnant human myometrium ex vivo

2023

Journal Article

Activity relationship of poly(ethylenimine)-based liposomes as group A Streptococcus vaccine delivery systems

Jin, Shengbin, Zhang, Jiahui, Nahar, Ummey J., Huang, Wenbin, Alharbi, Nedaa A., Shalash, Ahmed O., Koirala, Prashamsa, Yang, Jieru, Kiong, Jolynn J. E., Khalil, Zeinab G., Capon, Robert J., Stephenson, Rachel J., Skwarczynski, Mariusz, Toth, Istvan and Hussein, Waleed M. (2023). Activity relationship of poly(ethylenimine)-based liposomes as group A Streptococcus vaccine delivery systems. ACS Infectious Diseases, 9 (8), 1570-1581. doi: 10.1021/acsinfecdis.3c00159

Activity relationship of poly(ethylenimine)-based liposomes as group A Streptococcus vaccine delivery systems

2023

Journal Article

Optimization of an α-aminonaphthylmethylphosphonic acid inhibitor of purple acid phosphatase using rational structure-based design approaches

Feder, Daniel, Mohd-Pahmi, Siti Hajar, Adibi, Hadi, Guddat, Luke W., Schenk, Gerhard, McGeary, Ross P. and Hussein, Waleed M. (2023). Optimization of an α-aminonaphthylmethylphosphonic acid inhibitor of purple acid phosphatase using rational structure-based design approaches. European Journal of Medicinal Chemistry, 254 115383, 1-19. doi: 10.1016/j.ejmech.2023.115383

Optimization of an α-aminonaphthylmethylphosphonic acid inhibitor of purple acid phosphatase using rational structure-based design approaches

2023

Journal Article

Glyclauxins A–E: dimeric oxaphenalenone aminoglycosides from an Australian wasp nest-derived fungus Talaromyces sp. CMB-MW102

Samarasekera, Kaumadi, Hussein, Waleed M., Wu, Taizong, Salim, Angela A. and Capon, Robert J. (2023). Glyclauxins A–E: dimeric oxaphenalenone aminoglycosides from an Australian wasp nest-derived fungus Talaromyces sp. CMB-MW102. Journal of Natural Products, 86 (3), 517-525. doi: 10.1021/acs.jnatprod.2c01069

Glyclauxins A–E: dimeric oxaphenalenone aminoglycosides from an Australian wasp nest-derived fungus Talaromyces sp. CMB-MW102

2023

Journal Article

Liposomal formulations of a polyleucine–antigen conjugate as therapeutic vaccines against cervical cancer

Firdaus, Farrhana Z., Bartlett, Stacey, Hussein, Waleed M., Lu, Lantian, Wright, Quentin, Huang, Wenbin, Nahar, Ummey J., Yang, Jieru, Khongkow, Mattaka, Veitch, Margaret, Koirala, Prashamsa, Ruktanonchai, Uracha R., Monteiro, Michael J., Gonzalez Cruz, Jazmina L., Stephenson, Rachel J., Wells, James W., Toth, Istvan and Skwarczynski, Mariusz (2023). Liposomal formulations of a polyleucine–antigen conjugate as therapeutic vaccines against cervical cancer. Pharmaceutics, 15 (2) 602, 1-15. doi: 10.3390/pharmaceutics15020602

Liposomal formulations of a polyleucine–antigen conjugate as therapeutic vaccines against cervical cancer

2023

Journal Article

The development of surface-modified liposomes as an intranasal delivery system for group A Streptococcus vaccines

Yang, Jieru, Boer, Jennifer C., Khongkow, Mattaka, Phunpee, Sarunya, Khalil, Zeinab G., Bashiri, Sahra, Deceneux, Cyril, Goodchild, Georgia, Hussein, Waleed M., Capon, Robert J., Ruktanonchai, Uracha, Plebanski, Magdalena, Toth, Istvan and Skwarczynski, Mariusz (2023). The development of surface-modified liposomes as an intranasal delivery system for group A Streptococcus vaccines. Vaccines, 11 (2) 305. doi: 10.3390/vaccines11020305

The development of surface-modified liposomes as an intranasal delivery system for group A Streptococcus vaccines

2023

Journal Article

Polymeric nanoparticles as a self‐adjuvanting peptide vaccine delivery system: the role of shape

Koirala, Prashamsa, Chen, Sung‐Po R., Boer, Jennifer C., Khalil, Zeinab G., Deceneux, Cyril, Goodchild, Georgia, Lu, Lantian, Faruck, Mohammad Omer, Shalash, Ahmed O., Bashiri, Sahra, Capon, Robert J., Hussein, Waleed M., Monteiro, Michael J., Plebanski, Magdalena, Toth, Istvan and Skwarczynski, Mariusz (2023). Polymeric nanoparticles as a self‐adjuvanting peptide vaccine delivery system: the role of shape. Advanced Functional Materials, 33 (12) 2209304, 2209304. doi: 10.1002/adfm.202209304

Polymeric nanoparticles as a self‐adjuvanting peptide vaccine delivery system: the role of shape

2023

Journal Article

Polyphenylalanine as a self-adjuvanting delivery system for peptide-based vaccines: the role of peptide conformation

Skwarczynski, Mariusz, Zhao, Guangzu, Ozberk, Victoria, Giddam, Ashwini Kumar, Khalil, Zeinab G., Pandey, Manisha, Hussein, Waleed M., Nevagi, Reshma J., Batzloff, Michael R., Capon, Robert J., Good, Michael F. and Toth, Istvan (2023). Polyphenylalanine as a self-adjuvanting delivery system for peptide-based vaccines: the role of peptide conformation. Australian Journal of Chemistry, 76 (8), 429-436. doi: 10.1071/ch22167

Polyphenylalanine as a self-adjuvanting delivery system for peptide-based vaccines: the role of peptide conformation

2023

Conference Publication

Pro-relaxation of myometrial phosphodiesterase expression by histone deacetylase inhibitors

Barreda, Anna Paredes, Ilicic, Marina, Zakar, Tamas, Gregson, Amy, Hussein, Waleed, Walker, Frederick R., Smith, Roger and Paul, Jonathan W. (2023). Pro-relaxation of myometrial phosphodiesterase expression by histone deacetylase inhibitors. 70th Annual Meeting of the Society for Reproductive Investigation (SRI), Brisbane, QLD, Australia, 21-25 March 2023. Heidelberg, Germany: Springer.

Pro-relaxation of myometrial phosphodiesterase expression by histone deacetylase inhibitors

2022

Journal Article

Development of multilayer nanoparticles for the delivery of peptide-based subunit vaccine against group a Streptococcus

Kiong, Jolynn, Nahar, Ummey Jannatun, Jin, Shengbin, Shalash, Ahmed O., Zhang, Jiahui, Koirala, Prashamsa, Khalil, Zeinab G., Capon, Robert J., Skwarczynski, Mariusz, Toth, Istvan and Hussein, Waleed M. (2022). Development of multilayer nanoparticles for the delivery of peptide-based subunit vaccine against group a Streptococcus. Pharmaceutics, 14 (10) 2151, 1-12. doi: 10.3390/pharmaceutics14102151

Development of multilayer nanoparticles for the delivery of peptide-based subunit vaccine against group a Streptococcus

2022

Journal Article

Poly(hydrophobic amino acids) and liposomes for delivery of vaccine against Group A Streptococcus

Azuar, Armira, Madge, Harrison Y. R., Boer, Jennifer C., Gonzalez Cruz, Jazmina L., Wang, Jingwen, Khalil, Zeinab G., Deceneux, Cyril, Goodchild, Georgia, Yang, Jieru, Koirala, Prashamsa, Hussein, Waleed M., Capon, Robert J., Plebanski, Magdalena, Toth, Istvan and Skwarczynski, Mariusz (2022). Poly(hydrophobic amino acids) and liposomes for delivery of vaccine against Group A Streptococcus. Vaccines, 10 (8) 1212, 1-14. doi: 10.3390/vaccines10081212

Poly(hydrophobic amino acids) and liposomes for delivery of vaccine against Group A Streptococcus

Past funding

  • 2022 - 2024
    Targeted Delivery of Nucleic Acid Therapeutics for Preventing Preterm Birth (NHMRC Ideas Grant administered by University of New Castle).
    University of Newcastle
    Open grant
  • 2019 - 2021
    Uterine-Targeted Delivery of Dual Action Therapy for Preventing Preterm Birth (NHMRC Project Grant led by the University of Newcastle)
    University of Newcastle
    Open grant
  • 2016 - 2017
    Nanovaccines against Rheumatic Heart Disease
    HeartKids Limited
    Open grant

Availability

Dr Waleed Hussein is:
Available for supervision

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Supervision history

Completed supervision

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