Dr Waleed Hussein
Dr

Waleed Hussein

Email: 
Phone: 
+61 7 344 36285

Availability

Dr Waleed Hussein is:
Available for supervision

Fields of research

Chemical Sciences Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Bachelor of Pharmacy, Cairo University
  • Masters (Research), Helwan University
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Peptide-based vaccines

    I focus on the development of peptide-based vaccines against infectious diseases and cancer. This includes (1) synthesis of adjuvanting moieties for stimulation of immune system; (2) applying different methods for conjugation of peptides and lipids; (3) determination of the size, shape and charge of the self-assembled vaccine particles; (4) investigate the biological efficiency of vaccines in both in vitro and in vivo.

  • Gene delivery

    Currently, I am working on the development of targeted nanoparticle delivery system to deliver the siRNA to cytoplasm. This delivery system includes peptide-based, micelles and/or liposome formulations.

Search Professor Waleed Hussein’s works on UQ eSpace

115 works between 2009 and 2025
All (115) Journal Article (101) Book Chapter (6) Conference Publication (5) Book (2) Other Outputs (1)

21 - 40 of 115 works

2022

Journal Article

Development of multilayer nanoparticles for the delivery of peptide-based subunit vaccine against group a Streptococcus

Kiong, Jolynn, Nahar, Ummey Jannatun, Jin, Shengbin, Shalash, Ahmed O., Zhang, Jiahui, Koirala, Prashamsa, Khalil, Zeinab G., Capon, Robert J., Skwarczynski, Mariusz, Toth, Istvan and Hussein, Waleed M. (2022). Development of multilayer nanoparticles for the delivery of peptide-based subunit vaccine against group a Streptococcus. Pharmaceutics, 14 (10) 2151, 1-12. doi: 10.3390/pharmaceutics14102151

Development of multilayer nanoparticles for the delivery of peptide-based subunit vaccine against group a Streptococcus

2022

Journal Article

Poly(hydrophobic amino acids) and liposomes for delivery of vaccine against Group A Streptococcus

Azuar, Armira, Madge, Harrison Y. R., Boer, Jennifer C., Gonzalez Cruz, Jazmina L., Wang, Jingwen, Khalil, Zeinab G., Deceneux, Cyril, Goodchild, Georgia, Yang, Jieru, Koirala, Prashamsa, Hussein, Waleed M., Capon, Robert J., Plebanski, Magdalena, Toth, Istvan and Skwarczynski, Mariusz (2022). Poly(hydrophobic amino acids) and liposomes for delivery of vaccine against Group A Streptococcus. Vaccines, 10 (8) 1212, 1-14. doi: 10.3390/vaccines10081212

Poly(hydrophobic amino acids) and liposomes for delivery of vaccine against Group A Streptococcus

2022

Journal Article

Advances in infectious disease vaccine adjuvants

Fan, Jingyi, Jin, Shengbin, Gilmartin, Lachlan, Toth, Istvan, Hussein, Waleed M. and Stephenson, Rachel J. (2022). Advances in infectious disease vaccine adjuvants. Vaccines, 10 (7) 1120, 1-62. doi: 10.3390/vaccines10071120

Advances in infectious disease vaccine adjuvants

2022

Journal Article

Development of a peptide vaccine against hookworm infection: immunogenicity, efficacy, and immune correlates of protection

Shalash, Ahmed O., Becker, Luke, Yang, Jieru, Giacomin, Paul, Pearson, Mark, Hussein, Waleed M., Loukas, Alex, Toth, Istvan and Skwarczynski, Mariusz (2022). Development of a peptide vaccine against hookworm infection: immunogenicity, efficacy, and immune correlates of protection. Journal of Allergy and Clinical Immunology, 150 (1), 157-169.e10. doi: 10.1016/j.jaci.2022.02.020

Development of a peptide vaccine against hookworm infection: immunogenicity, efficacy, and immune correlates of protection

2022

Journal Article

Peptide-based vaccine against SARS-CoV-2: peptide antigen discovery and screening of adjuvant systems

Shalash, Ahmed O., Azuar, Armira, Madge, Harrison Y. R., Modhiran, Naphak, Amarilla, Alberto A., Liang, Benjamin, Khromykh, Alexander A., Hussein, Waleed M., Chappell, Keith J., Watterson, Daniel, Young, Paul R., Skwarczynski, Mariusz and Toth, Istvan (2022). Peptide-based vaccine against SARS-CoV-2: peptide antigen discovery and screening of adjuvant systems. Pharmaceutics, 14 (4) 856, 856. doi: 10.3390/pharmaceutics14040856

Peptide-based vaccine against SARS-CoV-2: peptide antigen discovery and screening of adjuvant systems

2022

Journal Article

Structure-activity relationship of lipid, cyclic peptide and antigen rearrangement of physically mixed vaccines

Huang, Wenbin, Madge, Harrison Y. R., Zhang, Jiahui, Gilmartin, Lachlan, Hussein, Waleed M., Khalil, Zeinab G., Koirala, Prashamsa, Capon, Robert J., Toth, Istvan and Stephenson, Rachel J. (2022). Structure-activity relationship of lipid, cyclic peptide and antigen rearrangement of physically mixed vaccines. International Journal of Pharmaceutics, 617 121614, 1-12. doi: 10.1016/j.ijpharm.2022.121614

Structure-activity relationship of lipid, cyclic peptide and antigen rearrangement of physically mixed vaccines

2022

Journal Article

Investigation of liposomal self-adjuvanting peptide epitopes derived from conserved blood-stage Plasmodium antigens

Islam, Md. Tanjir, Ho, Mei-Fong, Nahar, Ummey J., Shalash, Ahmed O., Koirala, Prashamsa, Hussein, Waleed M., Stanisic, Danielle I., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2022). Investigation of liposomal self-adjuvanting peptide epitopes derived from conserved blood-stage Plasmodium antigens. PLoS One, 17 (3) e0264961, e0264961. doi: 10.1371/journal.pone.0264961

Investigation of liposomal self-adjuvanting peptide epitopes derived from conserved blood-stage Plasmodium antigens

2022

Journal Article

Peptide-based nanovaccines in the treatment of cervical cancer: a review of recent advances

Zhang, Jiahui, Fan, Jingyi, Skwarczynski, Mariusz, Stephenson, Rachel J, Toth, Istvan and Hussein, Waleed M (2022). Peptide-based nanovaccines in the treatment of cervical cancer: a review of recent advances. International Journal of Nanomedicine, 17, 869-900. doi: 10.2147/ijn.s269986

Peptide-based nanovaccines in the treatment of cervical cancer: a review of recent advances

2022

Journal Article

Physical mixture of a cyclic lipopeptide vaccine induced high titres of opsonic IgG antibodies against group A streptococcus

Madge, Harrison Y. R., Huang, Wenbin, Gilmartin, Lachlan, Rigau-Planella, Berta, Hussein, Waleed M., Khalil, Zeinab G., Koirala, Prashamsa, Santiago, Viviene S., Capon, Robert J., Toth, Istvan and Stephenson, Rachel J. (2022). Physical mixture of a cyclic lipopeptide vaccine induced high titres of opsonic IgG antibodies against group A streptococcus. Biomaterials Science, 10 (1), 281-293. doi: 10.1039/d1bm01333e

Physical mixture of a cyclic lipopeptide vaccine induced high titres of opsonic IgG antibodies against group A streptococcus

2021

Journal Article

Hookworm infection: toward development of safe and effective peptide vaccines

Shalash, Ahmed O., Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2021). Hookworm infection: toward development of safe and effective peptide vaccines. Journal of Allergy and Clinical Immunology, 148 (6), 1394-1419.e6. doi: 10.1016/j.jaci.2021.10.013

Hookworm infection: toward development of safe and effective peptide vaccines

2021

Journal Article

Histone deacetylase inhibitors: providing new insights and therapeutic avenues for unlocking human birth

Ilicic, Marina, Zakar, Tamas, Gregson, Amy, Hussein, Waleed M., Smith, Roger and Paul, Jonathan W. (2021). Histone deacetylase inhibitors: providing new insights and therapeutic avenues for unlocking human birth. Reproductive Sciences, 29 (11), 1-13. doi: 10.1007/s43032-021-00778-x

Histone deacetylase inhibitors: providing new insights and therapeutic avenues for unlocking human birth

2021

Journal Article

Development and evaluation of a cryopreserved whole-parasite vaccine in a rodent model of blood-stage malaria

Stanisic, Danielle I., Ho, Mei-Fong, Nevagi, Reshma, Cooper, Emily, Walton, Maddison, Islam, Md Tanjir, Hussein, Waleed M., Skwarczynski, Mariusz, Toth, Istvan and Good, Michael F. (2021). Development and evaluation of a cryopreserved whole-parasite vaccine in a rodent model of blood-stage malaria. mBio, 12 (5) e02657-21, e0265721. doi: 10.1128/mBio.02657-21

Development and evaluation of a cryopreserved whole-parasite vaccine in a rodent model of blood-stage malaria

2021

Journal Article

Oral peptide vaccine against hookworm infection: correlation of antibody titers with protective efficacy

Shalash, Ahmed O., Becker, Luke, Yang, Jieru, Giacomin, Paul, Pearson, Mark, Hussein, Waleed M., Loukas, Alex, Skwarczynski, Mariusz and Toth, Istvan (2021). Oral peptide vaccine against hookworm infection: correlation of antibody titers with protective efficacy. Vaccines, 9 (9) 1034, 1034. doi: 10.3390/vaccines9091034

Oral peptide vaccine against hookworm infection: correlation of antibody titers with protective efficacy

2021

Journal Article

Poly(hydrophobic amino acid) conjugates for the delivery of multiepitope vaccine against Group A Streptococcus

Azuar, Armira, Shibu, Mohini A., Adilbish, Nomin, Marasini, Nirmal, Hung, Hong, Yang, Jieru, Luo, Yacheng, Khalil, Zeinab G., Capon, Robert J., Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2021). Poly(hydrophobic amino acid) conjugates for the delivery of multiepitope vaccine against Group A Streptococcus. Bioconjugate Chemistry, 32 (11) acs.bioconjchem.1c00333, 2307-2317. doi: 10.1021/acs.bioconjchem.1c00333

Poly(hydrophobic amino acid) conjugates for the delivery of multiepitope vaccine against Group A Streptococcus

2021

Journal Article

Rational design of potent inhibitors of a metallohydrolase using a fragment-based approach

Feder, Daniel, Mohd-Pahmi, Siti H., Hussein, Waleed M., Guddat, Luke W., McGeary, Ross P. and Schenk, Gerhard (2021). Rational design of potent inhibitors of a metallohydrolase using a fragment-based approach. ChemMedChem, 16 (21) cmdc.202100486, 3342-3359. doi: 10.1002/cmdc.202100486

Rational design of potent inhibitors of a metallohydrolase using a fragment-based approach

2021

Journal Article

Key considerations for the development of safe and effective SARS‐CoV‐2 subunit vaccine: a peptide‐based vaccine alternative

Shalash, Ahmed O., Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2021). Key considerations for the development of safe and effective SARS‐CoV‐2 subunit vaccine: a peptide‐based vaccine alternative. Advanced Science, 8 (16) 2100985, 1-35. doi: 10.1002/advs.202100985

Key considerations for the development of safe and effective SARS‐CoV‐2 subunit vaccine: a peptide‐based vaccine alternative

2021

Journal Article

Pre-clinical evaluation of a whole-parasite vaccine to control human babesiosis

Al-Nazal, Hanan A., Cooper, Emily, Ho, Mei Fong, Eskandari, Sharareh, Majam, Victoria, Giddam, Ashwini Kumar, Hussein, Waleed M., Islam, Md Tanjir, Skwarczynski, Mariusz, Toth, Istvan, Kumar, Sanjai, Zaid, Ali, Batzloff, Michael, Stanisic, Danielle I. and Good, Michael F. (2021). Pre-clinical evaluation of a whole-parasite vaccine to control human babesiosis. Cell Host and Microbe, 29 (6), 894-903. doi: 10.1016/j.chom.2021.04.008

Pre-clinical evaluation of a whole-parasite vaccine to control human babesiosis

2021

Journal Article

Polyethylenimine quantity and molecular weight influence its adjuvanting properties in liposomal peptide vaccines

Dai, Charles C., Huang, Wenbin, Yang, Jieru, Hussein, Waleed M., Wang, Jingwen, Khalil, Zeinab G., Capon, Robert J., Toth, Istvan and Stephenson, Rachel J. (2021). Polyethylenimine quantity and molecular weight influence its adjuvanting properties in liposomal peptide vaccines. Bioorganic and Medicinal Chemistry Letters, 40 127920, 1-7. doi: 10.1016/j.bmcl.2021.127920

Polyethylenimine quantity and molecular weight influence its adjuvanting properties in liposomal peptide vaccines

2021

Journal Article

Cell-penetrating peptides-based liposomal delivery system enhanced immunogenicity of peptide-based vaccine against group A streptococcus

Yang, Jieru, Firdaus, Farrhana, Azuar, Armira, Khalil, Zeinab G., Marasini, Nirmal, Capon, Robert J., Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2021). Cell-penetrating peptides-based liposomal delivery system enhanced immunogenicity of peptide-based vaccine against group A streptococcus. Vaccines, 9 (5) 499, 499. doi: 10.3390/vaccines9050499

Cell-penetrating peptides-based liposomal delivery system enhanced immunogenicity of peptide-based vaccine against group A streptococcus

2021

Journal Article

Discovery of a pyrimidine-dione derivative with potent inhibitory activity against Mycobacterium tuberculosis ketol-acid reductoisomerase

Lin, Xin, Kurz, Julia, Patel, Khushboo, Wun, Shun Jie, Hussein, Waleed, Lonhienne, Thierry, West, Nicholas P., McGeary, Ross P., Schenk, Gerhard and Guddat, Luke William (2021). Discovery of a pyrimidine-dione derivative with potent inhibitory activity against Mycobacterium tuberculosis ketol-acid reductoisomerase. Chemistry: A European Journal, 27 (9) chem.202004665, 3130-3141. doi: 10.1002/chem.202004665

Discovery of a pyrimidine-dione derivative with potent inhibitory activity against Mycobacterium tuberculosis ketol-acid reductoisomerase

Past funding

  • 2022 - 2024
    Targeted Delivery of Nucleic Acid Therapeutics for Preventing Preterm Birth (NHMRC Ideas Grant administered by University of New Castle).
    University of Newcastle
    Open grant
  • 2019 - 2021
    Uterine-Targeted Delivery of Dual Action Therapy for Preventing Preterm Birth (NHMRC Project Grant led by the University of Newcastle)
    University of Newcastle
    Open grant
  • 2016 - 2017
    Nanovaccines against Rheumatic Heart Disease
    HeartKids Limited
    Open grant

Availability

Dr Waleed Hussein is:
Available for supervision

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Supervision history

Completed supervision

Enquiries

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