Dr Waleed Hussein
Dr

Waleed Hussein

Email: 
Phone: 
+61 7 344 36285

Availability

Dr Waleed Hussein is:
Available for supervision

Fields of research

Chemical Sciences Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Bachelor of Pharmacy, Cairo University
  • Masters (Research), Helwan University
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Peptide-based vaccines

    I focus on the development of peptide-based vaccines against infectious diseases and cancer. This includes (1) synthesis of adjuvanting moieties for stimulation of immune system; (2) applying different methods for conjugation of peptides and lipids; (3) determination of the size, shape and charge of the self-assembled vaccine particles; (4) investigate the biological efficiency of vaccines in both in vitro and in vivo.

  • Gene delivery

    Currently, I am working on the development of targeted nanoparticle delivery system to deliver the siRNA to cytoplasm. This delivery system includes peptide-based, micelles and/or liposome formulations.

Search Professor Waleed Hussein’s works on UQ eSpace

115 works between 2009 and 2025
All (115) Journal Article (101) Book Chapter (6) Conference Publication (5) Book (2) Other Outputs (1)

101 - 115 of 115 works

2013

Journal Article

Microwave-assisted synthesis of difficult sequence-containing peptides using the isopeptide method

Hussein, Waleed M., Liu, Tzu-Yu, Toth, Istvan and Skwarczynski, Mariusz (2013). Microwave-assisted synthesis of difficult sequence-containing peptides using the isopeptide method. Organic and Biomolecular Chemistry, 11 (14), 2370-2376. doi: 10.1039/c3ob00030c

Microwave-assisted synthesis of difficult sequence-containing peptides using the isopeptide method

2012

Journal Article

Synthesis, biological activity and structure-activity relationship of endomorphin-1/substance P derivatives

Varamini, Pegah, Hussein, Waleed M., Mansfeld, Friederike M. and Toth, Istvan (2012). Synthesis, biological activity and structure-activity relationship of endomorphin-1/substance P derivatives. Bioorganic & Medicinal Chemistry, 20 (21), 6335-6343. doi: 10.1016/j.bmc.2012.09.003

Synthesis, biological activity and structure-activity relationship of endomorphin-1/substance P derivatives

2012

Journal Article

Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics

Feder, Daniel, Hussein, Waleed M., Clayton, Daniel J., Kan, Meng-Wei, Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke W. (2012). Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chemical Biology and Drug Design, 80 (5), 665-674. doi: 10.1111/cbdd.12001

Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics

2012

Journal Article

Synthesis and kinetic testing of tetrahydropyrimidine-2-thione and pyrrole derivatives as inhibitors of the metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa

Hussein, Waleed M., Fatahala, Samar S., Mohamed, Zainab M., McGeary, Ross P., Schenk, Gerhard, Ollis, David L. and Mohamed, Mosaad S. (2012). Synthesis and kinetic testing of tetrahydropyrimidine-2-thione and pyrrole derivatives as inhibitors of the metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa. Chemical Biology and Drug Design, 80 (4), 500-515. doi: 10.1111/j.1747-0285.2012.01440.x

Synthesis and kinetic testing of tetrahydropyrimidine-2-thione and pyrrole derivatives as inhibitors of the metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa

2012

Journal Article

Advances in peptide-based Human papillomavirus therapeutic vaccines

Liu, Tzu-Yu, Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2012). Advances in peptide-based Human papillomavirus therapeutic vaccines. Current Topics in Medicinal Chemistry, 12 (14), 1581-1592. doi: 10.2174/156802612802652402

Advances in peptide-based Human papillomavirus therapeutic vaccines

2012

Journal Article

2-Mercaptobenzothiazole and its derivatives: Syntheses, reactions and applications

Wu, Feng-Ling, Hussein, Waleed M., Ross, Benjamin P. and McGeary, Ross P. (2012). 2-Mercaptobenzothiazole and its derivatives: Syntheses, reactions and applications. Current Organic Chemistry, 16 (13), 1555-1580. doi: 10.2174/138527212800840964

2-Mercaptobenzothiazole and its derivatives: Syntheses, reactions and applications

2012

Journal Article

Penicillin inhibitors of purple acid phosphatase

Faridoon, Hussein, Waleed M., Islam, Nazar Ul, Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2012). Penicillin inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 22 (7), 2555-2559. doi: 10.1016/j.bmcl.2012.01.123

Penicillin inhibitors of purple acid phosphatase

2012

Journal Article

3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-beta-lactamase inhibitors

Faridoon, Hussein, Waleed M., Vella, Peter, Ul Islam, Nazar, Ollis, David L., Schenk, Gerhard and McGeary, Ross P. (2012). 3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-beta-lactamase inhibitors. Bioorganic and Medicinal Chemistry Letters, 22 (1), 380-386. doi: 10.1016/j.bmcl.2011.10.116

3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-beta-lactamase inhibitors

2011

Journal Article

Synthesis and kinetic testing of new inhibitors for a metallo-beta-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa

Mohamed, Mosaad S., Hussein, Waleed M., McGeary, Ross P., Vella, Peter, Schenk, Gerhard and Abd El-hameed, Rania H. (2011). Synthesis and kinetic testing of new inhibitors for a metallo-beta-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa. European Journal of Medicinal Chemistry, 46 (12), 6075-6082. doi: 10.1016/j.ejmech.2011.10.030

Synthesis and kinetic testing of new inhibitors for a metallo-beta-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa

2011

Journal Article

The identification of new metallo-beta-lactamase inhibitor leads from fragment-based screening

Vella, Peter, Hussein, Waleed M., Leung, Eleanor W. W., Clayton, Daniel, Ollis, David L., Schenk, Gerhard and McGeary, Ross P. (2011). The identification of new metallo-beta-lactamase inhibitor leads from fragment-based screening. Bioorganic and Medicinal Chemistry Letters, 21 (11), 3282-3285. doi: 10.1016/j.bmcl.2011.04.027

The identification of new metallo-beta-lactamase inhibitor leads from fragment-based screening

2011

Journal Article

Synthesis, modelling and kinetic assays of potent inhibitors of purple acid phosphatase

Mohd-Pahmi, Siti Hajar, Hussein, Waleed M., Schenk, Gerhard and McGeary, Ross P. (2011). Synthesis, modelling and kinetic assays of potent inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 21 (10), 3092-3094. doi: 10.1016/j.bmcl.2011.03.024

Synthesis, modelling and kinetic assays of potent inhibitors of purple acid phosphatase

2010

Journal Article

Molecular packing of functionalized fluorinated lipids in langmuir mono layers

Landsberg, MJ, Ruggles, JL, Hussein, WM, McGeary, RP, Gentle, IR and Hankamer, B (2010). Molecular packing of functionalized fluorinated lipids in langmuir mono layers. Langmuir, 26 (24), 18868-18873. doi: 10.1021/la103743e

Molecular packing of functionalized fluorinated lipids in langmuir mono layers

2009

Other Outputs

Synthesis of Nickel-Chelating Fluorinated Lipids for Membrane Protein Monolayer Crystallisations

Waleed Hussein (2009). Synthesis of Nickel-Chelating Fluorinated Lipids for Membrane Protein Monolayer Crystallisations. PhD Thesis, School of Chemistry and Molecular Bioscience, The University of Queensland.

Synthesis of Nickel-Chelating Fluorinated Lipids for Membrane Protein Monolayer Crystallisations

2009

Journal Article

Synthesis of nickel-chelating fluorinated lipids for protein monolayer crystallizations

Hussein, Waleed M., Ross, Benjamin P., Landsberg, Michael J., Levy, Daniel, Hankamer, Ben and McGeary, Ross P. (2009). Synthesis of nickel-chelating fluorinated lipids for protein monolayer crystallizations. Journal of Organic Chemistry, 74 (4), 1473-1479. doi: 10.1021/jo802651p

Synthesis of nickel-chelating fluorinated lipids for protein monolayer crystallizations

2009

Journal Article

Synthetic approaches to functionalized lipids for protein monolayer crystallizations

Hussein. Waleed M., Ross, Benjamin P., Landsberg, M. J., Hankamer, B and McGeary, Ross P. (2009). Synthetic approaches to functionalized lipids for protein monolayer crystallizations. Current Organic Chemistry, 13 (14), 1378-1405. doi: 10.2174/138527209789055081

Synthetic approaches to functionalized lipids for protein monolayer crystallizations

Past funding

  • 2022 - 2024
    Targeted Delivery of Nucleic Acid Therapeutics for Preventing Preterm Birth (NHMRC Ideas Grant administered by University of New Castle).
    University of Newcastle
    Open grant
  • 2019 - 2021
    Uterine-Targeted Delivery of Dual Action Therapy for Preventing Preterm Birth (NHMRC Project Grant led by the University of Newcastle)
    University of Newcastle
    Open grant
  • 2016 - 2017
    Nanovaccines against Rheumatic Heart Disease
    HeartKids Limited
    Open grant

Availability

Dr Waleed Hussein is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Completed supervision

Enquiries

For media enquiries about Dr Waleed Hussein's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au