Overview
Background
Mariusz Skwarczynski completed his Ph.D. in Chemistry in 1999 at Wroclaw University of Technology (Poland). His postdoctoral training began at Tokushima Bunri University (Japan), and then Kyoto Pharmaceutical University (Japan). In 2008 he joined Professor Istvan Toth’s group at The University of Queensland (Australia) to work on new vaccine development strategies. Currently his group activity is mainly focused on nanotechnology-based peptide vaccine delivery approaches and adjuvants discovery. He is Regional Editor of Australia in Vaccines, and Associate Editor in Frontiers in Pharmacology. He has published over 190 peer-reviewed publications, including 18 book chapters and three books.
Availability
- Associate Professor Mariusz Skwarczynski is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Masters (Coursework) of Science, Wroclaw University of Technology
- Doctor of Philosophy, Wroclaw University of Technology
- Member, Australian Infectious Diseases Research Centre, Australian Infectious Diseases Research Centre
- Journal Editorial Board Member, Current Drug Delivery, Current Drug Delivery
- Journal Editorial Board Member, Frontiers in Pharmacology (Associate Editor), Frontiers in Pharmacology (Associate Editor)
- Journal Editorial Board Member, Medicinal Chemistry, Medicinal Chemistry
- Member, Royal Australian Chemical Institute, Royal Australian Chemical Institute
- Member, The Japan Society for the Promotion of Science Alumni Association in Australia, The Japan Society for the Promotion of Science Alumni Association in Australia
- Journal Editorial Board Member, Vaccines (Regional Editor of Australia), Vaccines (Regional Editor of Australia)
Research interests
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Vaccines and Nanomedicine
Vaccine Design, Adjuvants, Nanotechnology, Peptide Chemistry, Medicinal Chemistry, Vaccine/Drug Delivery, Antimicrobial Agents, Macromolecules, Immunology
Research impacts
Mariusz Skwarczynski work focuses on nanotechnology-based approaches to vaccine adjuvants, with the potential for significant practical applications in developing novel vaccines. He has co-developed unique peptide, polymer, and liposomes-based adjuvanting systems used in vaccine development against malaria, hookworm, Group A Streptococcus, cancer and fertility vaccines.
As per January 2026:
He has published 3 books, 18 book chapters, and over 170 journal papers (~ 40 first and ~ 40 as last author, h index = 55, citations >9000), with a Field-Weighted Citation Impact of 2.14 (twice higher than the average researcher), and 29.9% of publications in last 5-years are in the top 10% of journals by CiteScore. Ranked 5th (Top 0.027% of 18,422) in the world in Subunit Vaccines (2012-2022; ExpertScape) and listed in World’s Top 2% Scientists by Stanford University in 2024, inside the top 0.35% in medicinal & biomolecular chemistry. His publications have received > 150 patent cites.
In the past 10 years, he secured $33.8M in grant funding, including $3.0M as the principle CI, $10.1M as a CI and $20.7M as the AI. He currently holds five grants as a CI: 2xNHMRC Ideas (CIA, 2024-27, $608K; CIA, 2024-27, $856K), CRE NHMRC (CIF, 2026-31, $3,000K), Synergy NHMRC (CIF, 2026-31, $5,000K), and ARC DP (CIA, 2026-30, $1,073K).
He has been invited 21 times in the last 5 years to present at international seminars and conferences,including invited lectures at National Nanotechnology Center (NANOTEC) (Bangkok, Thailand), Istituto Zooprofilattico Sperimentale del Mezzogiorno (Campania, Italy), University of Opole, (Opole, Poland), and 5th International Symposium on Synthetic Peptide as Human and Veterinary Pharmaceutical Products, (Varadero, Cuba). His work has received over 39 news articles from national and international agencies, including 11 interviews and articles in 2021 from Australia, India, Pakistan, Hungary, Kenya and New Zealand for his work on the oral hookworm vaccine.
He is the Regional Editor of Australia for Vaccines and Associate Editor for Frontiers in Pharmacology. He has organised 9 special issues in the last 5 years for journals such as Vaccines, Molecules and Frontiers in Pharmacology. Furthermore, he organised and chaired “Micro and Nanoparticles in Drug and Vaccine Delivery Symposium”, St Lucia, QLD, 3rd December 2021. He regularly reviews domestic grants, for example, 13 NHMRC Ideas grants in 2024, as well as international, for example, Austrian Science Fund, Netherlands Organisation for Scientific Research, The Wellcome Trust, Medical Research Council (UK). Peer reviews >10/year for top international journals (e.g. Nat. Commun.; Adv. Sci.; Adv. Mater.; Adv. Drug Deliv. Rev; Acta Biomater.).
He was/is co/supervisor of 33 PhD students (graduated and ongoing), and co/supervisor of over 30 research students. In the years 2019-2025, his supervised students received eleven awards, including the Dean’s Award for Outstanding Higher Degree by Research Theses, and awards at international conferences (travel, best poster, best oral presentations).
Works
Search Professor Mariusz Skwarczynski’s works on UQ eSpace
2022
Journal Article
Editorial: Advances in vaccine delivery: Adjuvants, carriers, formulations, and routes
Skwarczynski, Mariusz (2022). Editorial: Advances in vaccine delivery: Adjuvants, carriers, formulations, and routes. Frontiers in Pharmacology, 13 857792, 857792. doi: 10.3389/fphar.2022.857792
2022
Journal Article
Peptide-based nanovaccines in the treatment of cervical cancer: a review of recent advances
Zhang, Jiahui, Fan, Jingyi, Skwarczynski, Mariusz, Stephenson, Rachel J, Toth, Istvan and Hussein, Waleed M (2022). Peptide-based nanovaccines in the treatment of cervical cancer: a review of recent advances. International Journal of Nanomedicine, 17, 869-900. doi: 10.2147/ijn.s269986
2022
Book Chapter
Developments in vaccine adjuvants
Firdaus, Farrhana Ziana, Skwarczynski, Mariusz and Toth, Istvan (2022). Developments in vaccine adjuvants. Vaccine Design: Methods and Protocols, Volume 3: Resources for Vaccine Development. (pp. 145-178) edited by Sunil Thomas. New York, United States: Humana Press. doi: 10.1007/978-1-0716-1892-9_8
2022
Book Chapter
Preparation of Trimethyl Chitosan-Based Polyelectrolyte Complexes for Peptide Subunit Vaccine Delivery
Zhao, Lili, Bashiri, Sahra, Toth, Istvan and Skwarczynski, Mariusz (2022). Preparation of Trimethyl Chitosan-Based Polyelectrolyte Complexes for Peptide Subunit Vaccine Delivery. Methods in Molecular Biology. (pp. 141-149) New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-1900-1_9
2022
Book Chapter
Liposomes for the delivery of lipopeptide vaccines
Yang, Jieru, Azuar, Armira, Toth, Istvan and Skwarczynski, Mariusz (2022). Liposomes for the delivery of lipopeptide vaccines. Methods in Molecular Biology. (pp. 295-307) New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1892-9_15
2022
Book Chapter
Current Prospects in Peptide-Based Subunit Nanovaccines
Koirala, Prashamsa, Bashiri, Sahra, Toth, Istvan and Skwarczynski, Mariusz (2022). Current Prospects in Peptide-Based Subunit Nanovaccines. Methods in Molecular Biology. (pp. 309-338) New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-1892-9_16
2022
Book Chapter
Polymer–Peptide Conjugate Vaccine for Oral Immunization
Faruck, Mohammad Omer, Skwarczynski, Mariusz and Toth, Istvan (2022). Polymer–Peptide Conjugate Vaccine for Oral Immunization. Methods in Molecular Biology. (pp. 35-44) New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-1892-9_3
2022
Journal Article
Development of a hyperbranched polymer-based methotrexate nanomedicine for rheumatoid arthritis
Marasini, Nirmal, Er, Gerald, Fu, Changkui, Subasic, Christopher N., Ibrahim, Jibriil, Skwarczynski, Mariusz, Toth, Istvan, Whittaker, Andrew K. and Kaminskas, Lisa M. (2022). Development of a hyperbranched polymer-based methotrexate nanomedicine for rheumatoid arthritis. Acta Biomaterialia, 142, 298-307. doi: 10.1016/j.actbio.2022.01.054
2021
Journal Article
Detection and quantification of SARS-CoV-2 receptor binding domain neutralization by a sensitive competitive ELISA assay
Shalash, Ahmed O., Azuar, Armira, Madge, Harrison Y. R., Modhiran, Naphak, Amarilla, Alberto A., Liang, Benjamin, Khromykh, Alexander A., Watterson, Daniel, Young, Paul R., Toth, Istvan and Skwarczynski, Mariusz (2021). Detection and quantification of SARS-CoV-2 receptor binding domain neutralization by a sensitive competitive ELISA assay. Vaccines, 9 (12) 1493, 1-21. doi: 10.3390/vaccines9121493
2021
Journal Article
Hookworm infection: toward development of safe and effective peptide vaccines
Shalash, Ahmed O., Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2021). Hookworm infection: toward development of safe and effective peptide vaccines. Journal of Allergy and Clinical Immunology, 148 (6), 1394-1419.e6. doi: 10.1016/j.jaci.2021.10.013
2021
Conference Publication
Lipopeptide nanoparticulate vaccine candidates for the induction of protective immune responses
Tóth, István and Skwarczynski, Mariusz (2021). Lipopeptide nanoparticulate vaccine candidates for the induction of protective immune responses. DDRS 2021 Conference, Budapest, Hungary, 15-17 November 2021. Budapest, Hungary: Hungarian Pharmaceutical Association. doi: 10.33892/aph.2021.91.124-125
2021
Journal Article
Development and evaluation of a cryopreserved whole-parasite vaccine in a rodent model of blood-stage malaria
Stanisic, Danielle I., Ho, Mei-Fong, Nevagi, Reshma, Cooper, Emily, Walton, Maddison, Islam, Md Tanjir, Hussein, Waleed M., Skwarczynski, Mariusz, Toth, Istvan and Good, Michael F. (2021). Development and evaluation of a cryopreserved whole-parasite vaccine in a rodent model of blood-stage malaria. mBio, 12 (5) e02657-21, e0265721. doi: 10.1128/mBio.02657-21
2021
Journal Article
Cyclic dipeptides: the biological and structural landscape with special focus on the anti-cancer proline-based scaffold
Bojarska, Joanna, Mieczkowski, Adam, Ziora, Zyta, Skwarczynski, Mariusz, Toth, Istvan, Shalash, Ahmed O., Parang, Keykavous, El-Mowafi, Shaima A., Mohammed, Eman H. M., Elnagdy, Sherif, AlKhazindar, Maha and Wolf, Wojciech M. (2021). Cyclic dipeptides: the biological and structural landscape with special focus on the anti-cancer proline-based scaffold. Biomolecules, 11 (10) 1515, 1515. doi: 10.3390/biom11101515
2021
Journal Article
Oral peptide vaccine against hookworm infection: correlation of antibody titers with protective efficacy
Shalash, Ahmed O., Becker, Luke, Yang, Jieru, Giacomin, Paul, Pearson, Mark, Hussein, Waleed M., Loukas, Alex, Skwarczynski, Mariusz and Toth, Istvan (2021). Oral peptide vaccine against hookworm infection: correlation of antibody titers with protective efficacy. Vaccines, 9 (9) 1034, 1034. doi: 10.3390/vaccines9091034
2021
Journal Article
Poly(hydrophobic amino acid) conjugates for the delivery of multiepitope vaccine against Group A Streptococcus
Azuar, Armira, Shibu, Mohini A., Adilbish, Nomin, Marasini, Nirmal, Hung, Hong, Yang, Jieru, Luo, Yacheng, Khalil, Zeinab G., Capon, Robert J., Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2021). Poly(hydrophobic amino acid) conjugates for the delivery of multiepitope vaccine against Group A Streptococcus. Bioconjugate Chemistry, 32 (11) acs.bioconjchem.1c00333, 2307-2317. doi: 10.1021/acs.bioconjchem.1c00333
2021
Other Outputs
Self-assembling, self-adjuvanting system for delivery of vaccines
producer (2021). Self-assembling, self-adjuvanting system for delivery of vaccines . PCT/AU2021/050012.
2021
Journal Article
Polyacrylate-GnRH peptide conjugate as an oral contraceptive vaccine candidate
Faruck, Mohammad O., Koirala, Prashamsa, Yang, Jieru, D’Occhio, Michael J., Skwarczynski, Mariusz and Toth, Istvan (2021). Polyacrylate-GnRH peptide conjugate as an oral contraceptive vaccine candidate. Pharmaceutics, 13 (7) 1081, 1-15. doi: 10.3390/pharmaceutics13071081
2021
Journal Article
Key considerations for the development of safe and effective SARS‐CoV‐2 subunit vaccine: a peptide‐based vaccine alternative
Shalash, Ahmed O., Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2021). Key considerations for the development of safe and effective SARS‐CoV‐2 subunit vaccine: a peptide‐based vaccine alternative. Advanced Science, 8 (16) 2100985, 1-35. doi: 10.1002/advs.202100985
2021
Journal Article
Pre-clinical evaluation of a whole-parasite vaccine to control human babesiosis
Al-Nazal, Hanan A., Cooper, Emily, Ho, Mei Fong, Eskandari, Sharareh, Majam, Victoria, Giddam, Ashwini Kumar, Hussein, Waleed M., Islam, Md Tanjir, Skwarczynski, Mariusz, Toth, Istvan, Kumar, Sanjai, Zaid, Ali, Batzloff, Michael, Stanisic, Danielle I. and Good, Michael F. (2021). Pre-clinical evaluation of a whole-parasite vaccine to control human babesiosis. Cell Host and Microbe, 29 (6), 894-903. doi: 10.1016/j.chom.2021.04.008
2021
Journal Article
Chemical conjugation strategies for the development of protein-based subunit nanovaccines
Lu, Lantian, Duong, Viet Tram, Shalash, Ahmed O., Skwarczynski, Mariusz and Toth, Istvan (2021). Chemical conjugation strategies for the development of protein-based subunit nanovaccines. Vaccines, 9 (6) 563, 1-24. doi: 10.3390/vaccines9060563
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Mariusz Skwarczynski is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Available projects
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A nanonaccine against Invasive Group A Streptococcus and Rheumatic Heart Disease
The major challenge in any vaccine development is its formulation/delivery once the target antigens are identified. The main aim of this project is to adopt and further develop our immune-stimulating delivery systems to produce a multicomponent synthetic (poly)peptide vaccine candidate against Group A Streptococcus (GAS), the major causative agent of deadly diseases such as rheumatic heart disease (RHD) and invasive GAS infection. Notably, a variety of vaccines against GAS infection have reached clinical trials in the past decades; however, these vaccines have limited efficacy due to the high variability of GAS strains. We hypothesise that the incorporation of three conserved peptide antigens from GAS proteins into our newly developed nanoparticles-based vaccine delivery systems will overcome the above obstacles and produce an efficient and universal vaccine candidate against GAS. The project will deliver preclinical vaccine candidates against Group A Streptococcus, which, after oral dosing, will be able to induce robust opsonic antibody production against a wide range of GAS strains without triggering adverse effects and off-target immune responses. We will employ peptide antigens from the highly conserved region of M-protein, cell envelope proteinase, and fibronectin-binding protein 1. The optimized vaccine delivery system will be easily adaptable for the development of vaccines against other diseases.
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Oral anti-fertility vaccine for rabbits
Develop the first oral vaccines that suppress fertility in rabbits and enable responsible and ethical landscape population control. Expected outcomes of this project include the creation of a commercially attractive oral immunization platform.
Who can apply: medicinal/peptide chemists with preferable knowledge in immunology and pharmaceutical formulations.
Supervision history
Current supervision
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Doctor Philosophy
Hookworm vaccine: vaccine development toward clinical trials
Principal Advisor
Other advisors: Emeritus Professor Istvan Toth
-
Doctor Philosophy
A nanovaccine against Invasive Group A Streptococcus and Rheumatic Heart Disease
Principal Advisor
Other advisors: Dr Rachel Stephenson, Emeritus Professor Istvan Toth
-
Doctor Philosophy
A Nanovaccine against Invasive Group A Streptococcus and Rheumatic Heart Disease
Principal Advisor
Other advisors: Emeritus Professor Istvan Toth
-
Doctor Philosophy
Combating cervical cancer through a combination of anticancer therapy and vaccinations.
Principal Advisor
Other advisors: Dr Zyta M Ziora
-
Doctor Philosophy
Novel Vaccine Designs of Adjuvants and Delivery Systems against Infectious Diseases
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth, Dr Rachel Stephenson
Completed supervision
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2026
Doctor Philosophy
Development of mannose receptor ligands as novel immune adjuvants
Principal Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2025
Doctor Philosophy
Development of silver nanoparticles as novel adjuvants in vaccine
Principal Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2022
Doctor Philosophy
Development of a new peptide-based self-adjuvanting delivery system for vaccine against Group A Streptococcus (GAS)
Principal Advisor
Other advisors: Emeritus Professor Istvan Toth
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2022
Doctor Philosophy
Delivery of a peptide-based vaccine against group A streptococcus with the help of cell-penetrating peptides
Principal Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2025
Doctor Philosophy
Development of poly(hydrophobic amino acids)-based immunopotentiators for subunit vaccines against infectious diseases
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
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2023
Doctor Philosophy
Polymers as a nanoparticulate adjuvant and vaccine delivery system
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2023
Doctor Philosophy
The role of shape in vaccine delivery: Polymeric nanoparticles-based peptide vaccine against Group A Streptococci (GAS) infection
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2023
Doctor Philosophy
Lipophilic Peptides as Immune Stimulants
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2023
Doctor Philosophy
Cholesterol-based Vaccine Delivery Systems against Group A Streptococcal Infection
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2023
Doctor Philosophy
Development of Peptide-based Vaccines against Infectious Diseases: Hookworm, Liver fluke, and SARS-CoV-2 virus
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2022
Doctor Philosophy
Development of polyacrylate-based delivery systems for peptide vaccines
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2022
Doctor Philosophy
Targeting lectin receptors for vaccine delivery against group A streptococcus
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2022
Doctor Philosophy
Development of an effective prophylactic and therapeutic treatment for malaria
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2020
Doctor Philosophy
Design and evaluation of polysaccharide-based nanoparticles for mucosal vaccine delivery
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2020
Doctor Philosophy
Hydrophobic amino acid-based vaccine delivery systems to induce cellular and humoral immunity
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2019
Doctor Philosophy
Development of novel nanoparticulate polymeric delivery system for peptide vaccines against group A streptococcus
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2018
Doctor Philosophy
Epitope-focused vaccines against respiratory syncytial virus
Associate Advisor
Other advisors: Professor Keith Chappell, Professor Daniel Watterson, Emeritus Professor Istvan Toth
-
2018
Doctor Philosophy
Peptide-Based Self-Assembling Delivery System for Development of Group A Streptococcus Vaccine
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2017
Doctor Philosophy
Development of novel nanoparticle-based mucosal delivery systems for lipopeptide vaccine against group A streptococcus
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2016
Doctor Philosophy
Therapeutic and Preventive Potential of Synthetic Lipopeptides against Bacterial Infections
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2016
Doctor Philosophy
Development of Peptide-Based Vaccines Against Group A Streptococcus (GAS) and Malaria
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2016
Doctor Philosophy
Development of Novel Strategies for Delivery of Vaccine Candidates Against Group A Streptococcus
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2016
Doctor Philosophy
Liposome-based delivery system for the development of malaria vaccine
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2015
Doctor Philosophy
The Development of Peptide-Based Subunit Vaccines against Streptococcus pyogenes, Necator americanus and Schistosome mansoni.
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2015
Doctor Philosophy
Self-assembling and self-adjuvanting polymer-peptide conjugates as therapeutic vaccines against cervical cancer
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2010
Doctor Philosophy
The synthesis and characterization of peptide-based carriers for gene delivery and peptide therapeutics
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
-
2010
Doctor Philosophy
Lipopeptide-Carbohydrate-Antigen Platforms for Synthetic Vaccine Development
Associate Advisor
Other advisors: Emeritus Professor Istvan Toth
Media
Enquiries
Contact Associate Professor Mariusz Skwarczynski directly for media enquiries about:
- fertility control
- group A streptococcus
- hookworm
- immune adjuvants
- nanovaccines
- peptide vaccines
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