
Overview
Background
Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.
Availability
- Emeritus Professor Istvan Toth is:
- Not available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
- Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
Works
Search Professor Istvan Toth’s works on UQ eSpace
1976
Journal Article
Investigation On Chemistry of Berbans .3. Regiospecific Synthesis of Depyrroloyohimbinone by Dieckmann Condensation of Unsaturated Esters
Szabo, L, Toth, I, Honty, K, Toke, L, Tamas, J and Szantay, C (1976). Investigation On Chemistry of Berbans .3. Regiospecific Synthesis of Depyrroloyohimbinone by Dieckmann Condensation of Unsaturated Esters. Chemische Berichte-Recueil, 109 (5), 1724-1736. doi: 10.1002/cber.19761090516
1972
Journal Article
Untersuchungen über Verbindungen mit Berban‐Gerüst, II Aufbau des allo‐Berban und epi‐allo‐Berban‐Gerüsts
Szabó, Lajos, Honty, Katalin, Töke, László, Tóth, István and Szántay, Csaba (1972). Untersuchungen über Verbindungen mit Berban‐Gerüst, II Aufbau des allo‐Berban und epi‐allo‐Berban‐Gerüsts. Chemische Berichte, 105 (10), 3231-3243. doi: 10.1002/cber.19721051011
1972
Journal Article
Untersuchungen über Verbindungen mit Berban‐Gerüst, I Synthese von Dimethoxy‐despyrrolo‐yohimbin und Dimethoxy‐despyrrolo‐β‐yohimbin
Szabó, Lajos, Honty, Katalin, Töke, László, Tóth, István and Szántay, Csaba (1972). Untersuchungen über Verbindungen mit Berban‐Gerüst, I Synthese von Dimethoxy‐despyrrolo‐yohimbin und Dimethoxy‐despyrrolo‐β‐yohimbin. Chemische Berichte, 105 (10), 3215-3230. doi: 10.1002/cber.19721051010
Supervision
Availability
- Emeritus Professor Istvan Toth is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
A nanovaccine against Invasive Group A Streptococcus and Rheumatic Heart Disease
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski, Dr Rachel Stephenson
-
Doctor Philosophy
Development of a peptide-based delivery platform for targeted gene editing
Associate Advisor
Other advisors: Dr Anjuman Begum, Associate Professor Peter Moyle
-
Doctor Philosophy
Poly(hydrophobic amino acids) as immune stimulators.
Associate Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
Doctor Philosophy
Poly(hydrophobic amino acids) as immune stimulators.
Associate Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
Doctor Philosophy
Novel Vaccine Designs of Adjuvants and Delivery Systems against Infectious Diseases
Associate Advisor
Other advisors: Associate Professor Mariusz Skwarczynski, Dr Rachel Stephenson
-
Doctor Philosophy
L-Rhamnose-based nanovaccine derived from poly-rhamnose backbone of Group A Carbohydrate (GAC) against Invasive Group A Streptococcus and Rheumatic Heart Disease
Associate Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
Doctor Philosophy
Polymers and peptides for vaccine delivery.
Associate Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
Doctor Philosophy
Poly(hydrophobic amino acids) as immune stimulators.
Associate Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
Doctor Philosophy
Nanovaccines against infectious diseases
Associate Advisor
Other advisors: Dr Rachel Stephenson
-
Doctor Philosophy
Hookworm vaccine: vaccine development toward clinical trials
Associate Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
Completed supervision
-
2025
Doctor Philosophy
Development of poly(hydrophobic amino acids)-based immunopotentiators for subunit vaccines against infectious diseases
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski, Dr Jazmina Gonzalez Cruz
-
2023
Doctor Philosophy
Polymers as a nanoparticulate adjuvant and vaccine delivery system
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2023
Doctor Philosophy
The role of shape in vaccine delivery: Polymeric nanoparticles-based peptide vaccine against Group A Streptococci (GAS) infection
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2023
Doctor Philosophy
Lipophilic Peptides as Immune Stimulants
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2023
Doctor Philosophy
Cholesterol-based Vaccine Delivery Systems against Group A Streptococcal Infection
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2023
Doctor Philosophy
Development of Peptide-based Vaccines against Infectious Diseases: Hookworm, Liver fluke, and SARS-CoV-2 virus
Principal Advisor
Other advisors: Dr Waleed Hussein, Associate Professor Mariusz Skwarczynski
-
2022
Doctor Philosophy
Targeting lectin receptors for vaccine delivery against group A streptococcus
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2022
Doctor Philosophy
Development of polyacrylate-based delivery systems for peptide vaccines
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2022
Doctor Philosophy
Development of an effective prophylactic and therapeutic treatment for malaria
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2021
Doctor Philosophy
Novel Nanovaccines against Rheumatic Heart Disease
Principal Advisor
Other advisors: Dr Rachel Stephenson
-
2020
Doctor Philosophy
Hydrophobic amino acid-based vaccine delivery systems to induce cellular and humoral immunity
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2020
Doctor Philosophy
Design and evaluation of polysaccharide-based nanoparticles for mucosal vaccine delivery
Principal Advisor
Other advisors: Dr Waleed Hussein, Associate Professor Mariusz Skwarczynski
-
2019
Doctor Philosophy
Optimizing nuclear localization of non-viral DNA delivery vectors
Principal Advisor
Other advisors: Associate Professor Peter Moyle, Dr Waleed Hussein
-
2019
Doctor Philosophy
Development of novel nanoparticulate polymeric delivery system for peptide vaccines against group A streptococcus
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2018
Doctor Philosophy
Peptide-Based Self-Assembling Delivery System for Development of Group A Streptococcus Vaccine
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2018
Doctor Philosophy
Development of Glyco-lipopeptide Vaccines against Group A Streptococcus
Principal Advisor
Other advisors: Dr Rachel Stephenson
-
2018
Doctor Philosophy
Development of peptide-based multicomponent systems for the targeted delivery of oligonucleotides
Principal Advisor
Other advisors: Associate Professor Peter Moyle
-
2017
Doctor Philosophy
Development of peptide-based multicomponent delivery system for oligonucleotides
Principal Advisor
Other advisors: Associate Professor Peter Moyle
-
2017
Doctor Philosophy
Development of a Peptide-Based Multicomponent Oligonucleotide Delivery System
Principal Advisor
Other advisors: Associate Professor Peter Moyle, Dr Waleed Hussein
-
2017
Doctor Philosophy
Development of novel nanoparticle-based mucosal delivery systems for lipopeptide vaccine against group A streptococcus
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2016
Doctor Philosophy
Liposome-based delivery system for the development of malaria vaccine
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2016
Doctor Philosophy
Development of Peptide-Based Vaccines Against Group A Streptococcus (GAS) and Malaria
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2016
Doctor Philosophy
Therapeutic and Preventive Potential of Synthetic Lipopeptides against Bacterial Infections
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2016
Doctor Philosophy
Development of Novel Strategies for Delivery of Vaccine Candidates Against Group A Streptococcus
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski, Dr Waleed Hussein
-
2016
Doctor Philosophy
Synthesis and physicochemical examination of asymmetric amphoteric macromolecules containing OVA CD4 and OVA CD8 for the development of a model vaccine
Principal Advisor
Other advisors: Dr Rachel Stephenson
-
2016
Doctor Philosophy
Mannosylated lipopetides as model vaccines for targeting the mannose receptor
Principal Advisor
Other advisors: Dr Rachel Stephenson
-
2015
Doctor Philosophy
Design, synthesis, and evaluation of anti-LHRH vaccine candidates based on a lipopeptide delivery system
Principal Advisor
-
2015
Doctor Philosophy
Improving the Bioavailability and Stability of Luteinizing Hormone-Releasing Hormone (LHRH) Analogues
Principal Advisor
-
2015
Doctor Philosophy
Self-assembling and self-adjuvanting polymer-peptide conjugates as therapeutic vaccines against cervical cancer
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2015
Doctor Philosophy
The Development of Peptide-Based Subunit Vaccines against Streptococcus pyogenes, Necator americanus and Schistosome mansoni.
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2014
Doctor Philosophy
Lipid and carbohydrate-based systems to enhance the bioavailability and immunogenicity of therapeutic peptides
Principal Advisor
-
2012
Doctor Philosophy
Towards the Development of a Mucosally Active Vaccine against Group A Streptococcus (GAS)
Principal Advisor
-
2012
Doctor Philosophy
Synthesis and Pharmacological Characterization of Endomorphin-1 Analogues
Principal Advisor
Other advisors: Professor Joanne Blanchfield
-
2011
Doctor Philosophy
The Synthesis, Physicochemical Characterization and Biological Interactions of Polymer-coated Nanoparticles
Principal Advisor
Other advisors: Professor Michael Monteiro
-
2011
Doctor Philosophy
Synthesis and Evaluation of Influenza Virosome Gene Delivery and LCP-Based Hookworm Vaccine Delivery Systems
Principal Advisor
-
-
2010
Doctor Philosophy
Lipopeptide-Carbohydrate-Antigen Platforms for Synthetic Vaccine Development
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2010
Doctor Philosophy
The synthesis and characterization of peptide-based carriers for gene delivery and peptide therapeutics
Principal Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2009
Doctor Philosophy
Towards fully synthetic intranasal peptide-based vaccine against group A streptococcal infections
Principal Advisor
-
2008
Doctor Philosophy
Nanoparticulate Carriers And Adjuvants For Novel Synthetic Peptide Vaccines
Principal Advisor
Other advisors: Professor Michael Monteiro
-
2006
Doctor Philosophy
VACCINE-ADJUVANT-CARRIER DESIGN AGAINST GROUP A STREPTOCOCCUSI AND HUMAN PAPILLOMAVIRUS TYPE-16 INFECTION
Principal Advisor
Other advisors: Professor Joanne Blanchfield
-
2005
Doctor Philosophy
PEPTIDE ABSORPTION ENHANCEMENT USING GLYCOLIPID CHEMICAL CONJUGATION
Principal Advisor
-
2004
Doctor Philosophy
LIPOAMINO ACID- AND CARBOHYDRATE-BASED PENETRATION ENHANCERS FOR USE IN ORAL DRUG DELIVERY
Principal Advisor
Other advisors: Professor Joanne Blanchfield
-
2025
Doctor Philosophy
Optimising gene delivery platforms for future in vivo applications
Associate Advisor
Other advisors: Dr Anjuman Begum, Associate Professor Peter Moyle
-
2024
Doctor Philosophy
Design and Synthesis of Self-adjuvant, Pathogen Selective Group A Streptococcus Vaccines
Associate Advisor
Other advisors: Dr Rachel Stephenson
-
2022
Doctor Philosophy
Development of Vaccine Delivery Systems for Peptide Antigens and Small Molecule Haptens
Associate Advisor
Other advisors: Dr Rachel Stephenson
-
2022
Doctor Philosophy
Development of a blood stage DNA vaccine against Plasmodium falciparum
Associate Advisor
Other advisors: Associate Professor Peter Moyle
-
2022
Doctor Philosophy
Development of a new peptide-based self-adjuvanting delivery system for vaccine against Group A Streptococcus (GAS)
Associate Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2022
Doctor Philosophy
Delivery of a peptide-based vaccine against group A streptococcus with the help of cell-penetrating peptides
Associate Advisor
Other advisors: Associate Professor Mariusz Skwarczynski
-
2018
Doctor Philosophy
Epitope-focused vaccines against respiratory syncytial virus
Associate Advisor
Other advisors: Professor Keith Chappell, Professor Daniel Watterson, Associate Professor Mariusz Skwarczynski
-
-
2011
Doctor Philosophy
The Interaction of Synthetic Nanoparticles with Biological Systems
Associate Advisor
Other advisors: Professor Darren Martin
-
-
2009
Doctor Philosophy
Targeting central nervous system active peptides to the brain via nasal delivery
Associate Advisor
Other advisors: Professor Joanne Blanchfield
-
2008
Doctor Philosophy
The efficacy of bile pigment supplementation: In vitro and in vivo considerations
Associate Advisor
Other advisors: Professor Jeff Coombes, Professor Joanne Blanchfield
-
2007
Doctor Philosophy
A NOVEL LIPOSACCHARIDE SYSTEM FOR THE DELIVERY OF ENDOMORPHIN1 ACROSS THE BLOOD-BRAIN BARRIER
Associate Advisor
Other advisors: Professor Joanne Blanchfield
Media
Enquiries
Contact Emeritus Professor Istvan Toth directly for media enquiries about:
- Chemistry - lipid
- Chemistry - medicinal
- Chemistry - peptide
- Chemistry - sugar
- Drug - oral administration
- Drug delivery
- Genes and vaccines
- Immunisation
- Lipid chemistry
- Medicinal chemistry
- Oral administration of vaccines
- Peptide chemistry
- Peptide drug delivery
- Sugar chemistry
- Vaccines - oral administration
- Vaccines and genes
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