Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

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Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

621 - 640 of 683 works

1995

Conference Publication

The effects of phenothiazine derivatives on the membrane functions of cultured Leydig cells of rats

Valkusz Zs., Zs, Galfi, M., Molnar, J., Gardi, J., Toth, I., Julesz, J. and Szarvas, F. (1995). The effects of phenothiazine derivatives on the membrane functions of cultured Leydig cells of rats.

The effects of phenothiazine derivatives on the membrane functions of cultured Leydig cells of rats

1994

Journal Article

Spectroscopic and Conformational Studies of the C-Terminal Cytoplasmic Beta-Subunit 46-Peptide of the High-Affinity Ige Receptor

Zloh, M, Anderson, G, Clarklewis, I, Nicolau, A, Thomas, R, Toth, I and Gibbons, WA (1994). Spectroscopic and Conformational Studies of the C-Terminal Cytoplasmic Beta-Subunit 46-Peptide of the High-Affinity Ige Receptor. Biochemical Society Transactions, 22 (4), S450-S450.

Spectroscopic and Conformational Studies of the C-Terminal Cytoplasmic Beta-Subunit 46-Peptide of the High-Affinity Ige Receptor

1994

Journal Article

A Lipidic Alpha-Amino-Acid Based Synthetic Adjuvant Peptide Complex for Increasing Immunogenicity of Vaccines

Flinn, N, Danton, M, Hillery, AM, Wood, IP, Gibbons, WA and Toth, I (1994). A Lipidic Alpha-Amino-Acid Based Synthetic Adjuvant Peptide Complex for Increasing Immunogenicity of Vaccines. Biochemical Society Transactions, 22 (4), 1055-1058.

A Lipidic Alpha-Amino-Acid Based Synthetic Adjuvant Peptide Complex for Increasing Immunogenicity of Vaccines

1994

Journal Article

Nmr-Studies of the Cytoplasmic C-Terminal Beta-Subunit Domain of the High-Affinity Ige Receptor

Zloh, M, Anderson, G, Clarklewis, I, Thomas, R, Benedetti, E, Toth, I and Gibbons, WA (1994). Nmr-Studies of the Cytoplasmic C-Terminal Beta-Subunit Domain of the High-Affinity Ige Receptor. Biochemical Society Transactions, 22 (4), 1027-1029.

Nmr-Studies of the Cytoplasmic C-Terminal Beta-Subunit Domain of the High-Affinity Ige Receptor

1994

Journal Article

Circular dichroism, molecular modeling, and serology indicate that the structural basis of antigenic variation in foot-and-mouth disease virus is α-helix formation

France, LL, Piatti, PG, Newman, Jfe, Toth, I, Gibbons, WA and Brown, F (1994). Circular dichroism, molecular modeling, and serology indicate that the structural basis of antigenic variation in foot-and-mouth disease virus is α-helix formation. Proceedings of the National Academy of Sciences of the United States of America, 91 (18), 8442-8446. doi: 10.1073/pnas.91.18.8442

Circular dichroism, molecular modeling, and serology indicate that the structural basis of antigenic variation in foot-and-mouth disease virus is α-helix formation

1994

Journal Article

Synthesis and Oral Uptake Studies of Lipidic and Glyco-Lipidic Conjugates of Beta-Lactam Antibiotics

Toth, I, Hughes, RA, Dekany, G, Hillery, AM and Ward, P (1994). Synthesis and Oral Uptake Studies of Lipidic and Glyco-Lipidic Conjugates of Beta-Lactam Antibiotics. Liebigs Annalen der Chemie, 1994 (7), 685-688. doi: 10.1002/jlac.199419940709

Synthesis and Oral Uptake Studies of Lipidic and Glyco-Lipidic Conjugates of Beta-Lactam Antibiotics

1994

Journal Article

Lipophilic peptide inhibitors of ribonucleotide reductase enzyme of herpes simplex virus

Toth, I, Thompson, G and Ward, P (1994). Lipophilic peptide inhibitors of ribonucleotide reductase enzyme of herpes simplex virus. International Journal of Pharmaceutics, 106 (1), 85-88. doi: 10.1016/0378-5173(94)90279-8

Lipophilic peptide inhibitors of ribonucleotide reductase enzyme of herpes simplex virus

1994

Journal Article

Lipidic conjugates of luteinizing hormone releasing hormone (LHRH)+ and thyrotropin releasing hormone (TRH)+ that release and protect the native hormones in homogenates of human intestinal epithelial (Caco-2) cells

Toth, I, Flinn, N, Hillery, A, Gibbons, WA and Artursson, P (1994). Lipidic conjugates of luteinizing hormone releasing hormone (LHRH)+ and thyrotropin releasing hormone (TRH)+ that release and protect the native hormones in homogenates of human intestinal epithelial (Caco-2) cells. International Journal of Pharmaceutics, 105 (3), 241-247. doi: 10.1016/0378-5173(94)90108-2

Lipidic conjugates of luteinizing hormone releasing hormone (LHRH)+ and thyrotropin releasing hormone (TRH)+ that release and protect the native hormones in homogenates of human intestinal epithelial (Caco-2) cells

1994

Journal Article

Oral absorption of lipidic amino acid conjugates

Toth, I, Hillery, AM, Wood, IP, Magnusson, C and Artursson, P (1994). Oral absorption of lipidic amino acid conjugates. International Journal of Pharmaceutics, 102 (1-3), 223-230. doi: 10.1016/0378-5173(94)90059-0

Oral absorption of lipidic amino acid conjugates

1994

Journal Article

Spectroscopy and modelling of the cytoplasmic domain of the gamma-subunit of the high affinity immunoglobulin E receptor

Anderson, G. J., Biekofsky, R. R., Zloh, M., Toth, G. K., Toth, I., Benedetti, E. and Gibbons, W. A. (1994). Spectroscopy and modelling of the cytoplasmic domain of the gamma-subunit of the high affinity immunoglobulin E receptor. Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity, 1 (1), 31-38.

Spectroscopy and modelling of the cytoplasmic domain of the gamma-subunit of the high affinity immunoglobulin E receptor

1994

Journal Article

The Intersubunit Region of the Influenza Virus Haemagglutinin is Recognized by Antibodies During Infection

Nagy, Z, Rajnavolgyi, E, Hollosi, M, Toth, GK, Varadi, G, Penke, B, Toth, I, Horvath, A, Gergely, J and Kurucz, I (1994). The Intersubunit Region of the Influenza Virus Haemagglutinin is Recognized by Antibodies During Infection. Scandinavian Journal of Immunology, 40 (3), 281-291. doi: 10.1111/j.1365-3083.1994.tb03464.x

The Intersubunit Region of the Influenza Virus Haemagglutinin is Recognized by Antibodies During Infection

1994

Journal Article

In vitro inhibitory effects of 16-methyl-substituted steroids on 5α-reductase in rat and human prostates

Faredin, I., Toth, I., Wolfing, J., Schneider Gy., Gy and Mesko, E. (1994). In vitro inhibitory effects of 16-methyl-substituted steroids on 5α-reductase in rat and human prostates. Acta Pharmaceutica Hungarica, 64 (5), 171-174.

In vitro inhibitory effects of 16-methyl-substituted steroids on 5α-reductase in rat and human prostates

1994

Journal Article

A Novel Chemical Approach to Drug-Delivery - Lipidic Amino-Acid Conjugates

Toth, I (1994). A Novel Chemical Approach to Drug-Delivery - Lipidic Amino-Acid Conjugates. Journal of Drug Targeting, 2 (3), 217-239. doi: 10.3109/10611869408996805

A Novel Chemical Approach to Drug-Delivery - Lipidic Amino-Acid Conjugates

1994

Journal Article

Structure-retention relationships of diastereomeric mixtures of lipidic amino acid conjugates on reversed-phase stationary phases

Korakas, D, Valko, K, Wood, I, Gibbons, W and Toth, I (1994). Structure-retention relationships of diastereomeric mixtures of lipidic amino acid conjugates on reversed-phase stationary phases. Journal of Chromatography a, 659 (2), 307-315. doi: 10.1016/0021-9673(94)85072-0

Structure-retention relationships of diastereomeric mixtures of lipidic amino acid conjugates on reversed-phase stationary phases

1993

Journal Article

Immunogenicity Evaluation of a Lipidic Amino Acid-Based Synthetic Peptide Vaccine for Chlamydia-Trachomatis

Zhong, Guanming, Toth, Istvan, Reid, Ronald and Brunham, Robert C. (1993). Immunogenicity Evaluation of a Lipidic Amino Acid-Based Synthetic Peptide Vaccine for Chlamydia-Trachomatis. Journal of Immunology, 151 (7), 3728-3736.

Immunogenicity Evaluation of a Lipidic Amino Acid-Based Synthetic Peptide Vaccine for Chlamydia-Trachomatis

1993

Journal Article

A combined adjuvant and carrier system for enhancing synthetic peptides immunogenicity utilising lipidic amino acids

Toth, I, Danton, M, Flinn, N and Gibbons, WA (1993). A combined adjuvant and carrier system for enhancing synthetic peptides immunogenicity utilising lipidic amino acids. Tetrahedron Letters, 34 (24), 3925-3928. doi: 10.1016/S0040-4039(00)79265-3

A combined adjuvant and carrier system for enhancing synthetic peptides immunogenicity utilising lipidic amino acids

1993

Journal Article

Sequence-Specific Antipeptide Antibodies That Recognize Different Subunits of the High-Affinity Ige Receptor

Gao, B, Anderson, GJ, Brammer, MJ, James, CH, Danton, M, Toth, G, Toth, I and Gibbons, WA (1993). Sequence-Specific Antipeptide Antibodies That Recognize Different Subunits of the High-Affinity Ige Receptor. Biochemical Society Transactions, 21 (2), 302-304.

Sequence-Specific Antipeptide Antibodies That Recognize Different Subunits of the High-Affinity Ige Receptor

1993

Journal Article

Invitro Antimalarial and Cytotoxic Activities of Semisynthetic Derivatives of Brusatol

Allen, D, Toth, I, Wright, CW, Kirby, GC, Warhurst, DC and Phillipson, JD (1993). Invitro Antimalarial and Cytotoxic Activities of Semisynthetic Derivatives of Brusatol. European Journal of Medicinal Chemistry, 28 (3), 265-269. doi: 10.1016/0223-5234(93)90143-3

Invitro Antimalarial and Cytotoxic Activities of Semisynthetic Derivatives of Brusatol

1993

Book Chapter

Lipidic amino acid based synthetic peptide vaccine adjuvant

Toth, Istvan, Danton, Malcolm, Reid, Ronald E., Zhong, Guangming, Brunham, Robert, Tóth, Gábor K. and Gibbons, William A. (1993). Lipidic amino acid based synthetic peptide vaccine adjuvant. Peptides 1992. (pp. 823-824) Dordrecht, The Netherlands: Springer Netherlands. doi: 10.1007/978-94-011-1470-7_377

Lipidic amino acid based synthetic peptide vaccine adjuvant

1992

Journal Article

Synthetic and Conformational Studies of the Alpha-Subunit Cytoplasmic Domain of the Immunoglobulin-E Receptor

Thomas, RC, Anderson, GJ, Ashton, D, Drake, AF, Toth, I and Gibbons, WA (1992). Synthetic and Conformational Studies of the Alpha-Subunit Cytoplasmic Domain of the Immunoglobulin-E Receptor. Biochemical Society Transactions, 20 (4), 840-841. doi: 10.1042/bst0200840

Synthetic and Conformational Studies of the Alpha-Subunit Cytoplasmic Domain of the Immunoglobulin-E Receptor

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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