Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

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Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

601 - 620 of 683 works

1998

Journal Article

Synthesis and in vitro evaluation of lipoamino acid and carbohydrate-modified enkephalins as potential antinociceptive agents

Kellam, Barrie, Drouillat, Bruno, Dekany, Gyula, Starr, Mike S. and Toth, Istvan (1998). Synthesis and in vitro evaluation of lipoamino acid and carbohydrate-modified enkephalins as potential antinociceptive agents. International Journal of Pharmaceutics, 161 (1), 55-64. doi: 10.1016/S0378-5173(97)00328-1

Synthesis and in vitro evaluation of lipoamino acid and carbohydrate-modified enkephalins as potential antinociceptive agents

1998

Journal Article

Polymeric lipoamino acid based C-glycosides for drug and peptide delivery

Wright, K., Falconer, R., Dekany, G., Cocksedge, M. and Toth, I. (1998). Polymeric lipoamino acid based C-glycosides for drug and peptide delivery. Carbohydrate Letters, 3 (3), 187-190.

Polymeric lipoamino acid based C-glycosides for drug and peptide delivery

1998

Conference Publication

Biodistribution and stability of a dendrimer carrier

Sakthivel, T., Florence, A. T. and Toth, I. (1998). Biodistribution and stability of a dendrimer carrier.

Biodistribution and stability of a dendrimer carrier

1998

Journal Article

Novel liposaccharide conjugates for drug and peptide delivery

Drouillat, B, Hillery, AM, Dekany, G, Falconer, R, Wright, K and Toth, I (1998). Novel liposaccharide conjugates for drug and peptide delivery. Journal of Pharmaceutical Sciences, 87 (1), 25-30. doi: 10.1021/js9702123

Novel liposaccharide conjugates for drug and peptide delivery

1997

Journal Article

Solid phase synthesis of C-terminal carbohydrate modified enkephalins

Drouillat, Bruno, Kellam, Barrie, Dekany, Gyula, Starr, Mike S. and Toth, Istvan (1997). Solid phase synthesis of C-terminal carbohydrate modified enkephalins. Bioorganic and Medicinal Chemistry Letters, 7 (17), 2247-2250. doi: 10.1016/S0960-894X(97)00395-8

Solid phase synthesis of C-terminal carbohydrate modified enkephalins

1997

Journal Article

Synthesis of Sialyl Lewis X analogues 2

Dekany, Gyula, Wright, Karen, Ward, Peter and Toth, Istvan (1997). Synthesis of Sialyl Lewis X analogues 2. Journal of Carbohydrate Chemistry, 16 (1), 11-24. doi: 10.1080/07328309708006507

Synthesis of Sialyl Lewis X analogues 2

1997

Conference Publication

Novel liposaccharide colloidal drug carriers

Hillery, A. M., Drouillat, B. and Toth, I. (1997). Novel liposaccharide colloidal drug carriers.

Novel liposaccharide colloidal drug carriers

1997

Journal Article

Activity and inhibition of 3-beta-hydroxysteroid dehydrogenase/delta-5-4-lsomerase in human skin

Tóth, István, Szécsi, Mihály, Julesz, János and Faredin, Imre (1997). Activity and inhibition of 3-beta-hydroxysteroid dehydrogenase/delta-5-4-lsomerase in human skin. Skin Pharmacology and Physiology, 10 (3), 160-168. doi: 10.1159/000211481

Activity and inhibition of 3-beta-hydroxysteroid dehydrogenase/delta-5-4-lsomerase in human skin

1997

Journal Article

An economical synthesis of Lewis X, sialyl lewis X and their α-galactosyl analogues

Dekany, Gyula, Wright, Karen and Toth, Istvan (1997). An economical synthesis of Lewis X, sialyl lewis X and their α-galactosyl analogues. Journal of Carbohydrate Chemistry, 16 (7), 983-999. doi: 10.1080/07328309708005732

An economical synthesis of Lewis X, sialyl lewis X and their α-galactosyl analogues

1996

Journal Article

Biological activity of luteinizing hormone releasing hormone after oral dosing with a novel nanoparticulate delivery system: Co-polymerized peptide particles

Hillery, A. M., Toth, I. and Florence, A. T. (1996). Biological activity of luteinizing hormone releasing hormone after oral dosing with a novel nanoparticulate delivery system: Co-polymerized peptide particles. Pharmaceutical Sciences, 2 (6), 281-283.

Biological activity of luteinizing hormone releasing hormone after oral dosing with a novel nanoparticulate delivery system: Co-polymerized peptide particles

1996

Journal Article

Erratum: 'Oral absorption studies of lipid-polylysine conjugates of thyrotropin releasing hormone (TRH1) and luteinizing hormone releasing hormone (LHRH1)' (Int. J. of Pharaceutics 138 (1996) (167))

Flinn, Nicholas, Hussain, Ishfaq, Shaw, Andrew, Artursson, Per, Gibbons, William A. and Toth, Istvan (1996). Erratum: 'Oral absorption studies of lipid-polylysine conjugates of thyrotropin releasing hormone (TRH1) and luteinizing hormone releasing hormone (LHRH1)' (Int. J. of Pharaceutics 138 (1996) (167)). International Journal of Pharmaceutics, 143 (1). doi: 10.1016/S0378-5173(96)04762-X

Erratum: 'Oral absorption studies of lipid-polylysine conjugates of thyrotropin releasing hormone (TRH1) and luteinizing hormone releasing hormone (LHRH1)' (Int. J. of Pharaceutics 138 (1996) (167))

1996

Journal Article

Oral absorption studies of lipidic conjugates of thyrotropin releasing hormone (TRH) and luteinizing hormone-releasing hormone (LHRH)

Flinn, Nicholas, Coppard, Steve and Toth, Istvan (1996). Oral absorption studies of lipidic conjugates of thyrotropin releasing hormone (TRH) and luteinizing hormone-releasing hormone (LHRH). International Journal of Pharmaceutics, 137 (1), 33-39. doi: 10.1016/0378-5173(95)04391-8

Oral absorption studies of lipidic conjugates of thyrotropin releasing hormone (TRH) and luteinizing hormone-releasing hormone (LHRH)

1996

Journal Article

Synthesis of sialyl Lewis X analogues

Dekany, Gyula, Wright, Karen, Ward, Peter and Toth, Istvan (1996). Synthesis of sialyl Lewis X analogues. Journal of Carbohydrate Chemistry, 15 (4), 383-398. doi: 10.1080/07328309608005661

Synthesis of sialyl Lewis X analogues

1996

Journal Article

Co-polymerised peptide particles II: Oral uptake of a novel co-polymeric nanoparticulate delivery system for peptides

Hillery, Anya M., Toth, Istvan and Florence, Alexander T. (1996). Co-polymerised peptide particles II: Oral uptake of a novel co-polymeric nanoparticulate delivery system for peptides. Journal of Controlled Release, 42 (1), 65-73. doi: 10.1016/0168-3659(96)01368-5

Co-polymerised peptide particles II: Oral uptake of a novel co-polymeric nanoparticulate delivery system for peptides

1996

Journal Article

Co-polymerised peptide particles (CPP) I: Synthesis, characterisation and in vitro studies on a novel oral nanoparticuIate delivery system

Hillery, Anya M., Toth, Istvan, Shaw, Andrew J. and Florence, Alexander T. (1996). Co-polymerised peptide particles (CPP) I: Synthesis, characterisation and in vitro studies on a novel oral nanoparticuIate delivery system. Journal of Controlled Release, 41 (3), 271-281. doi: 10.1016/0168-3659(96)01342-9

Co-polymerised peptide particles (CPP) I: Synthesis, characterisation and in vitro studies on a novel oral nanoparticuIate delivery system

1996

Journal Article

Oral absorption studies of lipid-polylysine conjugates of thyrotropin releasing hormone (TRH) and luteinizing hormone releasing hormone (LHRH)

Flinn, Nicholas, Hussain, Ishfaq, Shaw, Andrew, Artursson, Per, Gibbons, William A. and Toth, Istvan (1996). Oral absorption studies of lipid-polylysine conjugates of thyrotropin releasing hormone (TRH) and luteinizing hormone releasing hormone (LHRH). International Journal of Pharmaceutics, 138 (2), 167-174. doi: 10.1016/0378-5173(96)04538-3

Oral absorption studies of lipid-polylysine conjugates of thyrotropin releasing hormone (TRH) and luteinizing hormone releasing hormone (LHRH)

1995

Journal Article

Design of potent lipophilic-peptide inhibitors of human neutrophil elastase: In vitro and in vivo studies

Toth, Istvan, Christodoulou, Marika, Bankowsky, Krzysztof, Flinn, Nick, Gibbons, William A, Godeau, Gastou, Moczar, Elemer and Hornebeck, William (1995). Design of potent lipophilic-peptide inhibitors of human neutrophil elastase: In vitro and in vivo studies. International Journal of Pharmaceutics, 125 (1), 117-122. doi: 10.1016/0378-5173(95)00127-5

Design of potent lipophilic-peptide inhibitors of human neutrophil elastase: In vitro and in vivo studies

1995

Conference Publication

A novel nanoparticulate delivery system for the oral absorption of peptides, II: In vivo studies

Hillery, A. M., Toth, I. and Florence, A. T. (1995). A novel nanoparticulate delivery system for the oral absorption of peptides, II: In vivo studies.

A novel nanoparticulate delivery system for the oral absorption of peptides, II: In vivo studies

1995

Conference Publication

A novel oral nanoparticulate delivery system, I: Development and in vitro studies

Hillery, A. M., Toth, I. and Florence, A. T. (1995). A novel oral nanoparticulate delivery system, I: Development and in vitro studies.

A novel oral nanoparticulate delivery system, I: Development and in vitro studies

1995

Conference Publication

Peptide substrates for AMP-activated protein kinase

Toomey, C. M., Flinn, N., Van der Walle, C., Toth, I. and Munday, M. R. (1995). Peptide substrates for AMP-activated protein kinase. Portland Press Ltd. doi: 10.1042/bst023141s

Peptide substrates for AMP-activated protein kinase

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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