Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

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Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

541 - 560 of 683 works

2001

Conference Publication

Enhanced immunogenicity of group A streptococcal peptide epitopes by lipoamino acid based adjuvant carrier system.

Schubert, A., Olive, C., Wong, A. K., Good, M. F. and Toth, I. (2001). Enhanced immunogenicity of group A streptococcal peptide epitopes by lipoamino acid based adjuvant carrier system.. APSA Annual Conference 2001, Melbourne, 9-12 Dec 2001. Melbourne: Australasian Pharmaceutical Science Association.

Enhanced immunogenicity of group A streptococcal peptide epitopes by lipoamino acid based adjuvant carrier system.

2001

Conference Publication

Allosamines and galactosamines from glucosamine: Control of stereochemical inversions at C-3 and C-4.

Mcgeary, R. P., Wright, K. and Toth, I. (2001). Allosamines and galactosamines from glucosamine: Control of stereochemical inversions at C-3 and C-4.. Brisbane Biological and Organic Chemistry Symposium 2001, UQ, Brisbane, 30 Nov 2001. Brisbane:

Allosamines and galactosamines from glucosamine: Control of stereochemical inversions at C-3 and C-4.

2001

Conference Publication

Enhancing peptide delivery using lipoamino acids and liposaccharides.

Mcgeary, R. P., Blanchfield, J. T., Rhee, H., Alewood, P.F. and Toth, I. (2001). Enhancing peptide delivery using lipoamino acids and liposaccharides.. 7th International Symposium on Solid Phase Synthesis & Combinatorial Chemical Libraries, Southampton, UK, 18-22 Sept 2001. UK: European Peptide Society & BS/RSC Protein & Peptide Group, UK.

Enhancing peptide delivery using lipoamino acids and liposaccharides.

2001

Conference Publication

Synthetic vaccines: Enhanced immunogenicity of Streptococcus peptide epitopes.

Mcgeary, R. P., Schubert, A., Olive, C., Hayman, W., Good, M. F. and Toth, I. (2001). Synthetic vaccines: Enhanced immunogenicity of Streptococcus peptide epitopes.. Brisbane Biological & Organic Chemistry Symposium 2001, University of Queensland, Brisbane, 30 Nov 2001.

Synthetic vaccines: Enhanced immunogenicity of Streptococcus peptide epitopes.

2001

Journal Article

Carbohydrate-based templates for synthetic vaccines and drug delivery

McGeary, R. P., Jablonkai, I. and Toth, I. (2001). Carbohydrate-based templates for synthetic vaccines and drug delivery. Tetrahedron, 57 (41), 8733-8742. doi: 10.1016/S0040-4020(01)00852-3

Carbohydrate-based templates for synthetic vaccines and drug delivery

2001

Conference Publication

Synthesis of cationic lipidic peptide dendrimer vectors for in vitro oligonucleotide delivery.

Kearns, P. S., Wimmer, N., Rakoczy, P. E. and Toth, I. (2001). Synthesis of cationic lipidic peptide dendrimer vectors for in vitro oligonucleotide delivery.. APSA Annual Conference 2001, Melbourne, 9-12 Dec 2001. Melbourne: Australasian Pharmaceutical Science Association.

Synthesis of cationic lipidic peptide dendrimer vectors for in vitro oligonucleotide delivery.

2001

Conference Publication

Synthesis of lipo- and liposacchride a-conotoxin MII conjugates

Blanchfield, J. T., Alewood, P.F., Lewis, R. J., Dutton, J. L., Craik, D. J. and Toth, I. (2001). Synthesis of lipo- and liposacchride a-conotoxin MII conjugates. World Chemistry Congress, Brisbane, Australia, 1-6 July, 2001. Royal Australian Chemical Institute.

Synthesis of lipo- and liposacchride a-conotoxin MII conjugates

2001

Conference Publication

Further characterization of an astrocyte secreted factor that increases transendothelial electrical resistance in an in vitro model of the blood-brain barrier

Jordan, L. R., Kearns, P. S. and Toth, I. (2001). Further characterization of an astrocyte secreted factor that increases transendothelial electrical resistance in an in vitro model of the blood-brain barrier. Int. Congress of Physiological Sciences 2001 Satellite, Tasmania, 21-24 August. International Union of Physiological Sciences (IUPS).

Further characterization of an astrocyte secreted factor that increases transendothelial electrical resistance in an in vitro model of the blood-brain barrier

2000

Journal Article

DNA transfection and transfected cell viability using amphipathic asymmetric dendrimers

Shah, DS, Sakthivel, T, Toth, I, Florence, AT and Wilderspin, AF (2000). DNA transfection and transfected cell viability using amphipathic asymmetric dendrimers. International Journal of Pharmaceutics, 208 (1-2), 41-48. doi: 10.1016/S0378-5173(00)00534-2

DNA transfection and transfected cell viability using amphipathic asymmetric dendrimers

2000

Conference Publication

Novel lipoamino acid and liposaccharide based peptide delivery system for tumor selective somatostatin analogs

Malkinson, JP, Keri, G, Artursson, P and Toth, I (2000). Novel lipoamino acid and liposaccharide based peptide delivery system for tumor selective somatostatin analogs. 16th American Peptide Symposium, Minneapolis Mn, Jun 26-Jul 01, 1999. DORDRECHT: SPRINGER.

Novel lipoamino acid and liposaccharide based peptide delivery system for tumor selective somatostatin analogs

2000

Conference Publication

Measurement of the transport across CaCo -2 cell monolayers of compounds varying in lipophilicity using LC-MS

Wong, A. K., Ross, B. P., Jones, A., Artursson, P., Lazorova, L. and Toth, I. (2000). Measurement of the transport across CaCo -2 cell monolayers of compounds varying in lipophilicity using LC-MS. The First Brisbane Biological & Organic Chemistry Symposium, Griffith University, 27 Nov. 2000. Australia: McGraw Hill.

Measurement of the transport across CaCo -2 cell monolayers of compounds varying in lipophilicity using LC-MS

2000

Conference Publication

Lipoamino acid based glycoconjugates for peptide and drug delivery

Falconer, RA and Toth, (2000). Lipoamino acid based glycoconjugates for peptide and drug delivery. 16th American Peptide Symposium, Minneapolis Mn, Jun 26-Jul 01, 1999. DORDRECHT: SPRINGER.

Lipoamino acid based glycoconjugates for peptide and drug delivery

2000

Conference Publication

Glycolipid-modified peptides: Enhancement of absorption of an anti-tumour somatostatin analogue

Malkinson, J. P., Lazorova, L., Artusson, P., Keri, G. and Toth, I. (2000). Glycolipid-modified peptides: Enhancement of absorption of an anti-tumour somatostatin analogue. 20th International Carbohydrate Symposium, Hamburg, Germany, 27 Aug - 1 Sep 2000. Hamburg, Germany: Carbohydrate Society.

Glycolipid-modified peptides: Enhancement of absorption of an anti-tumour somatostatin analogue

2000

Journal Article

Lipophilic methotrexate conjugates with antitumor activity

Pignatello, R., Spampinato, G., Sorrenti, V., Di Giacomo, C., Vicari, L., McGuire, J. J. and Toth, I. (2000). Lipophilic methotrexate conjugates with antitumor activity. European Journal of Pharmaceutical Sciences, 10 (3), 237-245. doi: 10.1016/S0928-0987(00)00062-2

Lipophilic methotrexate conjugates with antitumor activity

2000

Journal Article

Oral uptake and translocation of a polylysine dendrimer with a lipid surface

Florence, A. T., Sakthivel, T. and Toth, I. (2000). Oral uptake and translocation of a polylysine dendrimer with a lipid surface. Journal of Controlled Release, 65 (1-2), 253-259. doi: 10.1016/S0168-3659(99)00237-0

Oral uptake and translocation of a polylysine dendrimer with a lipid surface

2000

Conference Publication

Lipoamino acid and glycolipid conjugated peptides enhanced intestinal absorption of an anti-tumour somatostatin analogue

Malkinson, J. P., Lazorova, L., Artursson, P., Keri, G. and Toth, I. (2000). Lipoamino acid and glycolipid conjugated peptides enhanced intestinal absorption of an anti-tumour somatostatin analogue. Millennial World Congress of Pharmaceutical Sciences, San Francisco, USA, 16-20 April 2000. San Francisco, USA: International Pharmaceutical Federation USA.

Lipoamino acid and glycolipid conjugated peptides enhanced intestinal absorption of an anti-tumour somatostatin analogue

2000

Conference Publication

Liposaccharides: Applications for oral peptide delivery

Chan, Y., Wong, A. K. and Toth, I. (2000). Liposaccharides: Applications for oral peptide delivery. Departmental Seminar, School of Pharmacy, The University of Queensland, Brisbane, 8 November 2000. Brisbane: The University of Queensland.

Liposaccharides: Applications for oral peptide delivery

2000

Conference Publication

Synthesis of glycopeptide modified IgE epitopes

Jablonkai, I and Toth, I (2000). Synthesis of glycopeptide modified IgE epitopes. 16th American Peptide Symposium, Minneapolis Mn, Jun 26-Jul 01, 1999. DORDRECHT: SPRINGER.

Synthesis of glycopeptide modified IgE epitopes

2000

Journal Article

Characterization of intestinal cnf1+ Escherichia coli from weaned pigs

Tóth, Istvan, Oswald, Eric, Mainil, Jacques G., Awad-Masalmeh, Mohamed and Nagy, Béla (2000). Characterization of intestinal cnf1+ Escherichia coli from weaned pigs. International Journal of Medical Microbiology, 290 (6), 539-542. doi: 10.1016/S1438-4221(00)80019-3

Characterization of intestinal cnf1+ Escherichia coli from weaned pigs

2000

Conference Publication

A new approach to absorption enhancement based on the molecular structure of occludin

Tavelin, S., Hashimoto, K., Lazarova, L., Malkinson, J. P., Toth, I. and Artursson, P. (2000). A new approach to absorption enhancement based on the molecular structure of occludin. Millennial World Congress of Pharmaceutical Sciences, San Francisco, USA, 16-20 April 2000. San Francisco, USA: International Pharmaceutical Federation USA.

A new approach to absorption enhancement based on the molecular structure of occludin

Current funding

  • 2024 - 2025
    Single-shot anti-fertility vaccine in pigs
    Australia's Economic Accelerator Seed Grants
    Open grant

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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