Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

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Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

481 - 500 of 683 works

2003

Journal Article

Preface

Toth, Istvan (2003). Preface. Mini-Reviews in Medicinal Chemistry, 3 (7), I-I. doi: 10.2174/1389557033487764

Preface

2003

Conference Publication

Lipid and carbohydrate based macromolecules in drug and vaccine delivery

Toth, I., Horvath, A., Olive, C., Good, M. F., Wimmer, N. and Rakoczy, E. P. (2003). Lipid and carbohydrate based macromolecules in drug and vaccine delivery. 26th Australian Polymer Symposium, Noosa, Queensland, 13-17 July 2003. Australia: Royal Australian Chemical Institute.

Lipid and carbohydrate based macromolecules in drug and vaccine delivery

2003

Conference Publication

Liposacchride delivery system: Application to peptides conotoxin MII and endomorphin I

Blanchfield, J. T., Gallagher, O. P., Koda, Y. and Toth, I. (2003). Liposacchride delivery system: Application to peptides conotoxin MII and endomorphin I. Brisbane Biological and Organic Chemistry Symposium, Gold Coast, 28 Nov, 2003.

Liposacchride delivery system: Application to peptides conotoxin MII and endomorphin I

2003

Conference Publication

Use of synthetic dendrimer peptide's to mediate the delivery of a sense oligonucleotide

Marano, R. J., Wimmer, N., Kearns, P. S., Thomas, B. G., Toth, I., Wilson, A. S., Brankov, M. and Rakoczy, P. E. (2003). Use of synthetic dendrimer peptide's to mediate the delivery of a sense oligonucleotide. Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Ft Lauderdale Florida, May, 2003. Rockville, MD United States: Association for Research in Vision and Ophthalmology.

Use of synthetic dendrimer peptide's to mediate the delivery of a sense oligonucleotide

2003

Conference Publication

Vaccine design against streptococcal infection

Toth, I, Horvath, A, Olive, C and Good, MF (2003). Vaccine design against streptococcal infection. 18th American Peptide Symposium, Boston Ma, Jul 19-23, 2003. HOBOKEN: JOHN WILEY & SONS INC.

Vaccine design against streptococcal infection

2003

Journal Article

A new principle for tight junction modulation based on occludin peptides

Tavelin, S., Hashimoto, K., Malkinson, J., Lazorova, L., Toth, I. and Artursson, P. (2003). A new principle for tight junction modulation based on occludin peptides. Molecular Pharmacology, 64 (6), 1530-1540. doi: 10.1124/mol.64.6.1530

A new principle for tight junction modulation based on occludin peptides

2003

Journal Article

Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure

Russell, F. D., Meyers, D. E., Galbraith, A., Bett, N., Toth, I., Kearns, P. S. and Molenaar, P. (2003). Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure. American Journal of Physiology - Heart & Circulatory Physiology, 285 (Oct.2003), H1576-H1581. doi: 10.1152/ajpheart.00217.2003

Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure

2003

Book Chapter

Drug delivery systems utilizing lipids and sugars

Wong, A., Bender, V. and Toth, I. (2003). Drug delivery systems utilizing lipids and sugars. Molecular Pathomechanisms and New Trends in Drug Research. (pp. 599-612) edited by G. Keri and I. Toth. London & New York: Taylor & Francis. doi: 10.1201/9780203219973.ch45

Drug delivery systems utilizing lipids and sugars

2003

Conference Publication

Lipid and carbohydrate based macromolecules in drug and vaccine delivery

Toth, I., Horvath, A., Blanchfield, J. T., Olive, C., Good, M. F., Wimmer, N. and Rakoczy, E. P. (2003). Lipid and carbohydrate based macromolecules in drug and vaccine delivery. Brisbane Biological and Organic Chemistry Symposium, Gold Coast, 28 November, 2003.

Lipid and carbohydrate based macromolecules in drug and vaccine delivery

2003

Conference Publication

Oligonucleotide gene therapy for choroidal neovascularisation enhanced by dendrimer mediated delivery

Marano, R. J., Wimmer, N., Kearns, P. S., Thomas, B. G., Toth, I., Wilson, A. S., Brankov, M. and Rakoczy, P. E. (2003). Oligonucleotide gene therapy for choroidal neovascularisation enhanced by dendrimer mediated delivery. 3rd Meeting of the Australasian-Gene-Therapy-Society, Brisbane Australia, Apr 30-May 02, 2003. CHICHESTER: Wiley.

Oligonucleotide gene therapy for choroidal neovascularisation enhanced by dendrimer mediated delivery

2003

Journal Article

Biological properties and therapeutic potential of billirubin

McGeary, R. P., Szyczew, A. J. and Toth, I. (2003). Biological properties and therapeutic potential of billirubin. Mini Reviews in Medicinal Chemistry, 3 (3), 253-256. doi: 10.2174/1389557033488213

Biological properties and therapeutic potential of billirubin

2002

Journal Article

Syntheses of polycationic dendrimers on lipophilic peptide core for complexation and transport of oligonucleotides

Wimmer, Norbert, Marano, Robert J., Kearns, Phillip S., Rakoczy, Elizabeth P. and Toth, Istvan (2002). Syntheses of polycationic dendrimers on lipophilic peptide core for complexation and transport of oligonucleotides. Bioorganic and Medicinal Chemistry Letters, 12 (18), 2635-2637. doi: 10.1016/S0960-894X(02)00511-5

Syntheses of polycationic dendrimers on lipophilic peptide core for complexation and transport of oligonucleotides

2002

Journal Article

Determination of transport in the Caco-2 cell assay of compounds varying in lipophilicity using LC-MS: enhanced transport of Leu-enkephalin analogues

Wong, AK, Ross, BP, Chan, YN, Artursson, P, Lazorova, L, Jones, A and Toth, I (2002). Determination of transport in the Caco-2 cell assay of compounds varying in lipophilicity using LC-MS: enhanced transport of Leu-enkephalin analogues. European Journal of Pharmaceutical Sciences, 16 (3), 113-118. doi: 10.1016/S0928-0987(02)00078-7

Determination of transport in the Caco-2 cell assay of compounds varying in lipophilicity using LC-MS: enhanced transport of Leu-enkephalin analogues

2002

Journal Article

A lipid core peptide construct containing a conserved region determinant of the group a streptococcal M protein elicits heterologous opsonic antibodies

Olive, Colleen, Batzloff, Michael R., Horvath, Aniko, Wong, Allan, Clair, Timothy, Yarwood, Penny, Toth, Istvan and Good, Michael F. (2002). A lipid core peptide construct containing a conserved region determinant of the group a streptococcal M protein elicits heterologous opsonic antibodies. Infection And Immunity, 70 (5), 2734-2738. doi: 10.1128/IAI.70.5.2734-2738.2002

A lipid core peptide construct containing a conserved region determinant of the group a streptococcal M protein elicits heterologous opsonic antibodies

2002

Book Chapter

Lipoamino acid based glycoconjugates for peptide and drug delivery

Falconer, Robert A. and Toth, Istvan (2002). Lipoamino acid based glycoconjugates for peptide and drug delivery. Peptides for the New Millennium. (pp. 77-78) Dordrecht, The Netherlands: Kluwer Academic Publishers. doi: 10.1007/0-306-46881-6_310

Lipoamino acid based glycoconjugates for peptide and drug delivery

2002

Conference Publication

A novel immunoadjuvant carrier system for synthetic peptides

Horvath, A., Olive, C., Good, M. F. and Toth, I. (2002). A novel immunoadjuvant carrier system for synthetic peptides. 27th European Peptide Symposium, Sorrento, Italy, 31 Aug. - 6 Sept. 2002. Napoli, Italy: E. Ziino.

A novel immunoadjuvant carrier system for synthetic peptides

2002

Journal Article

Lipoamino acid-based adjuvant carrier system: Enhanced immunogenicity of group a streptococcal peptide epitopes

Horvath, Aniko, Olive, Colleen, Wong, Allan, Clair, Timothy, Yarwood, Penny, Good, Michael and Toth, Istvan (2002). Lipoamino acid-based adjuvant carrier system: Enhanced immunogenicity of group a streptococcal peptide epitopes. Journal of Medicinal Chemistry, 45 (6), 1387-1390. doi: 10.1021/jm0110441

Lipoamino acid-based adjuvant carrier system: Enhanced immunogenicity of group a streptococcal peptide epitopes

2002

Conference Publication

Liposaccharides in drug delivery

Toth, I., Blanchfield, J. T., McGeary, R. P., Ross, B. P. and Chan, Y. (2002). Liposaccharides in drug delivery. XX1st International Carbohydrate Symposium, Cairns, 7-12 July 2002.

Liposaccharides in drug delivery

2002

Other Outputs

A multiple antigen lipophilic adjuvant carrier system (MALAC)

Toth, I., Horvath, A., Good, M. F. and Olive, C. (2002). A multiple antigen lipophilic adjuvant carrier system (MALAC). Australian Provisional PS2233.

A multiple antigen lipophilic adjuvant carrier system (MALAC)

2002

Conference Publication

Reactions of carbohydrate tosylates and mesylates with nucleophiles: Control of inversions of stereochemistry

Toth, I., McGeary, R. P. and Tang, V.W.S. (2002). Reactions of carbohydrate tosylates and mesylates with nucleophiles: Control of inversions of stereochemistry. XX1st International Carbohydrate Symposium, Cairns, 7-12 July 2002.

Reactions of carbohydrate tosylates and mesylates with nucleophiles: Control of inversions of stereochemistry

Current funding

  • 2024 - 2025
    Single-shot anti-fertility vaccine in pigs
    Australia's Economic Accelerator Seed Grants
    Open grant

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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