Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

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Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

461 - 480 of 683 works

2004

Journal Article

Toward the development of a synthetic group A streptococcal vaccine of high purity and broad protective coverage

Horvath, Anikó, Olive, Colleen, Karpati, Levente, Sun, H. K., Good, Hsien K. and Toth, Istvan (2004). Toward the development of a synthetic group A streptococcal vaccine of high purity and broad protective coverage. Journal of Medicinal Chemistry, 47 (16), 4100-4104. doi: 10.1021/jm040041w

Toward the development of a synthetic group A streptococcal vaccine of high purity and broad protective coverage

2004

Conference Publication

Liposaccharide delivery system: Application to Conotoxin MII and Endomorphin 1

Blanchfield, J. T., Koda, Y., Gallagher, O. P. and Toth, I. (2004). Liposaccharide delivery system: Application to Conotoxin MII and Endomorphin 1. 20th RACI Organic Chemistry Conference, Cairns, 4-8 July, 2004.

Liposaccharide delivery system: Application to Conotoxin MII and Endomorphin 1

2004

Journal Article

Permeability studies of alkylamides and caffeic acid conjugates from echinacea using a Caco-2 cell monolayer model

Matthias, A., Blanchfield, J. T., Penman, K. G., Toth, I., Lang, C. S., De Voss, J. J. and Lehmann, R. P. (2004). Permeability studies of alkylamides and caffeic acid conjugates from echinacea using a Caco-2 cell monolayer model. Journal of Clinical Pharmacy And Therapeutics, 29 (1), 7-13. doi: 10.1046/j.1365-2710.2003.00530.x

Permeability studies of alkylamides and caffeic acid conjugates from echinacea using a Caco-2 cell monolayer model

2004

Conference Publication

Novel vaccine delivery systems

Toth, I. (2004). Novel vaccine delivery systems. GPEN 2004, Kyoto, 26-28 May, 2004.

Novel vaccine delivery systems

2004

Journal Article

Nucleophilic substitution reactions of pyranose polytosylates

McGeary, R. P., Rasoul Amini, S., Tang, V. W. S. and Toth, I. (2004). Nucleophilic substitution reactions of pyranose polytosylates. Journal of Organic Chemistry, 69 (8), 2727-2730. doi: 10.1021/jo035779k

Nucleophilic substitution reactions of pyranose polytosylates

2004

Journal Article

Design, Synthesis, and Evaluation of a Liposaccharide Drug Delivery Agent: Application to the Gastrointestinal Absorption of Gentamicin

Ross, B. P., DeCruz, S. E., Lynch, T. B., Davis-Goff, K. and Toth, I. (2004). Design, Synthesis, and Evaluation of a Liposaccharide Drug Delivery Agent: Application to the Gastrointestinal Absorption of Gentamicin. Journal of Medicinal Chemistry, 47 (5), 1251-1258. doi: 10.1021/jm030474j

Design, Synthesis, and Evaluation of a Liposaccharide Drug Delivery Agent: Application to the Gastrointestinal Absorption of Gentamicin

2004

Conference Publication

Lipid and carbohydrate based macromolecules in drug and vaccine delivery

Toth, I., Horvath, A., Blanchfield, J. T., Olive, C., Good, M. F., Wimmer, N. and Rakoczy, E.P. (2004). Lipid and carbohydrate based macromolecules in drug and vaccine delivery. 18th American Peptide Symposium, Boston, 19-23 July, 2004.

Lipid and carbohydrate based macromolecules in drug and vaccine delivery

2004

Journal Article

Lipid core peptide technology and group A streptococcal vaccine delivery

Olive, C., Batzloff, M.R. and Toth, I. (2004). Lipid core peptide technology and group A streptococcal vaccine delivery. Expert Review of Vaccines, 3 (1), 43-58. doi: 10.1586/14760584.3.1.43

Lipid core peptide technology and group A streptococcal vaccine delivery

2004

Conference Publication

A novel liposaccharide system for the delivery of Endormorphin 1

Koda, Y., Blanchfield, J. T., Okada, Y. and Toth, I. (2004). A novel liposaccharide system for the delivery of Endormorphin 1. PSWC 2004, Kyoto, 29 May- 3 June, 2004.

A novel liposaccharide system for the delivery of Endormorphin 1

2004

Conference Publication

Incorporation of lipoamino acids - peptide conjugates within liposomes: Effect of alkyl chain length, number of alkyl chains and method of liposome preparation

Liang, M.T., Davies, N. M. and Toth, I. (2004). Incorporation of lipoamino acids - peptide conjugates within liposomes: Effect of alkyl chain length, number of alkyl chains and method of liposome preparation. Annual Conference of the APSA, 2004, Melbourne, Vic, Australia, 4-7 December, 2004. Mount Waverley, Victoria: Australasian Pharmaceutical Science Association.

Incorporation of lipoamino acids - peptide conjugates within liposomes: Effect of alkyl chain length, number of alkyl chains and method of liposome preparation

2004

Journal Article

Mucosal immunization: Adjuvants and delivery systems

Moyle, P.M., McGeary, R. P., Blanchfield, J. T. and Toth, I. (2004). Mucosal immunization: Adjuvants and delivery systems. Current Drug Delivery, 1 (4), 385-396. doi: 10.2174/1567201043334588

Mucosal immunization: Adjuvants and delivery systems

2004

Conference Publication

Preparation of peptide functionalized nanoparticles by interfacial polymerisation of w/o microemulsions

Liang, M. T., Davies, N. M. and Toth, I. (2004). Preparation of peptide functionalized nanoparticles by interfacial polymerisation of w/o microemulsions. CTP 2004, Brisbane, 1-6 Aug 2004. Australia: Blackwell Publishing Asia.

Preparation of peptide functionalized nanoparticles by interfacial polymerisation of w/o microemulsions

2003

Edited Outputs

Mini-Reviews in Medicinal Chemistry

Mini-Reviews in Medicinal Chemistry. (2003). 3 (7)

Mini-Reviews in Medicinal Chemistry

2003

Journal Article

Development of lipid-core-peptide (LCP) based vaccines for the prevention of the group A streptococcal (GAS) infection

Moyle, P. M., Horvath, A., Olive, C., Good, M. F. and Toth, I. (2003). Development of lipid-core-peptide (LCP) based vaccines for the prevention of the group A streptococcal (GAS) infection. Letters In Peptide Science, 10 (5-6), 605-613. doi: 10.1007/BF02442594

Development of lipid-core-peptide (LCP) based vaccines for the prevention of the group A streptococcal (GAS) infection

2003

Journal Article

Transdermal delivery of a tetrapeptide: Evaluation of passive diffusion

Benson, Heather A. E., Caccetta, Rima, Chen, Yan, Kearns, Philip and Toth, Istvan (2003). Transdermal delivery of a tetrapeptide: Evaluation of passive diffusion. Letters in Peptide Science, 10 (5-6), 615-620. doi: 10.1007/BF02442595

Transdermal delivery of a tetrapeptide: Evaluation of passive diffusion

2003

Journal Article

Potential of lipid core peptide technology as a novel self-adjuvanting vaccine delivery system for multiple different synthetic peptide immunogens

Olive, Colleen, Batzloff, Michael, Horvath, Aniko, Clair, Timothy, Yarwood, Penny, Toth, Istvan and Good, Michael F. (2003). Potential of lipid core peptide technology as a novel self-adjuvanting vaccine delivery system for multiple different synthetic peptide immunogens. Infection And Immunity, 71 (5), 2373-2383. doi: 10.1128/IAI.71.5.2373-2383.2003

Potential of lipid core peptide technology as a novel self-adjuvanting vaccine delivery system for multiple different synthetic peptide immunogens

2003

Journal Article

Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of α-conotoxin MII

Blanchfield, J. T., Dutton, J. T., Hogg, R. C., Gallagher, O. P., Craik, D. J., Jones, A., Adams, D. J., Lewis, R. J., Alewood, P. F. and Toth, I. (2003). Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of α-conotoxin MII. Journal of Medicinal Chemistry, 46 (7), 1266-1272. doi: 10.1021/jm020426j

Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of α-conotoxin MII

2003

Journal Article

A new principle for tight junction modulation based on occludin peptides

Tavelin, S., Hashimoto, K., Malkinson, J., Lazorova, L., Toth, I. and Artursson, P. (2003). A new principle for tight junction modulation based on occludin peptides. Molecular Pharmacology, 64 (6), 1530-1540. doi: 10.1124/mol.64.6.1530

A new principle for tight junction modulation based on occludin peptides

2003

Journal Article

Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure

Russell, F. D., Meyers, D. E., Galbraith, A., Bett, N., Toth, I., Kearns, P. S. and Molenaar, P. (2003). Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure. American Journal of Physiology - Heart & Circulatory Physiology, 285 (Oct.2003), H1576-H1581. doi: 10.1152/ajpheart.00217.2003

Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure

2003

Book Chapter

Drug delivery systems utilizing lipids and sugars

Wong, A., Bender, V. and Toth, I. (2003). Drug delivery systems utilizing lipids and sugars. Molecular Pathomechanisms and New Trends in Drug Research. (pp. 599-612) edited by G. Keri and I. Toth. London & New York: Taylor & Francis. doi: 10.1201/9780203219973.ch45

Drug delivery systems utilizing lipids and sugars

Current funding

  • 2024 - 2025
    Single-shot anti-fertility vaccine in pigs
    Australia's Economic Accelerator Seed Grants
    Open grant

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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