Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

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Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

501 - 520 of 683 works

2002

Conference Publication

A novel immunoadjuvant carrier system for synthetic peptides

Horvath, A., Olive, C., Good, M. F. and Toth, I. (2002). A novel immunoadjuvant carrier system for synthetic peptides. 27th European Peptide Symposium, Sorrento, Italy, 31 Aug. - 6 Sept. 2002. Napoli, Italy: E. Ziino.

A novel immunoadjuvant carrier system for synthetic peptides

2002

Journal Article

Lipoamino acid-based adjuvant carrier system: Enhanced immunogenicity of group a streptococcal peptide epitopes

Horvath, Aniko, Olive, Colleen, Wong, Allan, Clair, Timothy, Yarwood, Penny, Good, Michael and Toth, Istvan (2002). Lipoamino acid-based adjuvant carrier system: Enhanced immunogenicity of group a streptococcal peptide epitopes. Journal of Medicinal Chemistry, 45 (6), 1387-1390. doi: 10.1021/jm0110441

Lipoamino acid-based adjuvant carrier system: Enhanced immunogenicity of group a streptococcal peptide epitopes

2002

Conference Publication

Liposaccharides in drug delivery

Toth, I., Blanchfield, J. T., McGeary, R. P., Ross, B. P. and Chan, Y. (2002). Liposaccharides in drug delivery. XX1st International Carbohydrate Symposium, Cairns, 7-12 July 2002.

Liposaccharides in drug delivery

2002

Other Outputs

A multiple antigen lipophilic adjuvant carrier system (MALAC)

Toth, I., Horvath, A., Good, M. F. and Olive, C. (2002). A multiple antigen lipophilic adjuvant carrier system (MALAC). Australian Provisional PS2233.

A multiple antigen lipophilic adjuvant carrier system (MALAC)

2001

Journal Article

Lipid, sugar and liposaccharide based delivery systems

Wong, A. and Toth, I. (2001). Lipid, sugar and liposaccharide based delivery systems. Current medicinal chemistry, 8 (9), 1123-36.

Lipid, sugar and liposaccharide based delivery systems

2001

Journal Article

The synthesis and structure of an n-terminal dodecanoic acid conjugate of a-conotoxin MII

Blanchfield, Joanne T., Dutton, Julie T., Hogg, R. C., Craik, D. J., Adams, D. J., Lewis, R. J., Alewood, P. and Toth, I. (2001). The synthesis and structure of an n-terminal dodecanoic acid conjugate of a-conotoxin MII. Letters in Peptide Science, 8 (3-5), 235-239. doi: 10.1023/A:1016577832311

The synthesis and structure of an n-terminal dodecanoic acid conjugate of a-conotoxin MII

2001

Conference Publication

Towards synthetic vaccines built on carbohydrate cores

McGeary, Ross P., Jablonkai, Istvan and Toth, Istvan (2001). Towards synthetic vaccines built on carbohydrate cores. Netherlands: Springer. doi: 10.1023/A:1016212726860

Towards synthetic vaccines built on carbohydrate cores

2001

Journal Article

Towards synthetic vaccines built on carbohydrate cores

McGeary, Ross P., Jablonkai, Istvan and Toth, Istvan (2001). Towards synthetic vaccines built on carbohydrate cores. Letters in Peptide Science, 8 (3-5), 273-276. doi: 10.1007/bf02446528

Towards synthetic vaccines built on carbohydrate cores

2001

Journal Article

A lipophilic adjuvant carrier system for antigenic peptides

Horvath, Aniko, Olive, Colleen, Wong, Allan, Clair, Timothy, Yarwood, Penny, Good, Michael and Toth, Istvan (2001). A lipophilic adjuvant carrier system for antigenic peptides. Letters in Peptide Science, 8 (3-5), 285-288. doi: 10.1007/BF02446530

A lipophilic adjuvant carrier system for antigenic peptides

2001

Journal Article

A novel method for solid-phase synthesis of oligosaccharides using the N-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl (Dde) linker

Drinnan, Nicholas, West, Michael L., Broadhurst, Max, Kellam, Barrie and Toth, Istvan (2001). A novel method for solid-phase synthesis of oligosaccharides using the N-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl (Dde) linker. Tetrahedron Letters, 42 (6), 1159-1162. doi: 10.1016/S0040-4039(00)02197-3

A novel method for solid-phase synthesis of oligosaccharides using the N-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl (Dde) linker

2001

Conference Publication

Enhanced immunogenicity of group A streptococcal peptide epitopes by lipoamino acid based adjuvant carrier system.

Schubert, A., Olive, C., Wong, A. K., Good, M. F. and Toth, I. (2001). Enhanced immunogenicity of group A streptococcal peptide epitopes by lipoamino acid based adjuvant carrier system.. APSA Annual Conference 2001, Melbourne, 9-12 Dec 2001. Melbourne: Australasian Pharmaceutical Science Association.

Enhanced immunogenicity of group A streptococcal peptide epitopes by lipoamino acid based adjuvant carrier system.

2001

Conference Publication

Allosamines and galactosamines from glucosamine: Control of stereochemical inversions at C-3 and C-4.

Mcgeary, R. P., Wright, K. and Toth, I. (2001). Allosamines and galactosamines from glucosamine: Control of stereochemical inversions at C-3 and C-4.. Brisbane Biological and Organic Chemistry Symposium 2001, UQ, Brisbane, 30 Nov 2001. Brisbane:

Allosamines and galactosamines from glucosamine: Control of stereochemical inversions at C-3 and C-4.

2001

Conference Publication

Enhancing peptide delivery using lipoamino acids and liposaccharides.

Mcgeary, R. P., Blanchfield, J. T., Rhee, H., Alewood, P.F. and Toth, I. (2001). Enhancing peptide delivery using lipoamino acids and liposaccharides.. 7th International Symposium on Solid Phase Synthesis & Combinatorial Chemical Libraries, Southampton, UK, 18-22 Sept 2001. UK: European Peptide Society & BS/RSC Protein & Peptide Group, UK.

Enhancing peptide delivery using lipoamino acids and liposaccharides.

2001

Conference Publication

Determination of the transport across Caco-2 cell monolayers of compounds varying in lipophilicity using LC-MS

Wong, A. K., Ross, B. P., Artusson, P., Lazorova, L. and Toth, I. (2001). Determination of the transport across Caco-2 cell monolayers of compounds varying in lipophilicity using LC-MS. 26th European Peptide Conference, Montpellier, France, 10th - 15th September, 2000. Paris, France: EDK.

Determination of the transport across Caco-2 cell monolayers of compounds varying in lipophilicity using LC-MS

2001

Journal Article

Lipophilic methotrexate conjugates with glucose-lipoamino acid moieties: Synthesis and in vitro antitumor activity

Pignatello, R., Vicari, L., Sorrenti, V., Di Giacomo, C., Spampinato, G., Puglisi, G. and Toth, I. (2001). Lipophilic methotrexate conjugates with glucose-lipoamino acid moieties: Synthesis and in vitro antitumor activity. Drug Development Research, 52 (3), 454-461. doi: 10.1002/ddr.1147

Lipophilic methotrexate conjugates with glucose-lipoamino acid moieties: Synthesis and in vitro antitumor activity

2001

Other Outputs

Oligosaccharide synthesis

Toth, I., Dekany, G. and Kellam, B. (2001). Oligosaccharide synthesis. 728149.

Oligosaccharide synthesis

2001

Conference Publication

Synthesis of cationic lipidic peptide dendrimer vectors for in vitro oligonucleotide delivery.

Kearns, P. S., Wimmer, N., Rakoczy, P. E. and Toth, I. (2001). Synthesis of cationic lipidic peptide dendrimer vectors for in vitro oligonucleotide delivery.. APSA Annual Conference 2001, Melbourne, 9-12 Dec 2001. Melbourne: Australasian Pharmaceutical Science Association.

Synthesis of cationic lipidic peptide dendrimer vectors for in vitro oligonucleotide delivery.

2001

Conference Publication

Synthesis of lipo- and liposacchride a-conotoxin MII conjugates

Blanchfield, J. T., Alewood, P.F., Lewis, R. J., Dutton, J. L., Craik, D. J. and Toth, I. (2001). Synthesis of lipo- and liposacchride a-conotoxin MII conjugates. World Chemistry Congress, Brisbane, Australia, 1-6 July, 2001. Royal Australian Chemical Institute.

Synthesis of lipo- and liposacchride a-conotoxin MII conjugates

2001

Conference Publication

Further characterization of an astrocyte secreted factor that increases transendothelial electrical resistance in an in vitro model of the blood-brain barrier

Jordan, L. R., Kearns, P. S. and Toth, I. (2001). Further characterization of an astrocyte secreted factor that increases transendothelial electrical resistance in an in vitro model of the blood-brain barrier. Int. Congress of Physiological Sciences 2001 Satellite, Tasmania, 21-24 August. International Union of Physiological Sciences (IUPS).

Further characterization of an astrocyte secreted factor that increases transendothelial electrical resistance in an in vitro model of the blood-brain barrier

2001

Conference Publication

Synthetic vaccines: Enhanced immunogenicity of Streptococcus peptide epitopes.

Mcgeary, R. P., Schubert, A., Olive, C., Hayman, W., Good, M. F. and Toth, I. (2001). Synthetic vaccines: Enhanced immunogenicity of Streptococcus peptide epitopes.. Brisbane Biological & Organic Chemistry Symposium 2001, University of Queensland, Brisbane, 30 Nov 2001.

Synthetic vaccines: Enhanced immunogenicity of Streptococcus peptide epitopes.

Current funding

  • 2024 - 2025
    Single-shot anti-fertility vaccine in pigs
    Australia's Economic Accelerator Seed Grants
    Open grant

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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