Emeritus Professor Istvan Toth
Emeritus Professor

Istvan Toth

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Background

Professor István Tóth is Chair in Biological Chemistry at The University of Queensland (UQ), Brisbane, Australia, and Affiliated Professorial Research Fellow at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary and was awarded his PhD for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate, then Scientific Group Leader at the Central Research Institute for Chemistry, Hungarian Academy of Science. He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctor of Science degree (DSc 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group. Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013). Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $85 million in competitive grants, research contracts and investment funds in the past 10 years. Professor Tóth has over 500 peer-reviewed publications, 45 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia, Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. and Feklloiw of the Hungarian Academy of Sciences (since 2016) In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development he obtained the Doctor Honoris Causa degree at Semmelweis university budapest Hungary (2019). Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society.

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Doctor of Philosophy of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics
  • Doctoral Diploma of Medicinal and Biomolecular Chemistry, Budapest University of Technology and Economics

Search Professor Istvan Toth’s works on UQ eSpace

683 works between 1972 and 2025
All (683) Journal Article (480) Book Chapter (42) Conference Publication (151) Book (3) Other Outputs (6) Edited Outputs (1)

421 - 440 of 683 works

2006

Journal Article

Investigation of the route of absorption of lipid and sugar modified leu-enkephalin analogues and their enzymatic stability using the Caco-2 cell monolayer system

Wu, S., Christopher, C., Koda, Y., Blanchfield, J. T. and Toth, I. (2006). Investigation of the route of absorption of lipid and sugar modified leu-enkephalin analogues and their enzymatic stability using the Caco-2 cell monolayer system. Medicinal Chemistry, 2 (2), 203-211. doi: 10.2174/157340606776056205

Investigation of the route of absorption of lipid and sugar modified leu-enkephalin analogues and their enzymatic stability using the Caco-2 cell monolayer system

2006

Conference Publication

Development of peptide vaccines against HPV-16 associated cervical cancer and group a streptococci

Moyle, Peter M., Horvath, Aniko, Karpati, Levente, Olive, Colleen, Barozzi, Nadia, Wimmer, Norbert, Good, Michael and Toth, Istvan (2006). Development of peptide vaccines against HPV-16 associated cervical cancer and group a streptococci. 19th American Peptide Symposium, San Diego, United States, 18-23 June 2005. New York, United States: Springer. doi: 10.1007/978-0-387-26575-9_169

Development of peptide vaccines against HPV-16 associated cervical cancer and group a streptococci

2006

Conference Publication

Novel glyco-lipid-arsenicals(III) with anti-proliferative effects on MCF-7 human breast cancer cells

Wimmer, N, Robinson, JA, Gopisetty-Venkatta, N, Roberts-Thomson, SJ, Monteith, GR and Toth, I (2006). Novel glyco-lipid-arsenicals(III) with anti-proliferative effects on MCF-7 human breast cancer cells. 19th American Peptide Symposium, San Diego, CA, United States, June 18-23 2005. New York, N.Y., United States: Springer. doi: 10.1007/978-0-387-26575-9_148

Novel glyco-lipid-arsenicals(III) with anti-proliferative effects on MCF-7 human breast cancer cells

2006

Conference Publication

Development of vaccines for the prevention and/or treatment of human papillomavirus type-16 associated cervical cancer

Simerska, P, Moyle, P. M., Olive, C., Sun, H., Ho, M.-F., Pandy, M.G., Dyer, J. R., Burgess, M L and Toth, I (2006). Development of vaccines for the prevention and/or treatment of human papillomavirus type-16 associated cervical cancer. Brisbane Biological & Organic Chemistry Symposium, Brisbane, 24 November 2006.

Development of vaccines for the prevention and/or treatment of human papillomavirus type-16 associated cervical cancer

2006

Journal Article

Polycationic lipophilic-core dendrons as penetration enhancers for the oral administration of low molecular weight heparin

Hayes, Patricia Y., Ross, Benjamin P., Thomas, Bradley G. and Toth, Istvan (2006). Polycationic lipophilic-core dendrons as penetration enhancers for the oral administration of low molecular weight heparin. Bioorganic & Medicinal Chemistry, 14 (1), 143-152. doi: 10.1016/j.bmc.2005.08.004

Polycationic lipophilic-core dendrons as penetration enhancers for the oral administration of low molecular weight heparin

2006

Conference Publication

Development of vaccines for the prevention and/or treatment of human papillomavirus type-16 associated cervical cancer

Simerska, P., Moyle, P. M., Olive, C., Sun, H. K., Ho, M. F., Pandy, M. G., Dyer, J. R., Burgess, M. L. and Toth, I. (2006). Development of vaccines for the prevention and/or treatment of human papillomavirus type-16 associated cervical cancer. GPEN 2006, Lawrence, USA, 25-27 October, 2006.

Development of vaccines for the prevention and/or treatment of human papillomavirus type-16 associated cervical cancer

2006

Conference Publication

Synthesis and immunological evaluation of M protein targeted tetra-valent and tri-valent group A streptococcal vaccine candidates based on the lipid-core peptide system

Moyle, Peter Michael, Olive, Colleen, Karpati, Levente, Barozzi, Nadia, Ho, Mei-Fong, Dyer, Joanne, Sun, Hsien Kuo, Good, Michael and Toth, Istvan (2006). Synthesis and immunological evaluation of M protein targeted tetra-valent and tri-valent group A streptococcal vaccine candidates based on the lipid-core peptide system. 6th Australian Peptide Conference, Whitsunday Islands, Australia, 9-14 October, 2005. Netherlands: Springer. doi: 10.1007/s10989-006-9021-8

Synthesis and immunological evaluation of M protein targeted tetra-valent and tri-valent group A streptococcal vaccine candidates based on the lipid-core peptide system

2006

Conference Publication

Uptake of a multi-component non-viral gene delivery system and gene expression in mammalian cells

Yang, S, Coles, D. J., Esposito, A., Mitchell, D J, Toth, I and Minchin, R F (2006). Uptake of a multi-component non-viral gene delivery system and gene expression in mammalian cells. Annual Conference of the Australasian Pharmaceutical Science n, Adelaide, 3-5 December, 2006.

Uptake of a multi-component non-viral gene delivery system and gene expression in mammalian cells

2006

Conference Publication

Synthesis and characterisation of Trp modified Leu-Enkephalin analogues

Del Borgo, M, Wang, R., Toth, I and Blanchfield, J T (2006). Synthesis and characterisation of Trp modified Leu-Enkephalin analogues. Brisbane Biological & Organic Chemistry Symposium, Brisbane, 24 Nov 2006.

Synthesis and characterisation of Trp modified Leu-Enkephalin analogues

2006

Journal Article

Method for the synthesis of highly pure vaccines using the lipid core peptide system

Moyle, P. M., Olive, C., Good, M. F. and Toth, I. (2006). Method for the synthesis of highly pure vaccines using the lipid core peptide system. Journal of Peptide Science, 12 (12), 800-807. doi: 10.1002/psc.815

Method for the synthesis of highly pure vaccines using the lipid core peptide system

2006

Journal Article

Enhancement of drug affinity for cell membranes by conjugation with lipoamino acids II. Experimental and computational evidence using biomembrane models

Pignatello, Rosario, Guccione, Salvatore, Castelli, Francesco, Sarpietro, Maria G., Giurato, Laura, Lombardo, Massimo, Puglisi, Giovanni and Toth, Istvan (2006). Enhancement of drug affinity for cell membranes by conjugation with lipoamino acids II. Experimental and computational evidence using biomembrane models. International Journal of Pharmaceutics, 310 (1-2), 53-63. doi: 10.1016/j.ijpharm.2005.11.044

Enhancement of drug affinity for cell membranes by conjugation with lipoamino acids II. Experimental and computational evidence using biomembrane models

2006

Conference Publication

Chemoselective peptide attachment to well-defined star polymer for peptide delivery

Liang, M, Monteiro, M J and Toth, I (2006). Chemoselective peptide attachment to well-defined star polymer for peptide delivery. Annual Conference of the Australasian Pharmaceutical Science n, Adelaide, 3-5 Dec, 2006.

Chemoselective peptide attachment to well-defined star polymer for peptide delivery

2006

Conference Publication

Synthetic lipopeptides formulated in liposomes: effect on their immune stimulatory capacity in vitro

Liang, Ming T., Hennessy, Tania, Toth, Istvan, Davies, Nigel M. and Hook, Sarah (2006). Synthetic lipopeptides formulated in liposomes: effect on their immune stimulatory capacity in vitro. International Conference on Nanoscience and Nanotechnology, Brisbane, QLD, Australia, 3-7 July 2006. Piscataway, NJ, United States: IEEE. doi: 10.1109/ICONN.2006.340608

Synthetic lipopeptides formulated in liposomes: effect on their immune stimulatory capacity in vitro

2006

Conference Publication

Liposaccharide based vaccine carrier adjuvant systems

Simerska, P., Bong, Y. K., McGeary, R. P., Moyle, P. M. and Toth, I. (2006). Liposaccharide based vaccine carrier adjuvant systems. Drug Design Amongst the Vines, Hunter Valley, 3 - 7 December 2006.

Liposaccharide based vaccine carrier adjuvant systems

2006

Conference Publication

Structure-activity relationships of potential self-adjuvanting vaccines against Group A streptococcus based on the carboxyl group of its M-protein

Abdel-Aal, A. M. and Toth, I (2006). Structure-activity relationships of potential self-adjuvanting vaccines against Group A streptococcus based on the carboxyl group of its M-protein. Brisbane Biological & Organic Chemistry Symposium, Brisbane, 24 November 2006.

Structure-activity relationships of potential self-adjuvanting vaccines against Group A streptococcus based on the carboxyl group of its M-protein

2006

Journal Article

Anti-proliferative effects of novel Glyco-lipid-arsenicals (III) on MCF-7 human breast cancer cells

Wimmer, N., Robinson, J. A., Gopisetty Venkata, N., Roberts-Thomson, S. J., Monteith, G. R. and Toth, I. (2006). Anti-proliferative effects of novel Glyco-lipid-arsenicals (III) on MCF-7 human breast cancer cells. Medicinal Chemistry, 2 (1), 79-87. doi: 10.2174/157340606775197714

Anti-proliferative effects of novel Glyco-lipid-arsenicals (III) on MCF-7 human breast cancer cells

2006

Journal Article

Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition

Parekh, H. S., Marano, R. J., Rakoczy, E. P., Blanchfield, J. and Toth, I. (2006). Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition. Bioorganic & Medicinal Chemistry, 14 (14), 4775-4780. doi: 10.1016/j.bmc.2006.03.029

Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition

2005

Journal Article

Dendrimer delivery of an anti-VEGF oligonucleotide into the eye: A long-term study into inhibition of laser-induced CNV, distribution, uptake and toxicity

Marano, R. J., Toth, I., Wimmer, N., Brankov, M. and Rakoczy, E. P. (2005). Dendrimer delivery of an anti-VEGF oligonucleotide into the eye: A long-term study into inhibition of laser-induced CNV, distribution, uptake and toxicity. Gene Therapy, 12 (21), 1544-1550. doi: 10.1038/sj.gt.3302579

Dendrimer delivery of an anti-VEGF oligonucleotide into the eye: A long-term study into inhibition of laser-induced CNV, distribution, uptake and toxicity

2005

Journal Article

Gastrointestinal absorption of Heparin by lipidization or coadministration with penetration enhancers

Ross, B. P. and Toth, I. (2005). Gastrointestinal absorption of Heparin by lipidization or coadministration with penetration enhancers. Current Drug Delivery, 2 (3), 277-287. doi: 10.2174/1567201054367968

Gastrointestinal absorption of Heparin by lipidization or coadministration with penetration enhancers

2005

Conference Publication

Protection against group A streptococcal infection by vaccination with self-adjuvanting lipid core M protein peptides

Olive, C., Hsien, K., Horvath, A., Clair, T., Yarwood, P., Toth, I. and Good, M. F. (2005). Protection against group A streptococcal infection by vaccination with self-adjuvanting lipid core M protein peptides. Oxford, U.K.: Elsevier. doi: 10.1016/j.vaccine.2005.01.041

Protection against group A streptococcal infection by vaccination with self-adjuvanting lipid core M protein peptides

Current funding

  • 2024 - 2025
    Single-shot anti-fertility vaccine in pigs
    Australia's Economic Accelerator Seed Grants
    Open grant

Availability

Emeritus Professor Istvan Toth is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Istvan Toth directly for media enquiries about:

  • Chemistry - lipid
  • Chemistry - medicinal
  • Chemistry - peptide
  • Chemistry - sugar
  • Drug - oral administration
  • Drug delivery
  • Genes and vaccines
  • Immunisation
  • Lipid chemistry
  • Medicinal chemistry
  • Oral administration of vaccines
  • Peptide chemistry
  • Peptide drug delivery
  • Sugar chemistry
  • Vaccines - oral administration
  • Vaccines and genes

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